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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:antiplatelet drug pathway
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Accession:PW:0002150 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of drugs that decrease platelet aggregation and inhibit blood clot formation. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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abciximab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga2b integrin subunit alpha 2b ISO SMPDB SMP:00265 NCBI chrNW_004624795:683,899...695,262
Ensembl chrNW_004624795:683,968...703,710 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO SMPDB SMP:00265 NCBI chrNW_004624849:1,895,378...1,952,755
Ensembl chrNW_004624849:1,895,914...1,952,665 		JBrowse link
acetylsalicylic acid pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00083 NCBI chrNW_004624786:9,542,966...9,555,235
Ensembl chrNW_004624786:9,542,970...9,555,214 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00083 NCBI chrNW_004624786:10,647,450...10,659,301
Ensembl chrNW_004624786:10,647,175...10,659,337 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00083 NCBI chrNW_004624966:168,244...220,430
Ensembl chrNW_004624966:168,250...220,522 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00083 NCBI chrNW_004624758:22,216,462...22,252,467
Ensembl chrNW_004624758:22,221,314...22,254,813 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00083 NCBI chrNW_004624747:10,030,034...10,048,554 JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00083 NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626 		JBrowse link
G LOC101708291 cytochrome P450 2U1 ISO SMPDB SMP:00083 NCBI chrNW_004624830:1,470,186...1,485,804
Ensembl chrNW_004624830:1,469,868...1,485,804 		JBrowse link
G LOC101722366 cytochrome P450 2E1 ISO SMPDB SMP:00083 NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00083 NCBI chrNW_004624750:11,274,506...11,314,683
Ensembl chrNW_004624750:11,274,664...11,314,581 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00083 NCBI chrNW_004624733:42,668,963...42,673,385
Ensembl chrNW_004624733:42,670,632...42,672,846 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00083 NCBI chrNW_004624804:9,017,154...9,026,977
Ensembl chrNW_004624804:9,016,487...9,026,621 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00083 NCBI chrNW_004624818:7,478,680...7,485,431
Ensembl chrNW_004624818:7,483,001...7,485,431 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00083 NCBI chrNW_004624760:920,292...923,174
Ensembl chrNW_004624760:920,877...923,283 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00083 NCBI chrNW_004624760:5,643,549...5,653,747
Ensembl chrNW_004624760:5,643,501...5,654,475 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00083 NCBI chrNW_004624790:5,850,647...5,885,754
Ensembl chrNW_004624790:5,850,810...5,886,014 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00083 NCBI chrNW_004624760:12,917,244...12,937,858
Ensembl chrNW_004624760:12,915,206...12,937,824 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00083 NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00083 NCBI chrNW_004624765:20,145,769...20,314,992
Ensembl chrNW_004624765:20,146,138...20,315,797 		JBrowse link
clopidogrel pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2ry12 purinergic receptor P2Y12 ISO SMPDB SMP:00260 NCBI chrNW_004624730:28,771,020...28,819,179
Ensembl chrNW_004624730:28,772,525...28,782,431 		JBrowse link
G Pon1 paraoxonase 1 ISO SMPDB SMP:00260 NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882 		JBrowse link
clopidogrel pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2ry12 purinergic receptor P2Y12 ISO SMPDB SMP:00610 NCBI chrNW_004624730:28,771,020...28,819,179
Ensembl chrNW_004624730:28,772,525...28,782,431 		JBrowse link
G Pon1 paraoxonase 1 ISO SMPDB SMP:00610 NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882 		JBrowse link
eptifibatide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga2b integrin subunit alpha 2b ISO SMPDB SMP:00266 NCBI chrNW_004624795:683,899...695,262
Ensembl chrNW_004624795:683,968...703,710 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO SMPDB SMP:00266 NCBI chrNW_004624849:1,895,378...1,952,755
Ensembl chrNW_004624849:1,895,914...1,952,665 		JBrowse link
salicylic acid pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00709 NCBI chrNW_004624786:9,542,966...9,555,235
Ensembl chrNW_004624786:9,542,970...9,555,214 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00709 NCBI chrNW_004624786:10,647,450...10,659,301
Ensembl chrNW_004624786:10,647,175...10,659,337 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00709 NCBI chrNW_004624966:168,244...220,430
Ensembl chrNW_004624966:168,250...220,522 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00709 NCBI chrNW_004624758:22,216,462...22,252,467
Ensembl chrNW_004624758:22,221,314...22,254,813 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00709 NCBI chrNW_004624747:10,030,034...10,048,554 JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00709 NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626 		JBrowse link
G LOC101708291 cytochrome P450 2U1 ISO SMPDB SMP:00709 NCBI chrNW_004624830:1,470,186...1,485,804
Ensembl chrNW_004624830:1,469,868...1,485,804 		JBrowse link
G LOC101722366 cytochrome P450 2E1 ISO SMPDB SMP:00709 NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00709 NCBI chrNW_004624750:11,274,506...11,314,683
Ensembl chrNW_004624750:11,274,664...11,314,581 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00709 NCBI chrNW_004624733:42,668,963...42,673,385
Ensembl chrNW_004624733:42,670,632...42,672,846 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00709 NCBI chrNW_004624804:9,017,154...9,026,977
Ensembl chrNW_004624804:9,016,487...9,026,621 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00709 NCBI chrNW_004624818:7,478,680...7,485,431
Ensembl chrNW_004624818:7,483,001...7,485,431 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00709 NCBI chrNW_004624760:920,292...923,174
Ensembl chrNW_004624760:920,877...923,283 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00709 NCBI chrNW_004624760:5,643,549...5,653,747
Ensembl chrNW_004624760:5,643,501...5,654,475 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00709 NCBI chrNW_004624790:5,850,647...5,885,754
Ensembl chrNW_004624790:5,850,810...5,886,014 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00709 NCBI chrNW_004624760:12,917,244...12,937,858
Ensembl chrNW_004624760:12,915,206...12,937,824 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00709 NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00709 NCBI chrNW_004624765:20,145,769...20,314,992
Ensembl chrNW_004624765:20,146,138...20,315,797 		JBrowse link
ticlopidine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2ry12 purinergic receptor P2Y12 ISO SMPDB SMP:00261 NCBI chrNW_004624730:28,771,020...28,819,179
Ensembl chrNW_004624730:28,772,525...28,782,431 		JBrowse link
ticlopidine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2ry12 purinergic receptor P2Y12 ISO SMPDB SMP:00611 NCBI chrNW_004624730:28,771,020...28,819,179
Ensembl chrNW_004624730:28,772,525...28,782,431 		JBrowse link
tirofiban pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga2b integrin subunit alpha 2b ISO SMPDB SMP:00267 NCBI chrNW_004624795:683,899...695,262
Ensembl chrNW_004624795:683,968...703,710 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO SMPDB SMP:00267 NCBI chrNW_004624849:1,895,378...1,952,755
Ensembl chrNW_004624849:1,895,914...1,952,665 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    drug pathway 349
      blood and blood forming organs drug pathway 44
        antithrombotic drug pathway 44
          antiplatelet drug pathway 22
            abciximab drug pathway + 2
            acetylsalicylic acid drug pathway + 18
            cilostazol drug pathway + 0
            clopidogrel drug pathway + 2
            dipyridamole drug pathway + 0
            eptifibatide drug pathway + 2
            salicylic acid drug pathway + 18
            ticlopidine drug pathway + 1
            tirofiban drug pathway + 2
paths to the root