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GENE - TERM ANNOTATION REPORT

RGD ID: 12252074
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: NPPA
Name: natriuretic peptide A
Acc ID: DOID:9003936
Term: Cardiomegaly
Definition: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Definition Source(s): MESH:D006332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPPA ISONppa (Mus musculus)9068941RGDmRNA, protein:increased expression:heart (mouse)PMID:26597775 REF_RGD_ID:11554891
NPPAamelioratesISONppa (Mus musculus)9068941RGD PMID:24275554 REF_RGD_ID:11252017
NPPAtreatmentISONppa (Mus musculus)9068941RGD PMID:23188126 REF_RGD_ID:155663352
NPPAtreatmentISONppa (Rattus norvegicus)9068941RGD PMID:23905381 REF_RGD_ID:7297051
NPPA ISONPPA (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:12224825 PMID:18056528 PMID:20886221 PMID:21242511 PMID:21297083 PMID:22083722
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