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ONTOLOGY REPORT - ANNOTATIONS

Term:non-membrane spanning protein tyrosine kinase activity
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Accession:GO:0004715 term browser browse the term
Definition:Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
Synonyms:narrow_synonym: Bruton's tyrosine kinase activity;   cytoplasmic protein tyrosine kinase activity;   focal adhesion kinase activity;   janus kinase 1 activity;   janus kinase 2 activity;   janus kinase 3 activity;   p60c-src protein tyrosine kinase activity
 broad_synonym: ATP:protein-tyrosine O-phosphotransferase activity
 related_synonym: ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity;   non-specific protein-tyrosine kinase activity
 xref: EC:2.7.10.2;   MetaCyc:2.7.10.1-RXN;   reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor";   reactome:R-HSA-1112703 "PTPN11 is phosphorylated";   reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2";   reactome:R-HSA-1168459 "Lyn activates ERK";   reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3";   reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499";   reactome:R-HSA-1369115 "SHP2 is phosphorylated";   reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK";   reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family";   reactome:R-HSA-453200 "SYK autophosphorylates";   reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6";   reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated";   reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation";   reactome:R-HSA-879910 "JAK2 is phosphorylated, activated";   reactome:R-HSA-8871373 "BMX phosphorylates RUFY1"


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non-membrane spanning protein tyrosine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase enables ISO (PMID:10518561), (PMID:28428613), (PMID:9461559) RGD PMID:9461559 PMID:10518561 PMID:28428613 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase enables IEA GO_REF:0000003
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase enables ISO
IBA		 (PMID:23555801), (PMID:876631)
GO_REF:0000033		 RGD
GO_Central		 PMID:876631 PMID:23555801 GO_REF:0000033 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031 		JBrowse link
G Bmx BMX non-receptor tyrosine kinase enables ISO
IBA		 (PMID:10688651), (PMID:11331870)
GO_REF:0000033		 RGD
GO_Central		 PMID:10688651 PMID:11331870 GO_REF:0000033 NCBI chr  X:30,227,251...30,290,015
Ensembl chr  X:30,227,251...30,289,993 		JBrowse link
G Btk Bruton tyrosine kinase enables ISO
IBA		 UniProtKB:P16885 (PMID:11606584), (PMID:14656219)
GO_REF:0000033		 RGD
GO_Central		 PMID:11606584 PMID:14656219 GO_REF:0000033 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Csk C-terminal Src kinase enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A enables ISO
IEA		 (PMID:9748265)
GO_REF:0000107		 RGD
Ensembl		 PMID:9748265 GO_REF:0000107 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Fer FER tyrosine kinase enables IEA
ISO
ISS		 GO_REF:0000003
(PMID:12972546), (PMID:19738202)
GO_REF:0000024
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:12972546 PMID:19738202 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase enables ISO (PMID:15485904) RGD PMID:15485904 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase enables ISO
IBA		 (PMID:8327512)
(MGI:3513574|PMID:15561106)
GO_REF:0000033		 RGD
GO_Central		 PMID:8327512 PMID:15561106 GO_REF:0000033 MGI:3513574 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Frk fyn-related Src family tyrosine kinase enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:11606584)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:11606584 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase enables IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Insl3 insulin-like 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Itk IL2-inducible T-cell kinase enables ISO
IBA		 (PMID:12186560)
GO_REF:0000033		 RGD
GO_Central		 PMID:12186560 GO_REF:0000033 NCBI chr10:30,753,344...30,814,685
Ensembl chr10:30,753,344...30,814,685 		JBrowse link
G Jak1 Janus kinase 1 enables ISO
IBA		 (PMID:7657660), (PMID:8232552)
GO_REF:0000033		 RGD
GO_Central		 PMID:7657660 PMID:8232552 GO_REF:0000033 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 enables TAS
IEA
IBA		 Reactome:R-RNO-1369099
GO_REF:0000002
GO_REF:0000033
GO_REF:0000118		 Reactome
InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 Reactome:R-RNO-1369099 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jak3 Janus kinase 3 enables IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:11606584), (PMID:8681956)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:8681956 PMID:11606584 GO_REF:0000003 GO_REF:0000033 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase enables ISO
