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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:activin signaling pathway
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Accession:PW:0000331 term browser browse the term
Definition:Activins are members of the TGF-beta superfamily of growth factors. The pathway plays important roles in embryonic development, inflammation and reproductive biology. Deregulation of activin signaling contributes to a number of pathological conditions.
Synonyms:related_synonym: Signaling by Activin;   activin receptor signaling pathway


show annotations for term's descendants           Sort by:
activin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor, type 1 ISS
ISO		 PID
RGD		 PMID:12770730 PID:200029, RGD:1559169 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Acvr1b activin A receptor, type 1B ISS
ISO		 RGD PMID:12770730 PMID:17040568 RGD:1559169, RGD:2315948 NCBI chr15:101,071,953...101,111,565
Ensembl chr15:101,071,948...101,111,565 		JBrowse link
G Acvr2a activin receptor IIA ISS RGD PMID:12770730 RGD:1559169 NCBI chr 2:48,704,121...48,793,276
Ensembl chr 2:48,704,121...48,793,281 		JBrowse link
G Acvr2b activin receptor IIB ISS RGD PMID:12770730 RGD:1559169 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Acvrl1 activin A receptor, type II-like 1 ISS
ISO		 PID
RGD		 PMID:12770730 PID:200029, RGD:1559169 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217 		JBrowse link
G Fkbp1a FK506 binding protein 1a ISO PID PID:200029 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Smad2 SMAD family member 2 ISS RGD PMID:12770730 RGD:1559169 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 ISS RGD PMID:12770730 RGD:1559169 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    signaling pathway 2500
      signaling pathway pertinent to development 536
        activin signaling pathway 8
Path 2
Term Annotations click to browse term
  pathway 6074
    signaling pathway 2500
      growth factor signaling pathway 529
        transforming growth factor-beta superfamily mediated signaling pathway 153
          activin signaling pathway 8
paths to the root