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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10226
Species: Mus musculus
RGD Object: Gene
Symbol: Bax
Name: BCL2-associated X protein
Acc ID: CHEBI:47657
Term: roflumilast
Definition: A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Chemical ID: MESH:C424423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDRoflumilast results in increased expression of BAX mRNA; Roflumilast results in increased expression of BAX proteinPMID:33757793
Baxmultiple interactionsISOBax (Rattus norvegicus)6480464CTDRoflumilast inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX protein]PMID:33757793
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Cisplatin co-treated with Roflumilast] results in increased expression of BAX mRNA; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of BAX protein]PMID:33757793
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