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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:octreotide
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Accession:CHEBI:7726 term browser browse the term
Definition:A homodetic cyclic peptide that has formula C49H66N10O10S2.
Synonyms:related_synonym: D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide;   D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2->7)-disulfide;   Formula=C49H66N10O10S2;   Formula=C49H66N10O10S2.2C2H4O2;   InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39?,40+,41+,42+/m1/s1;   InChIKey=DEQANNDTNATYII-FLDZURHUSA-N;   Longastatin;   SMILES=[H][C@]1(NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)NC(CO)[C@@H](C)O)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O;   SMS-201-995;   octreotida;   octreotide acetate;   octreotidum;   sandostatine
 xref: Beilstein:7246145;   CAS:83150-76-9;   DrugBank:DB00104;   Drug_Central:1980;   HMDB:HMDB0014262;   KEGG:C07306;   KEGG:D00442
 xref_mesh: MESH:D015282
 xref: PDB:1SOC;   Patent:EP29579;   Patent:US4395403;   Wikipedia:Octreotide



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octreotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO Octreotide results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Octreotide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:12890342 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO Octreotide results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein
CTD PMID:15046398 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of BECN1 protein]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of BECN1 mRNA]] CTD PMID:35307376 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO Octreotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO Octreotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Octreotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO Octreotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
[Octreotide results in increased activity of SSTR2 protein] which results in increased activity of CASP3 protein; Octreotide results in increased activity of CASP3 protein
Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]]
CTD PMID:16601281 PMID:16954443 PMID:35307376 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cck cholecystokinin decreases secretion
decreases response to substance
ISO Octreotide results in decreased secretion of CCK protein
Octreotide results in decreased susceptibility to CCK protein
CTD PMID:1631261 PMID:2883060 PMID:8314514 PMID:11148435 PMID:11552916 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
JBrowse link
G Cga glycoprotein hormones, alpha subunit decreases secretion ISO Octreotide results in decreased secretion of CGA protein CTD PMID:1518435 NCBI chr 4:34,893,779...34,907,374
Ensembl chr 4:34,893,779...34,907,370
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]
NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]
CTD PMID:23137853 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Octreotide results in increased expression of FAS protein CTD PMID:18642777 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand increases expression ISO Octreotide results in increased expression of FASLG protein CTD PMID:18642777 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions EXP
ISO
NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
Octreotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; Octreotide inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]; Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
CTD PMID:23137853 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA CTD PMID:17959037 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gh growth hormone decreases secretion
decreases expression
affects expression
multiple interactions
ISO Octreotide results in decreased secretion of GH1 protein
Octreotide results in decreased expression of GH protein; Octreotide results in decreased expression of GH1 protein
Octreotide affects the expression of GH1 protein
[Octreotide co-treated with Sodium Glutamate] results in decreased expression of and results in decreased secretion of GH1 protein
CTD PMID:1516598 PMID:1518433 PMID:1561523 PMID:1682667 PMID:1683947 More... NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
JBrowse link
G Ghrh growth hormone releasing hormone decreases expression
multiple interactions
ISO Octreotide results in decreased expression of GHRH mRNA
[Sodium Glutamate co-treated with Octreotide] results in decreased expression of GHRH mRNA
CTD PMID:9053782 NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble affects expression ISO Octreotide affects the expression of GPT protein CTD PMID:25338529 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Grk1 G protein-coupled receptor kinase 1 multiple interactions EXP Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA] CTD PMID:18624922 NCBI chr 8:13,455,081...13,471,951
Ensembl chr 8:13,455,081...13,471,951
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO Octreotide affects the expression of HMOX1 mRNA; Octreotide affects the expression of HMOX1 protein CTD PMID:25338529 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]] CTD PMID:23137853 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein multiple interactions ISO Octreotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]; Octreotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; Octreotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]; Octreotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
ISO Octreotide results in decreased expression of IGF1 protein
Octreotide affects the expression of IGF1 protein
CTD PMID:1516598 PMID:2111918 PMID:2404445 PMID:7711880 PMID:10806600 More... NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Ins2 insulin II affects secretion
decreases expression
decreases secretion
multiple interactions
ISO Octreotide affects the secretion of INS protein
Octreotide results in decreased expression of INS protein
Octreotide results in decreased secretion of INS protein
Octreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein]
CTD PMID:2111918 PMID:7493436 PMID:7792821 PMID:7917157 PMID:8261660 More... NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [Octreotide results in increased activity of SSTR2 protein] which results in increased expression of KRT18 protein modified form CTD PMID:16954443 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]; SIRT1 promotes the reaction [SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]; YAP1 promotes the reaction [SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]] CTD PMID:35307376 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Nog noggin multiple interactions EXP NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158
