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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA (guanine(46)-N7)-methyltransferase activity
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Accession:GO:0008176 term browser browse the term
Definition:Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine.
Synonyms:exact_synonym: tRNA (guanosine(46)-N(7))-methyltransferase activity;   tRNA (guanosine(46)-N7)-methyltransferase activity
 broad_synonym: tRNA (guanine-N7-)-methyltransferase activity
 related_synonym: 7-methylguanine transfer ribonucleate methylase activity;   N7-methylguanine methylase activity;   tRNA guanine 7-methyltransferase activity
 xref: EC:2.1.1.33;   MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN;   RHEA:42708;   reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46"


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tRNA (guanine(46)-N7)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl1 methyltransferase 1, tRNA methylguanosine enables ISO
IBA		 (PMID:12403464), (PMID:15861136), (PMID:36599982), (PMID:36599985), (PMID:37369656)
GO_REF:0000033		 RGD
GO_Central		 PMID:12403464 PMID:15861136 PMID:36599982 PMID:36599985 PMID:37369656 GO_REF:0000033 NCBI chr 7:62,864,860...62,869,202
Ensembl chr 7:62,864,853...62,869,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20488
    catalytic activity 6038
      catalytic activity, acting on a nucleic acid 630
        catalytic activity, acting on RNA 396
          RNA methyltransferase activity 62
            tRNA methyltransferase activity 31
              tRNA (guanine) methyltransferase activity 12
                tRNA (guanine(46)-N7)-methyltransferase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20488
    catalytic activity 6038
      transferase activity 2398
        transferase activity, transferring one-carbon groups 218
          methyltransferase activity 208
            RNA methyltransferase activity 62
              tRNA methyltransferase activity 31
                tRNA (guanine) methyltransferase activity 12
                  tRNA (guanine(46)-N7)-methyltransferase activity 1
paths to the root