The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
negative regulation of macromolecule metabolic process +
nucleic acid metabolic process +
polynucleotide 3' dephosphorylation
polynucleotide 5' dephosphorylation
polysaccharide metabolic process +
positive regulation of macromolecule metabolic process +