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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10812
Species: Mus musculus
RGD Object: Gene
Symbol: Ins2
Name: insulin II
Acc ID: CHEBI:7726
Term: octreotide
Definition: A homodetic cyclic peptide that has formula C49H66N10O10S2.
Chemical ID: MESH:D015282
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2affects secretionISOINS (Homo sapiens)6480464CTDOctreotide affects the secretion of INS proteinPMID:2111918
Ins2decreases expressionISOINS (Homo sapiens)6480464CTDOctreotide results in decreased expression of INS proteinPMID:7493436 PMID:7917157
Ins2decreases secretionISOIns2 (Rattus norvegicus)6480464CTDOctreotide results in decreased secretion of INS proteinPMID:8261660
Ins2decreases secretionISOINS (Homo sapiens)6480464CTDOctreotide results in decreased secretion of INS proteinPMID:8422773
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTDOctreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein]PMID:7792821 PMID:7917157
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