Phenominer Database Results (1259 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Sample Notes Experiment Notes Record ID Study ID
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 18 92.29 breaths/min 5.31 22.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15014 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 25.75 mmHg 4.11 7.11 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15160 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 1 13.06 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15542 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 1 -7.65 mmHg stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15650 381
BN/NHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 -1.53 degrees C 0.22 0.92 digital rectal thermometry Moms and pups used in studies were fed Teklad 15748 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 103.98 breaths/min 4.03 11.4 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15379 381
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 96.96 breaths/min 3.05 9.16 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14447 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 17 31.99 mmHg 0.62 2.55 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14482 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 294.98 beats/min 22.21 73.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15970 381
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 110.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 65462 151
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 95.0 days 11 9.6 ng/ml/h 1.0 3.32 ex vivo blood analysis 0 65474 151
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 96.03 breaths/min 3.91 18.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14873 381
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -74.95 beats/min 19.95 39.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51701 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -112.51 beats/min 21.22 60.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51716 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -13.09 beats/min 24.31 64.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51729 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 10 10.61 mg/d 1.41 4.46 automated urine analysis Moms and pups used in studies were fed Teklad 51761 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 3 2.06 ng/ml/h 0.69 1.19 radioimmunoassay Moms and pups used in studies were fed Teklad 51844 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -7.05 beats/min 10.76 21.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51858 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 10 10.9 mEq/d 0.8 2.54 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51894 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 104.25 mmHg 3.14 6.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52092 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 9 110.84 mmHg 1.12 3.36 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52874 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 8 0.26 ng/ml/h 0.03 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52918 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 15 1.13 ml/min 0.14 0.55 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52187 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 8 0.41 mg/dl 0.02 0.06 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52235 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 8 0.24 mg/dl 0.03 0.07 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52283 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 11 0.77 mEq/d 0.09 0.29 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52333 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 8 1.01 ng/ml/h 0.15 0.43 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52480 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 8 349.72 beats/min 7.76 21.94 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52524 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 8 120.84 mmHg 2.6 7.37 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52571 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 8 126.28 mmHg 8.23 23.29 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52572 482
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 10 73.25 mg/d 11.77 37.22 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52725 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 10 25.2 mEq/d 2.71 8.56 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52776 482
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 20.6 beats/min 13.45 26.91 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50513 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 101.04 mmHg 1.9 5.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50651 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 39.82 mmHg 2.4 6.8 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50665 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 -7.15 mmHg 2.83 6.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50812 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 5.4 mmHg 1.79 3.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50921 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 1 8.99 ng/ml/h radioimmunoassay Moms and pups used in studies were fed Teklad 51014 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 384.75 beats/min 35.54 71.08 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51123 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 8.88 mmHg 3.75 7.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51137 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -11.35 beats/min 12.39 24.77 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51241 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 43.38 mmHg 2.58 7.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51432 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 10 0.31 mg/d 0.05 0.17 automated urine analysis Moms and pups used in studies were fed Teklad 51478 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 2 1.55 ml/min 0.17 0.24 urine creatinine analysis Moms and pups used in studies were fed Dyets 51548 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 4 1.22 mg/d 0.23 0.45 automated urine analysis Moms and pups used in studies were fed Dyets 51571 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 364.17 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51587 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 437.8 beats/min 17.4 49.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51588 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -3.51 mmHg 2.57 5.13 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51601 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 103.82 mmHg 2.35 6.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51638 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 6 0.28 mg/dl 0.0 0.01 radioimmunoassay Moms and pups used in studies were fed Teklad 51656 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 23.04 mmHg 2.89 8.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51666 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -3.15 beats/min 20.75 41.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50428 481
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 13 27.67 mmHg 1.0 3.61 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13444 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 121.37 mmHg 4.32 13.66 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14375 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 470.72 beats/min 12.36 47.88 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13814 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 34.23 mmHg 0.85 2.26 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 13845 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 33.69 mmHg 1.47 2.95 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 13844 381
BN/NHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 90.0 days-94.0 days 10 1.7 ml/min 0.2 0.63 urine creatinine analysis 0.0 plasma creatinine analysis 67283 151
BN/NHsdMcwi plasma total cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood cholesterol amount female 92.0 days-94.0 days 10 56.0 mg/dl 2.1 6.64 plasma total cholesterol measurement test 0.0 67289 151
BN/NHsdMcwi plasma triglyceride level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood triglyceride amount female 92.0 days-94.0 days 7 0.72 mmol/l 0.11 0.3 plasma triglyceride analysis 0.0 67291 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 21 -1.4 ml/min/g 0.3 1.37 electromagnetic flowmetry 0.0 electromagnetic flowmetry change in renal blood flow rate 67305 151
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 0.3 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14002 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 138.98 % 6.98 20.94 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14038 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 144.23 % 11.49 32.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14039 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 475.49 beats/min 11.17 19.35 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14070 381
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 42 continuous mean 127.0 mmHg 3.0 19.44 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12006 229
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 42 continuous mean 109.0 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12012 229
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 37.87 degrees C 0.14 0.43 digital rectal thermometry Moms and pups used in studies were fed Dyets 19753 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19828 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 29.44 ml/min 1.78 5.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20707 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 119.67 % 6.41 27.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53765 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 112.33 mmHg 4.1 13.59 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19908 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 -5.27 mmHg 1.78 2.51 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20592 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 -5.17 mmHg 1.36 3.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20593 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 118.15 breaths/min 8.44 23.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20682 381
BN/NHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 100.19 mmHg 3.81 7.62 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19533 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 -7.76 mmHg 0.88 2.5 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19677 381
BN/NHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 17 365.45 beats/min 5.26 21.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17756 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 136.01 mmHg 0.64 1.1 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17777 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 113.63 % 4.18 12.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17920 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 -51.1 mmHg 6.77 11.73 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17942 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 -51.1 mmHg 2.72 7.19 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17943 381
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.22 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18062 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 113.0 breaths/min 7.86 31.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16991 381
BN/NHsdMcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 8 150.9 g 6.9 19.4 whole body digital scale Moms and pups used in studies were fed Dyets 18503 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 32.31 ml/min 1.43 6.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18741 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 13 120.55 mmHg 4.27 15.39 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18957 381
BN/NHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 14 5.04 g/dl 0.16 0.6 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37270 401
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 1 24.3 mmHg automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19031 381
BN/NHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 19 9.24 mg/dl 0.1 0.43 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36830 401
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass female 70.0 days-84.0 days 29 153.38 g 1.84 9.91 whole body digital scale 63651 529
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 %change=VE during 2-3 min hypercapnia/control during standard conditions 201.96 % 15.79 63.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19291 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 -43.74 mmHg 2.47 8.55 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19507 381
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 24.21 ml/min 1.5 4.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18190 381
BN/NHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 5 38.2 degrees C 0.45 1.0 digital rectal thermometry Moms and pups used in studies were fed Dyets 18225 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 26.3 ml/min 1.02 4.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20287 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 23 -1.64 degrees C 0.25 1.18 digital rectal thermometry Moms and pups used in studies were fed Teklad 20388 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 105.4 mmHg 9.2 15.93 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20401 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 26.91 mmHg 1.34 3.0 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20418 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 394.66 beats/min 17.27 38.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20441 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.05 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20546 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 -0.02 null 0.02 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20568 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 1 0.03 null stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20567 381
BN/NHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 20 0.71 g 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49138 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 19 5.51 mmHg 0.15 0.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49255 461
BN/NHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 24 875.85 s 23.17 113.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49376 461
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 18 2.29 % 0.69 2.95 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49475 461
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 24 163.8 g 3.8 18.5 whole body digital scale Moms and pups used in studies were fed Teklad 49580 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 8 7.23 IU/g 0.96 2.7 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49847 461
BN/NHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 24 43.88 mmHg 2.21 10.82 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50074 461
BN/NHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 19 899.05 s 56.67 247.03 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50197 461
BN/NHsdMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass female 70.0 days-84.0 days 29 0.11 g 0.0 0.01 digital scale post excision weight measurement 63333 529
BN/NHsdMcwi heart right ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart right ventricle mass male 70.0 days-84.0 days 44 0.15 g 0.0 0.03 digital scale post excision weight measurement 63332 529
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass male 70.0 days-84.0 days 45 0.81 g 0.01 0.09 digital scale post excision weight measurement 63404 529
BN/NHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 20 16.0 mmol/l 0.42 1.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42140 401
BN/NHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 11 0.66 x 1000 cells/ul 0.1 0.33 automated blood cell counting method Moms and pups used in studies were fed Teklad 38968 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 54.18 % 0.53 1.91 automated blood cell counting method Moms and pups used in studies were fed Teklad 39070 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 15 55.28 % 0.49 1.9 automated blood cell counting method Moms and pups used in studies were fed Teklad 39069 401
BN/NHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 20 3.65 g/dl 0.05 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42311 401
BN/NHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 17 110.65 mmol/l 0.74 3.04 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39196 401
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 17 101.29 U/l 8.24 33.96 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42849 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 134.12 % 8.01 33.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54338 381
BN/NHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 14 21.36 mmol/l 0.83 3.1 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43203 401
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 99.83 % 5.2 15.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54546 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 102.19 % 5.96 16.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54550 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 116.9 % 7.85 23.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54558 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 122.06 % 6.84 19.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54562 381
BN/NHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 19 105.58 mmol/l 0.82 3.56 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40077 401
BN/NHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 13 0.95 x 1000 cells/ul 0.28 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 43303 401
BN/NHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 18 0.29 x 1000 cells/ul 0.05 0.2 automated blood cell counting method Moms and pups used in studies were fed Teklad 40365 401
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 32 189.6 g 2.5 14.3 whole body digital scale Moms and pups used in studies were fed Teklad 59140 526
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 14 1.73 mg/kg 0.29 1.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59236 526
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 20 55.49 % 0.42 1.89 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59335 526
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 15 0.05 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59430 526
BN/NHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 20 1.56 g/kg 0.05 0.23 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59526 526
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 28 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59625 526
BN/NHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 17.43 g/dl 0.15 0.56 automated blood cell counting method Moms and pups used in studies were fed Teklad 38047 401
BN/NHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 19 166.74 mg/dl 5.69 24.79 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41265 401
BN/NHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 17 4.83 mmol/l 0.16 0.68 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38145 401
BN/NHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 20 23.8 mmol/l 0.48 2.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38339 401
BN/NHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 14 18.57 mg/dl 0.93 3.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41824 401
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 8 226.5 g 4.09 11.56 whole body digital scale 62964 528
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 1.23 E-7mole 0.27 0.76 wire myography using a Digi-Med tissue force analysis system with force transducer 63051 528
BN/NHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 11 54.57 fl 0.14 0.46 automated blood cell counting method Moms and pups used in studies were fed Teklad 38719 401
BN/NHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 142.5 mmHg 3.92 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45582 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 22 post-ischemic value/pre-ischemic value x 100% 52.63 % 2.7 12.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48604 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 22 140.93 mmHg 3.2 15.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48701 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 22 post-ischemic value/pre-ischemic value x 100% 76.24 % 3.86 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48834 461
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 24 2.35 g/mg 0.11 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57395 522
BN/NHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 11 44.04 % 0.76 2.53 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57559 526
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 38.78 mmHg 0.93 2.94 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16112 381
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 19.97 ml/min 1.18 4.72 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16227 381
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 25 155.9 g 2.1 10.6 whole body digital scale Moms and pups used in studies were fed Teklad 55240 522
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 17 -6.9 null 0.05 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55338 522
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 27 20.64 ml/min/kg 1.27 6.61 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57677 526
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 24 16.73 ml/min/kg 1.4 6.87 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57676 526
BN/NHsdMcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70.0 days-84.0 days 43 8.33 x 10E6 cells/ul 0.08 0.5 automated blood cell counting method 60609 527
BN/NHsdMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70.0 days-84.0 days 27 43.7 % 0.34 1.76 automated blood cell counting method 60692 527
BN/NHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 36.58 degrees C 0.15 0.46 digital rectal thermometry Moms and pups used in studies were fed Dyets 16334 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 373.44 beats/min 11.81 20.46 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16358 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 427.2 beats/min 11.52 25.76 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16359 381
BN/NHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 2 0.55 degrees C 0.55 0.78 digital rectal thermometry Moms and pups used in studies were fed Dyets 16381 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 17 96.35 mmHg 2.47 10.17 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16416 381
BN/NHsdMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70.0 days-84.0 days 43 1.78 x 1000 cells/ul 0.14 0.95 automated blood cell counting method 60895 527
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 23 36.11 degrees C 0.21 1.0 digital rectal thermometry Moms and pups used in studies were fed Teklad 16651 381
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 -6.8 null 0.07 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55687 522
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 0.02 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55758 522
BN/NHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 26 66.45 ml/min/kg 4.43 22.57 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58078 526
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70.0 days-84.0 days 27 0.29 mg/dl 0.02 0.08 automated plasma creatinine analysis 61060 527
BN/NHsdMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70.0 days-84.0 days 44 23.16 mmol/l 0.45 2.99 standard blood chemistry panel 61131 527
