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ONTOLOGY REPORT - ANNOTATIONS

Term:serotonin-activated cation-selective channel complex
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Accession:GO:1904602 term browser browse the term
Definition:A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist.
Comment:An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay).
Synonyms:exact_synonym: 5-HT-3 receptor complex;   5-HT3 receptor complex;   5-hydroxytryptamine receptor 3 complex;   5HT3 receptor complex
 broad_synonym: serotonin receptor complex


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serotonin-activated cation-selective channel complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR3A 5-hydroxytryptamine receptor 3A located_in
part_of		 ISO
IEA		 (PMID:16116092), (PMID:17392525) ComplexPortal
Ensembl		 PMID:16116092 PMID:17392525 GO_REF:0000107 NCBI chr 5:19,324,087...19,338,250
Ensembl chr 5:19,324,444...19,338,294 		JBrowse link
G HTR3B 5-hydroxytryptamine receptor 3B located_in
part_of		 ISO
IEA		 (PMID:16116092) ComplexPortal
Ensembl		 PMID:16116092 GO_REF:0000107 NCBI chr 5:19,361,011...19,393,206
Ensembl chr 5:19,362,382...19,414,912 		JBrowse link
G HTR3C 5-hydroxytryptamine receptor 3C located_in
part_of		 ISO
IEA		 (PMID:17392525) ComplexPortal
Ensembl		 PMID:17392525 GO_REF:0000107 NCBI chr34:16,969,213...16,976,401 JBrowse link
G LOC100856260 5-hydroxytryptamine receptor 3E located_in
part_of		 ISO
IEA		 (PMID:17392525) ComplexPortal
Ensembl		 PMID:17392525 GO_REF:0000107 NCBI chr34:17,011,403...17,019,214
Ensembl chr34:17,011,555...17,018,941 		JBrowse link
G LOC478649 5-hydroxytryptamine receptor 3C-like located_in ISO (PMID:17392525) ComplexPortal PMID:17392525 NCBI chr34:16,958,296...16,961,863
Ensembl chr34:16,958,083...16,961,857 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18906
    protein-containing complex 6506
      receptor complex 415
        serotonin receptor complex 5
          serotonin-activated cation-selective channel complex 5
Path 2
Term Annotations click to browse term
  cellular_component 18906
    cellular anatomical entity 18654
      membrane 9392
        membrane protein complex 1353
          transmembrane transporter complex 463
            monoatomic ion channel complex 329
              cation channel complex 204
                serotonin-activated cation-selective channel complex 5
paths to the root