Phenominer Database Results (1889 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 67 98.21 breaths/min 2.42 19.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15003 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 42 107.39 mmHg 1.29 8.36 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15047 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 62 125.01 mmHg 1.69 13.31 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15118 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 20.79 mmHg 3.5 8.56 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15154 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 -0.66 mmHg 3.81 11.44 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15180 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 1.9 mmHg 3.66 9.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15189 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 27.16 ml/min 1.72 6.22 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15612 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 418.52 beats/min 9.02 27.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15345 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during7-9 min hypercapnia/control during standard conditions 291.74 % 13.42 48.39 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14380 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 8 120.93 mmHg 6.37 18.01 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14410 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 46 33.49 mmHg 0.44 2.96 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14468 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 89.41 ml/min 6.14 21.28 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14573 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 21.82 mmHg 5.92 10.26 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14650 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 122.43 mmHg 4.51 9.02 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14658 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 111.75 mmHg 2.04 6.13 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 15976 381
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 95.0 days 7 4.7 ng/ml/h 1.6 4.23 ex vivo blood analysis 0 65473 151
SS/JrHsdMcwi timed urine volume to body weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. urine output male 70.0 days 10 13.7 ul/min/g 2.1 6.64 ultrasonic flowmeter 1200.0 urine flow to wt ratio 64927 272
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.39 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14908 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 29.89 mmHg 2.83 9.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51774 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 14.65 beats/min 53.53 107.05 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51791 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 14 1.94 ml/min 0.2 0.73 urine creatinine analysis Moms and pups used in studies were fed Dyets 51797 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 23.81 mmHg 5.74 9.95 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51813 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 135.0 mmHg 5.04 21.4 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51821 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -7.24 beats/min 8.54 33.06 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51920 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 5 1.67 ml/min 0.2 0.45 urine creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51931 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80.0 days-99.0 days 9 159.75 mmHg 6.83 20.5 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52865 482
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80.0 days-99.0 days 9 1.7 ml/min 0.13 0.39 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52177 482
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80.0 days-99.0 days 63 87.97 mg/d 9.45 74.97 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52610 482
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80.0 days-99.0 days 11 18.24 mEq/d 1.67 5.53 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52767 482
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 406.36 beats/min 7.25 29.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50523 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 451.75 beats/min 12.93 44.79 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50529 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 2 1.95 ng/ml/h 0.95 1.34 radioimmunoassay Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50566 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -37.31 beats/min 13.25 51.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50582 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 -22.81 mmHg 3.9 16.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50627 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 -17.53 mmHg 2.45 7.75 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50632 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 157.81 mmHg 6.04 25.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50640 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 33.3 mmHg 3.27 13.09 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50653 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 13 17.49 beats/min 12.18 43.9 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50680 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 6.61 mmHg 2.25 8.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50695 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -50.68 beats/min 14.96 51.82 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50723 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 8.29 beats/min 21.22 47.46 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50905 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 3.44 beats/min 4.53 17.54 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50977 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 12 1.15 ng/ml/h 0.27 0.94 radioimmunoassay Moms and pups used in studies were fed Teklad 51003 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 12 1.26 ml/min 0.24 0.84 urine creatinine analysis Moms and pups used in studies were fed Teklad 51052 481
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 168.05 % 2.45 20.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54163 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 8.89 mmHg 2.26 9.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51101 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 148.3 mmHg 5.49 19.02 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51147 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -63.27 beats/min 9.59 33.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51205 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -48.18 beats/min 8.64 34.54 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51218 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 -0.13 beats/min 21.53 37.29 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51303 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 19.93 mmHg 2.55 10.53 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51336 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 18.14 mmHg 3.11 10.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51342 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -26.39 beats/min 10.75 42.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51349 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -14.77 beats/min 11.54 39.96 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51373 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 -20.8 beats/min 34.71 60.12 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51405 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 30.86 mmHg 2.26 9.32 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51421 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 21.74 mmHg 2.32 4.63 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51489 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 9.52 mmHg 0.72 1.24 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51495 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -43.12 beats/min 5.21 21.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51503 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 20 1.21 mEq/d 0.14 0.65 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51516 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 -2.75 mmHg 3.49 12.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51597 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -50.41 beats/min 16.19 32.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50336 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 15 2.88 ng/ml/h 0.5 1.95 radioimmunoassay Moms and pups used in studies were fed Dyets 50388 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 9 3.86 ng/ml/h 0.51 1.54 radioimmunoassay Moms and pups used in studies were fed Dyets 50395 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 356.33 beats/min 4.7 8.14 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50445 481
SS/JrHsdMcwi post-insult time to mammary tumor formation 7,12-dimethyltetraphene (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152.0 days-162.0 days 40 79.8 d 0.59 3.71 manual palpation method 0 DMBA oral gavage 105 days 200ng DMBA/10 ml seasme oil 65568 86
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 51 370.19 beats/min 5.38 38.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14723 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 411.25 beats/min 8.66 27.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14728 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait female 86.0 days-89.0 days 12 177.0 mmHg 5.0 17.32 vascular fluid filled catheter left femoral artery 14400 on 3 consecutive days 5405 15
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 16 and 19 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. arterial blood pressure trait male 86.0 days-89.0 days 12 181.0 mmHg 2.9 10.05 vascular fluid filled catheter left femoral artery 259200 5406 15
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 37 heart rate during walking-heart rate during rest 82.39 beats/min 5.02 30.53 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13397 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 27.95 mmHg 0.64 1.8 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13436 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 121.8 mmHg 3.03 9.59 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13515 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 0.42 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13644 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 143.64 % 6.6 17.46 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14146 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 83.17 ml/min 5.66 17.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14170 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17079 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 9 28.49 mmHg 0.62 1.85 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17271 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 103.64 mmHg 2.36 6.25 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17309 381
SS/JrHsdMcwi plasma total cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood cholesterol amount female 92.0 days-94.0 days 12 76.0 mg/dl 4.4 15.24 plasma total cholesterol measurement test 0.0 67290 151
SS/JrHsdMcwi heart left ventricle wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart left ventricle mass female 97.0 days-101.0 days 11 0.66 g 0.04 0.13 post excision weight measurement 0.0 plasma creatinine analysis 67298 151
SS/JrHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 13 -2.4 ml/min/g 0.5 1.8 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67306 151
SS/JrHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 13 -2.4 ml/min/g 0.6 2.16 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67308 151
SS/JrHsdMcwi ratio of change in renal blood flow rate to kidney weight controlled sodium content diet (0.4 %) (for 16 hours) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renal blood flow trait female 97.0 days-101.0 days 9 1.9 ml/min/g 0.5 1.5 electromagnetic flowmetry 0.0 electromagnetic flowmetry 67310 151
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 134.71 mmHg 4.19 13.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13887 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 104.65 mmHg 2.31 4.62 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13900 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 0.44 ml 0.01 0.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13991 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 312.55 % 10.45 33.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14095 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 7 121.45 mmHg 3.1 8.21 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14120 381
SS/JrHsdMcwi mammary tumor number 7,12-dimethyltetraphene (65 mg/kg) (for 105 days) Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45 mammary gland integrity trait female 152.0 days-162.0 days 40 2.45 null 0.21 1.32 necropsy 0 DMBA oral gavage 105 days necropsy 11488 86
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 154.0 mmHg 6.0 27.5 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11852 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 35 continuous mean 206.0 mmHg 6.0 35.5 vascular indwelling catheter method femoral artery 259200.0 3 h per day 11984 229
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.43 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19738 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 37.01 mmHg 1.17 2.88 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19838 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 93.21 ml/min 2.39 19.57 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20829 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 86.39 ml/min 6.48 22.44 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20834 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 108.38 mmHg 1.76 5.29 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19982 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 -5.23 mmHg 0.9 1.55 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20020 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 40 -3.51 mmHg 0.37 2.35 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20085 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 38.46 ml/min 2.87 7.58 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20127 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 149.0 breaths/min 5.83 21.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20674 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 56.13 mmHg 1.56 4.41 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19558 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 307.07 % 15.01 47.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 19605 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 47 -6.23 mmHg 0.34 2.34 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19658 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 32.19 mmHg 1.2 2.4 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19693 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 14 37.76 degrees C 0.13 0.49 digital rectal thermometry Moms and pups used in studies were fed Dyets 17567 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 147.92 breaths/min 4.56 16.45 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17617 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 37.6 degrees C 0.17 0.64 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17718 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 130.87 mmHg 6.42 16.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17772 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 84.8 breaths/min 4.28 13.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17800 381
SS/JrHsdMcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 91 295.5 g 3.2 30.3 whole body digital scale Moms and pups used in studies were fed Dyets 17885 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 37.83 degrees C 0.13 0.52 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17946 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 -49.62 mmHg 2.89 8.19 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17944 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 38.01 degrees C 0.11 0.3 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17952 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 0.39 ml 0.01 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18050 381
SS/JrHsdMcwi urine sodium excretion rate to body weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. urine sodium amount male 70.0 days 10 0.52 uEq/min/g 0.12 0.38 flame atomic emission spectrometry 1200.0 urine sodium excretion rate to kidney weight ratio 64967 272
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 123.35 breaths/min 5.49 19.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18338 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 62.48 beats/min 17.33 42.44 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18361 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 96.51 breaths/min 4.66 18.04 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18376 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 7 82.03 breaths/min 1.2 3.17 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18382 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 56.02 ml/min 1.81 15.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18730 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 413.33 beats/min 15.97 45.17 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18754 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 25.49 mmHg 0.5 1.49 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18831 381
SS/JrHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 51 101.0 mmHg 1.01 7.24 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18893 381
SS/JrHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 12 31.88 g/dl 0.12 0.42 automated blood cell counting method Moms and pups used in studies were fed Dyets 36308 401
SS/JrHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 89 5.52 x 1000 cells/ul 0.14 1.35 automated blood cell counting method Moms and pups used in studies were fed Teklad 36918 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 4 19.75 mmol/l 1.93 3.86 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37045 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 4 0.3 mg/dl 0.0 0.0 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37065 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 3 19.23 pg 0.15 0.25 automated blood cell counting method Moms and pups used in studies were fed Dyets 37076 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 9 223.56 U/l 19.01 57.04 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37277 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 10 6.17 g/dl 0.1 0.32 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37411 401
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 -44.58 mmHg 2.78 6.81 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18645 381
SS/JrHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 92 143.62 mmol/l 0.31 2.97 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36539 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 10 19.0 mmol/l 0.58 1.83 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36590 401
SS/JrHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 12 9.5 mg/dl 0.16 0.55 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36598 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 7 121.86 mg/dl 12.45 32.94 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36712 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 4 135.0 U/l 16.1 32.2 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36733 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 10 8.99 mg/dl 0.09 0.3 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36732 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 7 142.71 U/l 8.0 21.16 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36738 401
SS/JrHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 92 9.41 mg/dl 0.06 0.62 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36808 401
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount male 84.0 days-88.0 days 12 77.5 mg/d 9.8 33.95 urine analysis 86400 65201 15
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 115.62 breaths/min 4.48 17.35 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18146 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 31.65 ml/min 2.01 7.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18182 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.38 degrees C 0.15 0.51 digital rectal thermometry Moms and pups used in studies were fed Dyets 18229 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 76 -0.22 degrees C 0.09 0.77 digital rectal thermometry Moms and pups used in studies were fed Teklad 20377 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 122.6 mmHg 8.28 21.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20403 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 29.76 mmHg 0.89 2.81 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20410 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 43.49 beats/min 12.01 31.77 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20431 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 55 54.51 mmHg 0.72 5.33 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20501 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 574.36 beats/min 4.48 11.85 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20535 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 0.0 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20560 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 69 36.89 degrees C 0.55 4.59 digital rectal thermometry Moms and pups used in studies were fed Teklad 19137 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.95 degrees C 0.14 0.5 digital rectal thermometry Moms and pups used in studies were fed Teklad 19142 381
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 904.99 s 89.21 252.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48928 461
SS/JrHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 98 1.06 g 0.02 0.16 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49127 461
SS/JrHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 20 0.9 g 0.03 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49132 461
SS/JrHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 9 1.21 g 0.07 0.21 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49606 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 54.4 mmHg 7.76 20.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49616 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 24.0 % 2.52 7.98 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49627 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 16 26.73 % 6.45 25.78 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49769 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 6 26.32 ml/min/g 10.73 26.28 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49866 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 97 50.08 mmHg 1.5 14.8 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50063 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 4 0.28 IU/g 0.05 0.1 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50090 461
SS/JrHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 18 794.91 s 52.63 223.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50191 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 97 1043.39 s 13.19 129.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50293 461
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.92 degrees C 0.13 0.47 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19176 381
SS/JrHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 38.1 degrees C 0.19 0.49 digital rectal thermometry Moms and pups used in studies were fed Dyets 19194 381
SS/JrHsdMcwi heart wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart mass male 70.0 days-84.0 days 47 1.13 g 0.02 0.14 digital scale post excision weight measurement 63226 529
SS/JrHsdMcwi body length, nose to rump controlled sodium content diet (1 %) (for 14 days) PhysGen General data body length female 70.0 days-84.0 days 17 21.38 cm 0.34 1.42 in vivo ruler method 63498 529
SS/JrHsdMcwi left kidney wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data kidney mass male 70.0 days-84.0 days 47 1.43 g 0.03 0.21 digital scale post excision weight measurement 63574 529
SS/JrHsdMcwi left kidney wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data kidney mass female 70.0 days-84.0 days 17 0.9 g 0.02 0.1 digital scale post excision weight measurement 63580 529
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 4 4.68 mmol/l 0.34 0.69 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 38828 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 96 17.61 mmol/l 0.37 3.67 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42129 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 12 93.67 U/l 10.96 37.98 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42146 401
SS/JrHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 12 20.75 mmol/l 1.6 5.53 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42197 401
SS/JrHsdMcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 11 299.18 g 5.3 17.59 whole body digital scale 63196 528
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 2.16 E-7mole 1.14 3.59 wire myography using a Digi-Med tissue force analysis system with force transducer 63216 528
SS/JrHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 9 23.89 mg/dl 1.7 5.09 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42333 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 9 54.67 U/l 4.78 14.34 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42341 401
SS/JrHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 12 7.7 x 10E6 cells/ul 0.15 0.51 automated blood cell counting method Moms and pups used in studies were fed Dyets 42377 401
SS/JrHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 7.81 x 10E6 cells/ul 0.35 1.06 automated blood cell counting method Moms and pups used in studies were fed Dyets 42385 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 10 107.9 mmol/l 0.6 1.91 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39189 401
SS/JrHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 12 98.17 mg/dl 4.94 17.13 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39201 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 11 65.09 U/l 2.9 9.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42474 401
SS/JrHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 9 23.44 mmol/l 0.75 2.24 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42517 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 90 19.92 pg 0.08 0.72 automated blood cell counting method Moms and pups used in studies were fed Teklad 42612 401
SS/JrHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 12 0.73 x 1000 cells/ul 0.1 0.35 automated blood cell counting method Moms and pups used in studies were fed Dyets 39358 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 2 17.7 g/dl 0.2 0.28 automated blood cell counting method Moms and pups used in studies were fed Dyets 39473 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 10 24.2 mmol/l 1.03 3.26 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39488 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 9 0.3 mg/dl 0.04 0.11 automated plasma creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39540 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 94 81.95 U/l 2.52 24.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42837 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 10 0.23 x 1000 cells/ul 0.04 0.14 automated blood cell counting method Moms and pups used in studies were fed Teklad 39746 401
SS/JrHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 11 0.15 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42940 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 10 3.93 g/dl 0.08 0.26 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42966 401
SS/JrHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 92 23.37 mmol/l 0.4 3.82 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43039 401
SS/JrHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 92 21.1 mmol/l 0.4 3.84 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43180 401
SS/JrHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 11 19.36 mmol/l 0.66 2.2 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43188 401
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 169.49 % 2.82 23.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54503 381
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 157.56 % 4.37 9.76 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54569 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 7 137.64 % 5.85 15.47 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53533 381
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 171.48 % 6.31 22.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53561 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 121.68 % 5.76 22.3 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53590 381
SS/JrHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 11 104.45 mmol/l 1.4 4.66 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40063 401
SS/JrHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 84 4.51 mmol/l 0.05 0.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43376 401
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 19 0.12 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 58862 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 1.11 g/kg 0.04 0.11 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58873 526
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 173.24 % 12.33 42.72 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53700 381
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 5 166.98 % 19.01 42.5 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53716 381
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59036 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 116 242.1 g 2.6 28.2 whole body digital scale Moms and pups used in studies were fed Teklad 59129 526
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 3 31.93 g/dl 0.15 0.25 automated blood cell counting method Moms and pups used in studies were fed Dyets 40534 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 10 103.2 mmol/l 0.77 2.44 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40660 401
SS/JrHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 91 206.45 U/l 4.53 43.24 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37499 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 9 0.34 mg/dl 0.05 0.15 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37531 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 10 0.28 mg/dl 0.03 0.09 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37535 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 20.48 pg 0.25 0.8 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37566 401
SS/JrHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 11 42.73 U/l 2.49 8.27 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37764 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 10 0.04 x 1000 cells/ul 0.02 0.05 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37808 401
SS/JrHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 92 2.17 g/dl 0.03 0.3 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41076 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 31.97 g/dl 0.22 0.71 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41120 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 4 33.5 U/l 2.9 5.8 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41154 401
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 0.68 null 0.05 0.13 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59745 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 6.93 ml/min/kg 1.07 3.03 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59749 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 11.15 ml/min/kg 1.47 4.64 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59754 526
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 3 9.33 x 10E6 cells/ul 0.14 0.25 automated blood cell counting method Moms and pups used in studies were fed Dyets 37920 401
SS/JrHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 11 156.36 mg/dl 5.1 16.93 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41251 401
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 88 44.42 % 0.22 2.04 automated blood cell counting method Moms and pups used in studies were fed Teklad 41351 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 4 35.5 mg/dl 2.1 4.2 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41380 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 2 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method Moms and pups used in studies were fed Dyets 38196 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 2 8.15 x 1000 cells/ul 0.25 0.35 automated blood cell counting method Moms and pups used in studies were fed Dyets 41482 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 90 5.7 x 1000 cells/ul 0.16 1.52 automated blood cell counting method Moms and pups used in studies were fed Teklad 41570 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 96 22.92 mmol/l 0.45 4.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38328 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 10 22.5 mmol/l 1.28 4.03 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38333 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 2 53.65 % 2.05 2.9 automated blood cell counting method Moms and pups used in studies were fed Dyets 38354 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 3 56.27 % 1.39 2.41 automated blood cell counting method Moms and pups used in studies were fed Dyets 38359 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 7 105.14 mmol/l 0.63 1.68 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38414 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 10 0.03 x 1000 cells/ul 0.02 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41719 401
SS/JrHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 92 18.49 mg/dl 0.4 3.8 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41801 401
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 -7.25 null 0.1 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 62886 528
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 -7.7 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter 62890 528
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 62976 528
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 9 137.89 mg/dl 8.16 24.47 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38624 401
SS/JrHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 89 57.47 fl 0.14 1.36 automated blood cell counting method Moms and pups used in studies were fed Teklad 38696 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 10 0.13 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41940 401
SS/JrHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 19 1054.01 s 28.2 122.93 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46620 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 5.23 mmHg 0.51 1.68 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47532 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 7 0.55 IU/g 0.14 0.36 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47559 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 4 66.25 mmHg 8.33 16.66 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47563 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 72.41 % 5.6 15.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48505 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 78 post-ischemic value/pre-ischemic value x 100% 34.81 % 2.3 20.28 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48593 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 75 124.69 mmHg 3.0 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48690 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 13 post-ischemic value/pre-ischemic value x 100% 79.83 % 4.57 16.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48827 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 12 5.77 mmHg 0.44 1.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48912 461