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 23.01 ml/min 1.1 5.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16769 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 14.73 mmHg 7.71 13.35 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16782 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 11.57 mmHg 5.5 12.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16783 381
BN/NHsdMcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70.0 days-84.0 days 27 7.49 x 1000 cells/ul 0.46 2.37 automated blood cell counting method 61430 527
BN/NHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 -8.81 null 0.05 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54632 522
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 24 -6.97 null 0.07 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56166 522
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 20 0.04 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56252 522
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 15 15.33 ml/min/kg 1.84 7.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58695 526
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 32 0.36 null 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58811 526
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 1.89 E-7mole 0.46 2.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56581 522
BN/NHsdMcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70.0 days-84.0 days 27 5.94 x 1000 cells/ul 0.39 2.0 automated blood cell counting method 62116 527
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 12 9.93 ml/min/kg 0.75 2.58 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60065 526
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 15 11.3 ml/min/kg 1.23 4.75 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60066 526
BN/NHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70.0 days-84.0 days 27 43.7 U/l 1.39 7.2 standard blood chemistry panel 60456 527
BN/NHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70.0 days-84.0 days 44 60.11 U/l 1.36 9.01 standard blood chemistry panel 60455 527
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.4 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17352 381
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 0.37 ml 0.02 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17449 381
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 22 17.81 ml/min/g 0.68 3.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46730 461
BN/NHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 136.9 mmHg 4.0 16.51 balloon tipped catheter with pressure transducer in isolated perfused heart 46828 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 18 38.91 mmHg 3.02 12.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47779 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 4 40.49 IU/g 5.92 11.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46011 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 21 post-ischemic value/pre-ischemic value x 100% 57.27 % 3.35 15.34 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47155 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 post-ischemic value/pre-ischemic value x 100% 77.68 % 6.75 26.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44997 461
BN/NHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 post-ischemic value/pre-ischemic value x 100% 80.05 % 5.86 24.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48485 461
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 132.9 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 69531 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 139.1 mmHg 3.6 16.5 vascular indwelling catheter method left femoral artery 120.0 69533 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 118.9 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 120.0 69529 151
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 27 0.86 g 0.03 0.16 post excision weight measurement 0.0 69505 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93.0 days 21 serial mean 127.2 mmHg 4.1 18.79 vascular indwelling catheter method left femoral artery 10800.0 69515 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93.0 days 20 serial mean 369.9 beats/min 5.1 22.81 vascular indwelling catheter method left femoral artery 10800.0 69519 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 94.0 days 16 serial mean 370.1 beats/min 6.3 25.2 vascular indwelling catheter method left femoral artery 10800.0 69525 151
BN/NHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84.0 days 33 167.0 g 3.4 19.53 body weighing method 0.0 69441 151
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 89.0 days-92.0 days 25 35.0 ml/d 2.0 10.0 urine volume measurement method 0.0 69451 151
BN/NHsdMcwi creatinine clearance to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 7 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. glomerular filtration trait male 161.0 days 10 0.44 ml/min/100g 0.03 0.09 automated blood creatinine analysis 0.0 . 102032 2645
BN/NHsdMcwi creatinine clearance to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 7 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. glomerular filtration trait male 175.0 days 10 0.44 ml/min/100g 0.02 0.06 automated blood creatinine analysis 0.0 . 102036 2645
BN/NHsdMcwi urine total protein excretion rate to body weight ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. total urine protein amount male 133.0 days 10 4.98 mg/d/100 g 0.29 0.92 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 . 102040 2645
BN/NHsdMcwi urine total protein excretion rate to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. total urine protein amount male 161.0 days 10 5.29 mg/d/100 g 0.23 0.73 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 . 102044 2645
BN/NHsdMcwi urine total protein excretion rate to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 14 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. total urine protein amount male 175.0 days 10 5.27 mg/d/100 g 0.21 0.66 pyrogallol red-molybdate complex-based urine total protein analysis 0.0 . 102048 2645
BN/NHsdMcwi urine sodium level to urine potassium level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 161.0 days 10 0.56 null 0.02 0.06 flame photometry 0.0 na/k 102068 2645
BN/NHsdMcwi urine sodium level to body weight ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 133.0 days 10 0.49 mmol/l/100g 0.04 0.13 flame photometry 0.0 . 102052 2645
BN/NHsdMcwi timed urine volume control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. urine output male 180.0 days 6 12.2 ml/d 1.1 2.69 metabolic cage urine volume measurement method 86400.0 n=6-27 110560 3177
BN/NHsdMcwi serum total cholesterol level fasting (for 16 hours) Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. blood cholesterol amount male 360.0 days 6 42.0 mg/dl 2.0 4.9 spectrometry 0.0 n=6-27 110575 3177
BN/NHsdMcwi serum triglyceride level fasting (for 16 hours) Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. blood triglyceride amount male 180.0 days 6 37.0 mg/dl 3.0 7.35 spectrometry 0.0 n=6-27 110578 3177
BN/NHsdMcwi kidney glomerulus diameter control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. kidney glomerulus size trait male 180.0 days 6 137.0 um 3.0 7.35 ex vivo light microscopy with histochemistry and digital image analysis 0.0 n=6-27 110584 3177
BN/NHsdMcwi total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 4.66 g 0.31 0.99 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138941 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 89.05 % 0.42 1.34 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138948 3292
BN/NHsdMcwi average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 28.0 days 10 10.44 g/d 0.32 1.02 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 138957 3292
BN/NHsdMcwi total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 5.08 % 0.16 0.52 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138955 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 28.0 days 10 87.94 % 0.42 1.33 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 138960 3292
BN/NHsdMcwi defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 70.0 days 10 1.69 g/d 0.16 0.5 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 138964 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 28.0 days 10 68.8 g 1.56 4.94 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138985 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 63.0 days 10 198.3 g 3.27 10.33 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138990 3292
BN/NHsdMcwi total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 10 13.87 % 0.4 1.28 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139007 3292
BN/NHsdMcwi total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 10 9.96 g 0.44 1.4 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139003 3292
BN/NHsdMcwi total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 10 4.06 g 0.15 0.46 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139005 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 10 86.13 % 0.4 1.28 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139010 3292
BN/NHsdMcwi total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 10 68.62 % 0.41 1.31 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139008 3292
BN/NHsdMcwi defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 28.0 days 10 1.79 g/d 0.08 0.25 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 139013 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 10 96.22 % 0.35 1.11 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139022 3292
BN/NHsdMcwi epididymal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass male 91.0 days 9 1.83 g 0.06 0.19 post excision weight measurement weight scale GWAT Changed sex from M to male to standardize across records, 7-30-2024 139033 3292
BN/NHsdMcwi inguinal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass male 91.0 days 10 2.63 g 0.18 0.55 post excision weight measurement weight scale IWAT Changed sex from M to male to standardize across records, 7-30-2024 139035 3292
BN/NHsdMcwi body length, nose to tail controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 10 37.9 cm 0.32 1.02 body length measuring method tape measure Nose:tail body length Changed sex from M to male to standardize across records, 7-30-2024 139042 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 70.0 days 11 220.0 g 2.17 7.21 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139053 3292
BN/NHsdMcwi total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 11 4.87 g 0.33 1.11 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139057 3292
BN/NHsdMcwi total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 11 3.9 g 0.14 0.48 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139067 3292
BN/NHsdMcwi total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 11 49.41 g 1.3 4.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139066 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 11 89.34 % 0.45 1.51 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139064 3292
BN/NHsdMcwi total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 11 67.97 % 0.23 0.75 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139070 3292
BN/NHsdMcwi calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 70.0 days 11 12.91 mL/d 0.53 1.76 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 139086 3292
BN/NHsdMcwi renal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass male 91.0 days 11 1.1 g 0.03 0.11 post excision weight measurement weight scale PWAT Changed sex from M to male to standardize across records, 7-30-2024 139096 3292
BN/NHsdMcwi body length, nose to tail controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 11 37.66 cm 0.18 0.61 body length measuring method tape measure Nose:tail body length Changed sex from M to male to standardize across records, 7-30-2024 139105 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 49.0 days 10 112.5 g 1.83 5.8 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138877 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 77.0 days 10 143.0 g 3.96 12.53 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138881 3292
BN/NHsdMcwi total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 67.97 % 0.46 1.47 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138897 3292
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 96.56 breaths/min 5.74 22.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15015 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 13 113.42 mmHg 2.4 8.66 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15060 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 22.11 mmHg 6.48 11.23 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15159 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 2 5.7 mmHg 1.15 1.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15187 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 0.28 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15312 381
BN/NHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 337.31 beats/min 24.18 48.36 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15344 381
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 25.0 mmHg 3.0 13.42 vascular indwelling catheter method left femoral artery 0.0 67303 151
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 83.34 breaths/min 5.83 16.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14448 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 42.42 ml/min 4.29 18.18 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14579 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 13 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14614 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 15 7.47 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14615 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 115.33 mmHg 2.7 6.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 15984 381
BN/NHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 17 -0.05 degrees C 0.23 0.93 digital rectal thermometry Moms and pups used in studies were fed Teklad 16020 381
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 42 continuous mean 4.5 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 0.0 left femoral artery increase 64928 229
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 138.05 % 8.45 23.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53528 381
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 19.38 mmHg 3.3 6.6 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51873 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 13.05 mmHg 2.64 7.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51874 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 11.63 mEq/d 1.0 3.17 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51893 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 8.94 mmHg 2.68 5.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51971 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 10.81 mEq/d 0.58 1.75 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52022 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 104.93 mmHg 2.81 7.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52091 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 7 1.23 ml/min 0.15 0.4 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52380 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 8 5.41 mg/d 1.01 2.85 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52426 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 10 4.05 mg/d 1.24 3.93 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52625 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 9 363.56 beats/min 5.85 17.55 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52676 482
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 32.45 beats/min 10.27 29.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50514 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 443.08 beats/min 14.63 43.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50534 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -47.96 beats/min 18.32 51.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50589 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 3 -2.03 mmHg 7.23 12.52 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50637 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 33.62 mmHg 2.46 7.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50760 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 31.33 mmHg 3.72 9.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50972 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 3 7.64 ng/ml/h 1.68 2.91 radioimmunoassay Moms and pups used in studies were fed Teklad 51015 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 7.32 mmHg 3.21 6.42 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51030 481
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 152.71 % 6.59 27.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54095 381
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 68.68 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51097 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 107.04 mmHg 4.18 12.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51152 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -3.93 beats/min 14.49 38.34 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51165 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -35.16 beats/min 11.36 32.12 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51166 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -24.8 beats/min 9.84 19.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51209 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -61.89 beats/min 17.82 47.14 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51229 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 409.37 beats/min 12.52 35.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51292 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -28.81 beats/min 15.57 46.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51514 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.05 mEq/d 0.12 0.36 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51528 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 31.19 mmHg 2.1 4.2 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51667 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 435.45 beats/min 18.67 37.34 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50331 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -8.48 beats/min 15.29 43.23 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50429 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 90.0 days-94.0 days 11 0.4 mg/dl 0.06 0.2 plasma creatinine analysis 0.0 plasma creatinine analysis 66153 151
BN/NHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 239.74 beats/min 14.05 44.43 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14740 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 15 0.0 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14776 381
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 heart rate during walking-heart rate during rest 63.87 beats/min 12.33 47.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13411 381
BN/NHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 34.81 degrees C 0.38 1.53 digital rectal thermometry Moms and pups used in studies were fed Teklad 13639 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.3 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13652 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 7.46 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14157 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 50.57 ml/min 5.81 17.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14168 381
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 %change=VE during7-9 min hypercapnia/control during standard conditions 192.2 % 15.96 63.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14278 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 119.99 mmHg 5.02 18.79 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14374 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 18 111.51 breaths/min 4.72 20.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17190 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 12 31.45 mmHg 1.19 4.12 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17284 381
BN/NHsdMcwi single kidney wet weight to body weight ratio controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 26 5.0 g/kg 0.2 1.02 post excision weight measurement 0.0 67287 151
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart left ventricle mass female 97.0 days-101.0 days 22 0.45 g 0.01 0.05 post excision weight measurement 0.0 67297 151
BN/NHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 114.1 mmHg 5.91 10.24 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13894 381
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 92.0 mmHg 3.0 13.75 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11851 151
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 7.41 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19743 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 41.74 ml/min 3.41 14.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20840 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 7.46 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20862 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 26.6 mmHg 8.91 17.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20883 381
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 124.05 % 8.41 25.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53840 381
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 122.47 % 6.81 19.27 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53844 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 118.59 % 6.31 26.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53897 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 109.62 % 4.44 21.31 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53996 381
BN/NHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20030 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 12 -5.94 mmHg 0.78 2.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20098 381
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89.0 days-92.0 days 20 serial mean 367.0 beats/min 5.0 22.36 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 13309 151
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 32.08 mmHg 1.64 3.67 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19569 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 33.67 mmHg 1.73 2.44 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19568 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 -1.2 degrees C 0.27 0.76 digital rectal thermometry Moms and pups used in studies were fed Dyets 19581 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 12 -7.85 mmHg 1.78 6.16 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19676 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 38.23 degrees C 0.25 0.71 digital rectal thermometry Moms and pups used in studies were fed Dyets 17575 381
BN/NHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 38.03 degrees C 0.12 0.51 digital rectal thermometry Moms and pups used in studies were fed Teklad 17658 381
BN/NHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 17 37.56 degrees C 0.21 0.86 digital rectal thermometry Moms and pups used in studies were fed Teklad 17659 381
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.35 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17679 381
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.39 ml 0.04 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17678 381
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 94.32 breaths/min 5.36 16.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17798 381
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 0.26 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18061 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 34.63 ml/min 3.33 9.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18075 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 23 37.75 degrees C 0.13 0.61 digital rectal thermometry Moms and pups used in studies were fed Teklad 16891 381
