Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
CC-preferring endodeoxyribonuclease activity
class II DNA-(apurinic or apyrimidinic site) endonuclease activity
deoxyribonuclease I activity
deoxyribonuclease IV (phage-T4-induced) activity
deoxyribonuclease V activity
type I site-specific deoxyribonuclease activity
type II site-specific deoxyribonuclease activity
type III site-specific deoxyribonuclease activity
Synonyms
Xrefs:
Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
;
reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA"
;
reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand"
;
reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)"
;
reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ"
;
reactome:R-HSA-69152 "Removal of remaining Flap"