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 12 0.05 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57302 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 1.25 g/mg 0.12 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57380 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 -7.13 null 0.13 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 57410 522
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 25.16 ml/min 2.68 5.99 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16249 381
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 46.0 % 11.05 24.7 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55363 522
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 21 0.23 null 0.01 0.04 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 57726 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 10 0.06 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 57760 526
SS/JrHsdMcwi serum glucose level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount male 70.0 days-84.0 days 41 123.0 mg/dl 3.19 20.42 standard blood chemistry panel 60615 527
SS/JrHsdMcwi serum bicarbonate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount male 70.0 days-84.0 days 41 19.34 mmol/l 0.37 2.38 standard blood chemistry panel 60809 527
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 6.64 mmHg 1.97 5.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16293 381
SS/JrHsdMcwi serum sodium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount female 70.0 days-84.0 days 17 143.24 mmol/l 0.86 3.53 flame atomic emission spectrometry 60907 527
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 0.43 ml 0.02 0.06 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16662 381
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 -6.98 null 0.12 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55727 522
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 7 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58097 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 3 55.33 % 2.06 3.56 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 58198 526
SS/JrHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 29.12 ml/min/kg 4.85 8.4 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58206 526
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount female 70.0 days-84.0 days 16 174.31 U/l 12.33 49.32 standard blood chemistry panel 61215 527
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 37.98 ml/min 1.19 10.24 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16758 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 5.11 mmHg 2.88 7.61 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16784 381
SS/JrHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.39 g/mg 0.1 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55836 522
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 81 1.53 E-7mole 0.12 1.11 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55934 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -8.35 null 0.1 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55999 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -8.43 null 0.08 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56012 522
SS/JrHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 4 0.76 g/kg 0.01 0.02 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58421 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 10.93 ml/min/kg 1.56 4.41 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58467 526
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 1.27 E-7mole 0.38 1.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54596 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54722 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 -7.29 null 0.12 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56151 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 18 97.5 % 1.45 6.15 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56193 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 27.23 % 2.64 9.53 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56204 522
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58561 526
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 62.4 % 4.98 15.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54826 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 50.42 % 4.9 16.97 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54856 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 90 0.06 umol/l 0.01 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54946 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.08 umol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54952 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 15.0 % 1.68 5.83 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56299 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 54 99.5 % 0.33 2.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56318 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 96.29 % 3.1 8.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56322 522
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 9 1.19 g/kg 0.04 0.12 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58702 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 9 1.42 g/kg 0.02 0.05 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58706 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 11 0.34 null 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58890 526
SS/JrHsdMcwi serum calcium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount female 70.0 days-84.0 days 17 10.29 mg/dl 0.1 0.43 standard blood chemistry panel 61749 527
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 12 0.63 umol/l 0.28 0.96 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54994 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 16 -7.1 null 0.07 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55027 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 41 28.66 % 2.15 13.8 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55058 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 46 35.33 % 2.65 18.01 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55086 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -6.47 null 0.05 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56449 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 54 98.54 % 0.9 6.58 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56478 522
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount male 70.0 days-84.0 days 41 40.71 U/l 1.32 8.47 standard blood chemistry panel 62193 527
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data heart pumping trait male 70.0 days-77.0 days 6 350.0 beats/min 5.25 12.85 radiotelemetry carotid artery - 43745 441
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 0.07 10E-7mol/l 0.02 0.07 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56692 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 35.83 % 2.85 9.86 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56727 522
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 92 9.88 ml/min/kg 0.36 3.43 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60043 526
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 19 45.62 % 1.08 4.72 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 60125 526
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart pumping trait male 70.0 days-77.0 days 6 344.67 beats/min 2.51 6.15 radiotelemetry carotid artery - 44055 441
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 79 -6.98 null 0.06 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56955 522
SS/JrHsdMcwi total white blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity male 70.0 days-84.0 days 39 8.01 x 1000 cells/ul 0.29 1.79 automated blood cell counting method 60287 527
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 17 33.06 g/dl 0.09 0.37 automated blood cell counting method 61861 527
SS/JrHsdMcwi serum globulin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount male 70.0 days-84.0 days 41 2.14 g/dl 0.03 0.22 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 61865 527
SS/JrHsdMcwi plasma anion gap controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait female 70.0 days-84.0 days 17 24.94 mmol/l 0.54 2.22 standard blood chemistry panel 61891 527
SS/JrHsdMcwi serum total cholesterol level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount male 70.0 days-84.0 days 41 97.0 mg/dl 3.58 22.95 standard blood chemistry panel 60533 527
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.58 ml 0.04 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17353 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 0.6 ml 0.02 0.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17438 381
SS/JrHsdMcwi right kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70.0 days-77.0 days 7 1.61 g 0.05 0.13 digital scale post excision weight measurement - 44364 441
SS/JrHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 6.83 g/kg 0.42 1.34 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45664 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 10.85 IU/g 1.23 3.7 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45705 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 80 129.36 mmHg 3.09 27.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45795 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 14 125.94 mmHg 4.36 16.31 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45800 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 17 10.45 ml/min/g 0.56 2.32 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46724 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 71 115.72 mmHg 3.11 26.22 balloon tipped catheter with pressure transducer in isolated perfused heart 46817 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 4 175.25 mmHg 11.56 23.13 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45812 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 79.37 mmHg 12.11 32.03 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45823 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 11 1.56 g 0.09 0.29 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 45826 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 48.56 mmHg 6.11 10.59 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45886 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 23.2 IU/g 3.38 10.15 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46000 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 2 0.44 IU/g 0.08 0.11 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47994 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 4 post-ischemic value/pre-ischemic value x 100% 14.78 % 14.78 29.56 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48002 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 16 6.97 ml/min/g 1.32 5.27 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44789 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 92 post-ischemic value/pre-ischemic value x 100% 62.8 % 2.23 21.36 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46132 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 70.6 % 3.25 14.17 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46137 461
SS/JrHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 91 57.63 mmHg 1.59 15.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48100 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 34.97 % 6.86 19.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48136 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 75 post-ischemic value/pre-ischemic value x 100% 88.06 % 3.15 27.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44985 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 106.74 mmHg 4.91 16.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45001 461
SS/JrHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 9 386.17 s 68.57 205.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45125 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 89 6.25 ml/min/g 0.31 2.95 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46268 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 30.63 % 5.05 16.74 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46391 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 16 5.59 mmHg 0.17 0.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47268 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 93 0.29 IU/g 0.02 0.22 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47347 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 19 0.39 IU/g 0.04 0.19 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47355 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 93 post-ischemic value/pre-ischemic value x 100% 80.21 % 2.88 27.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48361 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 1 14.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45243 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 16 41.3 mmHg 5.48 21.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45341 461
SS/JrHsdMcwi middle cerebral artery inner diameter controlled captopril content drinking water (100 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 245.0 um 6.1 14.94 ex vivo videomicroscopy 0.0 69562 732
SS/JrHsdMcwi middle cerebral artery inner diameter controlled losartan content drinking water (20 mg/kg/d) (for 7 days) then physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 7 147.0 um 2.3 6.09 ex vivo videomicroscopy 0.0 69567 732
SS/JrHsdMcwi middle cerebral artery inner diameter 0.9% sodium chloride solution (for 3 days) then physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 155.0 um 8.6 21.07 ex vivo videomicroscopy 0.0 69570 732
SS/JrHsdMcwi resting tone of middle cerebral artery controlled losartan content drinking water (20 mg/kg/d) (for 7 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 7 [(Dmax - Drest) /Dmax] x 100 38.0 % 2.1 5.56 ex vivo videomicroscopy 0.0 69569 732
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 126.0 mmHg 4.1 14.78 vascular indwelling catheter method left femoral artery 120.0 69528 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (20 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 131.3 mmHg 4.2 15.14 vascular indwelling catheter method left femoral artery 120.0 69530 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 132.0 mmHg 7.0 21.0 vascular indwelling catheter method left femoral artery 120.0 69542 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 134.7 mmHg 7.4 22.2 vascular indwelling catheter method left femoral artery 120.0 69544 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 159.0 mmHg 7.1 21.3 vascular indwelling catheter method left femoral artery 120.0 69546 151
SS/JrHsdMcwi urine potassium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92.0 days-94.0 days 14 124.4 mmol/l 8.8 32.93 unspecified method 0.0 urine potassium analysis 69472 151
SS/JrHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 89.0 days-92.0 days 17 1.02 mEq/d 0.07 0.3 unspecified method 0.0 urine potassium analysis umol/min 69470 151
SS/JrHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92.0 days-94.0 days 16 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 mg/min 69478 151
SS/JrHsdMcwi plasma total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood total protein amount female 89.0 days-92.0 days 13 40.4 mg/ml 3.1 11.18 unspecified method 0.0 69484 151
SS/JrHsdMcwi right kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 21 1.32 g 0.08 0.37 post excision weight measurement 0.0 69508 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days 16 serial mean 208.0 mmHg 7.6 30.4 vascular indwelling catheter method left femoral artery 10800.0 69510 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 92.0 days 21 serial mean 425.4 beats/min 10.5 48.12 vascular indwelling catheter method left femoral artery 10800.0 69514 151
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. blood creatinine amount not specified 84.0 days 0.34 mg/dl 0.04 unspecified method 0.0 69286 1057
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 15 serial mean 159.0 mmHg 6.0 23.24 vascular indwelling catheter method left femoral artery 0.0 69448 151
SS/JrHsdMcwi systolic blood pressure control condition (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44.0 days-53.0 days 14 serial mean 122.0 mmHg 1.0 3.74 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98479 2079
SS/JrHsdMcwi urine total protein excretion rate physical restraint (20-30 min/d) (for 4 days) McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. total urine protein amount male 126.0 days 20 88.0 mg/d 5.0 22.36 Bradford protein assay 0.0 100081 2418
SS/JrHsdMcwi heart rate control condition (0.4 %) (between 50 and 52 days) Cowley AW Jr, et al., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7. heart pumping trait male 50.0 days-52.0 days 8 serial mean 446.0 beats/min 5.0 14.14 intra-aortic thoracic radiotelemetry via carotid cannulation 86400.0 98641 2118
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. arterial blood pressure trait male 91.0 days 12 serial mean 182.0 mmHg 6.0 20.78 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 98699 2141
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. arterial blood pressure trait male 91.0 days 10 serial mean 179.0 mmHg 6.0 18.97 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 98719 2142
SS/JrHsdMcwi plasma creatinine level control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. blood creatinine amount male 126.0 days 13 0.52 mg/dl 0.03 0.11 plasma creatinine analysis 0.0 100089 2418
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. heart pumping trait male 44.0 days-53.0 days 14 serial mean 414.0 beats/min 5.0 18.71 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98514 2079
SS/JrHsdMcwi urine albumin excretion rate controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. urine albumin amount female 91.0 days 13 135.0 mg/d 15.0 54.08 urine microalbumin analysis 1.0 98710 2141
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 20 and 29 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 41.0 days-50.0 days 14 2.8 mg/d 0.5 1.87 urine microalbumin analysis 86400.0 98528 2079
SS/JrHsdMcwi body weight control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. body mass male 126.0 days 27 373.0 g 4.0 20.78 body weighing method 0.0 100069 2418
SS/JrHsdMcwi plasma triglyceride level control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. blood triglyceride amount male 42.0 days 9 0.46 mmol/l 0.07 0.2 enzyme linked immunosorbent assay 0.0 100075 2418
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 3 EDL/BW 0.43 mg/g 0.01 0.02 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99053 2198
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 3 EDL/BW 0.46 mg/g 0.01 0.02 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99054 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 3 TA/BW 1.88 mg/g 0.04 0.07 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99056 2198
SS/JrHsdMcwi heart left ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56.0 days 7 0.64 g 0.02 0.05 post excision weight measurement 0.0 106538 3032
SS/JrHsdMcwi non-muscularized arterioles to total arterioles ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. pulmonary arteriole morphology trait male 56.0 days 11 9.4 % 1.12 3.71 immunohistochemistry 0.0 106548 3032
SS/JrHsdMcwi right atrium weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 11 0.03 g 0.0 0.01 post excision weight measurement 0.0 106564 3032
SS/JrHsdMcwi left atrium weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56.0 days 11 0.01 g 0.0 0.0 post excision weight measurement 0.0 106568 3032
SS/JrHsdMcwi liver weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56.0 days 7 10.6 g 0.42 1.11 post excision weight measurement 0.0 106574 3032
SS/JrHsdMcwi lung weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56.0 days 11 0.89 % 0.03 0.09 post excision weight measurement 0.0 106592 3032
SS/JrHsdMcwi heart left atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56.0 days 7 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 106598 3032
SS/JrHsdMcwi single kidney wet weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56.0 days 11 7.88 g/kg 0.2 0.66 post excision weight measurement 0.0 106608 3032
SS/JrHsdMcwi heart left ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56.0 days 7 0.18 g/cm 0.01 0.02 post excision weight measurement 0.0 106614 3032
SS/JrHsdMcwi lung weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56.0 days 11 0.52 g/cm 0.01 0.04 post excision weight measurement 0.0 106620 3032
SS/JrHsdMcwi heart left ventricle end-diastolic posterior wall thickness isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 147.0 days 10 1.8 mm 0.1 0.32 transthoracic echocardiography 0.0 105796 3023
SS/JrHsdMcwi stroke volume isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 147.0 days 10 0.26 ml 0.01 0.03 transthoracic echocardiography 0.0 105804 3023
SS/JrHsdMcwi heart left ventricle end-diastolic anterior wall thickness isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 49.0 days-56.0 days 5 1.63 mm 0.08 0.18 transthoracic echocardiography 0.0 105808 3023
SS/JrHsdMcwi heart left ventricle end-diastolic diameter angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 77.0 days-84.0 days 5 7.15 mm 0.34 0.76 transthoracic echocardiography 0.0 should be inner diameter 105824 3023
SS/JrHsdMcwi heart left ventricle fractional shortening isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 49.0 days-56.0 days 5 48.0 % 1.2 2.68 transthoracic echocardiography 0.0 105826 3023
SS/JrHsdMcwi heart rate isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 49.0 days-56.0 days 5 384.0 beats/min 6.0 13.42 transthoracic echocardiography 0.0 105832 3023
SS/JrHsdMcwi heart rate angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 63.0 days-70.0 days 5 394.0 beats/min 6.0 13.42 transthoracic echocardiography 0.0 105834 3023
SS/JrHsdMcwi stroke volume isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 49.0 days-56.0 days 5 0.2 ml 0.01 0.02 transthoracic echocardiography 0.0 105838 3023
SS/JrHsdMcwi systolic blood pressure control condition (for 147 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. arterial blood pressure trait male 147.0 days 8 191.0 mmHg 5.0 14.14 tail cuff plethysmography 0.0 105861 3023
SS/JrHsdMcwi blood glucose level fasting (for 12 hours) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood glucose amount male 84.0 days 8 117.0 mg/dl 2.0 5.66 blood glucose analysis 0.0 105863 3023
SS/JrHsdMcwi blood glucose level fasting (for 12 hours) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood glucose amount male 84.0 days 8 114.0 mg/dl 3.0 8.49 blood glucose analysis 0.0 105862 3023
SS/JrHsdMcwi renal afferent arteriole diameter controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. kidney arteriole morphology trait not specified 91.0 days-133.0 days 9 19.8 um 0.9 2.7 ex vivo videomicroscopy renal afferent arteriole 120.0 ex vivo videomicroscopy (MMO:0000319) renal afferent arteriole diameter () renal arteriole morphology trait 106494 3030
SS/JrHsdMcwi renal afferent arteriole diameter controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. kidney arteriole morphology trait not specified 91.0 days-133.0 days 8 24.1 um 0.8 2.26 ex vivo videomicroscopy renal afferent arteriole 120.0 ex vivo videomicroscopy (MMO:0000319) renal afferent arteriole diameter (CMO:0003725) renal arteriole morphology trait 106499 3030
SS/JrHsdMcwi renal afferent arteriole diameter controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. kidney arteriole morphology trait not specified 91.0 days-133.0 days 10 24.6 um 0.8 2.53 ex vivo videomicroscopy renal afferent arteriole 120.0 ex vivo videomicroscopy (MMO:0000319) renal afferent arteriole diameter (CMO:0003725) renal arteriole morphology trait 106504 3030
SS/JrHsdMcwi spleen regulatory T cell count to total T cell count ratio controlled sodium chloride content diet (0.4 %) (for 42 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. T cell quantity not specified 63.0 days 4 3.5 % 0.1 0.2 flow cytometry method 0.0 n=4-7 -tregs blood % 106516 3031
SS/JrHsdMcwi blood regulatory T cell count to total T cell count ratio controlled sodium chloride content diet (0.4 %) (for 42 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. T cell quantity not specified 63.0 days 4 4.0 % 0.1 0.2 flow cytometry method 0.0 n=4-7 -tregs spleen % 106518 3031
SS/JrHsdMcwi mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. arterial blood pressure trait not specified 91.0 days 6 15sec/min for 3 hrs/day 175.5 mmHg 7.9 19.35 vascular fluid filled catheter 0.0 n=6-8 106522 3031
SS/JrHsdMcwi urine albumin excretion rate controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. urine albumin amount not specified 84.0 days 6 104.9 mg/d 8.9 21.8 urine albumin analysis 0.0 n=6-8 106528 3031
SS/JrHsdMcwi heart right atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 7 0.44 mg/mm 0.04 0.1 post excision weight measurement 0.0 106622 3032
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 8 105.23 mmHg 1.83 5.17 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 15052 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 11 124.5 mmHg 2.7 8.97 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15123 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 450.69 beats/min 12.38 24.77 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15197 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 126.83 mmHg 3.13 8.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15205 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 14.18 mmHg 1.52 4.55 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15535 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 10.6 mmHg 4.12 10.9 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15544 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 115.25 breaths/min 4.78 18.5 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15580 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 27.21 ml/min 1.55 4.91 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15621 381
SS/JrHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 -0.44 degrees C 0.22 0.76 digital rectal thermometry Moms and pups used in studies were fed Teklad 15742 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 14 121.97 breaths/min 3.38 12.66 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15371 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 %change=VE during7-9 min hypercapnia/control during standard conditions 260.42 % 24.64 55.09 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14386 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 87.8 breaths/min 4.7 16.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14440 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 96.27 ml/min 2.83 23.16 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14568 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14606 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.42 ml 0.02 0.06 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14626 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 0.37 ml 0.02 0.06 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14624 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 80.03 ml/min 4.17 15.04 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14634 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 122.15 mmHg 2.63 6.45 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14652 381
SS/JrHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 47 0.49 degrees C 0.13 0.89 digital rectal thermometry Moms and pups used in studies were fed Teklad 16006 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 12 serial mean 142.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 65467 151
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) then controlled exposure to ambient light (for 12 hours) then controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 35 continuous mean 7.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 0.0 left femoral artery decrease 64931 229
SS/JrHsdMcwi glomerular filtration rate to kidney weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. glomerular filtration trait male 70.0 days 10 0.3 ml/min/g 0.02 0.06 liquid scintillation counting 0 64941 272
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 0.01 null 0.01 0.01 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14896 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 0.38 ml 0.02 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14899 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 74.72 ml/min 3.01 10.84 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14912 381
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 6 1.67 ml/min 0.22 0.55 urine creatinine analysis Moms and pups used in studies were fed Dyets 51805 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 130.93 mmHg 4.07 12.88 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51826 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 18.85 mmHg 1.94 8.25 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51864 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 5 0.32 mg/dl 0.02 0.04 radioimmunoassay Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51900 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 11 7.72 mEq/d 1.23 4.07 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52017 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80.0 days-99.0 days 53 2.17 ml/min 0.11 0.8 urine creatinine analysis Moms were fed Teklad, pups used in studies were fed Dyets 52171 482
SS/JrHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80.0 days-99.0 days 9 416.02 beats/min 6.59 19.78 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52667 482
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80.0 days-99.0 days 11 161.82 mg/d 34.64 114.9 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52716 482
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80.0 days-99.0 days 64 14.23 mEq/d 0.97 7.78 flame atomic emission spectrometry Moms were fed Teklad, pups used in studies were fed Dyets 52761 482
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -30.56 beats/min 50.56 101.11 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50593 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 2.06 mmHg 2.57 10.89 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50600 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 21.03 mmHg 14.54 25.18 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50841 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 43.55 mmHg 0.46 0.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50898 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 1.04 mmHg 1.37 4.76 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50932 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -2.59 mmHg 3.89 7.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50991 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 5.72 beats/min 7.43 23.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51093 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 8 0.33 mg/dl 0.01 0.02 radioimmunoassay Moms and pups used in studies were fed Dyets 51180 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -27.92 beats/min 8.05 33.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51199 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 383.68 beats/min 7.38 31.32 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51245 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 31.81 mmHg 3.63 12.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51427 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 20 132.7 mg/d 21.27 95.13 automated urine analysis Moms and pups used in studies were fed Dyets 51435 481
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 6 5.71 mg/d 0.54 1.31 automated urine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51455 481
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 21 14.0 mg/d 3.02 13.86 automated urine analysis Moms and pups used in studies were fed Teklad 51466 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -46.0 beats/min 14.52 50.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51509 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 4 0.35 mg/dl 0.02 0.03 radioimmunoassay Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51534 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 8 1.36 ml/min 0.12 0.35 urine creatinine analysis Moms and pups used in studies were fed Dyets 51549 481
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 20 64.95 mg/d 13.87 62.02 automated urine analysis Moms and pups used in studies were fed Dyets 51561 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 144.43 mmHg 4.76 16.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51633 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 15 0.27 mg/dl 0.02 0.09 radioimmunoassay Moms and pups used in studies were fed Teklad 51644 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 387.81 beats/min 8.14 31.52 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50323 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -71.27 beats/min 21.14 42.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50344 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 7 1.67 ng/ml/h 0.24 0.62 radioimmunoassay Moms and pups used in studies were fed Dyets 50463 481
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 0.0 null 0.01 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14767 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 42 30.08 mmHg 0.41 2.63 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 13431 381
SS/JrHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 69 36.7 degrees C 0.55 4.54 digital rectal thermometry Moms and pups used in studies were fed Teklad 13627 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 -0.13 degrees C 0.12 0.31 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14136 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 142.6 % 5.82 22.53 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14140 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14149 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14158 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 55 7.52 null 0.0 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17074 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 148.41 % 7.07 24.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13753 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 162.89 breaths/min 4.95 17.85 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13776 381
SS/JrHsdMcwi resting tone of middle cerebral artery controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 9 [(Dmax - Drest) /Dmax] x 100 42.0 % 3.3 9.9 ex vivo videomicroscopy 0.0 67246 732
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 90.0 days-94.0 days 13 1.2 ml/min 0.2 0.72 urine creatinine analysis 0.0 plasma creatinine analysis 67284 151
SS/JrHsdMcwi single kidney wet weight to body weight ratio controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 19 6.0 g/kg 0.4 1.74 post excision weight measurement 0.0 plasma creatinine analysis 67288 151
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 -0.05 null 0.05 0.08 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13862 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 4.89 mmHg 3.31 8.75 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14028 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 166.29 % 19.96 63.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14040 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 531.15 beats/min 5.18 13.7 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14072 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 26.99 beats/min 41.14 71.26 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14107 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 1.5 days) then controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 96.0 days 24 continuous mean 141.0 mmHg 5.0 24.49 vascular indwelling catheter method femoral artery 10800.0 left femoral artery 12038 229
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 9 130.99 mmHg 4.35 13.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19704 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 133.2 mmHg 6.56 17.36 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19713 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.78 degrees C 0.15 0.44 digital rectal thermometry Moms and pups used in studies were fed Dyets 19755 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 119.38 mmHg 3.99 12.63 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19896 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 50 122.9 mmHg 2.03 14.37 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19891 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 44.55 ml/min 4.31 13.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20708 381