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 62.93 beats/min 23.36 40.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18367 381
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 90.24 breaths/min 3.98 19.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18489 381
BN/NHsdMcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 9 232.8 g 8.3 25.0 whole body digital scale Moms and pups used in studies were fed Dyets 18502 381
BN/NHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 95.74 mmHg 2.77 8.75 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18912 381
BN/NHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 14 98.82 mmHg 2.35 8.79 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18911 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 111.26 mmHg 2.83 10.95 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18958 381
BN/NHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 20 8.97 mg/dl 0.12 0.54 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36702 401
BN/NHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 14 8.8 mg/dl 0.1 0.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36831 401
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data body mass male 70.0 days-84.0 days 45 236.4 g 3.64 24.39 whole body digital scale 63650 529
BN/NHsdMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70.0 days-84.0 days 45 37.8 cm 0.27 1.82 in vivo ruler method 63722 529
BN/NHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 37.68 degrees C 0.13 0.53 digital rectal thermometry Moms and pups used in studies were fed Teklad 18142 381
BN/NHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 17 37.62 degrees C 0.08 0.32 digital rectal thermometry Moms and pups used in studies were fed Teklad 18143 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 36.54 degrees C 0.15 0.46 digital rectal thermometry Moms and pups used in studies were fed Dyets 18236 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 37.03 degrees C 0.2 0.56 digital rectal thermometry Moms and pups used in studies were fed Dyets 18237 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 434.13 beats/min 9.78 25.88 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20442 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 2 471.81 beats/min 40.33 57.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20533 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 36.91 degrees C 0.4 1.61 digital rectal thermometry Moms and pups used in studies were fed Teklad 19149 381
BN/NHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 18 211.19 beats/min 11.12 47.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49024 461
BN/NHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 23 931.69 s 37.66 180.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49377 461
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 17 3.12 % 0.87 3.57 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49474 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 23 101.61 mmHg 5.04 24.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49966 461
BN/NHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 23 33.83 mmHg 1.95 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50075 461
BN/NHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 17 867.1 s 35.89 147.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50198 461
BN/NHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 1126.09 s 23.27 113.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50304 461
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 101.43 beats/min 12.22 27.32 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19173 381
BN/NHsdMcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data kidney mass female 70.0 days-84.0 days 29 0.52 g 0.01 0.04 digital scale post excision weight measurement 63405 529
BN/NHsdMcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass male 70.0 days-84.0 days 45 0.74 g 0.01 0.08 digital scale post excision weight measurement 63476 529
BN/NHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 15 59.07 fl 0.23 0.88 automated blood cell counting method Moms and pups used in studies were fed Teklad 38823 401
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 2.42 g/mg 0.15 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 63192 528
BN/NHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 20 110.25 mmol/l 0.58 2.59 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39195 401
BN/NHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 15 9.36 x 10E6 cells/ul 0.07 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 39315 401
BN/NHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 9.54 x 10E6 cells/ul 0.11 0.41 automated blood cell counting method Moms and pups used in studies were fed Teklad 39316 401
BN/NHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 19 0.23 mg/dl 0.01 0.06 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42717 401
BN/NHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 15 0.18 x 1000 cells/ul 0.05 0.2 automated blood cell counting method Moms and pups used in studies were fed Teklad 39752 401
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 117.68 % 5.06 15.19 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54510 381
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 113.78 % 4.09 12.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53558 381
BN/NHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 14.87 g/dl 0.23 0.98 automated blood cell counting method Moms and pups used in studies were fed Teklad 40173 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 121.6 % 5.64 16.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53727 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 136.09 % 11.9 33.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53731 381
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 32 133.1 g 1.3 7.3 whole body digital scale Moms and pups used in studies were fed Teklad 59141 526
BN/NHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 19 3.63 g/dl 0.03 0.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40478 401
BN/NHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 20 2.11 g/dl 0.03 0.16 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40628 401
BN/NHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 17 1.75 g/dl 0.07 0.31 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40629 401
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 16 1.44 mg/kg 0.18 0.74 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59235 526
BN/NHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 19 170.26 U/l 6.03 26.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37521 401
BN/NHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 14 95.43 U/l 6.72 25.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37522 401
BN/NHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 14 1.81 g/dl 0.07 0.27 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41099 401
BN/NHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 17.83 g/dl 0.15 0.57 automated blood cell counting method Moms and pups used in studies were fed Teklad 38046 401
BN/NHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 11 44.04 % 0.76 2.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 41374 401
BN/NHsdMcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70.0 days-84.0 days 44 132.8 mg/dl 2.81 18.62 standard blood chemistry panel 62515 527
BN/NHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 16 4.95 mmol/l 0.18 0.71 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38144 401
BN/NHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 15 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 41725 401
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 2.01 E-7mole 0.22 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 63053 528
BN/NHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 post-ischemic value/pre-ischemic value x 100% 55.29 % 3.87 18.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48605 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 128.16 mmHg 3.9 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48702 461
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 61.94 % 3.77 16.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57286 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 62.67 % 3.92 16.65 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57287 522
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 -6.87 null 0.06 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55337 522
BN/NHsdMcwi red blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70.0 days-84.0 days 27 8.12 x 10E6 cells/ul 0.07 0.36 automated blood cell counting method 60610 527
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 15 10.73 mmHg 2.46 9.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16302 381
BN/NHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 36.74 degrees C 0.23 0.65 digital rectal thermometry Moms and pups used in studies were fed Dyets 16335 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 28.92 mmHg 1.0 1.73 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16454 381
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 24 22.43 ml/min/kg 1.63 8.01 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57878 526
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 24 0.46 null 0.02 0.12 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58191 526
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 43 33.51 g/dl 0.14 0.89 automated blood cell counting method 61203 527
BN/NHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 15 65.79 ml/min/kg 4.75 18.41 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58298 526
BN/NHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 20 211.5 g 2.5 11.0 whole body digital scale Moms and pups used in studies were fed Teklad 58409 526
BN/NHsdMcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70.0 days-84.0 days 27 5.15 g/dl 0.05 0.24 standard blood chemistry panel 61286 527
BN/NHsdMcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70.0 days-84.0 days 27 4.18 mmol/l 0.09 0.45 flame atomic emission spectrometry 61358 527
BN/NHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 19 -8.78 null 0.08 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54631 522
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 17 0.14 umol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54737 522
BN/NHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 20 -8.63 null 0.09 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56040 522
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 28 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58567 526
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 29 0.03 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58568 526
BN/NHsdMcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70.0 days-84.0 days 27 105.04 mmol/l 0.42 2.17 standard blood chemistry panel 62352 527
BN/NHsdMcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70.0 days-84.0 days 44 59.52 mg/dl 0.86 5.72 standard blood chemistry panel 62423 527
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 0.31 umol/l 0.12 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54966 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 59.0 % 3.48 9.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56295 522
BN/NHsdMcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70.0 days-84.0 days 27 0.13 x 1000 cells/ul 0.03 0.14 automated blood cell counting method 61738 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 17 47.18 % 3.2 13.19 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55066 522
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 15 0.1 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59959 526
BN/NHsdMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70.0 days-84.0 days 44 0.1 mg/dl 0.0 0.02 standard blood chemistry panel 62187 527
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 -6.67 null 0.11 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56975 522
BN/NHsdMcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70.0 days-84.0 days 27 9.97 mg/dl 0.09 0.47 standard blood chemistry panel 60282 527
BN/NHsdMcwi serum calcium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70.0 days-84.0 days 44 10.27 mg/dl 0.1 0.66 standard blood chemistry panel 60281 527
BN/NHsdMcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 27 14.4 g/dl 0.09 0.45 automated blood cell counting method 60364 527
BN/NHsdMcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70.0 days-84.0 days 44 3.89 g/dl 0.03 0.23 standard blood chemistry panel 61961 527
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70.0 days-84.0 days 26 167.77 U/l 9.72 49.55 standard blood chemistry panel 62034 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 43.77 % 9.19 24.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57158 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 40.71 % 5.97 22.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57190 522
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.44 ml 0.04 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17351 381
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 0.32 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17450 381
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 9.69 IU/g 0.76 2.4 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45711 461
BN/NHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 124.32 mmHg 4.29 16.61 balloon tipped catheter with pressure transducer in isolated perfused heart 46829 461
BN/NHsdMcwi body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 20 168.7 g 3.5 15.8 whole body digital scale Moms and pups used in studies were fed Teklad 47875 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 22 146.43 mmHg 3.24 15.18 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45806 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 18 108.97 mmHg 3.01 12.79 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44893 461
BN/NHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 240.99 beats/min 8.13 33.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48276 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 23 5.44 mmHg 0.17 0.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47275 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 16 0.61 IU/g 0.05 0.22 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47368 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 73.79 mmHg 3.69 17.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45348 461
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 111.8 mmHg 3.9 17.87 vascular indwelling catheter method left femoral artery 120.0 69527 151
BN/NHsdMcwi hematocrit controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. erythrocyte quantity female 89.0 days-92.0 days 15 41.6 % 0.4 1.55 hematocrit analysis 0.0 69481 151
BN/NHsdMcwi plasma high density lipoprotein cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood HDL cholesterol amount female 92.0 days-94.0 days 9 44.2 mg/dl 2.2 6.6 plasma high-density lipoprotein-cholesterol measurement test 0.0 69503 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days 20 serial mean 103.2 mmHg 2.8 12.52 vascular indwelling catheter method left femoral artery 10800.0 69511 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 92.0 days 21 serial mean 386.5 beats/min 9.6 43.99 vascular indwelling catheter method left femoral artery 10800.0 69513 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 20 serial mean 130.0 mmHg 3.5 15.65 vascular indwelling catheter method left femoral artery 0.0 69443 151
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 89.0 days-92.0 days 24 0.96 mEq/d 0.04 0.21 unspecified method 0.0 urine potassium analysis 69461 151
BN/NHsdMcwi plasma insulin level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175.0 days 10 20.37 mU/l 0.91 2.88 radioimmunoassay 0.0 102092 2645
BN/NHsdMcwi plasma glucose level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood glucose amount male 175.0 days 10 133.02 mg/dl 2.88 9.11 automated plasma glucose analysis 0.0 automated plasma glucose analysis (MMO:0000735) 102088 2645
BN/NHsdMcwi urine sodium level to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 161.0 days 10 1.32 mmol/l/100g 0.09 0.28 flame photometry 0.0 . 102056 2645
BN/NHsdMcwi timed urine volume control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. urine output male 360.0 days 6 10.8 ml/d 1.5 3.67 metabolic cage urine volume measurement method 86400.0 n=6-27 110563 3177
BN/NHsdMcwi body weight control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. body mass male 180.0 days 6 340.0 g 18.0 44.09 body weighing method 0.0 n=6-27 110590 3177
BN/NHsdMcwi body weight control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. body mass male 360.0 days 6 432.0 g 18.0 44.09 body weighing method 0.0 n=6-27 110593 3177
BN/NHsdMcwi single kidney wet weight control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. kidney mass male 360.0 days 6 1.3 g 0.4 0.98 post excision weight measurement 0.0 n=6-27 110599 3177
BN/NHsdMcwi single kidney wet weight to body weight ratio control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. kidney mass male 180.0 days 6 2.95 g/kg 0.1 0.24 post excision weight measurement 0.0 n=6-27 110602 3177
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 70.0 days 10 141.1 g 1.79 5.67 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138880 3292
BN/NHsdMcwi total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 3.24 g 0.1 0.32 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138886 3292
BN/NHsdMcwi total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 7.66 % 0.35 1.11 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138890 3292
BN/NHsdMcwi total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 5.07 % 0.12 0.37 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138898 3292
BN/NHsdMcwi renal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass female 91.0 days 10 0.45 g 0.02 0.06 post excision weight measurement weight scale PWAT Changed sex from F to female to standardize across records, 7-30-2024 138915 3292
BN/NHsdMcwi epididymal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass female 91.0 days 10 0.68 g 0.03 0.09 post excision weight measurement weight scale GWAT Changed sex from F to female to standardize across records, 7-30-2024 138914 3292
BN/NHsdMcwi both kidneys wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass female 91.0 days 10 1.0 g 0.03 0.08 post excision weight measurement weight scale Total Kidneys Changed sex from F to female to standardize across records, 7-30-2024 138913 3292
BN/NHsdMcwi interscapular fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass female 91.0 days 10 231.14 mg 7.19 22.75 post excision weight measurement weight scale BAT Changed sex from F to female to standardize across records, 7-30-2024 138917 3292
BN/NHsdMcwi both adrenal glands wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass female 91.0 days 10 49.96 mg 1.33 4.2 post excision weight measurement weight scale Adrenal glands Changed sex from F to female to standardize across records, 7-30-2024 138919 3292
BN/NHsdMcwi thyroid gland wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass female 91.0 days 10 7.24 mg 0.36 1.13 post excision weight measurement weight scale Thyroid gland Changed sex from F to female to standardize across records, 7-30-2024 138920 3292
BN/NHsdMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91.0 days 7 77.7 µg/dL 3.4 9.0 radioimmunoassay RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 138923 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 56.0 days 10 125.4 g 1.78 5.62 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138935 3292
BN/NHsdMcwi total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 69.38 % 0.44 1.4 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138946 3292
BN/NHsdMcwi total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 3.31 g 0.17 0.53 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138951 3292
BN/NHsdMcwi calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 70.0 days 10 10.0 mL/d 0.3 0.94 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 138962 3292
BN/NHsdMcwi body weight gain to calories absorbed ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait female 70.0 days 10 0.2 g/kcal 0.01 0.02 constant volume calorimetry "Body weight gain, bomb calorimetry"; Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed Energy efficiency Changed sex from F to female to standardize across records, 7-30-2024 138966 3292
BN/NHsdMcwi interscapular fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass female 91.0 days 10 237.07 mg 11.76 37.2 post excision weight measurement weight scale BAT Changed sex from F to female to standardize across records, 7-30-2024 138974 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 7.0 days 10 13.42 g 0.2 0.65 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138982 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 21.0 days 10 45.3 g 1.28 4.06 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138984 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 77.0 days 10 223.8 g 4.98 15.76 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138992 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 70.0 days 10 218.0 g 3.17 10.02 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138991 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 10 245.7 g 4.37 13.81 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138994 3292
BN/NHsdMcwi total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 10 11.31 % 0.45 1.42 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 138999 3292
BN/NHsdMcwi total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 10 5.66 % 0.11 0.34 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139009 3292
BN/NHsdMcwi calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 28.0 days 10 11.6 mL/d 0.48 1.51 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 139012 3292
BN/NHsdMcwi total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 10 8.34 g 0.82 2.6 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139015 3292
BN/NHsdMcwi total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 10 71.68 % 0.29 0.91 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139020 3292
BN/NHsdMcwi total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 10 3.78 % 0.35 1.11 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139019 3292
BN/NHsdMcwi both kidneys wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass male 91.0 days 10 1.59 g 0.04 0.12 post excision weight measurement weight scale Total Kidneys Changed sex from M to male to standardize across records, 7-30-2024 139032 3292
BN/NHsdMcwi body length, nose to rump controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 10 21.85 cm 0.17 0.53 body length measuring method tape measure Nose:Rump body length Changed sex from M to male to standardize across records, 7-30-2024 139041 3292
BN/NHsdMcwi body mass index (BMI) controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 10 0.51 g/cm2 0.01 0.02 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from M to male to standardize across records, 7-30-2024 139043 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 14.0 days 11 26.55 g 0.62 2.07 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139045 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 35.0 days 11 94.0 g 2.31 7.67 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139048 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 49.0 days 11 153.36 g 3.02 10.03 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139050 3292
BN/NHsdMcwi total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 11 3.59 g 0.09 0.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139059 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 11 245.91 g 2.22 7.35 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139056 3292
BN/NHsdMcwi total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 11 14.67 % 0.35 1.17 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139069 3292
BN/NHsdMcwi total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 11 158.82 g 1.62 5.39 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139074 3292