JBrowse link
G Prl prolactin decreases expression
multiple interactions
decreases secretion
affects expression
ISO Octreotide results in decreased expression of PRL protein
Colforsin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]; Octreotide inhibits the reaction [Colforsin results in increased expression of PRL protein]; Pertussis Toxin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]
Octreotide affects the expression of PRL protein
CTD PMID:1322274 PMID:2111918 PMID:15046398 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Rgs1 regulator of G-protein signaling 1 multiple interactions EXP Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] CTD PMID:18624922 NCBI chr 1:144,120,407...144,124,862
Ensembl chr 1:144,118,034...144,124,980
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SIRT1 mRNA]; SIRT1 promotes the reaction [SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]]; SIRT1 promotes the reaction [SNHG12 mRNA results in increased susceptibility to Octreotide]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SIRT1 mRNA]] CTD PMID:35307376 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Smad6 SMAD family member 6 decreases expression ISO Octreotide results in decreased expression of SMAD6 mRNA CTD PMID:23137853 NCBI chr 9:63,860,358...63,929,374
Ensembl chr 9:63,860,358...63,929,341
JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO Octreotide results in decreased expression of SMAD7 mRNA CTD PMID:23137853 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006
JBrowse link
G Snhg12 small nucleolar RNA host gene 12 multiple interactions
increases response to substance
EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SNHG12 mRNA]; SIRT1 promotes the reaction [SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]]; SIRT1 promotes the reaction [SNHG12 mRNA results in increased susceptibility to Octreotide]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of BECN1 mRNA]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SIRT1 mRNA]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SQSTM1 mRNA]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of TAF15 mRNA]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of YAP1 mRNA]]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]]; YAP1 promotes the reaction [SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]]; YAP1 promotes the reaction [SNHG12 mRNA results in increased susceptibility to Octreotide] CTD PMID:35307376 NCBI chr 4:132,035,989...132,038,335
Ensembl chr 4:132,035,932...132,038,762
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SQSTM1 protein]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SQSTM1 mRNA]] CTD PMID:35307376 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Sst somatostatin decreases secretion
decreases expression
ISO Octreotide results in decreased secretion of SST protein
Octreotide results in decreased expression of SST mRNA
CTD PMID:9053782 PMID:16601281 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708
JBrowse link
G Sstr1 somatostatin receptor 1 multiple interactions EXP Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]] CTD PMID:18624922 NCBI chr12:58,258,524...58,262,822
Ensembl chr12:58,258,558...58,260,673
JBrowse link
G Sstr2 somatostatin receptor 2 increases activity
affects response to substance
multiple interactions
ISO
EXP
[Octreotide results in increased activity of SSTR2 protein] which results in increased activity of CASP3 protein
SSTR2 protein affects the susceptibility to Octreotide
[Octreotide results in increased activity of SSTR2 protein] which results in increased expression of KRT18 protein modified form
CTD PMID:16954443 PMID:17363388 NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP
Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
CTD PMID:23137853 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Taf15 TATA-box binding protein associated factor 15 multiple interactions EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of TAF15 mRNA]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of TAF15 mRNA]] CTD PMID:35307376 NCBI chr11:83,363,897...83,397,569
Ensembl chr11:83,363,912...83,397,569
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Octreotide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:12890342 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
Octreotide results in decreased expression of TNF mRNA
Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased secretion of TNF protein]
CTD PMID:21692635 PMID:35307376 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a increases expression ISO Octreotide results in increased expression of TNFRSF1A mRNA CTD PMID:21692635 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b increases expression ISO Octreotide results in increased expression of TNFRSF1B mRNA; Octreotide results in increased expression of TNFRSF1B protein CTD PMID:21692635 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein] CTD PMID:1518433 NCBI chr 6:92,219,042...92,221,631
Ensembl chr 6:92,219,042...92,221,631
JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO Octreotide results in decreased expression of TP53 protein CTD PMID:21764706 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions
decreases secretion
ISO Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein]
Octreotide results in decreased secretion of TSHB protein
CTD PMID:1518433 PMID:1518435 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Octreotide results in decreased expression of VEGFA protein CTD PMID:19624890 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Yap1 yes-associated protein 1 multiple interactions EXP Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of YAP1 mRNA]; SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of YAP1 mRNA]]; YAP1 promotes the reaction [SNHG12 mRNA promotes the reaction [Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of MAP1LC3B protein]]]; YAP1 promotes the reaction [SNHG12 mRNA results in increased susceptibility to Octreotide] CTD PMID:35307376 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        pharmacological role 19771
          agonist 19260
            hormone agonist 2843
              octreotide 49
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              peptide 11229
                                                cyclic peptide 8983
                                                  homodetic cyclic peptide 8478
                                                    octreotide 49
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