SS/JrHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 5 37.98 degrees C 0.24 0.54 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20885 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 62 413.02 beats/min 4.88 38.45 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20947 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 11 451.63 beats/min 7.56 25.06 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20952 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 74 130.38 % 3.9 33.51 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53831 381
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 165.57 % 4.13 14.87 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53843 381
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 157.22 % 4.94 17.81 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53863 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 26 -0.05 null 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19916 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 22 524.94 beats/min 8.14 38.2 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19954 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 517.01 beats/min 6.36 16.81 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 19963 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 -5.69 mmHg 0.4 0.8 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20014 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 113.83 mmHg 3.8 10.74 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20056 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 7.49 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20119 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.47 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20162 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 -4.22 mmHg 0.87 2.62 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20585 381
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89.0 days-92.0 days 20 serial mean 437.0 beats/min 6.0 26.83 vascular indwelling catheter method left femoral artery 13310 151
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 38.19 degrees C 0.08 0.27 digital rectal thermometry Moms and pups used in studies were fed Dyets 17576 381
SS/JrHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 47 38.28 degrees C 0.1 0.67 digital rectal thermometry Moms and pups used in studies were fed Teklad 17645 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 473.71 beats/min 17.29 29.95 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17668 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 -7.9 mmHg 1.32 3.74 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17716 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 37.89 degrees C 0.14 0.38 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17724 381
SS/JrHsdMcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 15 310.5 g 6.7 25.8 whole body digital scale Moms and pups used in studies were fed Dyets 17924 381
SS/JrHsdMcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 7 204.4 g 5.3 14.1 whole body digital scale Moms and pups used in studies were fed Dyets 17930 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 52.46 ml/min 2.55 9.54 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18067 381
SS/JrHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 48 37.78 degrees C 0.06 0.42 digital rectal thermometry Moms and pups used in studies were fed Teklad 18129 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 171.15 breaths/min 9.85 34.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16984 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 22 113.5 beats/min 11.48 53.84 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18352 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 74 99.2 breaths/min 2.37 20.37 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18478 381
SS/JrHsdMcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 10 215.0 g 5.5 17.5 whole body digital scale Moms and pups used in studies were fed Dyets 18504 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 50.79 ml/min 3.97 13.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18735 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 5 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18784 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 27 27.63 mmHg 0.4 2.06 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18822 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 35.27 mmHg 0.96 1.65 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19001 381
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 4 140.0 mmol/l 1.68 3.37 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36334 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 96 231.75 U/l 4.04 39.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36446 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 10 5.88 g/dl 0.04 0.12 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37034 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 7 18.86 mmol/l 1.47 3.89 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37050 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 96 84.18 mg/dl 1.02 10.04 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37164 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 9 6.2 g/dl 0.16 0.47 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37407 401
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during 2-3 min hypercapnia/control during standard conditions 309.35 % 13.65 49.23 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19046 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 %change=VE during 2-3 min hypercapnia/control during standard conditions 272.9 % 29.98 67.04 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19052 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 0.36 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18628 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.36 ml 0.01 0.04 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18637 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 452.93 beats/min 8.97 28.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17534 381
SS/JrHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 11 143.0 mmol/l 0.69 2.28 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36547 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 9 18.33 mmol/l 0.44 1.32 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36586 401
SS/JrHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 11 9.75 mg/dl 0.14 0.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36816 401
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 131.45 mmHg 3.35 11.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19514 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 7 112.69 breaths/min 4.36 11.53 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18152 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 30.46 ml/min 2.03 6.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18191 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 107.54 mmHg 6.9 13.8 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18240 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 7.5 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20191 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 -0.22 degrees C 0.14 0.49 digital rectal thermometry Moms and pups used in studies were fed Teklad 20382 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 452.61 beats/min 5.11 16.16 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20443 381
SS/JrHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 2 1.07 g 0.17 0.24 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49828 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 5.97 mmHg 0.26 0.45 balloon tipped catheter with pressure transducer in isolated perfused heart 49870 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 16 96.55 mmHg 4.61 18.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49959 461
SS/JrHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 3 676.02 s 59.51 103.07 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50094 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 6 11.67 IU/g 2.31 5.66 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 50209 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 992.33 s 34.2 141.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50298 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 7 278.97 beats/min 33.96 89.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 50316 461
SS/JrHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 4 146.25 mg/dl 6.99 13.99 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38844 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 9 57.91 % 1.76 5.27 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38850 401
SS/JrHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 4 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38855 401
SS/JrHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 12 4.08 mmol/l 0.15 0.53 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42158 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 10 77.9 U/l 6.31 19.95 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42174 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 96 3.7 g/dl 0.02 0.22 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42300 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 4 185.5 mg/dl 14.54 29.08 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39320 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 7 176.43 mg/dl 8.27 21.89 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39325 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 10 4.14 mmol/l 0.29 0.93 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39336 401
SS/JrHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 4 18.5 mg/dl 1.04 2.08 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42495 401
SS/JrHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 12 25.58 mmol/l 0.83 2.87 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42509 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 20.02 pg 0.03 0.1 automated blood cell counting method Moms and pups used in studies were fed Teklad 42617 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 10 143.5 mmol/l 0.58 1.84 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39460 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 3 17.97 g/dl 0.39 0.68 automated blood cell counting method Moms and pups used in studies were fed Dyets 39478 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 2 1.65 x 1000 cells/ul 0.46 0.64 automated blood cell counting method Moms and pups used in studies were fed Dyets 42749 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 96 0.28 mg/dl 0.01 0.11 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39643 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 10 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 39648 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 90 0.4 x 1000 cells/ul 0.03 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 39741 401
SS/JrHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 4 14.9 g/dl 0.23 0.47 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39757 401
SS/JrHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 92 0.12 mg/dl 0.01 0.05 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42932 401
SS/JrHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 4 6.6 g/dl 0.09 0.18 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42967 401
SS/JrHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 11 23.64 mmol/l 1.25 4.13 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43047 401
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 117.5 % 3.25 12.57 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54304 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 74 133.46 % 3.99 34.33 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54404 381
SS/JrHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 89 6.77 x 1000 cells/ul 0.15 1.38 automated blood cell counting method Moms and pups used in studies were fed Teklad 39934 401
SS/JrHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 4 5.78 x 1000 cells/ul 0.71 1.42 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39969 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 9 94.67 mg/dl 7.01 21.04 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43103 401
SS/JrHsdMcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 4 24.25 mmol/l 0.75 1.5 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43108 401
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 171.84 % 5.62 20.28 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54513 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 104.47 % 3.93 14.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54549 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 119.94 % 7.67 24.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53544 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 105.28 % 4.19 16.23 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53574 381
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 5 168.42 % 18.4 41.15 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53579 381
SS/JrHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 92 103.88 mmol/l 0.38 3.64 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40055 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 90 0.89 x 1000 cells/ul 0.04 0.39 automated blood cell counting method Moms and pups used in studies were fed Teklad 43291 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 10 0.91 x 1000 cells/ul 0.23 0.73 automated blood cell counting method Moms and pups used in studies were fed Teklad 43296 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 4 83.0 U/l 9.03 18.06 standard blood chemistry panel Moms and pups used in studies were fed Dyets 43411 401
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 8 0.81 mg/kg 0.17 0.48 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58880 526
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 67 168.36 % 3.88 31.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53712 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 135.48 % 7.8 24.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53725 381
SS/JrHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 89 18.59 pg 0.05 0.48 automated blood cell counting method Moms and pups used in studies were fed Teklad 40247 401
SS/JrHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 89 0.37 x 1000 cells/ul 0.02 0.22 automated blood cell counting method Moms and pups used in studies were fed Teklad 40343 401
SS/JrHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 11 0.32 x 1000 cells/ul 0.04 0.12 automated blood cell counting method Moms and pups used in studies were fed Teklad 40351 401
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 19.61 ml/min/kg 2.24 7.43 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 58998 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 14 0.06 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59010 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 6 18.46 ml/min/kg 3.17 7.78 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59026 526
SS/JrHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 11 4.2 g/dl 0.04 0.12 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40464 401
SS/JrHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 9 102.56 mmol/l 1.25 3.75 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40526 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 2 33.0 g/dl 0.9 1.27 automated blood cell counting method Moms and pups used in studies were fed Dyets 40529 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 10 1.98 g/dl 0.03 0.09 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40622 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 9 104.78 mmol/l 0.76 2.28 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40656 401
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 45.8 % 2.1 6.3 automated blood cell counting method Moms and pups used in studies were fed Dyets 40686 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 10 49.4 U/l 2.5 7.91 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40786 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 10 56.07 % 0.44 1.38 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59329 526
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 20.56 pg 0.28 0.84 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37562 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 95 9.32 mg/dl 0.12 1.17 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37661 401
SS/JrHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 12 33.92 U/l 3.22 11.16 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37678 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 9 24.22 mg/dl 1.09 3.27 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40808 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 10 25.9 mg/dl 0.89 2.81 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40900 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 9 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37804 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 32.14 g/dl 0.14 0.41 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41116 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 3 3.56 x 1000 cells/ul 0.9 1.57 automated blood cell counting method Moms and pups used in studies were fed Dyets 41146 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 7 60.71 U/l 8.35 22.1 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41159 401
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 104 0.17 mmHg x min x kg x ml-1 0.0 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59614 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59619 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 3 0.09 mmHg-1 0.02 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59746 526
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 17.94 g/dl 0.12 0.38 automated blood cell counting method Moms and pups used in studies were fed Teklad 38040 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 85 5.44 mmol/l 0.08 0.77 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38133 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 10 4.6 mmol/l 0.18 0.56 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38138 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 3 60.27 fl 0.62 1.07 automated blood cell counting method Moms and pups used in studies were fed Dyets 38169 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 9 9.04 x 10E6 cells/ul 0.16 0.47 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38191 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 3 0.04 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms and pups used in studies were fed Dyets 38201 401
SS/JrHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 9 6.86 mg/dl 0.2 0.59 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38233 401
SS/JrHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 9 2.01 g/dl 0.12 0.37 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 41595 401
SS/JrHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 92 87.68 mg/dl 1.16 11.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38482 401
SS/JrHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 11 98.36 mg/dl 1.55 5.14 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38490 401
SS/JrHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 12 6.19 g/dl 0.11 0.38 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41833 401
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 -6.95 null 0.14 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer 62880 528
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 10 152.9 mg/dl 4.0 12.65 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38602 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 10 141.8 mg/dl 10.29 32.53 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38628 401
SS/JrHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 4 0.23 mg/dl 0.03 0.05 automated plasma creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41846 401
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 11 294.78 beats/min 8.27 27.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46511 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 8.82 ml/min/g 1.54 4.88 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46519 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 7 9.05 ml/min/g 1.37 3.62 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46526 461
SS/JrHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 91 1056.56 s 17.84 170.19 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46615 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 64.42 % 11.06 34.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48499 461
SS/JrHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 63.13 mmHg 7.91 22.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48720 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 95.45 mmHg 4.99 14.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48723 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 24 29.51 IU/g 3.22 15.8 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 48893 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 9 33.98 IU/g 2.63 7.89 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 48899 461
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 0.08 umol/l 0.02 0.05 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57304 522
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 12 46.13 % 0.54 1.85 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57544 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 15.03 ml/min/kg 1.18 3.53 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57572 526
SS/JrHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.7 degrees C 0.18 0.55 digital rectal thermometry Moms and pups used in studies were fed Dyets 16269 381
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 85 -7.51 null 0.05 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55315 522
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 21.81 ml/min/kg 1.5 4.49 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57716 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 1.38 null 0.21 0.68 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57752 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 8 57.11 % 1.77 5.02 microhematocrit tube assay with visual assessment Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57776 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 10 56.96 % 0.99 3.13 microhematocrit tube assay with visual assessment Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57780 526
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount male 70.0 days-84.0 days 41 70.76 U/l 2.74 17.52 standard blood chemistry panel 60697 527
SS/JrHsdMcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity male 70.0 days-84.0 days 41 0.24 x 1000 cells/ul 0.04 0.23 automated blood cell counting method 60707 527
SS/JrHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.19 degrees C 0.13 0.45 digital rectal thermometry Moms and pups used in studies were fed Dyets 16327 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 447.76 beats/min 12.54 37.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16360 381
SS/JrHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 0.7 degrees C 0.2 0.67 digital rectal thermometry Moms and pups used in studies were fed Dyets 16374 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 46 97.72 mmHg 1.11 7.53 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16402 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 1 114.15 mmHg automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16419 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood gas amount female 82.0 days-99.0 days 2 115.45 mmHg 17.0 24.04 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16425 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 29.04 mmHg 0.88 2.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16447 381
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -8.43 null 0.04 0.1 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55500 522
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 105 0.21 null 0.0 0.05 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57950 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 15 0.23 null 0.01 0.06 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 57958 526
SS/JrHsdMcwi hematocrit controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70.0 days-84.0 days 41 46.8 % 0.5 3.2 automated blood cell counting method 60983 527
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data blood vessel smooth muscle dilation trait male 70.0 days-84.0 days 12 99.42 % 0.26 0.9 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55715 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data blood vessel smooth muscle dilation trait female 70.0 days-84.0 days 8 98.88 % 0.58 1.64 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55717 522
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 0.3 null 0.02 0.04 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58185 526
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 3.72 E-7mole 0.53 1.84 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55975 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 19.2 % 1.99 6.29 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55997 522
SS/JrHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 50.08 ml/min/kg 4.83 15.27 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58283 526
SS/JrHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 4 325.5 g 5.6 11.1 whole body digital scale Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58416 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 6 15.86 ml/min/kg 1.29 3.17 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58427 526
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 53 -8.39 null 0.06 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54622 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 20 99.85 % 0.11 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56201 522
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 4 1.48 mg/kg 0.21 0.43 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58599 526
SS/JrHsdMcwi serum total bilirubin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount female 70.0 days-84.0 days 17 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 62435 527
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 52 0.08 10E-7mol/l 0.04 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56243 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 42 32.93 % 2.81 18.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56286 522
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 0.2 mmHg x min x kg x ml-1 0.02 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58714 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 19.72 ml/min/kg 2.28 3.96 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58715 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 11 209.2 g 3.6 11.9 whole body digital scale Moms and pups used in studies were fed Dyets 58823 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 17 1.35 mg/kg 0.17 0.7 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58845 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 11 1.19 g/kg 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58878 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 9 0.6 mg/kg 0.16 0.49 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58884 526
SS/JrHsdMcwi serum potassium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount male 70.0 days-84.0 days 40 4.12 mmol/l 0.12 0.77 flame atomic emission spectrometry 61753 527
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 45.0 % 9.1 20.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54982 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 0.06 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55128 522
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.45 null 0.05 0.16 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59829 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 0.09 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59945 526
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 0.03 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56700 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 51.93 % 6.95 25.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56714 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.84 g/mg 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56759 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.04 10E-7mol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56813 522
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 2.6 null 0.52 1.39 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60086 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 12.3 ml/min/kg 1.37 2.37 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 60138 526
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 0.89 g/mg 0.09 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56983 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 1.04 g/mg 0.13 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56991 522
SS/JrHsdMcwi total white blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data leukocyte quantity female 70.0 days-84.0 days 17 6.7 x 1000 cells/ul 0.42 1.73 automated blood cell counting method 60293 527
SS/JrHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 41 18.56 pg 0.09 0.6 automated blood cell counting method 60369 527
SS/JrHsdMcwi blood hemoglobin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 41 15.6 g/dl 0.16 1.0 automated blood cell counting method 61875 527
SS/JrHsdMcwi blood hemoglobin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 17 15.31 g/dl 0.22 0.89 automated blood cell counting method 61881 527
SS/JrHsdMcwi urine creatinine excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine creatinine amount male 70.0 days-77.0 days 7 9.31 mg/d 0.42 1.11 automated urine analysis - 44178 441
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine albumin amount male 70.0 days-77.0 days 7 75.58 mg/d 16.27 43.05 automated urine analysis - 44302 441
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 50.0 % 6.77 15.13 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57153 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 0.05 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57162 522
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data arterial blood pressure trait male 70.0 days-77.0 days 7 1/3 systolic pressure + 2/3 diastolic pressure 133.14 mmHg 6.74 17.84 radiotelemetry carotid artery - 44425 441
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 33.33 mmHg 4.95 14.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45685 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 43.14 mmHg 8.81 24.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45691 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 97 11.61 ml/min/g 0.23 2.26 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46719 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 1 post-ischemic value/pre-ischemic value x 100% 55.17 % isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46836 461
SS/JrHsdMcwi body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 20 162.9 g 2.1 9.6 whole body digital scale Moms and pups used in studies were fed Teklad 47861 461
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (for 12 days) PhysGen Knockout data heart pumping trait male 70.0 days-77.0 days 7 362.0 beats/min 6.26 16.56 radiotelemetry carotid artery - 44610 441
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 98.31 mmHg 3.31 10.46 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45816 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 11 509.8 s 68.73 227.95 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45834 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 4 169.75 mmHg 12.05 24.1 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45865 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 4 303.31 beats/min 13.52 27.03 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45870 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 134.03 mmHg 11.13 19.28 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45943 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 26 26.47 IU/g 2.86 14.59 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45994 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 1 9.68 ml/min/g isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46840 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 19 43.63 mmHg 4.53 19.76 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47983 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 96 5.62 ml/min/g 0.31 3.06 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 44784 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 85 106.79 mmHg 2.1 19.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44882 461
SS/JrHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 70.94 % 7.67 26.57 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46021 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 104.57 mmHg 5.0 15.0 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45008 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 11.47 ml/min/g 0.89 2.67 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46301 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 16 post-ischemic value/pre-ischemic value x 100% 81.61 % 12.49 49.96 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48366 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 89 209.31 beats/min 4.76 44.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45214 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 114.36 mmHg 4.32 13.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45372 461
SS/JrHsdMcwi middle cerebral artery inner diameter controlled captopril content drinking water (100 mg/kg/d) (for 3 days) then physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 145.0 um 8.4 20.58 ex vivo videomicroscopy 0.0 69561 732
SS/JrHsdMcwi resting tone of middle cerebral artery 0.9% sodium chloride solution (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 [(Dmax - Drest) /Dmax] x 100 38.0 % 2.1 5.14 ex vivo videomicroscopy 0.0 69572 732
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 157.0 um 2.0 4.9 ex vivo videomicroscopy 0.0 69573 732
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 246.0 um 3.7 8.27 ex vivo videomicroscopy 0.0 69577 732
SS/JrHsdMcwi middle cerebral artery inner diameter controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 255.0 um 2.9 6.48 ex vivo videomicroscopy 0.0 69583 732
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (0.5 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 141.7 mmHg 7.4 26.68 vascular indwelling catheter method left femoral artery 120.0 69536 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 159.0 mmHg 6.4 23.08 vascular indwelling catheter method left femoral artery 120.0 69538 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.1 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 160.0 mmHg 6.7 20.1 vascular indwelling catheter method left femoral artery 120.0 69548 151
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. glomerular filtration trait female 92.0 days-94.0 days 10 1.08 ml/min 0.37 1.17 urine creatinine analysis 0.0 mg/min 69480 151
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 92.0 days-94.0 days 11 1.05 mg/dl 0.23 0.76 plasma creatinine analysis 0.0 urine potassium analysis umol/min 69486 151
SS/JrHsdMcwi plasma high density lipoprotein cholesterol level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood HDL cholesterol amount female 92.0 days-94.0 days 12 68.1 mg/dl 4.5 15.59 plasma high-density lipoprotein-cholesterol measurement test 0.0 69504 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days 16 serial mean 163.0 mmHg 6.4 25.6 vascular indwelling catheter method left femoral artery 10800.0 69512 151
SS/JrHsdMcwi thymus wet weight controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. thymus mass not specified 84.0 days 560.0 mg 30.0 post excision weight measurement 0.0 69204 1057
SS/JrHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. body mass not specified 84.0 days 4 343.0 g 16.0 32.0 body weighing method 0.0 69287 1057