BN/NHsdMcwi total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 11 16.77 g 0.21 0.71 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139075 3292
BN/NHsdMcwi average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 28.0 days 11 11.75 g/d 0.32 1.07 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 139081 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 11 96.21 % 0.38 1.26 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139080 3292
BN/NHsdMcwi body weight gain to calories absorbed ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait male 70.0 days 11 0.31 g/kcal 0.01 0.02 constant volume calorimetry "Body weight gain, bomb calorimetry, Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed" Energy efficiency Changed sex from M to male to standardize across records, 7-30-2024 139090 3292
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 15 108.15 mmHg 2.26 8.75 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15061 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 14 117.38 mmHg 4.81 18.0 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15137 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 122.79 mmHg 5.11 19.13 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15136 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 10.92 mmHg 5.88 13.14 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15188 381
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 0.26 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15476 381
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 30.71 ml/min 2.29 6.88 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15619 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 -8.24 mmHg 1.41 3.16 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15651 381
BN/NHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 16 -2.11 degrees C 0.25 1.0 digital rectal thermometry Moms and pups used in studies were fed Teklad 15749 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 0.02 null 0.0 0.0 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15355 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 -0.01 null 0.01 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15356 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 107.96 breaths/min 5.4 16.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15378 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 40.0 ml/min 4.02 16.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14580 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 95.6 mmHg 4.17 11.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14669 381
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 16.0 mmHg 3.0 11.22 vascular indwelling catheter method left femoral artery 0 66149 151
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 115.0 mmHg automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 15983 381
BN/NHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 0.36 degrees C 0.15 0.62 digital rectal thermometry Moms and pups used in studies were fed Teklad 16019 381
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 72.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 65464 151
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 30.33 mmHg 2.51 5.03 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51778 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 2 1.65 ml/min 0.23 0.32 urine creatinine analysis Moms and pups used in studies were fed Dyets 51804 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 6 1.28 ml/min 0.07 0.17 urine creatinine analysis Moms and pups used in studies were fed Teklad 51956 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 11 39.43 mg/d 8.21 27.23 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52135 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 7 1.61 ng/ml/h 0.88 2.33 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52919 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 7 0.33 mg/dl 0.03 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52284 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 11 7.16 mg/d 2.64 8.76 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52427 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 18 384.5 beats/min 7.1 30.12 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52677 482
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 21 34.79 mg/d 5.13 23.51 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52726 482
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 39.26 mmHg 3.2 8.46 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50664 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -25.21 beats/min 19.43 54.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50728 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 101.3 mmHg 2.17 6.14 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50745 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 34.94 mmHg 9.38 18.76 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50759 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 -9.46 mmHg 3.26 6.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50813 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 375.46 beats/min 8.18 18.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50889 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 392.72 beats/min 8.3 16.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50890 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 3.95 mmHg 4.82 9.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50936 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 109.15 mmHg 2.9 7.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50950 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 3 1.39 ml/min 0.23 0.41 urine creatinine analysis Moms and pups used in studies were fed Teklad 51063 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 3 0.8 ml/min 0.26 0.45 urine creatinine analysis Moms and pups used in studies were fed Teklad 51064 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 17.52 mmHg 4.28 11.32 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51195 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -79.11 beats/min 25.39 71.8 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51230 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -1.39 beats/min 7.41 20.95 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51240 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 3 388.81 beats/min 6.13 10.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51255 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 3 0.29 mg/dl 0.0 0.01 radioimmunoassay Moms and pups used in studies were fed Teklad 51321 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -55.31 beats/min 15.31 43.3 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51361 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 9 0.78 mg/d 0.26 0.77 automated urine analysis Moms and pups used in studies were fed Dyets 51572 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 7.03 mmHg 3.14 9.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51602 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 -34.84 beats/min 18.09 51.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50362 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 11.73 mmHg 3.99 10.55 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50377 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 392.83 beats/min 17.75 46.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50482 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 402.34 beats/min 10.96 30.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50483 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90.0 days-94.0 days 20 8.6 mg/d 2.2 9.84 urine total protein analysis 0 66151 151
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 13 heart rate during walking-heart rate during rest 94.5 beats/min 11.11 40.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13410 381
BN/NHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 126.58 mmHg 4.94 13.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13526 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 2 7.48 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14156 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17091 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 8 31.77 mmHg 0.93 2.64 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17285 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 102.43 mmHg 4.63 10.35 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17308 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 120.13 mmHg 2.06 3.56 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13772 381
BN/NHsdMcwi body weight controlled sodium content diet (0.4 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84.0 days 33 175.0 g 3.0 17.23 body weighing method 0.0 after catheterization and jacket attachment 67293 151
BN/NHsdMcwi heart wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart mass female 97.0 days-101.0 days 27 0.69 g 0.02 0.1 post excision weight measurement 0.0 67295 151
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 27.0 mmHg 2.0 8.94 vascular indwelling catheter method left femoral artery 0.0 67299 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 20 -1.2 ml/min/g 0.7 3.13 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67309 151
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.25 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14003 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 19.7 mmHg stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14026 381
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during7-9 min hypercapnia/control during standard conditions 154.09 % 10.6 29.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14094 381
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96.0 days 21 continuous mean 96.0 mmHg 3.0 13.75 vascular indwelling catheter method femoral artery 10800.0 left femoral artery 13275 229
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 1 112.4 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19711 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 102.4 mmHg 5.22 11.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19712 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 33.17 ml/min 1.96 5.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20706 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 15.46 mmHg 2.5 9.67 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20743 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 37.17 ml/min 2.77 11.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20841 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 7.46 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20863 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 14 318.41 beats/min 11.5 43.05 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20966 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 106.19 % 3.96 16.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53998 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 -0.04 null 0.01 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19930 381
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 -0.08 null 0.03 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19931 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 457.78 beats/min 39.53 68.47 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19969 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 17 98.17 mmHg 3.27 13.48 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20064 381
BN/NHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.42 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20667 381
BN/NHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 101.99 mmHg 2.58 6.83 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19534 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 3 48.85 mmHg 1.43 2.47 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19556 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 50.89 mmHg 1.79 4.72 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19557 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 37.34 degrees C 0.19 0.57 digital rectal thermometry Moms and pups used in studies were fed Dyets 17574 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.5 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17613 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 109.86 breaths/min 3.79 11.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17624 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 113.35 mmHg 4.98 11.15 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17703 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -7.15 mmHg 1.45 3.83 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17715 381
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 86.77 breaths/min 5.42 15.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17799 381
BN/NHsdMcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 24 149.2 g 1.9 9.5 whole body digital scale Moms and pups used in studies were fed Dyets 17897 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 40.78 ml/min 3.23 9.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18074 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 110.37 breaths/min 5.06 24.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18344 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 22.22 mmHg 0.74 1.65 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18836 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 7.44 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19020 381
BN/NHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 20 5.76 g/dl 0.07 0.32 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37040 401
BN/NHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 17 58.41 mg/dl 1.09 4.5 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37176 401
BN/NHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 19 5.84 g/dl 0.06 0.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37269 401
BN/NHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 11 32.36 g/dl 0.14 0.48 automated blood cell counting method Moms and pups used in studies were fed Teklad 37400 401
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 %change=VE during7-9 min hypercapnia/control during standard conditions 115.93 % 2.56 12.29 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18622 381
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.29 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18636 381
BN/NHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 14 145.14 mmol/l 1.11 4.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36562 401
BN/NHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 17 8.76 mg/dl 0.1 0.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36703 401
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 -40.3 mmHg 1.83 5.18 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19508 381
BN/NHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 441.08 beats/min 11.92 26.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18202 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 23.31 ml/min 1.35 5.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20288 381
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 84.63 beats/min 13.79 30.84 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20430 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 53.58 mmHg 1.29 3.65 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20520 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 542.51 beats/min 6.08 13.6 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20534 381
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 24 6.26 % 2.01 9.87 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49775 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 7.39 IU/g 0.95 2.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49846 461
BN/NHsdMcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart mass female 70.0 days-84.0 days 29 0.52 g 0.01 0.04 digital scale post excision weight measurement 63477 529
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 2.07 g/mg 0.12 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 63190 528
BN/NHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 13 88.77 U/l 7.63 27.53 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42489 401
BN/NHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 18 100.67 U/l 7.17 30.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42488 401
BN/NHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 19.07 pg 0.09 0.34 automated blood cell counting method Moms and pups used in studies were fed Teklad 42623 401
BN/NHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 14 0.21 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42718 401
BN/NHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 19 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42954 401
BN/NHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 14 20.79 mmol/l 0.89 3.33 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43062 401
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 145.02 % 6.57 27.88 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54435 381
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 15 32.27 g/dl 0.09 0.34 automated blood cell counting method Moms and pups used in studies were fed Teklad 39855 401
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 142.08 % 4.88 13.8 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54514 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 107.62 % 6.63 18.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53550 381
BN/NHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 11 14.24 g/dl 0.23 0.78 automated blood cell counting method Moms and pups used in studies were fed Teklad 40174 401
BN/NHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 15 1.01 x 1000 cells/ul 0.51 1.97 automated blood cell counting method Moms and pups used in studies were fed Teklad 43302 401
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 120.18 % 8.59 34.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53646 381
BN/NHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 11 17.65 pg 0.06 0.19 automated blood cell counting method Moms and pups used in studies were fed Teklad 40270 401
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 18 1.44 mg/kg 0.17 0.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58984 526
BN/NHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 20 47.55 U/l 3.11 13.92 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40792 401
BN/NHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 17 47.94 U/l 5.69 23.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40793 401
BN/NHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 20 8.04 mg/dl 0.17 0.75 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37672 401
BN/NHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 17 24.0 mg/dl 0.92 3.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40907 401
BN/NHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 13 7.25 x 1000 cells/ul 0.39 1.4 automated blood cell counting method Moms and pups used in studies were fed Teklad 41005 401
BN/NHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 15 6.44 x 1000 cells/ul 0.52 2.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41004 401
BN/NHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 13 36.46 U/l 2.15 7.74 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37779 401
BN/NHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 14 7.74 mg/dl 0.27 1.03 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37899 401
BN/NHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 19 2.21 g/dl 0.04 0.17 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41098 401
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 29 0.12 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59626 526
BN/NHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 32 1.57 g/kg 0.03 0.18 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59736 526
BN/NHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 18 0.05 x 1000 cells/ul 0.01 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41475 401
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 66.75 % 4.42 12.5 wire myography using a Digi-Med tissue force analysis system with force transducer 62651 528
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 53.2 % 4.62 10.33 wire myography using a Digi-Med tissue force analysis system with force transducer 62653 528
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 62800 528
BN/NHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 17 21.41 mmol/l 0.43 1.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38340 401
BN/NHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 19 64.95 mg/dl 1.48 6.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38504 401
BN/NHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 19 17.58 mg/dl 0.54 2.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41823 401
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 -6.71 null 0.05 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer 62876 528
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 14 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 5 148.8 g 1.85 4.15 whole body digital scale 62966 528
BN/NHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 18 8.29 x 10E6 cells/ul 0.12 0.5 automated blood cell counting method Moms and pups used in studies were fed Teklad 42040 401
BN/NHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 23 0.59 g 0.02 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45483 461
BN/NHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 19 1266.15 s 29.58 128.92 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46626 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 19 0.78 IU/g 0.09 0.38 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47505 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 19 0.73 IU/g 0.06 0.28 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47506 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 247.22 beats/min 10.24 50.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47659 461
BN/NHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 18 45.19 % 0.57 2.4 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57558 526
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 14 39.92 mmHg 1.31 4.91 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16111 381
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 23.79 ml/min 2.06 8.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16226 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 43.65 ml/min 4.87 14.61 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 16239 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 37.14 ml/min 3.97 11.23 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 16240 381
BN/NHsdMcwi hematocrit controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70.0 days-84.0 days 43 44.38 % 0.38 2.47 automated blood cell counting method 60691 527
BN/NHsdMcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70.0 days-84.0 days 43 53.36 fl 0.34 2.21 automated blood cell counting method 60803 527
BN/NHsdMcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 20 230.8 g 2.8 12.7 whole body digital scale Moms and pups used in studies were fed Teklad 55476 522
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 27 27.59 ml/min/kg 2.07 10.77 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57879 526
BN/NHsdMcwi blood neutrophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70.0 days-84.0 days 27 1.32 x 1000 cells/ul 0.18 0.95 automated blood cell counting method 60896 527
BN/NHsdMcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70.0 days-84.0 days 44 1.93 g/dl 0.03 0.17 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 60977 527
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 0.39 ml 0.02 0.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16552 381
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 19 0.03 10E-7mol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55757 522
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 27 32.98 g/dl 0.14 0.7 automated blood cell counting method 61204 527
