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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10226
Species: Mus musculus
RGD Object: Gene
Symbol: Bax
Name: BCL2-associated X protein
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDSIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]]PMID:36800006
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDMetformin affects the expression of BAX proteinPMID:29226720
Baxincreases expressionISOBax (Rattus norvegicus)6480464CTDMetformin results in increased expression of BAX mRNAPMID:25596134
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDMetformin results in increased expression of BAX proteinPMID:21388661
Baxmultiple interactionsISOBax (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]PMID:26492952 PMID:28106847 PMID:30144576 PMID:35414346 PMID:36800006
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDCisplatin promotes the reaction [Metformin results in increased expression of BAX protein]PMID:21388661
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