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. urine albumin amount not specified 84.0 days 4 127.0 mg/d 17.0 34.0 unspecified method 0.0 69294 1057
SS/JrHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 89.0 days-92.0 days 17 30.0 ml/d 2.2 9.07 urine volume measurement method 0.0 69452 151
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 89.0 days-92.0 days 17 5.06 mEq/d 0.6 2.49 unspecified method 0.0 urine sodium analysis umol/min 69460 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 6.7 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 53.0 days-60.0 days 3 serial mean 139.0 mmHg 5.2 9.0 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 intra-carotid radiotelemetry 98595 2098
SS/JrHsdMcwi mean arterial blood pressure control condition (0.4 %) (between 50 and 52 days) Cowley AW Jr, et al., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7. arterial blood pressure trait male 50.0 days-52.0 days 8 serial mean 108.0 mmHg 1.0 2.83 intra-aortic thoracic radiotelemetry via carotid cannulation 86400.0 98645 2118
SS/JrHsdMcwi plasma insulin level control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. blood insulin amount male 42.0 days 8 7.8 mU/l 0.78 2.21 enzyme linked immunosorbent assay 0.0 100091 2418
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58.0 days-67.0 days 14 serial mean 185.0 mmHg 5.0 18.71 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98500 2079
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58.0 days-67.0 days 14 serial mean 163.0 mmHg 4.0 14.97 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98493 2079
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60.0 days-67.0 days 12 serial mean 204.0 mmHg 4.0 13.86 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 intra-carotid radiotelemetry 98566 2098
SS/JrHsdMcwi plasma leptin level control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. blood leptin amount male 42.0 days 5 2.1 ng/ml 0.4 0.89 enzyme linked immunosorbent assay 0.0 100071 2418
SS/JrHsdMcwi plasma total cholesterol level control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. blood cholesterol amount male 42.0 days 8 112.0 mg/dl 5.0 14.14 enzyme linked immunosorbent assay 0.0 100073 2418
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio control condition (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 5 EDL/BW 0.42 mg/g 0.01 0.02 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99045 2198
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 4 EDL/BW 0.41 mg/g 0.02 0.04 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99050 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 4 TA/BW 1.68 mg/g 0.04 0.08 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99051 2198
SS/JrHsdMcwi lung weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56.0 days 11 1.86 g 0.04 0.13 post excision weight measurement 0.0 106560 3032
SS/JrHsdMcwi heart right ventricle weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 11 1.16 mg/g 0.04 0.13 post excision weight measurement 0.0 106584 3032
SS/JrHsdMcwi heart left ventricle weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56.0 days 11 2.86 mg/g 0.1 0.33 post excision weight measurement 0.0 106588 3032
SS/JrHsdMcwi heart right atrium weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 7 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 106594 3032
SS/JrHsdMcwi liver weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56.0 days 11 39.9 g/kg 0.62 2.06 post excision weight measurement 0.0 106604 3032
SS/JrHsdMcwi heart right ventricle weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 11 6.81 mg/mm 0.29 0.96 post excision weight measurement 0.0 106612 3032
SS/JrHsdMcwi heart left ventricle fractional shortening isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 147.0 days 10 51.0 % 1.2 3.79 transthoracic echocardiography 0.0 105800 3023
SS/JrHsdMcwi heart left ventricle end-diastolic diameter isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 49.0 days-56.0 days 5 6.99 mm 0.16 0.36 transthoracic echocardiography 0.0 should be inner diameter 105820 3023
SS/JrHsdMcwi heart left ventricle end-diastolic diameter angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 63.0 days-70.0 days 5 6.63 mm 0.37 0.83 transthoracic echocardiography 0.0 should be inner diameter 105822 3023
SS/JrHsdMcwi cardiac output isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 49.0 days-56.0 days 5 77.0 ml/min 4.0 8.94 transthoracic echocardiography 0.0 105844 3023
SS/JrHsdMcwi lung weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. lung mass male 77.0 days-84.0 days 6 0.28 g/cm 0.01 0.02 post excision weight measurement 0.0 105854 3023
SS/JrHsdMcwi heart left ventricle weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle mass male 77.0 days-84.0 days 6 0.19 g/cm 0.01 0.02 post excision weight measurement 0.0 105850 3023
SS/JrHsdMcwi single kidney weight to tibia length ratio angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. kidney mass male 77.0 days-84.0 days 6 0.28 g/cm 0.01 0.02 post excision weight measurement 0.0 105852 3023
SS/JrHsdMcwi cardiac output angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 77.0 days-84.0 days 5 77.0 ml/min 6.0 13.42 transthoracic echocardiography 0.0 105848 3023
SS/JrHsdMcwi urine albumin excretion rate controlled sodium chloride content diet (0.4 %) (for 42 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. urine albumin amount not specified 63.0 days 6 20.0 mg/d 2.1 5.14 urine albumin analysis 0.0 n=6-8 106524 3031
SS/JrHsdMcwi kidney total CD45 positive leukocyte count controlled sodium chloride content diet (0.4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. leukocyte quantity not specified 84.0 days 5 2.13 x 10E6 cells/ml 0.36 0.8 flow cytometry method 0.0 n=5-6 106531 3031
SS/JrHsdMcwi kidney total CD3 positive T cell count controlled sodium chloride content diet (0.4 %) (for 84 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. T cell quantity not specified 84.0 days 5 0.21 x 10E6 cells/ml 0.03 0.07 flow cytometry method 0.0 n=5-6 (tissue T cell count) 106533 3031
SS/JrHsdMcwi heart left atrium weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56.0 days 7 0.41 mg/mm 0.02 0.05 post excision weight measurement 0.0 106626 3032
SS/JrHsdMcwi liver weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56.0 days 7 29.2 mg/mm 1.28 3.39 post excision weight measurement 0.0 106630 3032
SS/JrHsdMcwi single kidney weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56.0 days 7 0.06 g/cm 0.0 0.0 post excision weight measurement 0.0 106634 3032
SS/JrHsdMcwi systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 6 115.0 mmHg 4.76 11.66 vascular fluid filled catheter 0.0 106802 3032
SS/JrHsdMcwi diastolic blood pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 8 85.9 mmHg 2.35 6.65 vascular fluid filled catheter 0.0 106808 3032
SS/JrHsdMcwi mean aortic pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 8 93.2 mmHg 2.33 6.59 vascular fluid filled catheter 0.0 Mean aortic pressure 106812 3032
SS/JrHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 3 0.8 degrees C 0.35 0.6 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15169 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 126.99 mmHg 3.33 10.55 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15199 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 1 -11.05 mmHg stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15498 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 131.39 mmHg 4.31 12.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15556 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 -7.96 mmHg 0.89 2.68 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15643 381
SS/JrHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 69 -0.19 degrees C 0.09 0.72 digital rectal thermometry Moms and pups used in studies were fed Teklad 15737 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 1 47.76 mmHg vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15757 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 7.27 mmHg 10.91 18.9 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15763 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 96.13 mmHg 9.48 16.41 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15771 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 7.51 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15323 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.32 ml 0.02 0.08 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15325 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 24.0 mmHg 4.0 12.0 vascular indwelling catheter method left femoral artery 0.0 67304 151
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 1 7.31 null automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14420 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 2 7.46 null 0.05 0.07 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14426 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 42 7.47 null 0.0 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14601 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.37 ml 0.02 0.07 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14618 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 131.52 mmHg 2.55 8.47 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14661 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 452.55 beats/min 9.34 29.53 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15958 381
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 12 serial mean 160.0 mmHg 6.0 20.78 vascular indwelling catheter method left femoral artery 0 65463 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93.0 days 12 serial mean 427.0 beats/min 6.0 20.78 vascular indwelling catheter method left femoral artery 0 65469 151
SS/JrHsdMcwi glomerular filtration rate to kidney weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. glomerular filtration trait male 70.0 days 10 0.44 ml/min/g 0.04 0.13 liquid scintillation counting 0 64942 272
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 175.7 % 10.49 33.16 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53522 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 -0.41 null 0.36 0.72 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14890 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -74.49 beats/min 13.87 48.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51697 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -61.58 beats/min 12.05 48.19 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51704 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 27.49 mmHg 2.28 9.69 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51769 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 13 0.43 ng/ml/h 0.08 0.29 radioimmunoassay Moms and pups used in studies were fed Teklad 51833 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -5.13 beats/min 7.08 29.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51848 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 16.35 mmHg 2.77 9.58 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51869 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 20 9.28 mEq/d 1.19 5.33 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 52012 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 14 0.32 mg/dl 0.02 0.09 radioimmunoassay Moms and pups used in studies were fed Dyets 52036 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80.0 days-99.0 days 9 1.17 ng/ml/h 0.22 0.66 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52471 482
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80.0 days-99.0 days 11 73.53 mg/d 19.27 63.93 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52616 482
SS/JrHsdMcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80.0 days-99.0 days 59 400.39 beats/min 4.05 31.09 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52661 482
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 3 0.64 ng/ml/h 0.27 0.47 radioimmunoassay Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50536 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 27.75 mmHg 2.45 10.1 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50749 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 -8.98 mmHg 4.38 9.8 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50762 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 -12.57 mmHg 1.76 6.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50801 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 10.04 mmHg 1.85 7.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50913 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 -5.4 mmHg 2.47 10.48 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50927 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 24.54 mmHg 2.93 11.72 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50961 481
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 165.7 % 4.88 16.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54151 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 15.0 beats/min 17.09 29.6 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51070 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 5.27 mmHg 1.01 3.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51106 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 4.02 mmHg 2.34 9.04 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51129 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 15.97 mmHg 2.94 11.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51184 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 -13.26 beats/min 12.39 24.79 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51212 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 10.55 beats/min 16.42 63.61 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51233 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 117.49 mmHg 2.54 5.67 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51324 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -15.3 beats/min 12.74 54.04 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51368 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 393.13 beats/min 12.55 28.06 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51380 481
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 110.31 % 5.41 18.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54052 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 109.39 % 2.01 17.25 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54064 381
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 400.82 beats/min 9.27 39.31 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51577 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 157.55 mmHg 5.0 21.21 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51628 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 6.75 mmHg 1.79 7.15 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50366 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -2.02 mmHg 7.38 14.75 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50431 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 386.28 beats/min 7.72 30.88 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50471 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90.0 days-94.0 days 17 78.6 mg/d 9.0 37.11 urine total protein analysis 0 66152 151
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) then tactile electric shock exposure (2 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 8 serial mean 11.0 mmHg 3.0 8.49 vascular indwelling catheter method left femoral artery 0 66150 151
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 heart rate during walking-heart rate during rest 72.73 beats/min 16.0 45.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13402 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 -0.23 degrees C 0.17 0.66 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14130 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 75.92 ml/min 5.38 19.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14161 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 61 123.16 mmHg 2.06 16.07 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14356 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 67 155.03 breaths/min 2.12 17.39 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17179 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 103.21 mmHg 2.67 8.44 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17300 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 122.92 mmHg 3.54 11.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13765 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 5 151.84 breaths/min 8.35 18.66 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13782 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 446.53 beats/min 77.6 155.19 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13826 381
SS/JrHsdMcwi middle cerebral artery inner diameter controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 9 252.0 um 3.4 10.2 ex vivo videomicroscopy 0.0 67245 732
SS/JrHsdMcwi middle cerebral artery inner diameter physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 9 146.0 um 5.4 16.2 ex vivo videomicroscopy 0.0 67244 732
SS/JrHsdMcwi heart wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart mass female 97.0 days-101.0 days 21 1.03 g 0.05 0.23 post excision weight measurement 0.0 plasma creatinine analysis 67296 151
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 1 -0.19 null stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13856 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 9 8.11 mmHg 3.33 9.98 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14019 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 169.75 % 7.65 28.63 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14031 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 497.77 beats/min 4.55 13.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14063 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during7-9 min hypercapnia/control during standard conditions 283.63 % 13.08 47.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14086 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 1 145.33 beats/min vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14101 381
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 35 continuous mean 167.0 mmHg 4.0 23.66 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12002 229
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to darkness (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 35 continuous mean 172.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 14400.0 left femoral artery 12005 229
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.49 degrees C 0.14 0.51 digital rectal thermometry Moms and pups used in studies were fed Dyets 19746 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 38 11.35 mmHg 1.07 6.58 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20729 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 26 13.08 mmHg 1.99 10.15 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20869 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 44.0 beats/min 18.08 31.32 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20996 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 -0.04 null 0.01 0.03 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 19925 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 1 502.35 beats/min vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19932 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 42.4 ml/min 1.97 7.64 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20121 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 46 7.47 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20157 381
SS/JrHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.47 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20654 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 136.24 mmHg 5.73 16.22 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19523 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 -0.42 degrees C 0.2 0.68 digital rectal thermometry Moms and pups used in studies were fed Dyets 19573 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17605 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 396.58 beats/min 15.33 30.67 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17662 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 14 127.67 breaths/min 6.34 23.71 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17683 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 48 409.84 beats/min 3.74 25.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17743 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 -47.62 mmHg 2.17 6.85 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17935 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.36 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18055 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 0.36 ml 0.01 0.05 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16997 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 0.35 ml 0.01 0.03 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17003 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 97.69 breaths/min 4.65 16.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18483 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 424.61 beats/min 10.82 28.62 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18760 381
SS/JrHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 101.48 mmHg 3.12 7.63 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18923 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 38 130.32 mmHg 2.26 13.93 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18944 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 120.65 mmHg 4.0 11.99 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 18949 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 4 37.88 mmHg 1.48 2.97 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18995 381
SS/JrHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 12 0.2 mg/dl 0.01 0.04 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36272 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 7 138.86 mmol/l 1.14 3.02 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36339 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 10 149.0 U/l 4.94 15.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36451 401
SS/JrHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 11 4.85 x 1000 cells/ul 0.2 0.67 automated blood cell counting method Moms and pups used in studies were fed Teklad 36926 401
SS/JrHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 9 93.22 U/l 2.03 6.1 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37060 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 10 67.1 mg/dl 1.42 4.48 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37169 401
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 25.44 mmHg 1.66 4.4 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19033 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 133.13 % 5.42 18.76 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18616 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 %change=VE during7-9 min hypercapnia/control during standard conditions 140.1 % 3.76 32.3 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18611 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 61 412.19 beats/min 6.25 48.79 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17529 381
SS/JrHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 4 32.17 g/dl 0.2 0.4 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36580 401
SS/JrHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 9 9.42 mg/dl 0.17 0.52 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36606 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 4 119.25 mg/dl 15.65 31.31 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36707 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 9 8.96 mg/dl 0.13 0.4 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36728 401
SS/JrHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 4 5.01 x 1000 cells/ul 0.67 1.33 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36839 401
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during 2-3 min hypercapnia/control during standard conditions 286.63 % 20.98 72.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19284 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 0.42 ml 0.01 0.03 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18179 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 415.16 beats/min 9.54 28.61 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18194 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 51.99 ml/min 1.61 13.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20276 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 46.98 ml/min 5.06 17.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20281 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 52.83 mmHg 1.57 4.7 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20506 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 565.64 beats/min 9.72 27.48 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20526 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20538 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 -0.02 null 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20569 381
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 19 5.68 mmHg 0.13 0.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49249 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 97 787.44 s 19.12 188.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49365 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 19 20.2 % 2.12 9.23 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49468 461
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 133.5 g 6.1 19.2 whole body digital scale Moms and pups used in studies were fed Teklad 49566 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 8 0.36 IU/g 0.11 0.32 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 49681 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 2 9.2 IU/g 6.45 9.12 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49814 461
SS/JrHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 6 1.29 g 0.09 0.22 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49825 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 42 10.45 IU/g 1.03 6.68 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49831 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 17 47.0 mmHg 2.71 11.16 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50068 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 4 1012.83 s 61.58 123.16 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50098 461
SS/JrHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 91 843.81 s 16.07 153.27 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 50186 461
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 8 152.73 beats/min 13.5 38.18 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19165 381
SS/JrHsdMcwi heart wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart mass female 70.0 days-84.0 days 17 0.8 g 0.02 0.09 digital scale post excision weight measurement 63232 529
SS/JrHsdMcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data body mass male 70.0 days-84.0 days 47 308.98 g 3.63 24.91 whole body digital scale 63236 529
SS/JrHsdMcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data body mass female 70.0 days-84.0 days 17 200.65 g 2.5 10.31 whole body digital scale 63242 529
SS/JrHsdMcwi heart right ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart right ventricle mass female 70.0 days-84.0 days 17 0.13 g 0.0 0.02 digital scale post excision weight measurement 63252 529
SS/JrHsdMcwi body length, nose to tail controlled sodium content diet (1 %) (for 14 days) PhysGen General data body length female 70.0 days-84.0 days 17 38.53 cm 0.46 1.89 in vivo ruler method 63262 529
SS/JrHsdMcwi heart left ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart left ventricle mass female 70.0 days-84.0 days 17 0.56 g 0.02 0.08 digital scale post excision weight measurement 63488 529
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 10 62.51 fl 0.17 0.54 automated blood cell counting method Moms and pups used in studies were fed Teklad 38817 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 9 18.6 g/dl 0.56 1.67 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38873 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 9 88.44 U/l 9.23 27.68 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42170 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 4 6.1 g/dl 0.07 0.14 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42190 401
SS/JrHsdMcwi body weight controlled sodium content diet (1 %) (for 14 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 5 212.2 g 4.18 9.34 whole body digital scale 63202 528
SS/JrHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 89 0.76 x 1000 cells/ul 0.03 0.3 automated blood cell counting method Moms and pups used in studies were fed Teklad 38945 401
SS/JrHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 12 143.83 mmol/l 1.0 3.46 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39075 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 4 21.25 mmol/l 1.75 3.5 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39086 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 7 7.33 mg/dl 0.42 1.11 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42321 401
SS/JrHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 12 24.5 mg/dl 0.96 3.32 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42325 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 10 42.0 U/l 2.31 7.3 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42345 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 7 3.79 g/dl 0.09 0.24 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42398 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 9 25.0 mmol/l 0.62 1.87 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39484 401
SS/JrHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 12 0.32 x 1000 cells/ul 0.06 0.21 automated blood cell counting method Moms and pups used in studies were fed Dyets 39500 401
SS/JrHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 9 0.18 x 1000 cells/ul 0.06 0.17 automated blood cell counting method Moms and pups used in studies were fed Dyets 39508 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 3 0.52 x 1000 cells/ul 0.14 0.24 automated blood cell counting method Moms and pups used in studies were fed Dyets 42754 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 9 3.56 g/dl 0.11 0.34 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42962 401
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 104.84 % 4.35 11.5 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54301 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 127.57 % 4.58 15.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54392 381
SS/JrHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 4 100.5 mmol/l 0.65 1.29 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39860 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 10 86.6 mg/dl 4.04 12.77 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43107 401
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 103.49 % 5.79 15.32 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53571 381
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 198.43 % 9.84 35.49 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53582 381
SS/JrHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 11 14.97 g/dl 0.16 0.53 automated blood cell counting method Moms and pups used in studies were fed Teklad 40159 401
SS/JrHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 11 4.45 mmol/l 0.19 0.63 standard blood chemistry panel Moms and pups used in studies were fed Teklad 43384 401
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 14 0.1 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 58870 526
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 186.07 % 8.11 29.24 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53719 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 14 146.87 % 5.67 21.21 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53730 381
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 2 0.37 x 1000 cells/ul 0.05 0.07 automated blood cell counting method Moms and pups used in studies were fed Dyets 40383 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 3 0.25 x 1000 cells/ul 0.07 0.11 automated blood cell counting method Moms and pups used in studies were fed Dyets 40388 401
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 16 19.03 ml/min/kg 1.76 7.03 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 58990 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 19 0.07 mmHg-1 0.01 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59002 526
SS/JrHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 22 0.82 g/kg 0.02 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 59014 526
SS/JrHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 92 3.77 g/dl 0.03 0.29 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40456 401
SS/JrHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 12 197.17 mg/dl 10.49 36.33 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40666 401
SS/JrHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 9 206.33 mg/dl 12.47 37.4 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40674 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 10 9.93 mg/dl 0.37 1.18 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37576 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 9 9.58 mg/dl 0.28 0.83 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37572 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 94 22.36 mg/dl 0.38 3.64 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40895 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 10 7.11 x 1000 cells/ul 0.97 3.08 automated blood cell counting method Moms and pups used in studies were fed Teklad 40998 401
SS/JrHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 107 0.87 g/kg 0.01 0.12 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59503 526
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 9 63.96 fl 0.89 2.67 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37798 401
SS/JrHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 11 8.0 mg/dl 0.25 0.83 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37884 401
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 4 46.28 % 0.54 1.08 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41162 401
SS/JrHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 17 11.44 ml/min/kg 1.44 5.95 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59631 526
SS/JrHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 15.6 ml/min/kg 1.87 6.19 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 59639 526
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 7 28.86 mg/dl 1.92 5.08 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41385 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 2 60.75 fl 0.35 0.5 automated blood cell counting method Moms and pups used in studies were fed Dyets 38164 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 10 5.94 x 1000 cells/ul 0.77 2.44 automated blood cell counting method Moms and pups used in studies were fed Teklad 41575 401
SS/JrHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 12 14.29 g/dl 0.21 0.73 automated blood cell counting method Moms and pups used in studies were fed Dyets 41621 401
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (1 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 10 1.4 g/mg 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 62804 528
SS/JrHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 12 18.6 pg 0.14 0.49 automated blood cell counting method Moms and pups used in studies were fed Dyets 38384 401
SS/JrHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 18.81 pg 0.11 0.34 automated blood cell counting method Moms and pups used in studies were fed Dyets 38392 401
SS/JrHsdMcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 11 20.09 mg/dl 0.71 2.34 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41809 401
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 71.64 % 6.01 19.93 wire myography using a Digi-Med tissue force analysis system with force transducer 62980 528
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 94 0.15 mg/dl 0.01 0.08 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41935 401
