P2ry12 (purinergic receptor P2Y12) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: P2ry12 (purinergic receptor P2Y12) Heterocephalus glaber
Analyze
Symbol: P2ry12
Name: purinergic receptor P2Y12
RGD ID: 18919036
Description: ENCODES a protein that exhibits G protein-coupled adenosine receptor activity (ortholog); G protein-coupled ADP receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); arteriosclerosis (ortholog); FOUND IN basal plasma membrane (ortholog); caveola (ortholog); cell body membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: P2Y purinoceptor 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,772,525 - 28,782,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,771,020 - 28,819,179 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
blood coagulation  (IEA)
calcium ion transmembrane transport  (ISO)
calcium-mediated signaling  (ISO)
cell projection organization  (ISO)
cellular response to ATP  (ISO)
cellular response to organic cyclic compound  (ISO)
cerebral cortex radial glia-guided migration  (ISO)
establishment of localization in cell  (ISO)
G protein-coupled adenosine receptor signaling pathway  (ISO)
G protein-coupled purinergic nucleotide receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glial cell migration  (ISO)
lamellipodium assembly  (ISO)
monoatomic ion transport  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of norepinephrine secretion  (ISO)
obsolete calcium-mediated signaling using extracellular calcium source  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
platelet activation  (ISO)
platelet aggregation  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of integrin activation by cell surface receptor linked signal transduction  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of ruffle assembly  (ISO)
potassium ion transmembrane transport  (ISO)
regulation of calcium ion transport  (ISO)
regulation of chemotaxis  (ISO)
regulation of microglial cell migration  (ISO)
response to axon injury  (ISO)
substrate-dependent cell migration, cell extension  (ISO)
visual system development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
P2ry12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,772,525 - 28,782,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,771,020 - 28,819,179 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
P2RY12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383151,336,843 - 151,384,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3151,336,843 - 151,384,753 (-)EnsemblGRCh38hg38GRCh38
GRCh373151,054,631 - 151,102,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363152,538,066 - 152,585,234 (-)NCBINCBI36Build 36hg18NCBI36
Build 343152,538,073 - 152,541,283NCBI
Celera3149,468,086 - 149,515,254 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3148,427,988 - 148,475,876 (-)NCBIHuRef
CHM1_13151,017,744 - 151,065,720 (-)NCBICHM1_1
T2T-CHM13v2.03154,087,845 - 154,135,691 (-)NCBIT2T-CHM13v2.0
P2ry12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39359,123,692 - 59,170,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl359,123,693 - 59,170,292 (-)EnsemblGRCm39 Ensembl
GRCm38359,216,271 - 59,262,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl359,216,272 - 59,262,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37359,020,193 - 59,066,753 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36359,304,201 - 59,350,751 (-)NCBIMGSCv36mm8
Celera358,903,452 - 58,949,752 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map329.01NCBI
P2ry12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,631,487 - 145,673,194 (-)NCBIGRCr8
mRatBN7.22143,481,468 - 143,523,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2143,481,430 - 143,523,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2150,121,752 - 150,124,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02148,234,328 - 148,237,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,866,741 - 142,869,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02149,440,807 - 149,482,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2149,441,598 - 149,444,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,873,062 - 168,914,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,611,035 - 148,613,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12148,560,997 - 148,563,948 (-)NCBI
Celera2137,906,910 - 137,909,860 (-)NCBICelera
Cytogenetic Map2q26NCBI
P2ry12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554482,442,368 - 2,488,567 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554482,442,368 - 2,488,567 (-)NCBIChiLan1.0ChiLan1.0
P2RY12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,235,279 - 149,282,898 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13149,240,013 - 149,287,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03148,364,151 - 148,412,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,934,333 - 155,981,818 (-)NCBIpanpan1.1PanPan1.1panPan2
P2RY12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,908,574 - 45,954,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,909,485 - 45,910,526 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,774,299 - 45,775,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02346,535,240 - 46,581,332 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2346,535,243 - 46,581,291 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12346,125,167 - 46,126,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02346,177,435 - 46,178,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02346,454,355 - 46,455,396 (-)NCBIUU_Cfam_GSD_1.0
P2ry12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,143,659 - 90,185,986 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367581,581,897 - 1,592,222 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367581,581,828 - 1,624,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1391,521,817 - 91,572,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11391,522,754 - 91,572,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,604,550 - 99,654,172 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,315,140 - 39,361,614 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1539,359,612 - 39,360,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604112,130,267 - 12,177,497 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000023647   ⟹   ENSHGLP00000023430
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473028,772,525 - 28,782,431 (-)Ensembl
RefSeq Acc Id: XM_004834457   ⟹   XP_004834514
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473028,771,020 - 28,818,986 (-)NCBI
RefSeq Acc Id: XM_004834458   ⟹   XP_004834515
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473028,771,020 - 28,782,504 (-)NCBI
RefSeq Acc Id: XM_004834459   ⟹   XP_004834516
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473028,771,020 - 28,782,564 (-)NCBI
RefSeq Acc Id: XM_004834460   ⟹   XP_004834517
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473028,771,020 - 28,819,179 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004834517   ⟸   XM_004834460
- UniProtKB: A0A0N8ESB3 (UniProtKB/TrEMBL),   G5C102 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834514   ⟸   XM_004834457
- UniProtKB: A0A0N8ESB3 (UniProtKB/TrEMBL),   G5C102 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834516   ⟸   XM_004834459
- UniProtKB: A0A0N8ESB3 (UniProtKB/TrEMBL),   G5C102 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834515   ⟸   XM_004834458
- UniProtKB: A0A0N8ESB3 (UniProtKB/TrEMBL),   G5C102 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000023430   ⟸   ENSHGLT00000023647


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016707 Ensembl, ENTREZGENE
  ENSHGLG00100033090 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000023647 ENTREZGENE
  ENSHGLT00100043671 UniProtKB/TrEMBL
  ENSHGLT00100052278 UniProtKB/TrEMBL
  ENSHGLT00100074337 UniProtKB/TrEMBL
  ENSHGLT00100078685 UniProtKB/TrEMBL
  ENSHGLT00100090737 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  P2Y12_rcpt UniProtKB/TrEMBL
KEGG Report hgl:101701294 UniProtKB/TrEMBL
NCBI Gene P2ry12 ENTREZGENE
PANTHER P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24233:SF0 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  P2Y12PRNCPTR UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0N8ESB3 ENTREZGENE, UniProtKB/TrEMBL
  G5C102 ENTREZGENE, UniProtKB/TrEMBL