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ONTOLOGY REPORT - ANNOTATIONS

Term:5'-flap endonuclease activity
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Accession:GO:0017108 term browser browse the term
Definition:Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
Synonyms:xref: Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand";   reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA";   reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand";   reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)";   reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ";   reactome:R-HSA-69152 "Removal of remaining Flap"


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5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables IDA
ISO
IBA		 (MGI:5499273|PMID:23604072) BHF-UCL
MGI
GO_Central		 PMID:23604072 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5499273 NCBI chr10:62,782,762...62,809,967
Ensembl chr10:62,782,805...62,809,964 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055 		JBrowse link
G Fan1 FANCD2/FANCI-associated nuclease 1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:63,994,627...64,023,874
Ensembl chr 7:63,996,506...64,023,843 		JBrowse link
G Fen1 flap structure specific endonuclease 1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533 		JBrowse link
G Gen1 GEN1, Holliday junction 5' flap endonuclease enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:11,288,929...11,316,030
Ensembl chr12:11,288,921...11,315,802 		JBrowse link
G Slx1b SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:126,288,099...126,294,955
Ensembl chr 7:126,288,640...126,294,956 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28827
    catalytic activity 5720
      catalytic activity, acting on a nucleic acid 613
        catalytic activity, acting on DNA 244
          DNA nuclease activity 64
            DNA endonuclease activity 42
              flap endonuclease activity 7
                5'-flap endonuclease activity 6
Path 2
Term Annotations click to browse term
  molecular_function 28827
    catalytic activity 5720
      hydrolase activity 2454
        hydrolase activity, acting on ester bonds 785
          nuclease activity 224
            endonuclease activity 126
              DNA endonuclease activity 42
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters 13
                  5'-flap endonuclease activity 6
paths to the root