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 104 1.13 g 0.02 0.23 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45471 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 130.55 mmHg 4.14 13.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45576 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 16 55.26 mmHg 2.76 11.03 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46488 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 90 0.31 IU/g 0.05 0.45 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47483 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 19 0.46 IU/g 0.12 0.52 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47491 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 45.79 % 11.92 39.53 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47512 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 4.6 mmHg 0.54 1.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47538 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 94 255.87 beats/min 4.57 44.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47648 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 4 post-ischemic value/pre-ischemic value x 100% 1.98 % 1.98 3.96 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48709 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 92.0 mmHg 7.24 20.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48729 461
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 79.4 % 5.63 17.79 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57272 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 -6.9 null 0.08 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 57402 522
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 35.12 mmHg 1.18 3.53 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16098 381
SS/JrHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 15 207.8 g 3.3 13.0 whole body digital scale Moms and pups used in studies were fed Teklad 55225 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -6.6 null 0.06 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55368 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55375 522
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 20 0.23 null 0.01 0.04 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 57718 526
SS/JrHsdMcwi serum phosphate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount female 70.0 days-84.0 days 17 9.29 mg/dl 0.28 1.15 standard blood chemistry panel 60733 527
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 -6.13 mmHg 0.71 2.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16317 381
SS/JrHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.08 degrees C 0.12 0.35 digital rectal thermometry Moms and pups used in studies were fed Dyets 16336 381
SS/JrHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 3 38.23 degrees C 0.2 0.35 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16444 381
SS/JrHsdMcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 195.6 g 2.8 9.0 whole body digital scale Moms and pups used in studies were fed Teklad 55462 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 -8.49 null 0.13 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55484 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 -8.42 null 0.12 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55492 522
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 98 14.63 ml/min/kg 0.58 5.75 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57867 526
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 0.6 ml 0.02 0.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16541 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 76 37.4 degrees C 0.1 0.86 digital rectal thermometry Moms and pups used in studies were fed Teklad 16640 381
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 40.8 ml/min/kg 0.92 2.42 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58071 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 91 0.43 null 0.02 0.21 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58180 526
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 5.44 mmHg 2.1 6.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16775 381
SS/JrHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 89 1.12 g/mg 0.05 0.43 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55828 522
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 1.49 E-7mole 0.22 0.69 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55942 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 17 99.41 % 0.59 2.43 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55964 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 16.33 % 3.54 12.26 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55988 522
SS/JrHsdMcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 87 39.74 ml/min/kg 1.66 15.49 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58275 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 9 0.46 null 0.06 0.17 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58315 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 11 0.44 null 0.03 0.09 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58319 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 18.17 ml/min/kg 2.18 6.17 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58431 526
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 1.66 E-7mole 0.39 1.51 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54588 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 85 0.06 umol/l 0.01 0.13 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54714 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 -8.4 null 0.07 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56035 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 52 -8.49 null 0.07 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56031 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 -7.24 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56177 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.15 null 0.07 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56181 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 8 1.16 g/mg 0.22 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56214 522
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 4 1.02 mg/kg 0.17 0.34 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58471 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 104 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 58556 526
SS/JrHsdMcwi serum chloride level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount female 70.0 days-84.0 days 17 103.06 mmol/l 0.78 3.23 standard blood chemistry panel 62281 527
SS/JrHsdMcwi serum total protein level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount female 70.0 days-84.0 days 17 5.82 g/dl 0.07 0.29 standard blood chemistry panel 62445 527
SS/JrHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 17 1.25 g/mg 0.14 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56222 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 37.4 % 4.48 10.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56290 522
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 21.1 ml/min/kg 1.64 5.17 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58680 526
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 73.0 % 7.82 17.48 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56340 522
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.18 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58710 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 284.3 g 7.6 24.1 whole body digital scale Moms and pups used in studies were fed Dyets 58818 526
SS/JrHsdMcwi serum urea nitrogen level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount male 70.0 days-84.0 days 41 23.29 mg/dl 1.12 7.15 standard blood chemistry panel 61763 527
SS/JrHsdMcwi mean corpuscular volume controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait male 70.0 days-84.0 days 41 55.6 fl 0.35 2.21 automated blood cell counting method 61845 527
SS/JrHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 2.19 g/mg 0.2 0.61 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55014 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 6 40.33 % 4.82 11.81 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55090 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 42 26.4 % 1.88 12.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55146 522
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 95 0.12 mmHg x min x kg x ml-1 0.0 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59937 526
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data arterial blood pressure trait male 70.0 days-77.0 days 6 1/3 systolic pressure + 2/3 diastolic pressure 139.0 mmHg 4.91 12.02 radiotelemetry carotid artery - 43869 441
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 53.04 % 5.99 20.75 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56722 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 49.67 % 2.69 9.31 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56744 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 45.0 % 3.11 9.84 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56746 522
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 1.03 E-7mole 0.21 0.81 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56793 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 0.03 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56808 522
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 15.17 ml/min/kg 1.81 5.72 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 60051 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 16 12.35 ml/min/kg 1.11 4.42 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60075 526
SS/JrHsdMcwi red blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70.0 days-84.0 days 17 7.87 x 10E6 cells/ul 0.11 0.46 automated blood cell counting method 61513 527
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 0.21 umol/l 0.14 0.46 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56875 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -6.89 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56961 522
SS/JrHsdMcwi blood neutrophil count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity female 70.0 days-84.0 days 17 0.81 x 1000 cells/ul 0.09 0.38 automated blood cell counting method 60385 527
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount male 70.0 days-84.0 days 41 33.35 g/dl 0.09 0.56 automated blood cell counting method 61855 527
SS/JrHsdMcwi plasma anion gap controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data ion homeostasis trait male 70.0 days-84.0 days 40 24.23 mmol/l 0.35 2.24 standard blood chemistry panel 61885 527
SS/JrHsdMcwi blood lymphocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity male 70.0 days-84.0 days 39 6.55 x 1000 cells/ul 0.29 1.81 automated blood cell counting method 62039 527
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data urine sodium amount male 70.0 days-77.0 days 7 12.43 mEq/d 0.47 1.25 automated urine analysis - 44240 441
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 2.84 E-7mole 0.48 1.66 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57126 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 40 48.6 % 2.1 13.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57181 522
SS/JrHsdMcwi serum total cholesterol level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood cholesterol amount female 70.0 days-84.0 days 17 82.88 mg/dl 5.1 21.04 standard blood chemistry panel 60539 527
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.56 ml 0.04 0.13 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17443 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 48.14 ml/min 2.83 10.98 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17467 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 41.42 ml/min 1.75 4.64 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17473 381
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 125.0 mmHg 4.12 13.02 balloon tipped catheter with pressure transducer in isolated perfused heart 46822 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 84 61.56 mmHg 2.13 19.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47768 461
SS/JrHsdMcwi body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 87 217.3 g 3.4 31.3 whole body digital scale Moms and pups used in studies were fed Teklad 47853 461
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data heart pumping trait male 70.0 days-77.0 days 7 360.86 beats/min 6.22 16.45 radiotelemetry carotid artery - 44671 441
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 8 1.27 g 0.06 0.17 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 45832 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 11 114.08 mmHg 3.99 13.22 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45842 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 60.33 % 12.89 38.67 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45920 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 4 post-ischemic value/pre-ischemic value x 100% 17.76 % 17.76 35.53 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45924 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 89.95 % 7.83 13.56 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45946 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 68.83 % 9.81 33.97 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46843 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 26.72 % 5.22 18.09 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46952 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 11 post-ischemic value/pre-ischemic value x 100% 55.12 % 11.26 37.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46031 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 89.23 % 7.34 20.75 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46037 461
SS/JrHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 19 52.84 mmHg 3.45 15.05 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48105 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 62.16 mmHg 3.13 8.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45054 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 7.69 ml/min/g 2.42 7.27 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45093 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 128.01 mmHg 11.12 19.27 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45128 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 19 6.4 ml/min/g 0.54 2.36 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46273 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 68 post-ischemic value/pre-ischemic value x 100% 36.89 % 2.43 20.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46386 461
SS/JrHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 87 post-ischemic value/pre-ischemic value x 100% 89.31 % 4.61 43.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48473 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 7 25.16 mmHg 8.33 22.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48496 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 226.32 beats/min 12.63 35.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45247 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 89 44.01 mmHg 2.46 23.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45336 461
SS/JrHsdMcwi middle cerebral artery inner diameter controlled losartan content drinking water (20 mg/kg/d) (for 7 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 7 237.0 um 6.6 17.46 ex vivo videomicroscopy 0.0 69568 732
SS/JrHsdMcwi middle cerebral artery inner diameter 0.9% sodium chloride solution (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 249.0 um 8.5 20.82 ex vivo videomicroscopy 0.0 69571 732
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 247.0 um 7.8 17.44 ex vivo videomicroscopy 0.0 69574 732
SS/JrHsdMcwi middle cerebral artery inner diameter controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then physiological salt solution perfusate Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 133.0 um 3.4 8.33 ex vivo videomicroscopy 0.0 69582 732
SS/JrHsdMcwi resting tone of middle cerebral artery controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 [(Dmax - Drest) /Dmax] x 100 48.0 % 1.9 4.25 ex vivo videomicroscopy 0.0 69584 732
SS/JrHsdMcwi middle cerebral artery inner diameter controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 246.0 um 8.9 21.8 ex vivo videomicroscopy 0.0 69586 732
SS/JrHsdMcwi resting tone of middle cerebral artery controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 [(Dmax - Drest) /Dmax] x 100 44.0 % 3.3 8.08 ex vivo videomicroscopy 0.0 69587 732
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 168.4 mmHg 7.0 25.24 vascular indwelling catheter method left femoral artery 120.0 69540 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then NG-nitroarginine methyl ester (5 mg/kg) then acetylcholine (0.2 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 9 serial mean 159.1 mmHg 6.4 19.2 vascular indwelling catheter method left femoral artery 120.0 69550 151
SS/JrHsdMcwi urine creatinine excretion rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 89.0 days-92.0 days 17 0.0 mg/d 0.0 0.0 urine creatinine analysis 0.0 ug/min 69463 151
SS/JrHsdMcwi timed urine volume controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine output female 92.0 days-94.0 days 15 7.8 ml/d 0.6 2.32 urine volume measurement method 0.0 needs ml/d default 69465 151
SS/JrHsdMcwi white blood cell count controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. leukocyte quantity female 92.0 days-94.0 days 9 0.01 x 1000 cells/ul 1044.0 3132.0 isolated cell counting method 0.0 69496 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93.0 days 10 serial mean 146.5 mmHg 5.6 17.71 vascular indwelling catheter method left femoral artery 10800.0 69518 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 93.0 days 11 serial mean 446.8 beats/min 9.7 32.17 vascular indwelling catheter method left femoral artery 10800.0 69520 151
SS/JrHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. body mass not specified 84.0 days 395.0 g 10.0 body weighing method 0.0 69205 1057
SS/JrHsdMcwi spleen wet weight controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. spleen mass not specified 84.0 days 1.36 g 0.03 post excision weight measurement 0.0 69207 1057
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 15 serial mean 139.0 mmHg 6.0 23.24 vascular indwelling catheter method left femoral artery 0.0 69446 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 89.0 days-91.0 days 15 serial mean 442.0 beats/min 6.5 25.17 vascular indwelling catheter method left femoral artery 0.0 69450 151
SS/JrHsdMcwi urine total protein level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (0.4 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. total urine protein amount female 90.0 days-94.0 days 18 2.63 mg/ml 0.47 1.99 urine total protein analysis 0.0 mg/ml 69458 151
SS/JrHsdMcwi mean arterial blood pressure control condition (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44.0 days-53.0 days 14 serial mean 107.0 mmHg 1.0 3.74 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98472 2079
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (between 50 and 52 days) then controlled sodium content diet (4 %) (for 21 days) Cowley AW Jr, et al., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7. heart pumping trait male 71.0 days-73.0 days 8 serial mean 405.0 beats/min 2.0 5.66 intra-aortic thoracic radiotelemetry via carotid cannulation 86400.0 98639 2118
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (between 50 and 52 days) then controlled sodium content diet (4 %) (for 21 days) Cowley AW Jr, et al., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7. arterial blood pressure trait male 71.0 days-73.0 days 8 serial mean 151.0 mmHg 3.0 8.49 intra-aortic thoracic radiotelemetry via carotid cannulation 86400.0 98643 2118
SS/JrHsdMcwi mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 70 days) then controlled sodium chloride content diet (8 %) (for 21 days) Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. arterial blood pressure trait female 91.0 days 13 serial mean 174.0 mmHg 5.0 18.03 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 98700 2141
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Hoffman MJ, et al., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1. urine albumin amount male 91.0 days 12 198.0 mg/d 36.0 124.71 urine microalbumin analysis 1.0 98709 2141
SS/JrHsdMcwi systolic blood pressure physical restraint (20-30 min/d) (for 4 days) McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. arterial blood pressure trait male 126.0 days 16 155.0 mmHg 3.0 12.0 tail cuff plethysmography 0.0 100079 2418
SS/JrHsdMcwi body weight common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 56.0 days-70.0 days 5 271.8 g 13.4 29.96 body weighing method 0.0 99012 2198
SS/JrHsdMcwi body weight common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 56.0 days-70.0 days 3 282.8 g 2.9 5.02 body weighing method 0.0 99016 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 10 TA/BW 1.93 mg/g 0.07 0.22 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99048 2198
SS/JrHsdMcwi heart right ventricle weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 11 0.24 g 0.01 0.03 post excision weight measurement 0.0 106542 3032
SS/JrHsdMcwi fully muscularized arterioles to total arterioles ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. pulmonary arteriole morphology trait male 56.0 days 11 55.2 % 2.3 7.63 immunohistochemistry 0.0 106546 3032
SS/JrHsdMcwi body weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. body mass male 56.0 days 7 261.0 g 6.0 15.87 body weighing method 0.0 106550 3032
SS/JrHsdMcwi tibia length monocrotaline (40 null) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. tibia length male 56.0 days 11 3.56 cm 0.03 0.1 post excision length measurement 0.0 106556 3032
SS/JrHsdMcwi lung weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56.0 days 7 1.23 g 0.05 0.13 post excision weight measurement 0.0 106558 3032
SS/JrHsdMcwi right atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 7 0.02 g 0.0 0.0 post excision weight measurement 0.0 106562 3032
SS/JrHsdMcwi left atrium weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56.0 days 7 0.01 g 0.0 0.0 post excision weight measurement 0.0 106566 3032
SS/JrHsdMcwi heart right atrium weight to left atrium weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 7 1.09 null 0.09 0.24 post excision weight measurement 0.0 106570 3032
SS/JrHsdMcwi kidney weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56.0 days 11 1.65 g 0.03 0.1 post excision weight measurement 0.0 106580 3032
SS/JrHsdMcwi heart right ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 7 0.62 mg/g 0.03 0.08 post excision weight measurement 0.0 106582 3032
SS/JrHsdMcwi heart left ventricle weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56.0 days 7 2.43 mg/g 0.05 0.13 post excision weight measurement 0.0 106586 3032
SS/JrHsdMcwi heart right atrium weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 11 0.14 mg/g 0.01 0.03 post excision weight measurement 0.0 106596 3032
SS/JrHsdMcwi heart left ventricle end-diastolic anterior wall thickness isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 147.0 days 10 2.05 mm 0.09 0.28 transthoracic echocardiography 0.0 105794 3023
SS/JrHsdMcwi heart rate isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 147.0 days 10 383.0 beats/min 6.0 18.97 transthoracic echocardiography 0.0 105802 3023
SS/JrHsdMcwi heart left ventricle end-diastolic anterior wall thickness angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 77.0 days-84.0 days 5 2.13 mm 0.09 0.2 transthoracic echocardiography 0.0 105812 3023
SS/JrHsdMcwi heart left ventricle end-diastolic posterior wall thickness isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 49.0 days-56.0 days 5 1.74 mm 0.08 0.18 transthoracic echocardiography 0.0 105814 3023
SS/JrHsdMcwi stroke volume angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 63.0 days-70.0 days 5 0.2 ml 0.03 0.06 transthoracic echocardiography 0.0 105840 3023
SS/JrHsdMcwi cardiac output angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 63.0 days-70.0 days 5 78.0 ml/min 10.0 22.36 transthoracic echocardiography 0.0 105846 3023
SS/JrHsdMcwi tibia length angiotensin II (200 ng/kg/min) (for 28 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. tibia length male 77.0 days-84.0 days 6 3.96 cm 0.03 0.07 post excision length measurement 0.0 105856 3023
SS/JrHsdMcwi blood T lymphocyte count controlled sodium chloride content diet (0.4 %) (for 42 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. T cell quantity not specified 63.0 days 4 3.3 x 10E6 cells/ml 0.5 1.0 flow cytometry method 0.0 n=4-7 106512 3031
SS/JrHsdMcwi urine albumin excretion rate controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 10 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. urine albumin amount not specified 73.0 days 6 101.1 mg/d 15.4 37.72 urine albumin analysis 0.0 n=6-8 106526 3031
SS/JrHsdMcwi right ventricular end-systolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricular blood pressure trait male 56.0 days 6 26.0 mmHg 0.99 2.42 vascular fluid filled catheter 0.0 106796 3032
SS/JrHsdMcwi heart rate vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56.0 days 6 358.0 beats/min 7.95 19.47 vascular fluid filled catheter 0.0 106798 3032
SS/JrHsdMcwi heart rate monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart pumping trait male 56.0 days 8 340.0 beats/min 7.65 21.64 vascular fluid filled catheter 0.0 106800 3032
SS/JrHsdMcwi systolic blood pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 8 108.0 mmHg 2.62 7.41 vascular fluid filled catheter 0.0 106804 3032
SS/JrHsdMcwi diastolic blood pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 6 84.0 mmHg 4.05 9.92 vascular fluid filled catheter 0.0 106806 3032
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 22 21.73 mmHg 1.57 7.35 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15145 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 28.96 ml/min 0.9 2.38 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15177 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 34.18 ml/min 1.91 7.39 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15171 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 6 427.49 beats/min 15.86 38.84 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15191 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 -8.27 mmHg 0.28 0.39 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15504 381
SS/JrHsdMcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 11 131.2 mmHg 2.53 8.39 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15547 381
SS/JrHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 -0.28 degrees C 0.11 0.39 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15634 381
SS/JrHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 5 -0.28 degrees C 0.23 0.52 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15640 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -5.39 mmHg 1.49 3.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15652 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 98.74 mmHg 10.27 20.53 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15765 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 0.42 ml 0.01 0.11 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15301 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.39 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15306 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 7.07 null 0.37 0.75 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15317 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 385.58 beats/min 9.77 32.41 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 15336 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.01 null 0.01 0.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15357 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 114.38 breaths/min 4.73 14.95 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15380 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 28 days) then controlled sodium content diet (8 %) (for 30 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-93.0 days 35 continuous mean 173.0 mmHg 7.0 41.41 vascular indwelling catheter method femoral artery 259200.0 3 h per day decrease 66140 229
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.32 ml 0.02 0.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15470 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 132.16 mmHg 5.14 13.61 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14416 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 31.62 mmHg 0.5 1.5 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 14473 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 65.74 ml/min 4.38 9.79 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14640 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 4 8.8 mmHg 4.29 8.59 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14644 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 108.53 mmHg 1.86 4.93 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 15985 381
SS/JrHsdMcwi urine fractional sodium excretion controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. urine sodium amount male 70.0 days 10 3.91 % 0.85 2.69 flame atomic emission spectrometry 1200.0 Fractional sodium excretion 64935 272
SS/JrHsdMcwi urine fractional sodium excretion controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. urine sodium amount male 70.0 days 10 1.3 % 0.37 1.17 flame atomic emission spectrometry 1200.0 Fractional 64937 272
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 163.21 % 3.74 13.49 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53527 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 74 125.74 breaths/min 2.83 24.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14862 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 119.11 breaths/min 7.04 24.38 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14867 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.32 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14879 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 63.07 ml/min 2.76 6.17 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14918 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -45.26 beats/min 9.09 37.49 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51691 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -24.39 beats/min 8.55 34.19 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51718 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 129.64 mmHg 6.29 12.58 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51742 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -16.0 beats/min 15.69 54.35 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51854 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 19 11.47 mEq/d 0.98 4.28 flame atomic emission spectrometry Moms and pups used in studies were fed Teklad 51882 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 21.26 mmHg 2.2 8.51 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51963 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 1.67 beats/min 20.69 35.83 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51978 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 131.99 mmHg 3.79 14.69 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51997 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -28.65 beats/min 9.43 39.99 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52049 481
SS/JrHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80.0 days-99.0 days 11 1.15 mEq/d 0.05 0.18 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52963 482
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80.0 days-99.0 days 55 0.68 ng/ml/h 0.12 0.9 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52465 482
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80.0 days-99.0 days 63 213.87 mg/d 14.59 115.81 automated urine total protein analysis Moms were fed Teklad, pups used in studies were fed Dyets 52710 482
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 3.46 mmHg 3.06 10.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50605 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 17 -9.14 beats/min 7.81 32.2 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50613 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -42.28 beats/min 12.66 43.87 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50619 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 4 411.76 beats/min 26.24 52.48 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50667 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -40.21 beats/min 9.65 40.92 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50718 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 28.78 mmHg 3.03 10.51 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50755 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 16 139.76 mmHg 3.93 15.73 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50939 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 12.53 mmHg 2.38 9.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51020 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 -1.55 mmHg 1.88 3.77 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51081 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 432.92 beats/min 10.44 36.17 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51119 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 157.61 mmHg 4.84 19.98 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51141 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 16 -16.62 beats/min 6.53 26.13 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51154 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 20 1.46 mEq/d 0.2 0.9 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51266 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 15 1.61 ml/min 0.19 0.75 urine creatinine analysis Moms and pups used in studies were fed Dyets 51541 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 401.83 beats/min 4.13 13.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51583 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 17 3.92 mmHg 3.22 13.28 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51591 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 3 -12.6 beats/min 13.02 22.55 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51608 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 32.43 mmHg 3.05 11.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51659 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 -21.75 beats/min 16.71 64.71 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50355 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -9.03 beats/min 7.32 31.07 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50504 481
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 51 123.21 mmHg 1.69 12.1 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13510 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 1 25.75 mmHg stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13536 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 2 16.2 mmHg 1.5 2.12 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13542 381
SS/JrHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.51 degrees C 0.18 0.64 digital rectal thermometry Moms and pups used in studies were fed Teklad 13632 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 268.41 % 12.73 44.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14271 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 153.14 breaths/min 4.35 15.69 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17206 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 5 150.14 breaths/min 6.0 13.42 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17212 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82.0 days-99.0 days 53 27.33 mmHg 0.43 3.1 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 17266 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.52 ml 0.03 0.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17344 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 %change=VE during 2-3 min hypoxia/control during standard conditions 149.98 % 2.94 25.32 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13748 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 522.7 beats/min 7.28 21.83 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13805 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 517.71 beats/min 27.96 48.43 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13832 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 11 37.29 mmHg 0.84 2.78 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 13837 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 34.17 mmHg 0.86 2.59 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 13846 381