BN/NHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 2.25 g/mg 0.11 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55850 522
BN/NHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 20 138.3 g 1.6 7.1 whole body digital scale Moms and pups used in studies were fed Teklad 58410 526
BN/NHsdMcwi serum potassium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70.0 days-84.0 days 43 4.8 mmol/l 0.09 0.62 flame atomic emission spectrometry 61357 527
BN/NHsdMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity male 70.0 days-84.0 days 43 0.12 x 1000 cells/ul 0.02 0.13 automated blood cell counting method 62269 527
BN/NHsdMcwi blood eosinophil count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data eosinophil quantity female 70.0 days-84.0 days 27 0.1 x 1000 cells/ul 0.02 0.09 automated blood cell counting method 62270 527
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 24 0.19 umol/l 0.05 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54967 522
BN/NHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 0.02 10E-7mol/l 0.0 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56253 522
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 12 13.55 ml/min/kg 1.34 4.65 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58694 526
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 7 47.43 % 4.93 13.05 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55095 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 42.5 % 7.43 18.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55096 522
BN/NHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 19 99.37 % 0.31 1.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56487 522
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 15 0.1 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59960 526
BN/NHsdMcwi blood lymphocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70.0 days-84.0 days 43 5.05 x 1000 cells/ul 0.24 1.54 automated blood cell counting method 62115 527
BN/NHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70.0 days-84.0 days 41 51.83 U/l 5.79 37.07 standard blood chemistry panel 61501 527
BN/NHsdMcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70.0 days-84.0 days 27 7.45 mg/dl 0.09 0.49 standard blood chemistry panel 61594 527
BN/NHsdMcwi serum phosphate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70.0 days-84.0 days 44 7.61 mg/dl 0.1 0.67 standard blood chemistry panel 61593 527
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 -6.87 null 0.08 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56976 522
BN/NHsdMcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70.0 days-84.0 days 44 25.52 mg/dl 0.63 4.17 standard blood chemistry panel 60209 527
BN/NHsdMcwi blood hemoglobin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 43 14.87 g/dl 0.11 0.74 automated blood cell counting method 60363 527
BN/NHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 27 17.76 pg 0.07 0.39 automated blood cell counting method 60528 527
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 22 135.42 mmHg 3.67 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45807 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 23 9.42 ml/min/g 0.62 2.95 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44796 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 18 post-ischemic value/pre-ischemic value x 100% 54.05 % 4.54 19.26 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46143 461
BN/NHsdMcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 19 4.51 g/kg 0.15 0.67 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47054 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 23 post-ischemic value/pre-ischemic value x 100% 55.18 % 3.21 15.39 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47154 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 post-ischemic value/pre-ischemic value x 100% 73.09 % 5.15 21.23 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44996 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 post-ischemic value/pre-ischemic value x 100% 51.12 % 7.76 30.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46398 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 16 0.61 IU/g 0.06 0.25 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47367 461
BN/NHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 post-ischemic value/pre-ischemic value x 100% 94.79 % 6.88 33.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48372 461
BN/NHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 post-ischemic value/pre-ischemic value x 100% 86.83 % 2.21 10.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48373 461
BN/NHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 83.61 % 6.45 28.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48484 461
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 120.4 mmHg 5.3 24.29 vascular indwelling catheter method left femoral artery 120.0 69535 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 111.3 mmHg 4.6 21.08 vascular indwelling catheter method left femoral artery 120.0 69541 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 16 serial mean 118.6 mmHg 3.4 13.6 vascular indwelling catheter method left femoral artery 120.0 69543 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 138.6 mmHg 3.8 17.41 vascular indwelling catheter method left femoral artery 120.0 69547 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 17 serial mean 144.9 mmHg 3.1 12.78 vascular indwelling catheter method left femoral artery 120.0 69549 151
BN/NHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 89.0 days-92.0 days 23 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 ug/min 69462 151
BN/NHsdMcwi urine potassium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92.0 days-94.0 days 22 93.4 mmol/l 5.7 26.74 unspecified method 0.0 urine potassium analysis 69471 151
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92.0 days-94.0 days 22 0.88 mEq/d 0.06 0.27 unspecified method 0.0 urine potassium analysis umol/min 69473 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days 20 serial mean 140.6 mmHg 4.4 19.68 vascular indwelling catheter method left femoral artery 10800.0 69509 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93.0 days 21 serial mean 89.6 mmHg 2.5 11.46 vascular indwelling catheter method left femoral artery 10800.0 69517 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94.0 days 17 serial mean 91.6 mmHg 3.6 14.84 vascular indwelling catheter method left femoral artery 10800.0 69523 151
BN/NHsdMcwi urine total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (0.4 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90.0 days-94.0 days 20 0.24 mg/ml 0.05 0.22 urine total protein analysis 0.0 mg/ml 69457 151
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 89.0 days-92.0 days 24 6.35 mEq/d 0.35 1.74 unspecified method 0.0 urine sodium analysis umol/min 69459 151
BN/NHsdMcwi urine sodium level to urine potassium level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 14 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 175.0 days 10 0.2 null 0.01 0.03 flame photometry 0.0 . 102072 2645
BN/NHsdMcwi plasma triglyceride level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood triglyceride amount male 175.0 days 10 0.57 mmol/l 0.02 0.06 automated plasma triglyceride analysis 0.0 automated plasma triglyceride analysis (MMO:0000734) 102084 2645
BN/NHsdMcwi serum total cholesterol level fasting (for 16 hours) Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. blood cholesterol amount male 180.0 days 6 45.0 mg/dl 3.0 7.35 spectrometry n=6-27 110572 3177
BN/NHsdMcwi serum triglyceride level fasting (for 16 hours) Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. blood triglyceride amount male 360.0 days 6 34.0 mg/dl 5.0 12.25 spectrometry 0.0 n=6-27 110581 3177
BN/NHsdMcwi single kidney wet weight control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. kidney mass male 180.0 days 6 1.0 g 0.03 0.07 post excision weight measurement 0.0 n=6-27 110596 3177
BN/NHsdMcwi total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 69.21 % 0.41 1.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138889 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 88.73 % 0.56 1.76 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138891 3292
BN/NHsdMcwi total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 56.29 g 1.74 5.49 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138895 3292
BN/NHsdMcwi defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 28.0 days 10 1.71 g/d 0.08 0.25 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 138902 3292
BN/NHsdMcwi defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 70.0 days 10 1.74 g/d 0.13 0.42 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 138907 3292
BN/NHsdMcwi heart left ventricle weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass female 91.0 days 10 0.37 g 0.01 0.03 post excision weight measurement weight scale Left ventricle of the heart Changed sex from F to female to standardize across records, 7-30-2024 138912 3292
BN/NHsdMcwi body mass index (BMI) controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 0.41 g/cm2 0.01 0.02 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from F to female to standardize across records, 7-30-2024 138927 3292
BN/NHsdMcwi body length, nose to rump controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 19.42 cm 0.17 0.53 body length measuring method tape measure Nose:Rump body length Changed sex from F to female to standardize across records, 7-30-2024 138925 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 14.0 days 10 25.35 g 0.58 1.84 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138929 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 35.0 days 10 81.7 g 2.01 6.36 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138932 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 49.0 days 10 112.9 g 1.93 6.12 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138934 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 63.0 days 10 134.5 g 2.11 6.67 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138936 3292
BN/NHsdMcwi total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 3.23 g 0.11 0.36 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138943 3292
BN/NHsdMcwi total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 37.54 g 1.19 3.77 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138944 3292
BN/NHsdMcwi total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 7.73 % 0.35 1.09 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138947 3292
BN/NHsdMcwi total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 44.17 g 1.36 4.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138950 3292
BN/NHsdMcwi timed urine mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait female 70.0 days 10 3.92 g/d 0.16 0.52 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from F to female to standardize across records, 7-30-2024 138963 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 70.0 days 10 89.24 % 0.62 1.95 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 138965 3292
BN/NHsdMcwi both adrenal glands wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass female 91.0 days 10 52.35 mg 1.77 5.61 post excision weight measurement weight scale Adrenal glands Changed sex from F to female to standardize across records, 7-30-2024 138976 3292
BN/NHsdMcwi thyroid gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass female 91.0 days 10 7.19 mg 0.32 1.02 post excision weight measurement weight scale Thyroid gland Changed sex from F to female to standardize across records, 7-30-2024 138977 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 14.0 days 10 26.1 g 0.59 1.86 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138983 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 35.0 days 10 95.2 g 2.19 6.92 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138986 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 56.0 days 10 181.2 g 3.57 11.3 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138989 3292
BN/NHsdMcwi total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 10 69.98 % 0.35 1.11 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139000 3292
BN/NHsdMcwi total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 10 7.75 % 0.24 0.76 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139001 3292
BN/NHsdMcwi total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 10 49.15 g 1.14 3.6 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139004 3292
BN/NHsdMcwi total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 10 61.74 g 1.61 5.11 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139006 3292
BN/NHsdMcwi total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 10 16.65 g 0.3 0.95 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139017 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 28.0 days 10 88.74 % 0.3 0.94 constant volume calorimetry "Bomb calorimetry, 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food" Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 139014 3292
BN/NHsdMcwi average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 70.0 days 10 15.52 g/d 0.5 1.57 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 139023 3292
BN/NHsdMcwi liver wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass male 91.0 days 10 6.64 g 0.21 0.66 post excision weight measurement weight scale Liver Changed sex from M to male to standardize across records, 7-30-2024 139030 3292
BN/NHsdMcwi heart left ventricle weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass male 91.0 days 10 0.53 g 0.01 0.04 post excision weight measurement weight scale Left ventricle of the heart Changed sex from M to male to standardize across records, 7-30-2024 139031 3292
BN/NHsdMcwi serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91.0 days 8 70.24 µg/dL 4.85 13.71 radioimmunoassay RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 139039 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 56.0 days 11 181.55 g 2.47 8.2 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139051 3292
BN/NHsdMcwi total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 11 31.74 g 0.95 3.14 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139058 3292
BN/NHsdMcwi total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 11 70.14 % 0.29 0.96 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139062 3292
BN/NHsdMcwi total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 11 10.67 g 0.4 1.32 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139065 3292
BN/NHsdMcwi total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 11 5.37 % 0.14 0.48 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139071 3292
BN/NHsdMcwi total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 11 3.79 % 0.38 1.26 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139077 3292
BN/NHsdMcwi total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 11 71.67 % 0.42 1.38 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139078 3292
BN/NHsdMcwi timed urine mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait male 70.0 days 11 4.79 g/d 0.19 0.62 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from M to male to standardize across records, 7-30-2024 139087 3292
BN/NHsdMcwi average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 70.0 days 11 15.23 g/d 0.49 1.62 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 139085 3292
BN/NHsdMcwi defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 70.0 days 11 2.71 g/d 0.1 0.33 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 139088 3292
BN/NHsdMcwi blood glucose level controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount male 91.0 days 11 72.36 mg/dl 1.6 5.3 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien , animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from M to male to standardize across records, 7-30-2024 139091 3292
BN/NHsdMcwi liver wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass male 91.0 days 11 6.52 g 0.09 0.3 post excision weight measurement weight scale Liver Changed sex from M to male to standardize across records, 7-30-2024 139092 3292
BN/NHsdMcwi interscapular fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass male 91.0 days 11 290.17 mg 9.53 31.62 post excision weight measurement weight scale BAT Changed sex from M to male to standardize across records, 7-30-2024 139098 3292
BN/NHsdMcwi inguinal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass male 91.0 days 11 2.96 g 0.14 0.47 post excision weight measurement weight scale IWAT Changed sex from M to male to standardize across records, 7-30-2024 139097 3292
BN/NHsdMcwi both adrenal glands wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass male 91.0 days 11 50.51 mg 1.02 3.39 post excision weight measurement weight scale Adrenal glands Changed sex from M to male to standardize across records, 7-30-2024 139100 3292
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 0.21 ml 0.01 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15477 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 9.55 mmHg 3.54 7.91 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15543 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 102.23 mmHg 1.72 4.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15555 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 107.08 mmHg 1.69 3.78 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15554 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 16 34.61 mmHg 0.56 2.22 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14481 381
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93.0 days 14 serial mean 395.0 beats/min 7.0 26.19 vascular indwelling catheter method left femoral artery 0 65468 151
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.32 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14886 381
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.29 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14887 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.31 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14906 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 0.28 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14907 381
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -63.92 beats/min 13.12 39.35 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51702 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -96.57 beats/min 21.74 57.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51715 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -38.48 beats/min 13.18 37.27 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51730 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 3 97.79 mmHg 9.11 15.78 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51831 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 7.06 mmHg 2.33 6.6 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51970 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 91.79 mmHg 3.28 6.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52009 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 91.89 mmHg 3.36 7.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52008 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 2 0.27 mg/dl 0.04 0.06 radioimmunoassay Moms and pups used in studies were fed Dyets 52043 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -6.75 beats/min 8.96 17.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52058 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 11 15.99 mEq/d 2.14 7.08 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52821 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 8 19.07 mEq/d 1.63 4.62 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52820 482
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 18 112.49 mmHg 2.77 11.74 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52875 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 10 1.47 mEq/d 0.11 0.36 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52972 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 21 0.95 mEq/d 0.05 0.24 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52973 482
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 15 0.35 mg/dl 0.02 0.08 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52236 482
BN/NHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 8 394.19 beats/min 16.08 45.49 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52525 482
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 21 2.16 mg/d 0.38 1.73 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52626 482
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 21 15.57 mEq/d 1.26 5.76 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52777 482
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 399.8 beats/min 23.32 46.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50533 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -24.45 beats/min 31.16 62.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50590 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.7 mmHg 0.63 1.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50610 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -26.25 beats/min 11.9 23.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50623 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 2.83 beats/min 19.88 56.24 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50687 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 34.55 beats/min 25.93 51.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50688 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 102.53 mmHg 2.47 6.98 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50746 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 4 5.65 mmHg 0.84 1.68 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50782 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 33.35 mmHg 3.43 9.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50973 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 -28.94 beats/min 6.27 14.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50988 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -5.24 beats/min 10.35 20.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50989 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 13.07 mmHg 1.59 4.78 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51031 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 3 -11.61 beats/min 15.08 26.12 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51098 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 8.96 mmHg 2.29 4.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51110 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 0.6 mmHg 0.68 1.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51111 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 0.1 mmHg 1.74 4.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51136 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 18.33 mmHg 3.71 10.49 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51196 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 -16.65 beats/min 19.02 57.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51210 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 3 0.95 mEq/d 0.15 0.26 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51275 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 9 1.23 mEq/d 0.15 0.45 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51276 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 3 0.3 mg/dl 0.02 0.04 radioimmunoassay Moms and pups used in studies were fed Teklad 51322 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 9 20.68 mmHg 2.71 8.13 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51347 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 0.75 beats/min 17.84 35.68 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51377 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 10.88 beats/min 4.58 12.97 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51378 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 39.47 mmHg 5.6 11.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51431 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 4 16.76 mg/d 2.9 5.8 automated urine analysis Moms and pups used in studies were fed Dyets 51445 481
