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ONTOLOGY REPORT - ANNOTATIONS

Term:flap endonuclease activity
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Accession:GO:0048256 term browser browse the term
Definition:Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


show annotations for term's descendants           Sort by:
flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exo1 exonuclease 1 enables ISO (PMID:10608837), (PMID:11842105) RGD PMID:10608837 PMID:11842105 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO (PMID:18499658)
(PMID:12162748)		 RGD PMID:12162748 PMID:18499658 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
3'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mus81 MUS81 structure-specific endonuclease subunit enables ISO
IEA
IBA		 (PMID:19595721)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:19595721 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables ISO
IBA		 (PMID:20603015), (PMID:20603016), (PMID:20603073), (PMID:24981866)
GO_REF:0000033		 RGD
GO_Central		 PMID:20603015 PMID:20603016 PMID:20603073 PMID:24981866 GO_REF:0000033 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:11986308), (PMID:18995831), (PMID:8621570)
GO_REF:0000033		 RGD
GO_Central		 PMID:8621570 PMID:11986308 PMID:18995831 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO
IBA		 (PMID:26578604)
GO_REF:0000033		 RGD
GO_Central		 PMID:26578604 GO_REF:0000033 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      catalytic activity, acting on a nucleic acid 650
        catalytic activity, acting on DNA 283
          DNA nuclease activity 64
            DNA endonuclease activity 43
              flap endonuclease activity 8
                3'-flap endonuclease activity 1
                5'-flap endonuclease activity 7
Path 2
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      hydrolase activity 2585
        hydrolase activity, acting on ester bonds 814
          nuclease activity 228
            endonuclease activity 132
              DNA endonuclease activity 43
                flap endonuclease activity 8
                  3'-flap endonuclease activity 1
                  5'-flap endonuclease activity 7
paths to the root