SS/JrHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 13 37.63 degrees C 0.1 0.37 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13848 381
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood creatinine amount female 90.0 days-94.0 days 15 0.7 mg/dl 0.1 0.39 plasma creatinine analysis 0.0 plasma creatinine analysis 67282 151
SS/JrHsdMcwi kidney glomerulus diameter controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney glomerulus size trait female 97.0 days-101.0 days 16 117.0 um 3.8 15.2 ex vivo light microscopy 0.0 plasma creatinine analysis glomerular diameter 67286 151
SS/JrHsdMcwi body weight controlled sodium content diet (0.4 %) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84.0 days 28 230.0 g 3.0 15.87 body weighing method 0.0 after catheterization and jacket attachment 67294 151
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 34.0 mmHg 3.0 10.82 vascular indwelling catheter method left femoral artery 0.0 67300 151
SS/JrHsdMcwi body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 5 37.62 degrees C 0.19 0.43 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13854 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 132.8 mmHg 6.49 18.34 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13896 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 108.33 mmHg 5.29 9.16 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13906 381
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 197.0 mmHg 7.0 32.08 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11850 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-92.0 days 21 serial mean 174.0 mmHg 6.0 27.5 vascular indwelling catheter method left femoral artery 3 hrs (during inactive phase) 3 consecutive days, and 4 extra hrs (during active phase) next day 11854 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 84.0 days 28 continuous mean 125.0 mmHg 3.0 15.87 vascular indwelling catheter method femoral artery 3.0 left femoral artery 12024 229
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 32.5 mmHg 1.68 4.1 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19832 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.48 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20864 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 436.5 beats/min 7.29 19.29 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20977 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 2 26.2 mmHg 0.65 0.92 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 21004 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 122.76 % 5.75 19.93 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53819 381
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 179.66 % 9.26 29.27 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53838 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 27 109.1 mmHg 1.4 7.27 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19973 381
SS/JrHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 11 7.45 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20023 381
SS/JrHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 7.44 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20032 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20113 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 143.13 breaths/min 2.98 9.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20683 381
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. renin activity female 92.0 days 7 2.2 ng/ml/h 0.58 1.53 ex vivo blood analysis 0.0 enzyme assay 13307 151
SS/JrHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 11 101.3 mmHg 1.61 5.34 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19526 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17614 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 142.82 breaths/min 2.99 9.47 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17626 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.52 ml 0.03 0.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17671 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.59 ml 0.03 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17680 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 112.85 breaths/min 5.02 15.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17692 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 8 448.96 beats/min 12.9 36.5 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17748 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 22 136.46 mmHg 2.42 11.36 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 17763 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 14 88.11 breaths/min 4.86 18.18 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17791 381
SS/JrHsdMcwi body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 14 194.9 g 5.0 18.6 whole body digital scale Moms and pups used in studies were fed Dyets 17890 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 %change=VE during7-9 min hypoxia/control during standard conditions 149.62 % 9.13 34.16 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17913 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 148.65 % 12.89 40.77 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 17922 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 430.16 beats/min 6.98 23.14 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18101 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 9 430.66 beats/min 12.88 38.63 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18110 381
SS/JrHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 38.12 degrees C 0.23 0.7 digital rectal thermometry Moms and pups used in studies were fed Teklad 18134 381
SS/JrHsdMcwi urine sodium excretion rate to body weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (150 mmHg) (for 0.3 hours) then controlled in situ renal perfusion pressure (170-175 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. urine sodium amount male 70.0 days 10 2.58 uEq/min/g 0.68 2.15 flame atomic emission spectrometry 1200.0 urine sodium excretion rate to kidney weight ratio 64968 272
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 74 128.62 breaths/min 2.85 24.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 18333 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 133.12 % 9.95 26.33 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18374 381
SS/JrHsdMcwi body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 14 311.9 g 8.6 32.1 whole body digital scale Moms and pups used in studies were fed Dyets 18495 381
SS/JrHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 103.79 mmHg 3.04 7.45 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18917 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 6 56.9 mmHg 0.73 1.8 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18978 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 115.6 mmHg 10.41 18.04 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19009 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19012 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19021 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 9 26.83 mmHg 1.07 3.2 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19024 381
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 2 20.05 pg 0.65 0.92 automated blood cell counting method Moms and pups used in studies were fed Dyets 37071 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 7 0.26 mg/dl 0.02 0.05 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37070 401
SS/JrHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 4 18.65 pg 0.06 0.13 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37077 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 10 132.4 U/l 4.75 15.01 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37281 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 4 9.68 mg/dl 0.06 0.13 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37292 401
SS/JrHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 12 5.25 x 1000 cells/ul 0.51 1.78 automated blood cell counting method Moms and pups used in studies were fed Dyets 37299 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 7 9.2 mg/dl 0.14 0.36 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37297 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 89 32.35 g/dl 0.05 0.44 automated blood cell counting method Moms and pups used in studies were fed Teklad 37377 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 11 32.31 g/dl 0.1 0.33 automated blood cell counting method Moms and pups used in studies were fed Teklad 37385 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 10 142.1 mmol/l 1.31 4.15 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36596 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 94 9.23 mg/dl 0.06 0.55 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36691 401
SS/JrHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 4 19.0 mmol/l 1.47 2.94 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36846 401
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 5 -4.67 mmHg 0.69 1.55 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19327 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 49 -47.43 mmHg 1.07 7.51 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19489 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 30.22 mmHg 0.63 1.55 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18171 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.49 ml 0.02 0.07 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18173 381
SS/JrHsdMcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 487.67 beats/min 8.92 23.59 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 18203 381
SS/JrHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 38.43 degrees C 0.15 0.41 digital rectal thermometry Moms and pups used in studies were fed Dyets 18226 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 117.95 mmHg 14.95 25.89 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18246 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 117.48 mmHg 3.71 11.72 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20394 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 28.41 mmHg 0.8 2.12 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20419 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 8 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20547 381
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 84 5.65 mmHg 0.09 0.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49244 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 17 742.79 s 32.97 135.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49370 461
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 85 199.8 g 3.9 36.3 whole body digital scale Moms and pups used in studies were fed Teklad 49558 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 12 22.98 % 1.56 5.41 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49635 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 44.5 mmHg 4.55 12.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49798 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 3 40.55 % 3.63 6.28 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49850 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 2 15.62 ml/min/g 10.28 14.54 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49869 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 90 100.65 mmHg 1.99 18.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49954 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 13.15 IU/g 2.12 6.69 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 50202 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 11 241.06 beats/min 19.12 63.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 50309 461
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 86.7 beats/min 12.11 32.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 19174 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 5 37.9 degrees C 0.13 0.3 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19182 381
SS/JrHsdMcwi heart right ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart right ventricle mass male 70.0 days-84.0 days 47 0.19 g 0.0 0.03 digital scale post excision weight measurement 63246 529
SS/JrHsdMcwi body length, nose to tail controlled sodium content diet (1 %) (for 14 days) PhysGen General data body length male 70.0 days-84.0 days 47 43.39 cm 0.22 1.52 in vivo ruler method 63256 529
SS/JrHsdMcwi heart left ventricle wet weight controlled sodium content diet (1 %) (for 14 days) PhysGen General data heart left ventricle mass male 70.0 days-84.0 days 47 0.8 g 0.02 0.13 digital scale post excision weight measurement 63482 529
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 6 4.78 mmol/l 0.31 0.75 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 38833 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 56.96 % 0.99 3.13 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38854 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 18.21 g/dl 0.31 0.97 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38877 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 10 17.8 mmol/l 1.0 3.16 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42134 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 9 89.33 U/l 8.5 25.5 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42154 401
SS/JrHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 9 4.16 mmol/l 0.07 0.22 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42166 401
SS/JrHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 4 2.88 g/dl 0.08 0.15 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42185 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 7 5.97 g/dl 0.17 0.44 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42195 401
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 0.63 E-7mole 0.18 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer 63222 528
SS/JrHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 11 0.52 x 1000 cells/ul 0.09 0.28 automated blood cell counting method Moms and pups used in studies were fed Teklad 38953 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 7 20.0 mmol/l 1.18 3.11 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39091 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 10 3.9 g/dl 0.03 0.11 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42305 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 4 77.25 U/l 7.61 15.22 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42388 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 4 3.33 g/dl 0.15 0.3 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42393 401
SS/JrHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 4 0.2 mg/dl 0.0 0.0 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39326 401
SS/JrHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 9 0.48 x 1000 cells/ul 0.07 0.2 automated blood cell counting method Moms and pups used in studies were fed Dyets 39366 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 96 142.69 mmol/l 0.31 3.02 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39455 401
SS/JrHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 12 3.72 g/dl 0.12 0.4 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39522 401
SS/JrHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 9 3.86 g/dl 0.1 0.29 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39530 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 10 0.42 mg/dl 0.05 0.15 automated plasma creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39544 401
SS/JrHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 92 0.24 mg/dl 0.01 0.08 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42695 401
SS/JrHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 11 0.26 mg/dl 0.02 0.05 automated plasma creatinine analysis Moms and pups used in studies were fed Teklad 42703 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 10 85.5 U/l 5.19 16.41 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42842 401
SS/JrHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 11 5.73 x 1000 cells/ul 0.23 0.77 automated blood cell counting method Moms and pups used in studies were fed Teklad 39942 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 4 2.78 g/dl 0.18 0.36 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39963 401
SS/JrHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 12 0.29 mg/dl 0.04 0.13 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 43089 401
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 174.48 % 7.95 27.56 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54491 381
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 177.67 % 9.66 30.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54508 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 108.25 % 6.21 19.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54544 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 136.61 % 5.97 18.86 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54556 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 15 121.93 % 4.97 19.27 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53536 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 115.93 % 4.67 17.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53549 381
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 176.86 % 9.08 28.72 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 53556 381
SS/JrHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 88 14.38 g/dl 0.07 0.62 automated blood cell counting method Moms and pups used in studies were fed Teklad 40151 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 10 0.49 x 1000 cells/ul 0.13 0.4 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43410 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 6 110.0 U/l 24.49 59.99 standard blood chemistry panel Moms and pups used in studies were fed Dyets 43416 401
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.43 null 0.02 0.07 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 58885 526
SS/JrHsdMcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 4 3.73 g/dl 0.05 0.1 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40372 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 4 0.35 mg/dl 0.12 0.24 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 40377 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 7 0.4 mg/dl 0.08 0.21 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 40382 401
SS/JrHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 21 0.97 g/kg 0.02 0.08 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 59022 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 59031 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 182.2 g 1.7 5.3 whole body digital scale Moms and pups used in studies were fed Teklad 59134 526
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 9 2.64 g/dl 0.07 0.22 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40496 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 10 2.24 g/dl 0.03 0.11 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40500 401
SS/JrHsdMcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 12 101.67 mmol/l 1.14 3.94 standard blood chemistry panel Moms and pups used in studies were fed Dyets 40518 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 9 5.01 x 1000 cells/ul 0.81 2.43 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40512 401
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 12 44.93 % 0.69 2.39 automated blood cell counting method Moms and pups used in studies were fed Dyets 40678 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 90 57.97 % 0.34 3.26 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 59324 526
SS/JrHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 11 110.82 U/l 4.04 13.4 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37507 401
SS/JrHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 9 38.78 U/l 2.83 8.5 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37686 401
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 95 0.06 mmHg-1 0.01 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59407 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 11 0.06 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Teklad 59415 526
SS/JrHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 92 56.28 U/l 2.03 19.5 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37756 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 10 64.07 fl 0.85 2.69 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37802 401
SS/JrHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 11 2.02 g/dl 0.02 0.08 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41084 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 2 6.14 x 1000 cells/ul 0.26 0.37 automated blood cell counting method Moms and pups used in studies were fed Dyets 41141 401
SS/JrHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 4 57.9 fl 0.38 0.76 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41147 401
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 5 0.81 null 0.09 0.2 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59741 526
SS/JrHsdMcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 92 162.71 mg/dl 2.13 20.44 standard blood chemistry panel Moms and pups used in studies were fed Teklad 41243 401
SS/JrHsdMcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 4 34.5 U/l 4.63 9.26 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38159 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 8.89 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38195 401
SS/JrHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 12 58.38 fl 0.5 1.74 automated blood cell counting method Moms and pups used in studies were fed Dyets 38203 401
SS/JrHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 9 58.62 fl 0.22 0.67 automated blood cell counting method Moms and pups used in studies were fed Dyets 38211 401
SS/JrHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 12 7.88 mg/dl 0.22 0.78 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38225 401
SS/JrHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 89 0.01 x 1000 cells/ul 0.0 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41453 401
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (1 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 1.29 g/mg 0.11 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 62809 528
SS/JrHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 12 0.07 x 1000 cells/ul 0.02 0.06 automated blood cell counting method Moms and pups used in studies were fed Dyets 38363 401
SS/JrHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 9 0.04 x 1000 cells/ul 0.01 0.03 automated blood cell counting method Moms and pups used in studies were fed Dyets 38371 401
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 5 -7.82 null 0.1 0.23 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter 62896 528
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (1 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 5 78.8 % 7.02 15.69 wire myography using a Digi-Med tissue force analysis system with force transducer 62986 528
SS/JrHsdMcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 11 59.75 fl 0.29 0.97 automated blood cell counting method Moms and pups used in studies were fed Teklad 38704 401
SS/JrHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 9 5.87 g/dl 0.12 0.36 standard blood chemistry panel Moms and pups used in studies were fed Dyets 41841 401
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 89 56.0 mmHg 1.75 16.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 46483 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 317.09 beats/min 22.83 64.57 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46517 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 post-ischemic value/pre-ischemic value x 100% 78.72 % 11.48 32.48 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47518 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 12 0.25 IU/g 0.02 0.07 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 47552 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 38.73 % 6.03 20.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48598 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 122.57 mmHg 3.05 8.62 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48737 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 84 post-ischemic value/pre-ischemic value x 100% 80.61 % 2.77 25.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48822 461
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 57.08 % 5.68 19.69 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57295 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 90 1.09 g/mg 0.06 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57374 522
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 11.39 ml/min/kg 1.28 3.39 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57567 526
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 76.31 ml/min 4.87 17.55 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 16232 381
SS/JrHsdMcwi minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 84.06 ml/min 3.63 11.48 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 16241 381
SS/JrHsdMcwi absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 -0.24 degrees C 0.17 0.58 digital rectal thermometry Moms and pups used in studies were fed Dyets 16260 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 40 9.93 mmHg 1.27 8.06 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16288 381
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 45.77 % 9.32 29.48 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55355 522
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 100 10.69 ml/min/kg 0.32 3.16 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57665 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 16 2.02 null 0.28 1.13 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57744 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 8 0.06 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms and pups used in studies were fed Dyets 57755 526
SS/JrHsdMcwi serum glucose level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood glucose amount female 70.0 days-84.0 days 17 121.06 mg/dl 2.95 12.18 standard blood chemistry panel 60621 527
SS/JrHsdMcwi serum albumin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount male 70.0 days-84.0 days 41 3.4 g/dl 0.06 0.37 standard blood chemistry panel 60717 527
SS/JrHsdMcwi serum albumin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood albumin amount female 70.0 days-84.0 days 17 3.81 g/dl 0.07 0.28 standard blood chemistry panel 60723 527
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 411.41 beats/min 9.43 31.29 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 16351 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 98.99 mmHg 1.14 3.41 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16407 381
SS/JrHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 4 38.48 degrees C 0.13 0.26 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16438 381
SS/JrHsdMcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 84 298.8 g 3.0 27.7 whole body digital scale Moms and pups used in studies were fed Teklad 55454 522
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 4 0.32 null 0.03 0.06 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57979 526
SS/JrHsdMcwi blood eosinophil count controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data eosinophil quantity male 70.0 days-84.0 days 41 0.07 x 1000 cells/ul 0.02 0.1 automated blood cell counting method 60819 527
SS/JrHsdMcwi hematocrit controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity female 70.0 days-84.0 days 17 46.26 % 0.61 2.53 automated blood cell counting method 60989 527
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.53 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16546 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.65 degrees C 0.13 0.43 digital rectal thermometry Moms and pups used in studies were fed Teklad 16645 381
SS/JrHsdMcwi tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 0.49 ml 0.03 0.1 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16656 381
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 -6.87 null 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55673 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 13 -6.84 null 0.2 0.73 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55704 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 12 -6.44 null 0.13 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55712 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 53 0.06 10E-7mol/l 0.01 0.08 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55748 522
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood aspartate transaminase amount male 70.0 days-84.0 days 41 157.29 U/l 7.13 45.64 standard blood chemistry panel 61209 527
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 35.38 ml/min 3.43 11.89 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16763 381
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.87 degrees C 0.13 0.46 digital rectal thermometry Moms and pups used in studies were fed Teklad 16885 381
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 2.42 E-7mole 0.39 1.04 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55977 522
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 11 176.7 g 3.7 12.2 whole body digital scale Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58437 526
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 90 -7.44 null 0.05 0.47 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56145 522
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 0.1 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58594 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 7 1.26 mg/kg 0.45 1.18 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58604 526
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 78 66.83 % 2.39 21.11 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 54820 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 42.47 % 7.22 26.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54848 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 0.04 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56247 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 11 0.05 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56259 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 0.07 10E-7mol/l 0.03 0.12 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56267 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 11.1 % 2.12 6.71 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56301 522
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 13 1.11 mg/kg 0.24 0.85 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 58853 526
SS/JrHsdMcwi serum calcium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood calcium amount male 70.0 days-84.0 days 41 9.8 mg/dl 0.09 0.6 standard blood chemistry panel 61743 527
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 13 0.38 umol/l 0.14 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54986 522
SS/JrHsdMcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 13 1.88 g/mg 0.12 0.45 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55009 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 84.07 % 4.74 17.72 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55100 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 85.77 % 5.76 20.77 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55108 522
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 12 0.07 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55123 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 82.94 % 4.9 17.66 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56438 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 -6.65 null 0.06 0.17 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56451 522
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 98 1.6 mg/kg 0.11 1.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58973 526
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alanine transaminase amount female 70.0 days-84.0 days 17 40.94 U/l 3.17 13.06 standard blood chemistry panel 62199 527
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 40.78 % 3.05 9.16 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56732 522
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 11 12.55 ml/min/kg 1.43 4.73 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60083 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 2.26 null 0.35 1.05 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 60091 526
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 20 44.77 % 0.43 1.9 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 60117 526
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount male 70.0 days-84.0 days 41 0.35 mg/dl 0.02 0.15 automated plasma creatinine analysis 61517 527
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data blood creatinine amount female 70.0 days-84.0 days 17 0.33 mg/dl 0.02 0.08 automated plasma creatinine analysis 61523 527
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 15 80.47 % 5.91 22.88 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56848 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 46.42 % 3.72 12.89 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56994 522
SS/JrHsdMcwi mean corpuscular hemoglobin controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood hemoglobin amount female 70.0 days-84.0 days 17 19.45 pg 0.1 0.41 automated blood cell counting method 60375 527
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 1.65 E-7mole 0.22 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57131 522
SS/JrHsdMcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.04 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57164 522
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 110.14 mmHg 3.1 5.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16029 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 49 33.91 mmHg 0.54 3.81 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 16093 381
SS/JrHsdMcwi left kidney wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data kidney mass male 70.0 days-77.0 days 7 1.58 g 0.06 0.15 digital scale post excision weight measurement - 44487 441
SS/JrHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 85 5.54 g/kg 0.09 0.86 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45656 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 6 9.46 ml/min/g 1.42 3.47 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46837 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 19 55.44 mmHg 5.08 22.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47773 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 112.53 mmHg 4.24 12.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45849 461
SS/JrHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 12 867.22 s 55.3 191.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45874 461
SS/JrHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 854.01 s 49.01 138.62 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45881 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 94 9.6 ml/min/g 0.25 2.44 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46936 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 18.21 % 6.43 19.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46959 461
SS/JrHsdMcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 87 4.83 g/kg 0.06 0.58 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47031 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 19 99.78 mmHg 5.26 22.94 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44887 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 1 3.23 ml/min/g isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44899 461
SS/JrHsdMcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 855.28 s 44.18 76.53 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46016 461
SS/JrHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 72.25 % 16.5 49.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46028 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 97 post-ischemic value/pre-ischemic value x 100% 46.49 % 1.74 17.11 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47143 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 23.52 % 5.03 15.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48130 461
