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ONTOLOGY REPORT - ANNOTATIONS

Term:superoxide-generating NAD(P)H oxidase activity
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Accession:GO:0016175 term browser browse the term
Definition:Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-.
Synonyms:related_synonym: cytochrome B-245
 xref: Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen";   reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2";   reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide";   reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen";   reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP";   reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen";   reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen";   reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-"


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superoxide-generating NAD(P)H oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYBA cytochrome b-245 alpha chain contributes_to ISO PMID:8798532
(PMID:1763037)		 BHF-UCL PMID:1763037 PMID:8798532 RGD:2317869 NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893 		JBrowse link
G CYBB cytochrome b-245 beta chain contributes_to
enables		 ISO
IEA		 (PMID:12042318) BHF-UCL
Ensembl
TreeGrafter		 PMID:12042318 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:32,533,365...32,568,149
Ensembl chr  X:32,533,320...32,568,217 		JBrowse link
G DUOX1 dual oxidase 1 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr30:11,556,024...11,588,203
Ensembl chr30:11,556,024...11,588,202 		JBrowse link
G DUOX2 dual oxidase 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr30:11,521,833...11,541,719
Ensembl chr30:11,521,845...11,541,716 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 enables
contributes_to		 IEA
ISO		 (PMID:9490028) Ensembl
MGI		 PMID:9490028 GO_REF:0000107 NCBI chr 7:16,914,629...16,946,370
Ensembl chr 7:16,904,031...16,945,372 		JBrowse link
G NOX1 NADPH oxidase 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:74,784,627...74,811,796
Ensembl chr  X:74,785,168...74,811,698 		JBrowse link
G NOX3 NADPH oxidase 3 enables IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:45,129,112...45,186,510
Ensembl chr 1:45,128,958...45,186,510 		JBrowse link
G NOX4 NADPH oxidase 4 enables
NOT|enables		 IEA
ISO		 (PMID:15721269) Ensembl
UniProt
TreeGrafter		 PMID:15721269 GO_REF:0000107 GO_REF:0000118 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277 		JBrowse link
G NOX5 NADPH oxidase 5 enables
NOT|contributes_to		 IEA
ISO		 (PMID:22427510) Ensembl
UniProt
TreeGrafter		 PMID:22427510 GO_REF:0000107 GO_REF:0000118 NCBI chr30:32,929,287...32,985,944
Ensembl chr30:32,951,501...32,986,559 		JBrowse link
G SPESP1 sperm equatorial segment protein 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr30:32,900,322...32,904,206
Ensembl chr30:32,900,750...32,902,581 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18798
    catalytic activity 5741
      oxidoreductase activity 782
        oxidoreductase activity, acting on NAD(P)H 67
          oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 17
            superoxide-generating NAD(P)H oxidase activity 11
              superoxide-generating NADH oxidase activity 0
              superoxide-generating NADPH oxidase activity 0
paths to the root