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Ontology Browser
Term:
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Annotations: Rat: (61) Mouse: (61) Human: (68) Chinchilla: (44) Bonobo: (58) Dog: (58) Squirrel: (59) Pig: (61) Naked Mole-rat: (55) Green Monkey: (56)
Parent Terms Term With Siblings Child Terms
histone H2AXY142 kinase activity  
histone H3Y41 kinase activity  
non-membrane spanning protein tyrosine kinase activity  
transmembrane receptor histidine kinase activity +  
transmembrane receptor protein serine/threonine kinase activity +   
transmembrane receptor protein tyrosine kinase activity +   
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

Synonyms
Related Synonyms: receptor protein tyrosine kinase activity
Xrefs: EC:2.7.10.1 ;   MetaCyc:2.7.10.1-RXN ;   Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase" ;   reactome:R-HSA-166544 "TrkA receptor autophosphorylates" ;   reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated" ;   reactome:R-HSA-167683 "TrkA phosphorylates PLCG1" ;   reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor" ;   reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR" ;   reactome:R-HSA-198295 "TRKA phosphorylates IRS" ;   reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA" ;   reactome:R-HSA-74711 "Phosphorylation of IRS" ;   reactome:R-HSA-74742 "Phosphorylation of SHC1" ;   reactome:R-HSA-8852552 "MST1R autophosphorylates" ;   reactome:R-HSA-8853792 "RET tyrosine phosphorylation" ;   reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor" ;   reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation" ;   reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction" ;   reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated" ;   reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated" ;   reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated" ;   reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4" ;   reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction" ;   reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated" ;   reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated" ;   reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated" ;   reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" ;   reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1" ;   reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1" ;   reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5" ;   reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2" ;   reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5" ;   reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2" ;   reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA" ;   reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1" ;   reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1" ;   reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" ;   reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3" ;   reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1" ;   reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" ;   reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated" ;   reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3" ;   reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3" ;   reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" ;   reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" ;   reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3"
Definition Sources: EC:2.7.10.1, GOC:mah

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