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ONTOLOGY REPORT - ANNOTATIONS

Term:5'-flap endonuclease activity
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Accession:GO:0017108 term browser browse the term
Definition:Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
Synonyms:xref: Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand";   reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA";   reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand";   reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)";   reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ";   reactome:R-HSA-69152 "Removal of remaining Flap"


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5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNA2 DNA replication helicase/nuclease 2 enables IEA UniProt
Ensembl
TreeGrafter		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr14:71,550,405...71,607,067
Ensembl chr14:71,552,121...71,610,740 		JBrowse link
G EXO1 exonuclease 1 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:15,317,555...15,360,593
Ensembl chr10:15,317,581...15,359,839 		JBrowse link
G FAN1 FANCD2 and FANCI associated nuclease 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:143,919,695...143,961,678
Ensembl chr 1:143,913,551...143,961,646 		JBrowse link
G FEN1 flap structure-specific endonuclease 1 enables IEA
IBA		 Ensembl
UniProt
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:9,752,004...9,756,863
Ensembl chr 2:9,752,013...9,756,728 		JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease enables IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:120,067,792...120,097,305
Ensembl chr 3:120,065,973...120,097,056 		JBrowse link
G SLC25A16 solute carrier family 25 member 16 enables IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr14:71,612,273...71,651,341
Ensembl chr14:71,610,475...71,651,102 		JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit enables IEA
IBA		 UniProt
InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr 3:18,346,501...18,349,509 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18689
    catalytic activity 5662
      catalytic activity, acting on a nucleic acid 614
        catalytic activity, acting on DNA 246
          DNA nuclease activity 65
            DNA endonuclease activity 42
              flap endonuclease activity 8
                5'-flap endonuclease activity 7
Path 2
Term Annotations click to browse term
  molecular_function 18689
    catalytic activity 5662
      hydrolase activity 2403
        hydrolase activity, acting on ester bonds 778
          nuclease activity 210
            endonuclease activity 121
              DNA endonuclease activity 42
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters 13
                  5'-flap endonuclease activity 7
paths to the root