BN/NHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 10 0.44 mg/d 0.07 0.22 automated urine analysis Moms and pups used in studies were fed Teklad 51477 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -38.7 beats/min 18.21 36.42 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51513 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 10 1.17 mEq/d 0.16 0.49 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51527 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 389.05 beats/min 11.35 32.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50330 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 3.61 mmHg 1.8 5.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50378 481
BN/NHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 0.02 null 0.0 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14775 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 15 25.59 mmHg 0.79 3.07 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13445 381
BN/NHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 119.56 mmHg 2.71 8.59 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13527 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.36 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13651 381
BN/NHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 47.32 ml/min 4.17 11.8 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14169 381
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 %change=VE during7-9 min hypercapnia/control during standard conditions 177.97 % 9.79 41.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14277 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17092 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 113.8 breaths/min 6.23 24.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17191 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 104.41 mmHg 3.03 6.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13773 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 13 464.29 beats/min 9.4 33.88 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13813 381
BN/NHsdMcwi kidney glomerulus diameter controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney glomerulus size trait female 97.0 days-101.0 days 22 95.0 um 1.2 5.63 ex vivo light microscopy 0.0 plasma creatinine analysis 67285 151
BN/NHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 19 serial mean 22.0 mmHg 3.0 13.08 vascular indwelling catheter method left femoral artery 0.0 67301 151
BN/NHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 19 -1.4 ml/min/g 0.2 0.87 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67307 151
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 5 525.71 beats/min 7.93 17.74 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14071 381
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 130.0 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11849 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 42 continuous mean 114.0 mmHg 4.0 25.92 vascular indwelling catheter method femoral artery 14400.0 left femoral artery 12016 229
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 5 7.37 null 0.03 0.07 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19744 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 38.25 degrees C 0.27 0.77 digital rectal thermometry Moms and pups used in studies were fed Dyets 19754 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 6.7 mmHg 5.42 12.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20884 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 107.67 % 2.68 12.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53763 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 117.29 % 5.01 24.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53895 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 112.28 mmHg 4.09 9.16 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19988 381
BN/NHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.45 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20031 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 17 96.27 mmHg 2.31 9.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20065 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 15 -6.33 mmHg 0.7 2.73 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20099 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 113.55 breaths/min 4.78 14.34 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20681 381
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 92.0 days 14 1.4 ng/ml/h 0.4 1.5 ex vivo blood analysis enzyme assay 13308 151
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 164.32 % 13.77 41.31 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 19603 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 103.54 breaths/min 7.73 21.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17625 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 9 112.83 breaths/min 4.01 12.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17690 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 2 103.28 mmHg 3.43 4.84 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17702 381
BN/NHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 17 408.4 beats/min 9.15 37.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17757 381
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 92.09 beats/min 13.91 24.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18366 381
BN/NHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 88.49 breaths/min 4.64 19.67 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18490 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 28.92 ml/min 1.73 7.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18742 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 21.24 mmHg 1.0 2.24 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18837 381
BN/NHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 32.48 g/dl 0.07 0.31 automated blood cell counting method Moms and pups used in studies were fed Teklad 37399 401
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 23.84 mmHg 0.85 1.91 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19032 381
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during7-9 min hypercapnia/control during standard conditions 124.99 % 6.31 26.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18623 381
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass female 70.0 days-84.0 days 29 0.35 g 0.0 0.02 digital scale post excision weight measurement 63795 529
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 18 %change=VE during 2-3 min hypercapnia/control during standard conditions 177.88 % 8.99 38.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19290 381
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 29.27 ml/min 1.47 4.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18189 381
BN/NHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 2 38.45 degrees C 0.45 0.64 digital rectal thermometry Moms and pups used in studies were fed Dyets 18224 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 -1.79 degrees C 0.22 0.94 digital rectal thermometry Moms and pups used in studies were fed Teklad 20389 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 92.85 mmHg 6.46 14.43 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20402 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 28.4 mmHg 0.05 0.07 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20417 381
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 23 115.0 g 2.4 11.7 whole body digital scale Moms and pups used in studies were fed Teklad 49581 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 110.81 mmHg 3.12 15.27 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49965 461
BN/NHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 1201.4 s 34.75 166.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50305 461
BN/NHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 2 37.9 degrees C 0.1 0.14 digital rectal thermometry Moms and pups used in studies were fed Dyets 19192 381
BN/NHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 5 38.14 degrees C 0.33 0.73 digital rectal thermometry Moms and pups used in studies were fed Dyets 19193 381
BN/NHsdMcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length male 70.0 days-84.0 days 45 22.29 cm 0.16 1.11 in vivo ruler method 63568 529
BN/NHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 17 16.53 mmol/l 0.56 2.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42141 401
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 -7.96 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter 63121 528
BN/NHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 18 0.9 x 1000 cells/ul 0.13 0.54 automated blood cell counting method Moms and pups used in studies were fed Teklad 38967 401
BN/NHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 20 144.75 mmol/l 0.42 1.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39466 401
BN/NHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 17 143.82 mmol/l 0.52 2.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39467 401
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 20 95.1 U/l 6.0 26.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42848 401
BN/NHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 17 0.25 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39655 401
BN/NHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 20 0.24 mg/dl 0.01 0.05 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39654 401
BN/NHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 12 0.08 x 1000 cells/ul 0.04 0.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 39753 401
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 23 123.27 % 3.81 18.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54336 381
BN/NHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 18 22.33 mmol/l 0.66 2.81 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43202 401
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 126.91 % 8.97 25.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53562 381
BN/NHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 19 4.44 mmol/l 0.14 0.6 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43398 401
BN/NHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 18 17.92 pg 0.08 0.32 automated blood cell counting method Moms and pups used in studies were fed Teklad 40269 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 17 54.05 % 0.45 1.85 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59336 526
BN/NHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 17 7.92 mg/dl 0.2 0.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37673 401
BN/NHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 18 57.06 U/l 4.83 20.51 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37778 401
BN/NHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 19 7.62 mg/dl 0.19 0.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37898 401
BN/NHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 13 6.03 x 1000 cells/ul 0.42 1.51 automated blood cell counting method Moms and pups used in studies were fed Teklad 41582 401
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 62798 528
BN/NHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 14 66.43 mg/dl 1.47 5.49 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38505 401
BN/NHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 18 55.2 fl 0.23 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 38718 401
BN/NHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 11 8.07 x 10E6 cells/ul 0.13 0.44 automated blood cell counting method Moms and pups used in studies were fed Teklad 42041 401
BN/NHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 24 0.74 g 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45482 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 15 131.1 mmHg 4.39 17.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45583 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 39.16 mmHg 2.2 10.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46494 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 21 32.91 mmHg 2.72 12.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46495 461
BN/NHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 1122.01 s 33.31 137.33 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46627 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 post-ischemic value/pre-ischemic value x 100% 78.22 % 1.72 8.45 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48833 461
BN/NHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 1.91 g/mg 0.08 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57394 522
BN/NHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 -1.29 degrees C 0.22 0.65 digital rectal thermometry Moms and pups used in studies were fed Dyets 16267 381
BN/NHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 8 -1.51 degrees C 0.25 0.7 digital rectal thermometry Moms and pups used in studies were fed Dyets 16268 381
BN/NHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 20 239.5 g 5.1 22.9 whole body digital scale Moms and pups used in studies were fed Teklad 55239 522
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 5 -10.3 mmHg 0.85 1.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16323 381
BN/NHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 5 0.06 degrees C 0.37 0.82 digital rectal thermometry Moms and pups used in studies were fed Dyets 16382 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 16 92.99 mmHg 2.46 9.84 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16415 381
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 20 0.2 null 0.01 0.05 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57972 526
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 19 0.21 null 0.01 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57973 526
BN/NHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 0.35 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16553 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 35.56 degrees C 0.25 1.05 digital rectal thermometry Moms and pups used in studies were fed Teklad 16652 381
BN/NHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 28 49.29 ml/min/kg 3.1 16.42 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58077 526
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 18.86 ml/min 0.95 4.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16770 381
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 1.35 E-7mole 0.19 0.79 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55957 522
BN/NHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 0.17 umol/l 0.03 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54736 522
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 20 -6.8 null 0.1 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56165 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 60.83 % 3.75 15.89 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54840 522
BN/NHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 66.8 % 3.88 17.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54841 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 54.5 % 9.09 22.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56296 522
BN/NHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 99.19 % 0.38 1.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56328 522
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 32 0.32 null 0.02 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58812 526
BN/NHsdMcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70.0 days-84.0 days 27 19.15 mmol/l 0.47 2.46 standard blood chemistry panel 61666 527
BN/NHsdMcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70.0 days-84.0 days 27 140.81 mmol/l 0.36 1.86 flame atomic emission spectrometry 61840 527
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 15 0.22 null 0.02 0.06 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59844 526
BN/NHsdMcwi serum total bilirubin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70.0 days-84.0 days 27 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 62188 527
BN/NHsdMcwi serum urea nitrogen level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70.0 days-84.0 days 27 24.59 mg/dl 0.82 4.27 standard blood chemistry panel 60210 527
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70.0 days-84.0 days 41 190.41 U/l 13.79 88.28 standard blood chemistry panel 62033 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 47.5 % 5.6 13.71 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57159 522
BN/NHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 43 17.87 pg 0.08 0.54 automated blood cell counting method 60527 527
BN/NHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 23 5.16 g/kg 0.18 0.85 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45679 461
BN/NHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 24 4.53 g/kg 0.1 0.48 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45678 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 18 33.66 mmHg 4.0 16.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47780 461
BN/NHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 18 69.33 mmHg 6.38 27.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47990 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 24 10.02 ml/min/g 0.75 3.69 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44795 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 18 107.55 mmHg 4.39 18.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44894 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 3 34.51 IU/g 7.7 13.34 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46012 461
BN/NHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 17 43.0 mmHg 2.61 10.78 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48112 461
BN/NHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 19 42.11 mmHg 2.6 11.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48111 461
BN/NHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 19 260.74 beats/min 9.01 39.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48275 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 18 8.39 ml/min/g 0.75 3.2 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46279 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 18 10.61 ml/min/g 1.14 4.84 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46280 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 17 post-ischemic value/pre-ischemic value x 100% 48.94 % 4.62 19.06 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46397 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 24 222.91 beats/min 8.17 40.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45225 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 71.06 mmHg 3.3 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45347 461
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 128.6 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 69537 151
BN/NHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 92.0 days-94.0 days 25 9.86 ml/d 0.4 2.0 urine volume measurement method 0.0 needs ml/d default 69464 151
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92.0 days-94.0 days 22 0.46 mEq/d 0.03 0.13 unspecified method 0.0 urine sodium analysis umol/min 69468 151
BN/NHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92.0 days-94.0 days 25 56.4 mg/dl 4.95 24.75 urine creatinine analysis 0.0 69475 151
BN/NHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 92.0 days-94.0 days 8 1.1 ml/min 0.2 0.57 urine creatinine analysis 0.0 mg/min 69479 151
BN/NHsdMcwi plasma total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood total protein amount female 89.0 days-92.0 days 13 38.6 mg/ml 2.0 7.21 unspecified method 0.0 69483 151
BN/NHsdMcwi right kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 27 0.76 g 0.02 0.1 post excision weight measurement 0.0 69507 151
BN/NHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89.0 days-91.0 days 18 serial mean 386.0 beats/min 4.1 17.39 vascular indwelling catheter method left femoral artery 0.0 69449 151
BN/NHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 89.0 days-92.0 days 24 370.0 mmol/l 14.3 70.06 unspecified method 0.0 urine sodium analysis 69453 151
BN/NHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 89.0 days-92.0 days 24 30.2 mg/dl 3.87 18.96 urine creatinine analysis 0.0 69455 151
BN/NHsdMcwi creatinine clearance to body weight ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. glomerular filtration trait male 133.0 days 10 0.46 ml/min/100g 0.03 0.09 automated blood creatinine analysis 0.0 . 102028 2645
BN/NHsdMcwi urine sodium level to urine potassium level ratio control condition Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 133.0 days 10 0.21 null 0.02 0.06 flame photometry 0.0 na/k 102064 2645
BN/NHsdMcwi urine sodium level to body weight ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 14 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. urine sodium amount male 175.0 days 10 0.44 mmol/l/100g 0.03 0.09 flame photometry 0.0 . 102060 2645
BN/NHsdMcwi plasma total cholesterol level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood cholesterol amount male 175.0 days 9 61.39 mg/dl 1.93 5.79 automated plasma total cholesterol analysis 0.0 102080 2645
BN/NHsdMcwi urine albumin excretion rate control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. urine albumin amount male 180.0 days 0.7 mg/d 0.1 albumin blue 580-based urine albumin analysis with spectrophotometric readout 86400.0 albumin blue 580-based urine albumin analysis with spectrophotometric readout (MMO:0000756) n=6-27 110566 3177
BN/NHsdMcwi urine albumin excretion rate control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. urine albumin amount male 360.0 days 0.7 mg/d 0.3 albumin blue 580-based urine albumin analysis with spectrophotometric readout 86400.0 albumin blue 580-based urine albumin analysis with spectrophotometric readout (MMO:0000756) n=6-27 110569 3177
BN/NHsdMcwi kidney glomerulus diameter control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. kidney glomerulus size trait male 360.0 days 6 140.0 um 2.0 4.9 ex vivo light microscopy with histochemistry and digital image analysis 0.0 n=6-27 110587 3177
BN/NHsdMcwi single kidney wet weight to body weight ratio control condition Nobrega MA, et al., Diabetes 2004 Mar;53(3):735-42. kidney mass male 360.0 days 6 3.01 g/kg 0.1 0.24 post excision weight measurement 0.0 n=6-27 110605 3177
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 7.0 days 10 13.45 g 0.31 0.99 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138871 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 42.0 days 10 99.7 g 1.62 5.12 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138876 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 14.0 days 10 25.7 g 0.54 1.72 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138872 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 84.0 days 10 151.4 g 2.65 8.37 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138882 3292
BN/NHsdMcwi total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 29.66 g 1.14 3.6 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138885 3292
BN/NHsdMcwi total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 3.35 g 0.1 0.33 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 138894 3292
BN/NHsdMcwi total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 15.0 % 0.41 1.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138896 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 85.01 % 0.41 1.29 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138899 3292
BN/NHsdMcwi calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 28.0 days 9 10.56 mL/d 0.34 1.01 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 138901 3292
BN/NHsdMcwi average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 70.0 days 9 11.2 g/d 0.5 1.5 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 138904 3292
BN/NHsdMcwi body weight gain to calories absorbed ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait female 70.0 days 9 0.19 g/kcal 0.01 0.02 constant volume calorimetry "Body weight gain, bomb calorimetry"; Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed Energy efficiency Changed sex from F to female to standardize across records, 7-30-2024 138909 3292