IBA		 (MGI:5913054|PMID:28098138)
(PMID:23555801)
GO_REF:0000033		 RGD
GO_Central		 PMID:23555801 PMID:28098138 GO_REF:0000033 MGI:5913054 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Matk megakaryocyte-associated tyrosine kinase enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022 		JBrowse link
G Melk maternal embryonic leucine zipper kinase enables ISO
IBA		 (PMID:16216881)
GO_REF:0000033		 RGD
GO_Central		 PMID:16216881 GO_REF:0000033 NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937 		JBrowse link
G Peak1 pseudopodium-enriched atypical kinase 1 enables ISO (PMID:20534451) RGD PMID:20534451 NCBI chr 8:56,605,040...56,819,748
Ensembl chr 8:56,609,015...56,819,096 		JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic enables ISO
IBA		 (PMID:25171405)
(MGI:5604027|PMID:25171405)
GO_REF:0000033		 RGD
GO_Central		 PMID:25171405 GO_REF:0000033 MGI:5604027 NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556 		JBrowse link
G Ptk2 protein tyrosine kinase 2 enables IEA
ISS
ISO
IBA		 GO_REF:0000003
GO_REF:0000024
(PMID:10655584), (PMID:11331870)
GO_REF:0000033
(MGI:5770069|PMID:18297732), (PMID:27994061)		 UniProt
RGD
GO_Central		 PMID:10655584 PMID:11331870 PMID:18297732 PMID:27994061 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 MGI:5770069 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta enables ISS
ISO
IMP
IDA
IBA		 GO_REF:0000024
(PMID:10518561), (PMID:7544443)
(MGI:3713957|PMID:17537919)
PMID:15814199
PMID:15537634
PMID:17188509
PMID:11239437
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:7544443 PMID:10518561 PMID:17537919 PMID:15814199 PMID:15537634 More... GO_REF:0000024 GO_REF:0000033 MGI:3713957, RGD:8655534, RGD:8554065, RGD:8554817, RGD:8553497 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptk6 protein tyrosine kinase 6 enables ISO
IBA		 (PMID:10913193)
GO_REF:0000033		 RGD
GO_Central		 PMID:10913193 GO_REF:0000033 NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase enables ISO
IBA		 (PMID:11606584), (PMID:33963050)
GO_REF:0000033		 RGD
GO_Central		 PMID:11606584 PMID:33963050 GO_REF:0000033 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:168,318,511...168,324,915
Ensembl chr 3:168,318,512...168,324,915 		JBrowse link
G Stk16 serine/threonine kinase 16 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:76,705,591...76,708,859
Ensembl chr 9:76,705,602...76,708,855 		JBrowse link
G Syk spleen associated tyrosine kinase enables IEA
ISS
ISO
IBA		 GO_REF:0000003
GO_REF:0000024
UniProtKB:P16885 (PMID:11606584), (PMID:14656219), (PMID:8163536)
GO_REF:0000033
(PMID:8626447)		 UniProt
RGD
GO_Central		 PMID:8163536 PMID:8626447 PMID:11606584 PMID:14656219 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tec tec protein tyrosine kinase enables ISO
IBA		 (PMID:10518561)
GO_REF:0000033		 RGD
GO_Central		 PMID:10518561 GO_REF:0000033 NCBI chr14:35,352,551...35,461,585
Ensembl chr14:35,352,829...35,461,557 		JBrowse link
G Tnk1 tyrosine kinase, non-receptor, 1 enables ISO (MGI:2664463|PMID:12789265) RGD PMID:12789265 MGI:2664463 NCBI chr10:54,571,396...54,580,547
Ensembl chr10:54,571,117...54,579,940 		JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:68,114,725...68,154,254
Ensembl chr11:68,114,726...68,154,009 		JBrowse link
G Txk TXK tyrosine kinase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:35,463,369...35,519,448
Ensembl chr14:35,463,944...35,519,448 		JBrowse link
G Tyk2 tyrosine kinase 2 enables ISO
IBA		 (PMID:7526154), (PMID:7657660), (PMID:8232552), (PMID:8605876)
GO_REF:0000033		 RGD
GO_Central		 PMID:7526154 PMID:7657660 PMID:8232552 PMID:8605876 GO_REF:0000033 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase enables IEA GO_REF:0000003
GO_REF:0000104		 UniProt GO_REF:0000003 GO_REF:0000104 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
G Wee2 WEE2 oocyte meiosis inhibiting kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:69,239,043...69,261,576
Ensembl chr 4:69,239,299...69,261,093 		JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000118		 UniProt
GO_Central
TreeGrafter		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 enables ISO
IBA		 (PMID:12447358)
GO_REF:0000033		 RGD
GO_Central		 PMID:12447358 GO_REF:0000033 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a protein 2516
        protein kinase activity 628
          protein tyrosine kinase activity 138
            non-membrane spanning protein tyrosine kinase activity 41
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      transferase activity 2451
        transferase activity, transferring phosphorus-containing groups 983
          kinase activity 814
            protein kinase activity 628
              protein tyrosine kinase activity 138
                non-membrane spanning protein tyrosine kinase activity 41
paths to the root