SS/JrHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 3 80.67 mmHg 6.94 12.01 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48138 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 100.16 % 4.79 20.86 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 44990 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 119.07 mmHg 5.54 9.6 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45011 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 52.57 mmHg 4.49 12.69 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45060 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 1 4.65 IU/g isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45114 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 11 11.14 ml/min/g 0.74 2.44 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46294 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 4 5.5 mmHg 0.65 1.29 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47375 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 14 265.53 beats/min 34.79 130.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45219 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 284.37 beats/min 31.65 89.53 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45253 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 8 10.41 IU/g 1.62 4.59 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45364 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 8 127.2 mmHg 2.65 7.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45378 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 4 1.6 g 0.02 0.04 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45381 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 4 780.59 s 43.73 87.46 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45386 461
SS/JrHsdMcwi resting tone of middle cerebral artery angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 [(Dmax - Drest) /Dmax] x 100 37.0 % 1.5 3.35 ex vivo videomicroscopy 0.0 69575 732
SS/JrHsdMcwi middle cerebral artery inner diameter angiotensin II (3 ng/kg/min) (for 3 days) then physiological salt solution perfusate then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 113.0 um 4.2 9.39 ex vivo videomicroscopy 0.0 69576 732
SS/JrHsdMcwi urine potassium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine potassium amount female 92.0 days-94.0 days 14 0.92 mEq/d 0.07 0.27 unspecified method 0.0 urine potassium analysis umol/min 69474 151
SS/JrHsdMcwi hematocrit controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. erythrocyte quantity female 89.0 days-92.0 days 15 38.8 % 1.4 5.42 hematocrit analysis 0.0 69482 151
SS/JrHsdMcwi left kidney wet weight controlled sodium content diet (0.4 %) (for 35 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. kidney mass female 97.0 days-101.0 days 20 1.27 g 0.07 0.31 post excision weight measurement 0.0 69506 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94.0 days 11 serial mean 182.9 mmHg 4.1 13.6 vascular indwelling catheter method left femoral artery 10800.0 69522 151
SS/JrHsdMcwi thymus wet weight controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. thymus mass not specified 84.0 days 4 500.0 mg 100.0 200.0 post excision weight measurement 0.0 69289 1057
SS/JrHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 84.0 days 28 221.0 g 2.7 14.29 body weighing method 0.0 69442 151
SS/JrHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 89.0 days-92.0 days 17 31.2 mg/dl 2.74 11.3 urine creatinine analysis 0.0 69456 151
SS/JrHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 89.0 days-92.0 days 17 338.0 mmol/l 29.2 120.39 unspecified method 0.0 urine sodium analysis 69454 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) then controlled sodium content diet (8 %) (for 7 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 74.0 days-84.0 days 12 serial mean 137.0 mmHg 5.0 17.32 intra-aortic abdominal radiotelemetry 14400.0 abdominal aorta 4 hrs for 3 consecutive days 96861 1718
SS/JrHsdMcwi mean arterial blood pressure control condition (0.4 %) (between 46 and 50.8 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 46.0 days-53.0 days 3 serial mean 107.0 mmHg 3.46 6.0 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 intra-carotid radiotelemetry 98602 2098
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. urine albumin amount male 60.0 days-67.0 days 12 278.0 mg/d 18.0 62.35 urine microalbumin analysis 0.0 98624 2098
SS/JrHsdMcwi urine podocalyxin excretion rate physical restraint (20-30 min/d) (for 4 days) McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. urine podocalyxin amount male 42.0 days 6 17.0 ug/d 2.0 4.9 enzyme linked immunosorbent assay 0.0 100083 2418
SS/JrHsdMcwi urine podocalyxin excretion rate physical restraint (20-30 min/d) (for 4 days) McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. urine podocalyxin amount male 126.0 days 6 47.0 ug/d 7.0 17.15 enzyme linked immunosorbent assay 0.0 100085 2418
SS/JrHsdMcwi kidney weight control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. kidney mass male 126.0 days 27 1.41 g 0.0 0.02 post excision weight measurement 0.0 100087 2418
SS/JrHsdMcwi heart rate controlled sodium chloride content diet (0.4 %) (between 23 and 32 days) then controlled sodium chloride content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. heart pumping trait male 58.0 days-67.0 days 14 serial mean 387.0 beats/min 6.0 22.45 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98521 2079
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. arterial blood pressure trait male 89.0 days 16 serial mean 186.0 mmHg 5.0 20.0 intra-aortic abdominal radiotelemetry via femoral cannulation 10800.0 98671 2138
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (0.4 %) (for 68 days) then controlled sodium content diet (8 %) (for 21 days) Moreno C, et al., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21. total urine protein amount male 89.0 days 16 365.0 mg/d 37.0 148.0 Bradford protein assay 1.0 98685 2138
SS/JrHsdMcwi body weight control condition Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 49.0 days-63.0 days 5 249.8 g 14.4 32.2 body weighing method 0.0 99011 2198
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 5 EDL/BW 0.44 mg/g 0.01 0.02 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99046 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio control condition (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 10 TA/BW 1.8 mg/g 0.06 0.19 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99047 2198
SS/JrHsdMcwi heart right ventricle weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 7 0.16 g 0.01 0.02 post excision weight measurement 0.0 106540 3032
SS/JrHsdMcwi tibia length vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. tibia length male 56.0 days 7 3.64 cm 0.06 0.16 post excision length measurement 0.0 106554 3032
SS/JrHsdMcwi heart right atrium weight to left atrium weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 11 2.27 null 0.13 0.43 post excision weight measurement 0.0 106572 3032
SS/JrHsdMcwi liver weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56.0 days 11 8.38 g 0.18 0.6 post excision weight measurement 0.0 106576 3032
SS/JrHsdMcwi kidney weight vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56.0 days 7 2.13 g 0.05 0.13 post excision weight measurement 0.0 106578 3032
SS/JrHsdMcwi lung weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56.0 days 7 0.4 % 0.08 0.2 post excision weight measurement 0.0 106590 3032
SS/JrHsdMcwi heart right ventricle weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 7 4.51 mg/mm 0.22 0.58 post excision weight measurement 0.0 106610 3032
SS/JrHsdMcwi lung weight to tibia length ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. lung mass male 56.0 days 7 0.29 g/cm 0.05 0.12 post excision weight measurement 0.0 106618 3032
SS/JrHsdMcwi heart left ventricle end-diastolic diameter isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 147.0 days 10 7.8 mm 0.14 0.44 transthoracic echocardiography 0.0 should be inner diameter 105798 3023
SS/JrHsdMcwi cardiac output isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. cardiac output trait male 147.0 days 10 101.0 ml/min 4.0 12.65 transthoracic echocardiography 0.0 105806 3023
SS/JrHsdMcwi heart left ventricle end-diastolic posterior wall thickness angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 63.0 days-70.0 days 5 2.17 mm 0.11 0.25 transthoracic echocardiography 0.0 105816 3023
SS/JrHsdMcwi heart left ventricle fractional shortening angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 63.0 days-70.0 days 5 57.2 % 2.7 6.04 transthoracic echocardiography 0.0 105828 3023
SS/JrHsdMcwi heart left ventricle fractional shortening angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle end-diastolic diameter male 77.0 days-84.0 days 5 51.9 % 3.7 8.27 transthoracic echocardiography 0.0 105830 3023
SS/JrHsdMcwi heart rate angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart pumping trait male 77.0 days-84.0 days 5 358.0 beats/min 17.0 38.01 transthoracic echocardiography 0.0 105836 3023
SS/JrHsdMcwi plasma interleukin-6 level control condition (for 84 days) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood interleukin-6 amount male 84.0 days 6 17.0 pg/ml 2.0 4.9 enzyme linked immunosorbent assay 0.0 105858 3023
SS/JrHsdMcwi spleen weight controlled sodium chloride content diet (0.4 %) (for 42 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. spleen mass not specified 63.0 days 4 1.5 g 0.1 0.2 post excision weight measurement 0.0 n=4-7 106508 3031
SS/JrHsdMcwi blood B lymphocyte count controlled sodium chloride content diet (0.4 %) (for 42 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. B cell quantity not specified 63.0 days 4 1.0 x 10E6 cells/ml 0.2 0.4 flow cytometry method 0.0 n=4-7 106514 3031
SS/JrHsdMcwi mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (for 70 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. arterial blood pressure trait not specified 70.0 days 6 15sec/min for 3 hrs/day for 7days 127.5 mmHg 1.5 3.67 vascular fluid filled catheter 0.0 n=6-8 106520 3031
SS/JrHsdMcwi kidney total CD45 positive leukocyte count controlled sodium chloride content diet (0.4 %) (for 21 days) then controlled sodium chloride content diet (4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. leukocyte quantity not specified 84.0 days 5 3.92 x 10E6 cells/ml 0.42 0.94 flow cytometry method 0.0 n=5-6 106535 3031
SS/JrHsdMcwi heart right atrium weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right atrium mass male 56.0 days 11 0.81 mg/mm 0.05 0.17 post excision weight measurement 0.0 106624 3032
SS/JrHsdMcwi liver weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56.0 days 11 23.6 mg/mm 0.47 1.56 post excision weight measurement 0.0 106632 3032
SS/JrHsdMcwi mean aortic pressure vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. arterial blood pressure trait male 56.0 days 6 94.4 mmHg 4.27 10.46 vascular fluid filled catheter 0.0 Mean aortic pressure 106810 3032
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 101.47 breaths/min 4.43 15.36 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15008 381
SS/JrHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 4 0.63 degrees C 0.28 0.57 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15163 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 7 105.23 breaths/min 4.16 11.01 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15586 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 7 381.66 beats/min 15.84 41.9 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15588 381
SS/JrHsdMcwi heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 4 401.38 beats/min 19.18 38.37 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15594 381
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 0.27 ml 0.01 0.01 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15331 381
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 9 0.02 null 0.0 0.01 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 15348 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then norepinephrine (3 ug/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 39.0 mmHg 6.0 21.63 vascular indwelling catheter method left femoral artery 0.0 67302 151
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 0.36 ml 0.01 0.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 15465 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 10 82.66 breaths/min 4.51 14.26 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14449 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 7 0.37 ml 0.01 0.02 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14632 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 9 122.02 mmHg 7.52 22.57 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 14670 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 50 419.34 beats/min 5.77 40.82 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 15953 381
SS/JrHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.49 degrees C 0.27 0.81 digital rectal thermometry Moms and pups used in studies were fed Teklad 16011 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 126.47 mmHg 4.99 9.97 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16023 381
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 92.0 days-94.0 days 12 serial mean 126.0 mmHg 5.0 17.32 vascular indwelling catheter method left femoral artery 0 65465 151
SS/JrHsdMcwi timed urine volume to body weight ratio controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. urine output male 70.0 days 10 6.9 ul/min/g 0.7 2.21 ultrasonic flowmeter 1200 urine flow to wt ratio 64926 272
SS/JrHsdMcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.33 ml 0.02 0.05 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 14888 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 4 14.83 mmHg 6.29 12.58 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51736 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 21 53.74 mg/d 5.94 27.24 automated urine analysis Moms and pups used in studies were fed Teklad 51750 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 14 1.64 ml/min 0.17 0.64 urine creatinine analysis Moms and pups used in studies were fed Teklad 51944 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 6 0.27 mg/dl 0.02 0.04 radioimmunoassay Moms and pups used in studies were fed Dyets 52044 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -26.95 beats/min 8.55 29.62 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 52054 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 137.62 mmHg 4.07 15.75 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 52084 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80.0 days-99.0 days 59 176.81 mmHg 2.61 20.06 vascular fluid filled catheter Moms were fed Teklad, pups used in studies were fed Dyets 52859 482
SS/JrHsdMcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80.0 days-99.0 days 64 1.29 mEq/d 0.06 0.5 flame atomic emission spectrometry urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52957 482
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80.0 days-99.0 days 53 0.37 mg/dl 0.01 0.1 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52220 482
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80.0 days-99.0 days 9 0.35 mg/dl 0.02 0.07 radioimmunoassay Moms were fed Teklad, pups used in studies were fed Dyets 52226 482
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 10 148.46 mmHg 3.82 12.09 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50646 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 118.36 mmHg 3.5 6.07 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50673 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 18 144.0 mmHg 3.04 12.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50734 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 15 5.95 mmHg 2.39 9.25 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50774 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 3 49.33 mmHg 4.56 7.91 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50785 481
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 5 126.48 mmHg 5.04 11.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50794 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 15 386.98 beats/min 5.77 22.33 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 50878 481
SS/JrHsdMcwi absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 12 1.89 mmHg 2.65 9.18 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51026 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 6 1.39 mEq/d 0.12 0.29 flame atomic emission spectrometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51045 481
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 154.59 % 5.64 19.52 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54285 381
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -17.17 beats/min 7.62 32.34 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51088 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 405.69 beats/min 11.75 49.86 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51114 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 15 0.39 mg/dl 0.06 0.21 radioimmunoassay Moms and pups used in studies were fed Dyets 51172 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 10 407.56 beats/min 6.03 19.06 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 51250 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 11 0.78 mEq/d 0.1 0.33 flame atomic emission spectrometry Moms and pups used in studies were fed Dyets 51271 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 393.77 beats/min 10.28 43.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 51280 481
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 5 9.79 mEq/d 1.85 4.14 flame atomic emission spectrometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51294 481
SS/JrHsdMcwi plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 12 0.31 mg/dl 0.01 0.04 radioimmunoassay Moms and pups used in studies were fed Teklad 51310 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 11 41.53 mg/d 8.23 27.31 automated urine analysis Moms and pups used in studies were fed Dyets 51441 481
SS/JrHsdMcwi creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 4 1.51 ml/min 0.23 0.45 urine creatinine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51448 481
SS/JrHsdMcwi heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 5 384.83 beats/min 13.09 29.27 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51482 481
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 6 91.93 mg/d 45.61 111.73 automated urine analysis Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 51553 481
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 11 17.56 mg/d 3.43 11.37 automated urine analysis Moms and pups used in studies were fed Dyets 51567 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 18 -35.02 beats/min 11.98 50.83 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50419 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -47.58 beats/min 14.04 48.64 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50424 481
SS/JrHsdMcwi plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 14 0.93 ng/ml/h 0.15 0.56 radioimmunoassay Moms and pups used in studies were fed Dyets 50456 481
SS/JrHsdMcwi absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 12 -0.13 beats/min 12.28 42.54 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 50509 481
SS/JrHsdMcwi renal arterial blood flow rate controlled in situ renal perfusion pressure (125-130 mmHg) (for 0.3 hours) Roman RJ, et al., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5. renal blood flow trait male 70.0 days 10 4.7 ml/min/g 0.2 0.63 ultrasonic flowmeter 1200 64952 272
SS/JrHsdMcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 40 0.0 null 0.0 0.02 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14762 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 0.42 ml 0.02 0.07 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 13653 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 13 84.2 breaths/min 4.55 16.41 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13655 381
SS/JrHsdMcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 5 94.02 breaths/min 9.76 21.81 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 13661 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 %change=VE during7-9 min hypercapnia/control during standard conditions 274.4 % 7.15 58.53 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 14266 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 122.71 mmHg 2.46 7.78 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 14361 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 155.01 breaths/min 5.07 17.57 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 17184 381
SS/JrHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 6 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17313 381
SS/JrHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17319 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 127.72 mmHg 7.58 20.05 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 13774 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 37 492.45 beats/min 5.9 35.89 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 13800 381
SS/JrHsdMcwi plasma triglyceride level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. blood triglyceride amount female 92.0 days-94.0 days 11 1.4 mmol/l 0.21 0.71 plasma triglyceride analysis 0.0 67292 151
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.41 ml 0.03 0.1 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 13996 381
SS/JrHsdMcwi mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 4 119.26 mmHg 4.6 9.21 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14126 381
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (0.1 %) (for 28 days) then controlled sodium content diet (8 %) (for 31 days) and controlled exposure to ambient light (for 12 hours) Cowley AW Jr, et al., Physiol Genomics 2000 Apr 27;2(3):107-15. arterial blood pressure trait male 91.0 days-94.0 days 35 continuous mean 185.0 mmHg 5.0 29.58 vascular indwelling catheter method femoral artery 259200.0 3 h per day 12004 229
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 27 7.43 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19729 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 49 0.05 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19810 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 9 0.05 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19815 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 14 45.77 ml/min 2.25 8.44 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20699 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 8 8.82 mmHg 1.21 3.41 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20734 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 10 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20855 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 9.39 mmHg 2.15 6.46 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20878 381
SS/JrHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 3 37.43 degrees C 0.28 0.49 digital rectal thermometry Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20891 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 10 419.73 beats/min 8.86 28.02 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20971 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 4 49.95 beats/min 66.91 133.82 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20990 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 1 24.9 mmHg automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20998 381
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 5 162.47 % 8.06 18.02 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53860 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 116.02 % 3.05 10.58 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53951 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 74 114.78 % 1.91 16.44 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 53963 381
SS/JrHsdMcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 500.7 beats/min 32.3 55.95 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19938 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 48 117.4 mmHg 1.68 11.62 vascular fluid filled catheter Moms and pups used in studies were fed Teklad 20051 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 -3.64 mmHg 0.58 1.65 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 20090 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -2.43 mmHg 0.6 1.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 20594 381
SS/JrHsdMcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 51 7.47 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 20649 381
SS/JrHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 105.92 mmHg 2.47 7.4 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19535 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 53.39 mmHg 0.97 3.05 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19549 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 34.84 mmHg 0.98 3.09 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19561 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 30.84 mmHg 0.84 2.23 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 19570 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 -0.42 degrees C 0.11 0.34 digital rectal thermometry Moms and pups used in studies were fed Dyets 19582 381
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 %change=VE during 2-3 min hypercapnia/control during standard conditions 279.46 % 9.11 32.84 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 19596 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 9 -6.63 mmHg 0.8 2.4 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19663 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 30.03 mmHg 1.64 2.84 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19699 381
SS/JrHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.63 degrees C 0.15 0.44 digital rectal thermometry Moms and pups used in studies were fed Teklad 17650 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 10 101.7 mmHg 2.38 7.53 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17695 381
SS/JrHsdMcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 105.54 mmHg 2.05 5.41 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17704 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 10 -8.35 mmHg 0.56 1.77 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 17707 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 10 48.3 ml/min 3.95 12.5 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 18076 381
SS/JrHsdMcwi respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 67 161.09 breaths/min 2.98 24.41 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16979 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 127.69 % 6.86 26.56 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18368 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 6 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18790 381
SS/JrHsdMcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 100.49 mmHg 2.87 8.61 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 18898 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 6 56.83 mmHg 0.82 2.01 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18972 381
SS/JrHsdMcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 1 152.36 mmHg vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19003 381
SS/JrHsdMcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 9 0.22 mg/dl 0.01 0.04 standard blood chemistry panel Moms and pups used in studies were fed Dyets 36280 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 32.09 g/dl 0.13 0.39 automated blood cell counting method Moms and pups used in studies were fed Dyets 36316 401
SS/JrHsdMcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 4 9.48 mg/dl 0.19 0.39 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36329 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 96 6.07 g/dl 0.04 0.39 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37029 401
SS/JrHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 12 120.33 U/l 6.41 22.22 standard blood chemistry panel Moms and pups used in studies were fed Dyets 37052 401
SS/JrHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 92 5.94 g/dl 0.05 0.47 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37247 401
SS/JrHsdMcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 11 6.22 g/dl 0.05 0.15 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37255 401
SS/JrHsdMcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 9 2.94 x 1000 cells/ul 0.46 1.39 automated blood cell counting method Moms and pups used in studies were fed Dyets 37307 401
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 5 -45.39 mmHg 3.63 8.12 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18639 381
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 9 143.56 mmol/l 0.38 1.13 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36592 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 9 8.86 mg/dl 0.08 0.23 standard blood chemistry panel Moms and pups used in studies were fed Teklad 36696 401
SS/JrHsdMcwi percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 %change=VE during 2-3 min hypercapnia/control during standard conditions 280.58 % 6.04 49.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19279 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 6 -6.79 mmHg 0.65 1.6 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19333 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 9 -47.66 mmHg 2.86 8.59 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Teklad 19494 381
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (8 %) (for 18 days) Moreno et al. Physiol Genomics 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. urine albumin amount female 84.0 days-88.0 days 12 39.5 mg/d 5.1 17.67 urine analysis 86400 65200 15
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 6 28.08 mmHg 1.15 2.81 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18165 381
SS/JrHsdMcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 38.22 degrees C 0.19 0.64 digital rectal thermometry Moms and pups used in studies were fed Dyets 18217 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 9 37.72 degrees C 0.09 0.26 digital rectal thermometry Moms and pups used in studies were fed Dyets 18238 381
SS/JrHsdMcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 4 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 20185 381
SS/JrHsdMcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 9 82.61 beats/min 9.27 27.8 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20422 381
SS/JrHsdMcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 11 409.67 beats/min 10.1 33.5 vascular fluid filled catheter Moms and pups used in studies were fed Dyets 20434 381
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 83 236.93 beats/min 8.57 78.04 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49012 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 19 234.02 beats/min 12.74 55.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 49017 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 69.94 mmHg 0.85 1.47 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49040 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 1 107.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49156 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 90 27.03 % 1.95 18.49 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49463 461
SS/JrHsdMcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 12 1.45 g 0.03 0.09 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49599 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 61.51 mmHg 5.64 17.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49609 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 8 17.04 % 3.19 9.01 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49633 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 6 22.28 % 3.61 8.85 digital scale post excision weight measurement Moms and pups used in studies were fed Dyets 49642 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 0.19 IU/g 0.05 0.16 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 49675 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 96 19.81 % 1.68 16.5 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 49764 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 11 51.64 mmHg 4.09 13.56 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 49792 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 1 93.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49818 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 176.76 beats/min 23.92 41.43 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49822 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 5.44 IU/g 0.84 2.66 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 49840 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 2 31.48 % 3.88 5.48 digital scale post excision weight measurement Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49853 461
SS/JrHsdMcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.52 degrees C 0.19 0.62 digital rectal thermometry Moms and pups used in studies were fed Dyets 19185 381
SS/JrHsdMcwi body length, nose to rump controlled sodium content diet (1 %) (for 14 days) PhysGen General data body length male 70.0 days-84.0 days 47 24.07 cm 0.13 0.87 in vivo ruler method 63492 529
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 90 61.77 fl 0.17 1.63 automated blood cell counting method Moms and pups used in studies were fed Teklad 38812 401
SS/JrHsdMcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 9 18.56 mmol/l 1.29 3.88 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42205 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 90 57.79 % 0.32 2.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 39058 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 56.07 % 0.44 1.38 automated blood cell counting method Moms and pups used in studies were fed Teklad 39063 401
SS/JrHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 9 140.44 mmol/l 0.69 2.07 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39083 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 4 9.23 mg/dl 0.51 1.02 standard blood chemistry panel Moms and pups used in studies were fed Dyets 42316 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 96 107.97 mmol/l 0.29 2.89 standard blood chemistry panel Moms and pups used in studies were fed Teklad 39184 401
SS/JrHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 9 123.22 mg/dl 5.68 17.04 standard blood chemistry panel Moms and pups used in studies were fed Dyets 39209 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 90 9.36 x 10E6 cells/ul 0.05 0.49 automated blood cell counting method Moms and pups used in studies were fed Teklad 39304 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 10 8.97 x 10E6 cells/ul 0.06 0.2 automated blood cell counting method Moms and pups used in studies were fed Teklad 39309 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 8 4.49 mmol/l 0.12 0.35 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39332 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 92 92.33 U/l 3.74 35.9 standard blood chemistry panel Moms and pups used in studies were fed Teklad 42466 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 9 0.2 x 1000 cells/ul 0.06 0.18 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39534 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 10 0.22 x 1000 cells/ul 0.05 0.16 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39538 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 9 6.3 x 1000 cells/ul 0.72 2.17 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39546 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 10 5.29 x 1000 cells/ul 0.44 1.38 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39550 401
SS/JrHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 4 8.0 x 10E6 cells/ul 0.14 0.27 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42724 401
SS/JrHsdMcwi percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 67 162.33 % 3.43 28.08 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 54297 381
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 90 32.24 g/dl 0.07 0.68 automated blood cell counting method Moms and pups used in studies were fed Teklad 39844 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 10 32.03 g/dl 0.07 0.21 automated blood cell counting method Moms and pups used in studies were fed Teklad 39849 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 7 2.19 g/dl 0.11 0.3 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39968 401
SS/JrHsdMcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 9 0.39 mg/dl 0.06 0.18 automated plasma creatinine analysis Moms and pups used in studies were fed Dyets 43097 401
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 14 142.66 % 7.0 26.2 stop flow air displacement plethysmography Moms and pups used in studies were fed Dyets 54561 381