BN/NHsdMcwi blood glucose level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount female 91.0 days 10 76.7 mg/dl 3.19 10.09 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien "; "animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from F to female to standardize across records, 7-30-2024 138910 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 70.0 days 10 88.84 % 1.07 3.37 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 138908 3292
BN/NHsdMcwi liver wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass female 91.0 days 10 4.48 g 0.15 0.48 post excision weight measurement weight scale Liver Changed sex from F to female to standardize across records, 7-30-2024 138911 3292
BN/NHsdMcwi both ovaries wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. ovary mass female 91.0 days 10 61.36 mg 1.75 5.54 post excision weight measurement weight scale Ovaries Changed sex from F to female to standardize across records, 7-30-2024 138918 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 21.0 days 10 42.2 g 1.47 4.64 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138930 3292
BN/NHsdMcwi body length, nose to tail controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 33.83 cm 0.19 0.6 body length measuring method tape measure Nose:tail body length Changed sex from F to female to standardize across records, 7-30-2024 138926 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 7.0 days 10 13.02 g 0.25 0.8 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138928 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 77.0 days 10 143.5 g 4.12 13.03 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138938 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 155.2 g 2.68 8.48 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138940 3292
BN/NHsdMcwi total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 29.27 g 1.0 3.17 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138942 3292
BN/NHsdMcwi total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 55.19 g 1.85 5.85 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138952 3292
BN/NHsdMcwi blood glucose level controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount female 91.0 days 10 75.7 mg/dl 3.05 9.65 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien "; "animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from F to female to standardize across records, 7-30-2024 138967 3292
BN/NHsdMcwi heart left ventricle weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass female 91.0 days 10 0.37 g 0.01 0.02 post excision weight measurement weight scale Left ventricle of the heart Changed sex from F to female to standardize across records, 7-30-2024 138969 3292
BN/NHsdMcwi epididymal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass female 91.0 days 10 0.72 g 0.05 0.16 post excision weight measurement weight scale GWAT Changed sex from F to female to standardize across records, 7-30-2024 138971 3292
BN/NHsdMcwi renal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass female 91.0 days 10 0.42 g 0.03 0.08 post excision weight measurement weight scale PWAT Changed sex from F to female to standardize across records, 7-30-2024 138972 3292
BN/NHsdMcwi body length, nose to rump controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 19.42 cm 0.21 0.66 body length measuring method tape measure Nose:Rump body length Changed sex from F to female to standardize across records, 7-30-2024 138979 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 42.0 days 10 124.6 g 2.71 8.57 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138987 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 84.0 days 10 237.5 g 3.55 11.24 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138993 3292
BN/NHsdMcwi total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 10 31.67 g 0.8 2.54 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 138996 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 10 88.69 % 0.45 1.42 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139002 3292
BN/NHsdMcwi average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 28.0 days 10 11.78 g/d 0.33 1.05 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 139011 3292
BN/NHsdMcwi blood glucose level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount male 91.0 days 10 74.9 mg/dl 1.78 5.63 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien , animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from M to male to standardize across records, 7-30-2024 139029 3292
BN/NHsdMcwi renal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass male 91.0 days 10 1.07 g 0.07 0.24 post excision weight measurement weight scale PWAT Changed sex from M to male to standardize across records, 7-30-2024 139034 3292
BN/NHsdMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91.0 days 8 4.19 ng/dL 0.21 0.6 radioimmunoassay RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 139040 3292
BN/NHsdMcwi both testes wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. testis mass male 91.0 days 9 2.99 g 0.04 0.11 post excision weight measurement weight scale Testes Changed sex from M to male to standardize across records, 7-30-2024 139037 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 21.0 days 11 45.27 g 1.4 4.65 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139046 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 28.0 days 11 68.55 g 1.88 6.23 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139047 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 63.0 days 11 201.45 g 2.59 8.61 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139052 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 84.0 days 11 238.45 g 2.4 7.95 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139055 3292
BN/NHsdMcwi total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 11 40.4 g 1.1 3.65 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139060 3292
BN/NHsdMcwi total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 11 62.05 g 1.71 5.67 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139068 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 11 85.33 % 0.35 1.17 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139072 3292
BN/NHsdMcwi total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 11 8.43 g 0.89 2.97 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139073 3292
BN/NHsdMcwi total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 11 7.57 % 0.09 0.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139079 3292
BN/NHsdMcwi calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 28.0 days 11 10.55 mL/d 0.43 1.44 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 139082 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 70.0 days 11 86.89 % 0.49 1.62 constant volume calorimetry "Bomb calorimetry, 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food" Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 139089 3292
BN/NHsdMcwi body mass index (BMI) controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 11 0.52 g/cm2 0.01 0.03 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from M to male to standardize across records, 7-30-2024 139106 3292
BN/NHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 23.83 ml/min 1.38 3.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15620 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 0.23 ml 0.01 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15313 381
BN/NHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 283.69 beats/min 2.77 4.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15343 381
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 42 continuous mean 109.0 mmHg 3.0 19.44 vascular indwelling catheter method femoral artery 259200.0 3 h per day increase 66139 229
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 99.09 mmHg 1.82 3.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14668 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 271.02 beats/min 36.44 103.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15969 381
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 14 serial mean 89.0 mmHg 2.0 7.48 vascular indwelling catheter method left femoral artery 0 65466 151
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 137.97 % 8.03 24.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53524 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 103.25 breaths/min 4.73 20.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14874 381
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 10 19.71 mg/d 4.56 14.41 automated urine analysis Moms and pups used in studies were fed Teklad 51762 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 16.08 mmHg 3.41 9.65 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51779 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 112.16 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51830 481
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 5 1.48 ng/ml/h 0.33 0.74 radioimmunoassay Moms and pups used in studies were fed Teklad 51845 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 11.12 beats/min 17.12 51.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51859 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -26.7 beats/min 9.39 18.78 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51928 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 7.17 beats/min 11.83 33.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51927 481
BN/NHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 3 1.49 ml/min 0.16 0.28 urine creatinine analysis Moms and pups used in studies were fed Teklad 51955 481
BN/NHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 3 12.33 mEq/d 1.71 2.97 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52021 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 -6.25 beats/min 7.6 21.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52059 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 8 32.25 mg/d 4.9 13.87 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52134 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 8 1.74 ml/min 0.15 0.44 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52186 482
BN/NHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 8 1.06 mEq/d 0.04 0.12 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52332 482
BN/NHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 8 2.55 ml/min 0.26 0.72 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52379 482
BN/NHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 15 4.4 ng/ml/h 1.26 4.87 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52481 482
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 2.63 mmHg 2.19 4.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50609 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 9 0.28 beats/min 13.27 39.81 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50624 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 5.59 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50636 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 1 106.57 mmHg vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50650 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 0.72 mmHg 2.7 7.14 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50706 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 3.55 mmHg 3.77 10.66 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50707 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -12.7 beats/min 20.48 40.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50727 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 3.46 mmHg 1.52 4.29 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50781 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 8 4.68 mmHg 2.12 5.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50920 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 2.23 mmHg 1.67 4.71 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50937 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 8 110.47 mmHg 3.23 9.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50951 481
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 168.87 % 7.75 30.99 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54097 381
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 18 124.88 % 6.92 29.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54229 381
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 16 123.17 % 9.36 37.44 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54231 381
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 8 431.06 beats/min 10.72 30.33 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51124 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 114.16 mmHg 3.59 7.17 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51151 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 2 0.26 mg/dl 0.06 0.08 radioimmunoassay Moms and pups used in studies were fed Dyets 51179 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 1 432.84 beats/min vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51254 481
BN/NHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 8 408.04 beats/min 7.45 21.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51291 481
BN/NHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 17.74 mmHg 6.47 12.94 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51346 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -19.96 beats/min 18.9 50.01 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51360 481
BN/NHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 9 10.75 mg/d 1.32 3.95 automated urine analysis Moms and pups used in studies were fed Dyets 51446 481
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 107.88 mmHg 3.52 7.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51637 481
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 3 0.28 mg/dl 0.03 0.05 radioimmunoassay Moms and pups used in studies were fed Teklad 51655 481
BN/NHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 4 -45.27 beats/min 22.01 44.02 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50363 481
BN/NHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 202.48 beats/min 19.79 55.98 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14739 381
BN/NHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 35.52 degrees C 0.29 1.24 digital rectal thermometry Moms and pups used in studies were fed Teklad 13638 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 2 97.58 mmHg 2.28 3.22 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17307 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 23 %change=VE during 2-3 min hypoxia/control during standard conditions 141.88 % 3.93 18.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13759 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 154.48 % 7.68 32.59 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13760 381
BN/NHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 5 104.25 mmHg 2.28 5.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13895 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 5 12.9 mmHg 5.59 12.5 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14027 381
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 143.08 % 12.59 37.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14093 381
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 110.0 mmHg 3.0 13.75 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11853 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 42 continuous mean 94.0 mmHg 2.0 12.96 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12009 229
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19827 381
BN/NHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 13 25.28 mmHg 2.6 9.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20742 381
BN/NHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 13 264.71 beats/min 13.8 49.76 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20965 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 112.48 mmHg 3.95 11.17 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19907 381
BN/NHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 468.56 beats/min 15.05 26.06 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19968 381
BN/NHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 121.54 mmHg 3.45 7.72 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19987 381
BN/NHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 14 7.4 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20666 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 3 101.71 mmHg 1.74 3.01 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19521 381
BN/NHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 105.34 mmHg 2.06 4.12 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19522 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 9 -0.8 degrees C 0.23 0.7 digital rectal thermometry Moms and pups used in studies were fed Dyets 19580 381
BN/NHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during 2-3 min hypercapnia/control during standard conditions 196.09 % 10.2 28.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 19604 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 7.51 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17612 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 8 116.03 breaths/min 8.65 24.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17691 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 3 -6.23 mmHg 1.02 1.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17714 381
BN/NHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 114.18 mmHg 3.76 6.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17778 381
BN/NHsdMcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 23 227.9 g 3.0 14.2 whole body digital scale Moms and pups used in studies were fed Dyets 17896 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 8 %change=VE during7-9 min hypoxia/control during standard conditions 123.13 % 6.51 18.42 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17921 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 449.47 beats/min 14.97 36.66 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18109 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 349.4 beats/min 28.52 57.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18108 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 18 37.34 degrees C 0.17 0.71 digital rectal thermometry Moms and pups used in studies were fed Teklad 16892 381
BN/NHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 18 106.21 breaths/min 5.25 22.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16990 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 18 116.6 breaths/min 7.75 32.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18345 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 1 7.51 null automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19019 381
BN/NHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 20 178.3 U/l 5.17 23.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36457 401
BN/NHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 17 125.94 U/l 4.8 19.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36458 401
BN/NHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 11 4.06 x 1000 cells/ul 0.67 2.23 automated blood cell counting method Moms and pups used in studies were fed Teklad 36941 401
BN/NHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 18 5.01 x 1000 cells/ul 0.51 2.17 automated blood cell counting method Moms and pups used in studies were fed Teklad 36940 401
BN/NHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 17 5.38 g/dl 0.1 0.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37041 401
BN/NHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 20 62.0 mg/dl 1.05 4.69 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37175 401
BN/NHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 0.31 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18635 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 13 226.69 beats/min 13.62 49.11 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17547 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 273.08 beats/min 29.68 93.86 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17548 381
BN/NHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 19 144.79 mmol/l 0.73 3.19 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36561 401
BN/NHsdMcwi body length, nose to tail controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70.0 days-84.0 days 26 34.88 cm 0.12 0.63 in vivo ruler method 63723 529
BN/NHsdMcwi heart left ventricle wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen General data heart left ventricle mass male 70.0 days-84.0 days 45 0.51 g 0.01 0.05 digital scale post excision weight measurement 63794 529
BN/NHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 394.7 beats/min 20.25 35.08 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18201 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 16 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20170 381
BN/NHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 17 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20171 381
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 3 80.79 beats/min 31.42 54.42 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20429 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 54.33 mmHg 1.8 6.25 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20519 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 3 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20545 381
BN/NHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 18 37.05 degrees C 0.27 1.16 digital rectal thermometry Moms and pups used in studies were fed Teklad 19148 381
BN/NHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 18 225.77 beats/min 11.59 49.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49023 461
BN/NHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 19 0.54 g 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49139 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 17 5.51 mmHg 0.14 0.59 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49256 461
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 23 4.31 % 1.05 5.04 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49776 461
BN/NHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 2 96.37 beats/min 51.17 72.37 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19172 381
BN/NHsdMcwi body length, nose to rump controlled sodium content diet (4 %) (for 14 days) PhysGen General data body length female 70.0 days-84.0 days 26 20.38 cm 0.14 0.73 in vivo ruler method 63569 529
BN/NHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 13 56.81 fl 0.18 0.64 automated blood cell counting method Moms and pups used in studies were fed Teklad 38824 401
BN/NHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 -8.13 null 0.03 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter 63123 528
BN/NHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 17 3.62 g/dl 0.05 0.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42312 401
BN/NHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 18.26 pg 0.09 0.31 automated blood cell counting method Moms and pups used in studies were fed Teklad 42624 401
BN/NHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 14 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42955 401
BN/NHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 18 21.28 mmol/l 0.53 2.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43061 401
BN/NHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 16 157.88 % 7.8 31.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54437 381
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 32.17 g/dl 0.11 0.39 automated blood cell counting method Moms and pups used in studies were fed Teklad 39856 401
BN/NHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 18 6.54 x 1000 cells/ul 0.48 2.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 39956 401
BN/NHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 11 5.52 x 1000 cells/ul 0.58 1.91 automated blood cell counting method Moms and pups used in studies were fed Teklad 39957 401
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 9 114.4 % 4.57 13.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53546 381
BN/NHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 14 107.21 mmol/l 1.04 3.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40078 401
