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GENE - TERM ANNOTATION REPORT

RGD ID: 12486175
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: DOID:1824
Term: status epilepticus
Definition: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
Definition Source(s): MESH:D013226
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnf ISOBdnf (Rattus norvegicus)9068941RGD PMID:19366663 PMID:19686240 REF_RGD_ID:4891125 REF_RGD_ID:5684912
Bdnf ISOBDNF (Homo sapiens)9068941RGD PMID:19686240 REF_RGD_ID:5684912
Bdnf ISOBDNF (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:8635431 PMID:8821376
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