SS/JrHsdMcwi percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 157.59 % 5.67 20.46 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54572 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 7 128.24 % 4.63 12.24 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53587 381
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 9 1.08 x 1000 cells/ul 0.37 1.12 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43406 401
SS/JrHsdMcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 4 4.18 mmol/l 0.08 0.15 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43417 401
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 4 46.28 % 0.54 1.08 microhematocrit tube assay with visual assessment Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58856 526
SS/JrHsdMcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 11 19.28 pg 0.07 0.24 automated blood cell counting method Moms and pups used in studies were fed Teklad 40255 401
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 7 25.94 ml/min/kg 3.61 9.54 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59030 526
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 10 4.55 x 1000 cells/ul 0.41 1.29 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40516 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 96 2.36 g/dl 0.04 0.34 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40617 401
SS/JrHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 12 6.36 x 1000 cells/ul 0.62 2.15 automated blood cell counting method Moms and pups used in studies were fed Dyets 40634 401
SS/JrHsdMcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 9 3.63 x 1000 cells/ul 0.54 1.62 automated blood cell counting method Moms and pups used in studies were fed Dyets 40642 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 94 52.34 U/l 1.5 14.58 standard blood chemistry panel Moms and pups used in studies were fed Teklad 40781 401
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 88 1.36 mg/kg 0.1 0.97 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59213 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 12 1.11 mg/kg 0.17 0.6 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 59221 526
SS/JrHsdMcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 4 152.5 U/l 19.3 38.6 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37536 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 10 8.36 mg/dl 0.28 0.88 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37666 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 10 25.1 mg/dl 0.62 1.97 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40812 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 90 7.0 x 1000 cells/ul 0.18 1.66 automated blood cell counting method Moms and pups used in studies were fed Teklad 40993 401
SS/JrHsdMcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 15 1.1 g/kg 0.04 0.15 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59511 526
SS/JrHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 92 8.83 mg/dl 0.1 1.0 standard blood chemistry panel Moms and pups used in studies were fed Teklad 37876 401
SS/JrHsdMcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 4 0.27 x 1000 cells/ul 0.02 0.03 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41171 401
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 116 1.22 g/kg 0.01 0.13 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59724 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 1.53 g/kg 0.08 0.25 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 59729 526
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 2 8.83 x 10E6 cells/ul 0.38 0.54 automated blood cell counting method Moms and pups used in studies were fed Dyets 37915 401
SS/JrHsdMcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 4 9.03 mg/dl 0.47 0.93 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37921 401
SS/JrHsdMcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 4 0.49 x 1000 cells/ul 0.09 0.18 automated blood cell counting method Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37948 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 90 18.63 g/dl 0.1 0.99 automated blood cell counting method Moms and pups used in studies were fed Teklad 38035 401
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 11 46.33 % 0.55 1.81 automated blood cell counting method Moms and pups used in studies were fed Teklad 41359 401
SS/JrHsdMcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 11 0.04 x 1000 cells/ul 0.02 0.05 automated blood cell counting method Moms and pups used in studies were fed Teklad 41461 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 3 4.37 x 1000 cells/ul 1.1 1.9 automated blood cell counting method Moms and pups used in studies were fed Dyets 41487 401
SS/JrHsdMcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 12 2.48 g/dl 0.12 0.41 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 41587 401
SS/JrHsdMcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 14.68 g/dl 0.66 1.98 automated blood cell counting method Moms and pups used in studies were fed Dyets 41629 401
SS/JrHsdMcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 4 139.75 mmol/l 1.6 3.2 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38378 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 4 103.75 mmol/l 1.49 2.99 standard blood chemistry panel Moms and pups used in studies were fed Dyets 38409 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 90 0.01 x 1000 cells/ul 0.0 0.03 automated blood cell counting method Moms and pups used in studies were fed Teklad 41714 401
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (1 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 62970 528
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 95 150.75 mg/dl 2.11 20.52 standard blood chemistry panel Moms and pups used in studies were fed Teklad 38597 401
SS/JrHsdMcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 4 82.25 mg/dl 6.81 13.62 standard blood chemistry panel Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38725 401
SS/JrHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 88 7.74 x 10E6 cells/ul 0.05 0.43 automated blood cell counting method Moms and pups used in studies were fed Teklad 42018 401
SS/JrHsdMcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 11 7.75 x 10E6 cells/ul 0.1 0.34 automated blood cell counting method Moms and pups used in studies were fed Teklad 42026 401
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 19 1.05 g 0.05 0.22 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 45476 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 75 122.02 mmHg 2.87 24.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 45571 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 17 285.02 beats/min 10.4 42.89 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47653 461
SS/JrHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 77.79 % 8.79 15.23 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48509 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 13 119.11 mmHg 4.55 16.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48695 461
SS/JrHsdMcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 12 60.33 mmHg 3.4 11.79 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48713 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 108.9 mmHg 4.52 14.29 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48731 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 6.6 mmHg 0.36 1.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48919 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 11 904.72 s 28.86 95.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48922 461
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 82 57.74 % 2.41 21.84 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57264 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 67.88 % 6.02 17.02 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57300 522
SS/JrHsdMcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 87 44.51 % 0.27 2.5 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Teklad 57536 526
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 67 35.06 ml/min 1.08 8.82 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16215 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 32.4 ml/min 2.21 7.64 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16220 381
SS/JrHsdMcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 13 26.5 ml/min 1.97 7.11 stop flow air displacement plethysmography Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16243 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 4 21.82 mmHg 3.62 7.24 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16251 381
SS/JrHsdMcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 1.8 mmHg 8.01 13.87 vascular fluid filled catheter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 16257 381
SS/JrHsdMcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 85 306.8 g 3.0 27.6 whole body digital scale Moms and pups used in studies were fed Teklad 55219 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 -7.91 null 0.09 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55323 522
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -6.81 null 0.07 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55373 522
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 98.75 % 0.45 1.28 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55380 522
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 10.26 ml/min/kg 0.57 1.61 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57670 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 15.87 ml/min/kg 1.81 4.79 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Dyets 57711 526
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood alkaline phosphatase amount female 70.0 days-84.0 days 17 56.53 U/l 2.15 8.85 standard blood chemistry panel 60703 527
SS/JrHsdMcwi blood monocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data monocyte quantity female 70.0 days-84.0 days 17 0.15 x 1000 cells/ul 0.04 0.16 automated blood cell counting method 60713 527
SS/JrHsdMcwi serum phosphate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood phosphate amount male 70.0 days-84.0 days 41 8.11 mg/dl 0.15 0.99 standard blood chemistry panel 60727 527
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 26 -6.38 mmHg 0.42 2.12 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 16308 381
SS/JrHsdMcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 7 0.33 degrees C 0.15 0.39 digital rectal thermometry Moms and pups used in studies were fed Dyets 16383 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 8 26.67 mmHg 1.24 3.52 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 16456 381
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 -8.62 null 0.14 0.49 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55495 522
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 8 12.47 ml/min/kg 0.63 1.78 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 57872 526
SS/JrHsdMcwi serum bicarbonate level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bicarbonate amount female 70.0 days-84.0 days 17 19.12 mmol/l 0.48 1.96 standard blood chemistry panel 60815 527
SS/JrHsdMcwi blood eosinophil count controlled sodium content diet (1 %) (for 14 days) then fasting (between 16 and 1 hours) PhysGen Biochemistry data eosinophil quantity female 70.0 days-84.0 days 17 0.07 x 1000 cells/ul 0.02 0.08 automated blood cell counting method 60825 527
SS/JrHsdMcwi serum sodium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood sodium amount male 70.0 days-84.0 days 40 143.98 mmol/l 0.37 2.33 flame atomic emission spectrometry 60901 527
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 81 -6.94 null 0.05 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 55665 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 11 -7.13 null 0.16 0.54 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms and pups used in studies were fed Dyets 55719 522
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 98 36.53 ml/min/kg 1.42 14.05 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58066 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 7 0.07 mmHg-1 0.02 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58093 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 4 55.68 % 1.15 2.3 microhematocrit tube assay with visual assessment Moms and pups used in studies were fed Dyets 58203 526
SS/JrHsdMcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 76 37.62 degrees C 0.08 0.66 digital rectal thermometry Moms and pups used in studies were fed Teklad 16880 381
SS/JrHsdMcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 17 99.82 % 0.18 0.73 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55972 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 16.22 % 4.1 12.29 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55993 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 17.17 % 3.02 10.45 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 55995 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 -8.64 null 0.12 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56007 522
SS/JrHsdMcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -8.51 null 0.18 0.62 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56010 522
SS/JrHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 107 268.6 g 2.6 27.3 whole body digital scale Moms and pups used in studies were fed Teklad 58387 526
SS/JrHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 15 178.0 g 5.9 22.7 whole body digital scale Moms and pups used in studies were fed Teklad 58395 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 8 259.9 g 11.7 33.0 whole body digital scale Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58433 526
SS/JrHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 23 312.5 g 3.6 17.1 whole body digital scale Moms and pups used in studies were fed Dyets 58451 526
SS/JrHsdMcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 21 215.9 g 2.4 10.9 whole body digital scale Moms and pups used in studies were fed Dyets 58459 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 6 11.19 ml/min/kg 0.8 1.96 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58463 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 3 0.69 null 0.08 0.13 isolated perfused lung vascular effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58468 526
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 12 -7.2 null 0.06 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56172 522
SS/JrHsdMcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 12 -7.39 null 0.1 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56179 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 24.0 % 3.53 10.59 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56209 522
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 91 13.99 ml/min/kg 0.52 4.96 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 58672 526
SS/JrHsdMcwi serum chloride level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood chloride amount male 70.0 days-84.0 days 40 104.63 mmol/l 0.55 3.48 standard blood chemistry panel 62275 527
SS/JrHsdMcwi serum total bilirubin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood bilirubin amount male 70.0 days-84.0 days 40 0.1 mg/dl 0.0 0.02 standard blood chemistry panel 62429 527
SS/JrHsdMcwi serum total protein level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood total protein amount male 70.0 days-84.0 days 41 5.55 g/dl 0.06 0.39 standard blood chemistry panel 62439 527
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 51.77 % 9.31 29.44 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 54974 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 10 55.04 % 7.02 22.2 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56332 522
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 115 0.39 null 0.01 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58800 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.31 null 0.03 0.1 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 58805 526
SS/JrHsdMcwi serum potassium level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood potassium amount female 70.0 days-84.0 days 17 3.85 mmol/l 0.07 0.31 flame atomic emission spectrometry 61759 527
SS/JrHsdMcwi serum urea nitrogen level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood urea nitrogen amount female 70.0 days-84.0 days 17 24.82 mg/dl 1.35 5.55 standard blood chemistry panel 61769 527
SS/JrHsdMcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -6.94 null 0.1 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 55019 522
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 70.39 % 6.17 21.38 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56446 522
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 79 1.63 E-7mole 0.17 1.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56560 522
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 13 1.46 E-7mole 0.26 0.95 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 56566 522
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 9 1.32 mg/kg 0.29 0.88 stop flow air displacement plethysmography Moms and pups used in studies were fed Teklad 58978 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 84 0.36 null 0.01 0.11 isolated perfused lung vascular effluent collection Moms and pups used in studies were fed Teklad 59821 526
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (for 13 days) PhysGen Knockout data arterial blood pressure trait male 70.0 days-77.0 days 6 1/3 systolic pressure + 2/3 diastolic pressure 131.0 mmHg 6.09 14.93 radiotelemetry carotid artery - 43807 441
SS/JrHsdMcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 12 1.38 g/mg 0.11 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56757 522
SS/JrHsdMcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 1.53 E-7mole 0.34 1.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56785 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 71.4 % 7.62 29.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56840 522
SS/JrHsdMcwi red blood cell count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte quantity male 70.0 days-84.0 days 41 8.42 x 10E6 cells/ul 0.09 0.6 automated blood cell counting method 61507 527
SS/JrHsdMcwi body weight controlled sodium content diet (4 %) (for 10 days) PhysGen Knockout data body mass male 70.0 days-77.0 days 7 327.3 g 6.6 17.4 whole body digital scale - 43932 441
SS/JrHsdMcwi urine total protein excretion rate controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data total urine protein amount male 70.0 days-77.0 days 7 124.25 mg/d 25.55 67.59 automated urine analysis - 43993 441
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (for 11 days) PhysGen Knockout data arterial blood pressure trait male 70.0 days-77.0 days 7 1/3 systolic pressure + 2/3 diastolic pressure 130.57 mmHg 4.7 12.45 radiotelemetry carotid artery - 44116 441
SS/JrHsdMcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 15 0.19 umol/l 0.07 0.28 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Dyets 56883 522
SS/JrHsdMcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 7 49.86 % 7.38 19.53 wire myography using a Digi-Med tissue force analysis system with force transducer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 56996 522
SS/JrHsdMcwi blood neutrophil count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data neutrophil quantity male 70.0 days-84.0 days 41 1.13 x 1000 cells/ul 0.08 0.54 automated blood cell counting method 60379 527
SS/JrHsdMcwi mean corpuscular volume controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data erythrocyte size trait female 70.0 days-84.0 days 17 58.82 fl 0.27 1.12 automated blood cell counting method 61851 527
SS/JrHsdMcwi serum globulin level controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data blood globulin amount female 70.0 days-84.0 days 17 2.01 g/dl 0.06 0.23 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 61871 527
SS/JrHsdMcwi blood lymphocyte count controlled sodium content diet (1 %) (for 14 days) then fasting (for 16 hours) PhysGen Biochemistry data lymphocyte quantity female 70.0 days-84.0 days 17 5.67 x 1000 cells/ul 0.34 1.38 automated blood cell counting method 62045 527
SS/JrHsdMcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 40 54.13 % 2.52 15.94 wire myography using a Digi-Med tissue force analysis system with force transducer Moms and pups used in studies were fed Teklad 57149 522
SS/JrHsdMcwi heart wet weight controlled sodium content diet (4 %) (for 14 days) PhysGen Knockout data heart mass male 70.0 days-77.0 days 7 1.15 g 0.04 0.1 digital scale post excision weight measurement - 44549 441
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 33 9.64 IU/g 0.9 5.18 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 45696 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 4 8.04 ml/min/g 0.43 0.86 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46634 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 243.29 % 80.08 196.16 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46833 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 12 307.19 beats/min 12.38 42.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47676 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 306.28 beats/min 21.0 63.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 47683 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 481.04 s 111.83 316.3 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45840 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 12 post-ischemic value/pre-ischemic value x 100% 55.46 % 8.37 28.99 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45913 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 3 post-ischemic value/pre-ischemic value x 100% 38.59 % 6.14 10.64 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45928 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 54.87 % 12.96 38.88 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 46850 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 19 8.96 ml/min/g 0.5 2.16 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 46941 461
SS/JrHsdMcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 20 5.53 g/kg 0.19 0.83 digital scale post excision weight measurement Moms and pups used in studies were fed Teklad 47039 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 85 45.05 mmHg 2.42 22.34 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47978 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 16 post-ischemic value/pre-ischemic value x 100% 56.18 % 3.93 15.71 isolated perfused heart effluent collection Moms and pups used in studies were fed Teklad 47148 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 4 post-ischemic value/pre-ischemic value x 100% 11.82 % 11.82 23.65 isolated perfused heart effluent collection Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47170 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 2 282.35 beats/min 17.65 24.96 balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48153 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 89 260.18 beats/min 3.7 34.91 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48264 461
SS/JrHsdMcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 19 251.86 beats/min 7.82 34.1 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48269 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 1 187.41 beats/min balloon tipped catheter with pressure transducer in isolated perfused heart Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45077 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 12.67 ml/min/g 3.42 9.68 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45099 461
SS/JrHsdMcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 12 435.64 s 63.82 221.08 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 45118 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 10.76 ml/min/g 0.87 2.76 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46284 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 8 14.87 ml/min/g 2.49 7.05 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 46290 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 84 5.61 mmHg 0.08 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 47263 461
SS/JrHsdMcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 19 post-ischemic value/pre-ischemic value x 100% 93.83 % 5.71 24.87 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Teklad 48478 461
SS/JrHsdMcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 36.49 mmHg 5.18 16.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms and pups used in studies were fed Dyets 48489 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 8 14.25 IU/g 2.36 6.66 isolated perfused heart effluent collection Moms and pups used in studies were fed Dyets 45370 461
SS/JrHsdMcwi resting tone of middle cerebral artery controlled captopril content drinking water (100 mg/kg/d) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 [(Dmax - Drest) /Dmax] x 100 41.0 % 3.3 8.08 ex vivo videomicroscopy 0.0 69563 732
SS/JrHsdMcwi resting tone of middle cerebral artery angiotensin II (3 ng/kg/min) (for 3 days) then controlled calcium ion content physiological salt solution perfusate (0 %) then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 5 [(Dmax - Drest) /Dmax] x 100 54.0 % 2.2 4.92 ex vivo videomicroscopy 0.0 69578 732
SS/JrHsdMcwi middle cerebral artery inner diameter controlled tempol content drinking water (15 mg/kg/d) (for 3 days) then physiological salt solution perfusate then NG-nitroarginine methyl ester (100 umol/l) (for 0.3 hours) Durand MJ, et al., Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. Epub 2010 Sep 17. cerebral artery size trait male 63.0 days-98.0 days 6 138.0 um 10.1 24.74 ex vivo videomicroscopy 0.0 69585 732
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (100 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 147.2 mmHg 3.9 14.06 vascular indwelling catheter method left femoral artery 120.0 69532 151
SS/JrHsdMcwi mean arterial blood pressure furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 7 days) then angiotensin II (200 ng/kg/min) (for 0.1 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 101.0 days-103.0 days 13 serial mean 160.2 mmHg 3.5 12.62 vascular indwelling catheter method left femoral artery 120.0 69534 151
SS/JrHsdMcwi urine sodium excretion rate controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92.0 days-94.0 days 14 0.56 mEq/d 0.06 0.21 unspecified method 0.0 urine sodium analysis umol/min 69469 151
SS/JrHsdMcwi urine sodium level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine sodium amount female 92.0 days-94.0 days 14 149.5 mmol/l 5.2 19.46 unspecified method 0.0 urine sodium analysis 69467 151
SS/JrHsdMcwi urine creatinine level controlled sodium content diet (0.4 %) (for 16 hours) and furosemide (10 mg/kg) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. urine creatinine amount female 92.0 days-94.0 days 17 111.7 mg/dl 10.5 43.29 urine creatinine analysis 0.0 69476 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 93.0 days 11 serial mean 183.0 mmHg 10.0 33.17 vascular indwelling catheter method left femoral artery 10800.0 69516 151
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 94.0 days 11 serial mean 140.0 mmHg 7.0 23.22 vascular indwelling catheter method left femoral artery 10800.0 69524 151
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. heart pumping trait female 94.0 days 10 serial mean 411.7 beats/min 10.6 33.52 vascular indwelling catheter method left femoral artery 10800.0 69526 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (4 %) (for 21 days) Mattson DL, et al., Am J Physiol Regul Integr Comp Physiol. 2013 Jan 30. arterial blood pressure trait not specified 84.0 days 4 181.0 mmHg 9.0 18.0 vascular indwelling catheter method 0.0 69292 1057
SS/JrHsdMcwi body weight controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) and controlled sodium content diet (8 %) (between 22 and 24 days) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. body mass female 89.0 days-92.0 days 16 211.0 g 6.0 24.0 body weighing method 0.0 69440 151
SS/JrHsdMcwi systolic blood pressure controlled sodium content diet (0.4 %) (for 35 days) then controlled sodium content diet (0.1 %) (for 35 days) then controlled sodium content diet (8 %) (between 22 and 24 days) then controlled exposure to darkness (for 12 hours) Moreno C, et al., Physiol Genomics 2003 Nov 11;15(3):243-57. arterial blood pressure trait female 89.0 days-91.0 days 15 serial mean 184.0 mmHg 7.7 29.82 vascular indwelling catheter method left femoral artery 0.0 69444 151
SS/JrHsdMcwi mean arterial blood pressure controlled sodium content diet (1 %) (for 77 days) Flister MJ, et al., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6. arterial blood pressure trait male 67.0 days-77.0 days 12 serial mean 121.0 mmHg 3.0 10.39 intra-aortic abdominal radiotelemetry 14400.0 abdominal aorta 4 hrs for 3 consecutive days 96860 1718
SS/JrHsdMcwi heart rate controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. heart pumping trait male 60.0 days-67.0 days 12 serial mean 388.0 beats/min 6.0 20.78 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 intra-carotid radiotelemetry intra-carotid radiotelemetry 98609 2098
SS/JrHsdMcwi diastolic blood pressure control condition (0.4 %) (between 23 and 32 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 44.0 days-53.0 days 14 serial mean 88.0 mmHg 1.0 3.74 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98486 2079
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (for 70 days) then controlled sodium content diet (8 %) (for 21 days) Flister MJ, et al., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. urine albumin amount male 91.0 days 10 231.0 mg/d 30.0 94.87 urine microalbumin analysis 10800.0 98725 2142
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60.0 days-67.0 days 12 serial mean 152.0 mmHg 5.0 17.32 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 intra-carotid radiotelemetry 98580 2098
SS/JrHsdMcwi diastolic blood pressure controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. arterial blood pressure trait male 58.0 days-67.0 days 14 serial mean 141.0 mmHg 4.0 14.97 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 carotid a. to thoracic aorta implant 98507 2079
SS/JrHsdMcwi mean arterial blood pressure controlled sodium chloride content diet (0.4 %) (between 46 and 50.8 days) then controlled sodium chloride content diet (8 %) (for 13.4 days) Cowley AW, et al., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8. arterial blood pressure trait male 60.0 days-67.0 days 12 serial mean 177.0 mmHg 4.0 13.86 intra-aortic thoracic radiotelemetry via carotid cannulation 10800.0 intra-carotid radiotelemetry 98551 2098
SS/JrHsdMcwi urine albumin excretion rate controlled sodium content diet (0.4 %) (between 23 and 32 days) then controlled sodium content diet (8 %) (for 14 days) Cowley AW Jr, et al., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3. urine albumin amount male 59.0 days-68.0 days 14 278.0 mg/d 18.0 67.35 urine microalbumin analysis 86400.0 98535 2079
SS/JrHsdMcwi body weight control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. body mass male 42.0 days 27 176.0 g 6.0 31.18 body weighing method 0.0 100067 2418
SS/JrHsdMcwi plasma triglyceride level control condition McPherson KC, et al., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. blood triglyceride amount male 126.0 days 6 1.86 mmol/l 0.31 0.75 enzyme linked immunosorbent assay 0.0 100077 2418
SS/JrHsdMcwi body weight control condition Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 49.0 days-63.0 days 4 259.4 g 5.9 11.8 body weighing method 0.0 99013 2198
SS/JrHsdMcwi body weight control condition Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 49.0 days-63.0 days 3 278.8 g 3.0 5.2 body weighing method 0.0 99015 2198
SS/JrHsdMcwi body weight common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. body mass male 56.0 days-70.0 days 4 270.8 g 7.8 15.6 body weighing method 0.0 99014 2198
SS/JrHsdMcwi extensor digitorum longus muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 4 EDL/BW 0.4 mg/g 0.02 0.04 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99049 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio common peroneal nerve direct electrical stimulation (3 V) (for 8 hours) then angiotensin II (3 ng/kg/min) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 4 TA/BW 1.74 mg/g 0.08 0.16 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99052 2198
SS/JrHsdMcwi tibialis anterior muscle weight to body weight ratio control condition (for 7 days) then angiotensin II (3 ng/kg/min) (for 7 days) then controlled losartan content drinking water (50 mg/kg/d) (for 7 days) Stodola TJ, et al., Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. skeletal muscle mass male 56.0 days-70.0 days 3 TA/BW 1.77 mg/g 0.05 0.09 ex vivo method 0.0 TA or EDL muscle weight body weight ratio 99055 2198
SS/JrHsdMcwi heart right ventricle weight to left ventricle plus septum weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 7 0.25 g/g 0.02 0.05 post excision weight measurement 0.0 heart right ventricle weight to left ventricle plus septum weight ratio 106536 3032
SS/JrHsdMcwi heart right ventricle weight to left ventricle plus septum weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricle mass male 56.0 days 11 0.41 g/g 0.01 0.03 post excision weight measurement 0.0 heart right ventricle weight to left ventricle plus septum weight ratio 106544 3032
SS/JrHsdMcwi body weight monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. body mass male 56.0 days 11 208.0 g 4.1 13.6 body weighing method 0.0 106552 3032
SS/JrHsdMcwi liver weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. liver mass male 56.0 days 7 40.5 g/kg 1.02 2.7 post excision weight measurement 0.0 106602 3032
SS/JrHsdMcwi heart left atrium weight to body weight ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56.0 days 11 0.06 mg/g 0.01 0.03 post excision weight measurement 0.0 106600 3032
SS/JrHsdMcwi single kidney wet weight to body weight ratio vehicle control condition Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56.0 days 7 8.14 g/kg 0.11 0.29 post excision weight measurement 0.0 106606 3032
SS/JrHsdMcwi heart left ventricle weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left ventricle mass male 56.0 days 11 0.17 g/cm 0.0 0.01 post excision weight measurement 0.0 106616 3032
SS/JrHsdMcwi heart left ventricle end-diastolic anterior wall thickness angiotensin II (200 ng/kg/min) (for 14 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle anterior wall thickness male 63.0 days-70.0 days 5 2.19 mm 0.21 0.47 transthoracic echocardiography 0.0 105810 3023
SS/JrHsdMcwi heart left ventricle end-diastolic posterior wall thickness angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. heart left ventricle posterior wall thickness male 77.0 days-84.0 days 5 1.94 mm 0.18 0.4 transthoracic echocardiography 0.0 105818 3023
SS/JrHsdMcwi stroke volume angiotensin II (200 ng/kg/min) (for 28 days) then isoflurane (1-2 %) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood flow trait male 77.0 days-84.0 days 5 0.22 ml 0.02 0.05 transthoracic echocardiography 0.0 105842 3023
SS/JrHsdMcwi blood glucose level fasting (for 12 hours) Nayak S, et al., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18. blood glucose amount male 140.0 days-168.0 days 8 102.0 mg/dl 2.0 5.66 blood glucose analysis 0.0 105864 3023
SS/JrHsdMcwi blood mononuclear cell count controlled sodium chloride content diet (0.4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. leukocyte quantity not specified 84.0 days 4 5.9 x 10E6 cells/ml 0.9 1.8 flow cytometry method 0.0 n=4-7 106510 3031
SS/JrHsdMcwi kidney total CD3 positive T cell count controlled sodium chloride content diet (0.4 %) (for 42 days) then controlled sodium chloride content diet (4 %) (for 21 days) Rudemiller NP, et al., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16. T cell quantity not specified 84.0 days 5 0.42 x 10E6 cells/ml 0.04 0.09 flow cytometry method 0.0 n=5-6 (tissue T cell count) 106532 3031
SS/JrHsdMcwi heart left atrium weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart left atrium mass male 56.0 days 11 0.3 mg/mm 0.02 0.07 post excision weight measurement 0.0 106628 3032
SS/JrHsdMcwi right ventricular end-systolic blood pressure monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. heart right ventricular blood pressure trait male 56.0 days 11 48.6 mmHg 1.8 5.97 vascular fluid filled catheter 0.0 106638 3032
SS/JrHsdMcwi single kidney weight to tibia length ratio monocrotaline (40 mg/kg) Xu D, et al., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5. kidney mass male 56.0 days 11 0.05 g/cm 0.0 0.0 post excision weight measurement 0.0 106636 3032