BN/NHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 14 4.23 mmol/l 0.13 0.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43399 401
BN/NHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 18 117.99 % 5.79 24.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53644 381
BN/NHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 11 0.21 x 1000 cells/ul 0.05 0.16 automated blood cell counting method Moms and pups used in studies were fed Teklad 40366 401
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 19 2.97 mg/kg 0.71 3.09 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58985 526
BN/NHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 14 3.24 g/dl 0.11 0.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40479 401
BN/NHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 20 19.6 mg/dl 0.44 1.96 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40906 401
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 15 0.06 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59429 526
BN/NHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 20 1.04 g/kg 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59525 526
BN/NHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 32 1.34 g/kg 0.03 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59735 526
BN/NHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 14 164.36 mg/dl 9.43 35.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41266 401
BN/NHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 18 45.79 % 0.77 3.26 automated blood cell counting method Moms and pups used in studies were fed Teklad 41373 401
BN/NHsdMcwi serum glucose level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70.0 days-84.0 days 26 145.0 mg/dl 3.68 18.76 standard blood chemistry panel 62516 527
BN/NHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 11 0.09 x 1000 cells/ul 0.03 0.09 automated blood cell counting method Moms and pups used in studies were fed Teklad 41476 401
BN/NHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 15 5.7 x 1000 cells/ul 0.53 2.06 automated blood cell counting method Moms and pups used in studies were fed Teklad 41581 401
BN/NHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 13 0.18 x 1000 cells/ul 0.05 0.18 automated blood cell counting method Moms and pups used in studies were fed Teklad 41726 401
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 8 -6.98 null 0.1 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer 62874 528
BN/NHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 20 159.35 mg/dl 4.56 20.37 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38608 401
BN/NHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 17 171.94 mg/dl 6.33 26.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38609 401
BN/NHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 20 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41946 401
BN/NHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 17 0.1 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41947 401
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 264.61 beats/min 9.44 45.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47660 461
BN/NHsdMcwi mean corpuscular volume controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70.0 days-84.0 days 27 53.86 fl 0.3 1.55 automated blood cell counting method 60804 527
BN/NHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 19.85 mmHg 3.76 13.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16301 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -12.17 mmHg 0.96 1.92 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16322 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 27.08 mmHg 1.33 3.52 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16455 381
BN/NHsdMcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 20 147.9 g 2.3 10.4 whole body digital scale Moms and pups used in studies were fed Teklad 55477 522
BN/NHsdMcwi serum globulin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70.0 days-84.0 days 27 1.55 g/dl 0.03 0.14 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 60978 527
BN/NHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 -6.94 null 0.06 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55688 522
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 24 0.42 null 0.03 0.15 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58192 526
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70.0 days-84.0 days 44 0.31 mg/dl 0.01 0.09 automated plasma creatinine analysis 61059 527
BN/NHsdMcwi plasma anion gap controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70.0 days-84.0 days 27 20.93 mmol/l 0.61 3.17 standard blood chemistry panel 61132 527
BN/NHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 2.46 g/mg 0.15 0.68 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55851 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 2.06 E-7mole 0.37 1.57 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55956 522
BN/NHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 13 57.09 ml/min/kg 3.16 11.39 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58297 526
BN/NHsdMcwi serum total protein level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70.0 days-84.0 days 44 5.82 g/dl 0.05 0.33 standard blood chemistry panel 61285 527
BN/NHsdMcwi total white blood cell count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70.0 days-84.0 days 43 7.07 x 1000 cells/ul 0.29 1.91 automated blood cell counting method 61429 527
BN/NHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 -8.92 null 0.07 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56041 522
BN/NHsdMcwi serum chloride level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70.0 days-84.0 days 44 103.82 mmol/l 0.5 3.34 standard blood chemistry panel 62351 527
BN/NHsdMcwi serum total cholesterol level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70.0 days-84.0 days 27 54.26 mg/dl 1.17 6.06 standard blood chemistry panel 62424 527
BN/NHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 20 99.2 % 0.44 1.99 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56327 522
BN/NHsdMcwi serum bicarbonate level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70.0 days-84.0 days 44 19.23 mmol/l 0.52 3.42 standard blood chemistry panel 61665 527
BN/NHsdMcwi blood monocyte count controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70.0 days-84.0 days 43 0.13 x 1000 cells/ul 0.02 0.12 automated blood cell counting method 61737 527
BN/NHsdMcwi serum sodium level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70.0 days-84.0 days 44 141.27 mmol/l 0.43 2.86 flame atomic emission spectrometry 61839 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 53.36 % 3.27 12.24 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55067 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 17 39.53 % 3.87 15.95 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55154 522
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 14 53.21 % 2.9 10.85 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55155 522
BN/NHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 98.45 % 0.64 2.86 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56488 522
BN/NHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 3.1 E-7mole 0.51 2.18 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56580 522
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 12 0.23 null 0.01 0.04 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59843 526
BN/NHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (4 %) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70.0 days-84.0 days 26 37.46 U/l 2.48 12.62 standard blood chemistry panel 61502 527
BN/NHsdMcwi serum albumin level controlled sodium content diet (4 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70.0 days-84.0 days 27 3.6 g/dl 0.03 0.18 standard blood chemistry panel 61962 527
BN/NHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 17 45.82 % 3.52 14.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57189 522
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 11.48 IU/g 0.82 2.59 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45710 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 21 16.32 ml/min/g 0.83 3.8 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46731 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 18 14.39 ml/min/g 0.86 3.64 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46947 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 18 14.68 ml/min/g 0.67 2.85 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46948 461
BN/NHsdMcwi body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 19 120.6 g 2.8 12.1 whole body digital scale Moms and pups used in studies were fed Teklad 47876 461
BN/NHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 18 70.53 mmHg 4.1 17.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47989 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 62.66 % 5.0 21.81 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46144 461
BN/NHsdMcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 20 4.25 g/kg 0.11 0.47 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47053 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 24 5.45 mmHg 0.13 0.63 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47274 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 23 227.28 beats/min 6.69 32.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45226 461
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 20 serial mean 135.6 mmHg 3.2 14.31 vascular indwelling catheter method left femoral artery 120.0 69539 151
BN/NHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 21 serial mean 137.4 mmHg 4.0 18.33 vascular indwelling catheter method left femoral artery 120.0 69545 151
BN/NHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92.0 days-94.0 days 22 100.4 mmol/l 6.5 30.49 unspecified method 0.0 urine sodium analysis 69466 151
BN/NHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92.0 days-94.0 days 25 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 mg/min 69477 151
BN/NHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 92.0 days-94.0 days 8 0.42 mg/dl 0.11 0.31 plasma creatinine analysis 0.0 urine potassium analysis umol/min 69485 151
BN/NHsdMcwi white blood cell count controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. leukocyte quantity female 92.0 days-94.0 days 13 0.02 x 1000 cells/ul 1306.0 4708.85 isolated cell counting method 0.0 69495 151
BN/NHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94.0 days 17 serial mean 134.6 mmHg 4.1 16.9 vascular indwelling catheter method left femoral artery 10800.0 69521 151
BN/NHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 89.0 days-92.0 days 24 168.0 g 2.3 11.27 body weighing method 0.0 69439 151
BN/NHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 20 serial mean 96.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 69445 151
BN/NHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 20 serial mean 111.0 mmHg 2.7 12.07 vascular indwelling catheter method left femoral artery 0.0 69447 151
BN/NHsdMcwi plasma insulin level to plasma glucose level ratio controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. blood insulin amount male 175.0 days 10 2.76 mU/mmol 0.13 0.41 radioimmunoassay 0.0 mU/mmol plasma insulin level to plasma glucose level ratio (CMO:0003555) 102096 2645
BN/NHsdMcwi plasma renin activity level controlled sodium chloride content drinking water (1 %) (for 7 days) then controlled sodium chloride content drinking water (2 %) (for 7 days) then controlled sodium chloride content drinking water (1 %) (for 9 days) then water (for 12 days) Gilibert S, et al., J Hypertens. 2009 Jun;27(6):1186-93. renin activity male 175.0 days 10 24.6 ng/ml/h 2.51 7.94 plasma renin activity assay 0.0 102076 2645
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 35.0 days 10 83.5 g 1.77 5.58 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138875 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 28.0 days 10 63.0 g 1.81 5.73 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138874 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 21.0 days 10 42.9 g 1.75 5.55 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138873 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 56.0 days 10 124.9 g 1.59 5.04 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138878 3292
BN/NHsdMcwi total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 4.91 g 0.43 1.35 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138884 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 153.8 g 2.27 7.18 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138883 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 63.0 days 10 133.7 g 1.89 5.96 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138879 3292
BN/NHsdMcwi total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 37.99 g 1.36 4.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138887 3292
BN/NHsdMcwi total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 11.27 % 0.56 1.76 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138888 3292
BN/NHsdMcwi total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 9.91 g 0.36 1.15 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138892 3292
BN/NHsdMcwi total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 44.98 g 1.29 4.08 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138893 3292
BN/NHsdMcwi average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 28.0 days 10 10.55 g/d 0.18 0.57 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 138900 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 28.0 days 10 87.91 % 0.33 1.03 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 138903 3292
BN/NHsdMcwi timed urine mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait female 70.0 days 10 3.66 g/d 0.23 0.73 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from F to female to standardize across records, 7-30-2024 138906 3292
BN/NHsdMcwi calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 70.0 days 10 10.2 mL/d 0.55 1.75 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 138905 3292
BN/NHsdMcwi inguinal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass female 91.0 days 10 1.17 g 0.05 0.15 post excision weight measurement weight scale IWAT Changed sex from F to female to standardize across records, 7-30-2024 138916 3292
BN/NHsdMcwi pituitary gland wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass female 91.0 days 9 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from F to female to standardize across records, 7-30-2024 138921 3292
BN/NHsdMcwi serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91.0 days 7 3.47 ng/dL 0.19 0.51 radioimmunoassay RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 138924 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 42.0 days 10 98.9 g 2.02 6.38 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138933 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 28.0 days 10 61.9 g 1.8 5.7 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138931 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 70.0 days 10 142.3 g 2.25 7.12 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138937 3292
BN/NHsdMcwi body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 84.0 days 10 151.6 g 2.57 8.11 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 138939 3292
BN/NHsdMcwi total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 10.95 % 0.42 1.34 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138945 3292
BN/NHsdMcwi total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 9.81 g 0.32 1.02 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138949 3292
BN/NHsdMcwi total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 15.15 % 0.46 1.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 138953 3292
BN/NHsdMcwi calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 28.0 days 10 9.5 mL/d 0.34 1.08 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 138958 3292
BN/NHsdMcwi defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 28.0 days 10 1.8 g/d 0.07 0.23 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 138959 3292
BN/NHsdMcwi total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 67.96 % 0.32 1.02 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 138954 3292
BN/NHsdMcwi total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 84.86 % 0.46 1.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 138956 3292
BN/NHsdMcwi average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 70.0 days 10 11.51 g/d 0.54 1.71 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 138961 3292
BN/NHsdMcwi liver wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass female 91.0 days 10 4.57 g 0.17 0.55 post excision weight measurement weight scale Liver Changed sex from F to female to standardize across records, 7-30-2024 138968 3292
BN/NHsdMcwi both kidneys wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass female 91.0 days 10 1.02 g 0.02 0.05 post excision weight measurement weight scale Total Kidneys Changed sex from F to female to standardize across records, 7-30-2024 138970 3292
BN/NHsdMcwi both ovaries wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. ovary mass female 91.0 days 10 63.06 mg 2.42 7.64 post excision weight measurement weight scale Ovaries Changed sex from F to female to standardize across records, 7-30-2024 138975 3292
BN/NHsdMcwi inguinal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass female 91.0 days 9 1.16 g 0.06 0.18 post excision weight measurement weight scale IWAT Changed sex from F to female to standardize across records, 7-30-2024 138973 3292
BN/NHsdMcwi body length, nose to tail controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 33.9 cm 0.23 0.74 body length measuring method tape measure Nose:tail body length Changed sex from F to female to standardize across records, 7-30-2024 138980 3292
BN/NHsdMcwi body mass index (BMI) controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 0.41 g/cm2 0.01 0.02 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from F to female to standardize across records, 7-30-2024 138981 3292
BN/NHsdMcwi pituitary gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass female 91.0 days 10 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from F to female to standardize across records, 7-30-2024 138978 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 49.0 days 10 153.7 g 3.92 12.39 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 138988 3292
BN/NHsdMcwi total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 10 3.49 g 0.1 0.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 138997 3292
BN/NHsdMcwi total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 10 5.16 g 0.32 1.01 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 138995 3292
BN/NHsdMcwi total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 10 40.14 g 1.02 3.21 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 138998 3292
BN/NHsdMcwi total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 10 211.56 g 2.99 9.46 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139018 3292
BN/NHsdMcwi total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 10 157.59 g 2.09 6.61 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 139016 3292
BN/NHsdMcwi total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 10 7.58 % 0.1 0.31 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139021 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 70.0 days 10 87.21 % 0.51 1.61 constant volume calorimetry "Bomb calorimetry, 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food" Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 139027 3292
BN/NHsdMcwi calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 70.0 days 10 13.8 mL/d 0.29 0.92 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 139024 3292
BN/NHsdMcwi timed urine mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait male 70.0 days 10 4.86 g/d 0.41 1.29 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from M to male to standardize across records, 7-30-2024 139025 3292
BN/NHsdMcwi defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 70.0 days 10 2.62 g/d 0.08 0.25 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 139026 3292
BN/NHsdMcwi body weight gain to calories absorbed ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait male 70.0 days 10 0.3 g/kcal 0.01 0.03 constant volume calorimetry "Body weight gain, bomb calorimetry, Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed" Energy efficiency Changed sex from M to male to standardize across records, 7-30-2024 139028 3292
BN/NHsdMcwi interscapular fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass male 91.0 days 10 310.8 mg 15.31 48.41 post excision weight measurement weight scale BAT Changed sex from M to male to standardize across records, 7-30-2024 139036 3292
BN/NHsdMcwi body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 7.0 days 11 13.43 g 0.36 1.18 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139044 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 42.0 days 11 124.27 g 2.56 8.49 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139049 3292
BN/NHsdMcwi body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 77.0 days 11 219.55 g 5.45 18.07 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 139054 3292
BN/NHsdMcwi total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 11 10.66 % 0.45 1.51 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 139061 3292
BN/NHsdMcwi total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 11 8.01 % 0.31 1.04 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 139063 3292
BN/NHsdMcwi total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 11 213.21 g 2.08 6.89 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 139076 3292
BN/NHsdMcwi calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 28.0 days 11 89.29 % 0.33 1.08 constant volume calorimetry "Bomb calorimetry, 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food" Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 139084 3292
BN/NHsdMcwi defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 28.0 days 11 1.73 g/d 0.08 0.27 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 139083 3292
BN/NHsdMcwi heart left ventricle weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass male 91.0 days 11 0.53 g 0.01 0.03 post excision weight measurement weight scale Left ventricle of the heart Changed sex from M to male to standardize across records, 7-30-2024 139093 3292
BN/NHsdMcwi both kidneys wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass male 91.0 days 11 1.57 g 0.03 0.09 post excision weight measurement weight scale Total Kidneys Changed sex from M to male to standardize across records, 7-30-2024 139094 3292
BN/NHsdMcwi epididymal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass male 91.0 days 11 1.86 g 0.07 0.23 post excision weight measurement weight scale GWAT Changed sex from M to male to standardize across records, 7-30-2024 139095 3292
BN/NHsdMcwi thyroid gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass male 91.0 days 11 9.4 mg 0.5 1.67 post excision weight measurement weight scale Thyroid gland Changed sex from M to male to standardize across records, 7-30-2024 139101 3292
BN/NHsdMcwi pituitary gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass male 91.0 days 11 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from M to male to standardize across records, 7-30-2024 139102 3292
BN/NHsdMcwi both testes wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. testis mass male 91.0 days 10 3.03 g 0.03 0.11 post excision weight measurement weight scale Testes Changed sex from M to male to standardize across records, 7-30-2024 139099 3292
BN/NHsdMcwi body length, nose to rump controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 11 21.68 cm 0.1 0.34 body length measuring method tape measure Nose:Rump body length Changed sex from M to male to standardize across records, 7-30-2024 139104 3292
BN/NHsdMcwi thymus wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thymus mass male 91.0 days 3 338.0 mg 5.51 9.54 post excision weight measurement weight scale Thymus gland Changed sex from M to male to standardize across records, 7-30-2024 139103 3292