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ONTOLOGY REPORT - ANNOTATIONS


Term:tRNA methyltransferase activity
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Accession:GO:0008175 term browser browse the term
Definition:Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.
Synonyms:xref: reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34";   reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine"



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tRNA methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcdin3d BCDIN3 domain containing RNA methyltransferase enables ISS
ISO
GO_REF:0000024
(PMID:28119416), (PMID:31919512)
UniProt
RGD
PMID:28119416 PMID:31919512 GO_REF:0000024 NCBI chr 7:130,605,540...130,610,134 JBrowse link
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:14,243,684...14,256,555 JBrowse link
G Lcmt2 leucine carboxyl methyltransferase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:108,099,960...108,102,084 JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 enables ISO (PMID:16424344)
MGI:3695409 (PMID:16424344)
RGD PMID:16424344 NCBI chr17:76,601,966...76,646,104 JBrowse link
G Trmt12 tRNA methyltransferase 12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:90,417,846...90,419,472 JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:204,533,630...204,547,711 JBrowse link
G Trmt5 tRNA methyltransferase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:91,963,558...91,987,660 JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) enables ISO (PMID:23381944) RGD PMID:23381944 NCBI chr16:55,740,551...55,792,198 JBrowse link
G Tyw3 tRNA-yW synthesizing protein 3 homolog enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:243,529,912...243,552,043 JBrowse link
tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh8 alkB homolog 8, tRNA methyltransferase enables IBA
ISO
GO_REF:0000033
(PMID:20583019)
GO_Central
RGD
PMID:20583019 GO_REF:0000033 NCBI chr 6:378,779...449,382 JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:55,740,551...55,792,198 JBrowse link
tRNA (adenine(58)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt61a tRNA methyltransferase 61A enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr 6:130,737,230...130,743,251 JBrowse link
tRNA (adenine(9)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit enables ISO (PMID:23042678) RGD PMID:23042678 NCBI chr11:44,584,388...44,589,466 JBrowse link
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO (PMID:25404562), (PMID:26310293), (PMID:36720500) RGD PMID:25404562 PMID:26310293 PMID:36720500 NCBI chr  X:14,243,684...14,256,555 JBrowse link
tRNA (cytidine-3-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl2 methyltransferase like 2 enables ISO
IBA
(PMID:28655767), (PMID:34268557)
GO_REF:0000033
MGI:5903740 (PMID:28655767)
RGD
GO_Central
PMID:28655767 PMID:34268557 GO_REF:0000033 NCBI chr10:90,095,527...90,109,354 JBrowse link
G Mettl6 methyltransferase 6, tRNA N3-cytidine enables ISO (PMID:32923617), (PMID:34268557), (PMID:34862464), (PMID:34922197)
MGI:5903741 (PMID:28655767)
RGD PMID:28655767 PMID:32923617 PMID:34268557 PMID:34862464 PMID:34922197 NCBI chr16:6,683,820...6,699,013 JBrowse link
G Mettl8 methyltransferase 8, tRNA N3-cytidine enables ISO
IBA
(PMID:34774131), (PMID:35017528)
GO_REF:0000033
RGD
GO_Central
PMID:34774131 PMID:35017528 GO_REF:0000033 NCBI chr 3:55,731,453...55,863,652 JBrowse link
tRNA (cytidine-5-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsun2 NOP2/Sun RNA methyltransferase 2 enables ISO
IBA
(PMID:17071714), (PMID:31287866), (PMID:34556860)
(PMID:22885326), (PMID:23871666), (PMID:31276587), (PMID:31287866)
GO_REF:0000033
RGD
GO_Central
PMID:17071714 PMID:22885326 PMID:23871666 PMID:31276587 PMID:31287866 More... GO_REF:0000033 NCBI chr 1:33,662,139...33,685,887 JBrowse link
G Nsun3 NOP2/Sun RNA methyltransferase 3 enables ISO (PMID:27214402), (PMID:27356879), (PMID:27497299) RGD PMID:27214402 PMID:27356879 PMID:27497299 NCBI chr11:37,490,832...37,575,607 JBrowse link
G Nsun6 NOP2/Sun RNA methyltransferase 6 enables ISO (PMID:26160102), (PMID:27703015), (PMID:28531330), (PMID:37226891) RGD PMID:26160102 PMID:27703015 PMID:28531330 PMID:37226891 NCBI chr17:77,912,374...77,955,694 JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 enables ISS
ISO
GO_REF:0000024
(PMID:22885326), (PMID:26271101)
(PMID:16424344), (PMID:18567810)
UniProt
RGD
PMID:16424344 PMID:18567810 PMID:22885326 PMID:26271101 GO_REF:0000024 NCBI chr17:76,601,966...76,646,104 JBrowse link
tRNA (guanine(10)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt11 tRNA methyltransferase 11 homolog enables IEA
ISO
ISS
GO_REF:0000002
(PMID:37283053)
GO_REF:0000024
InterPro
RGD
UniProt
PMID:37283053 GO_REF:0000002 GO_REF:0000024 NCBI chr 1:27,054,437...27,109,765 JBrowse link
tRNA (guanine(26)-N2)-dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt1 tRNA methyltransferase 1 enables ISO (PMID:10982862) RGD PMID:10982862 NCBI chr19:23,456,756...23,471,581 JBrowse link
tRNA (guanine(37)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt5 tRNA methyltransferase 5 enables IEA GO_REF:0000116
GO_REF:0000104
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000104 GO_REF:0000116 NCBI chr 6:91,963,558...91,987,660 JBrowse link
tRNA (guanine(46)-N7)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl1 methyltransferase 1, tRNA methylguanosine enables ISO
IBA
(PMID:12403464), (PMID:15861136), (PMID:36599982), (PMID:36599985), (PMID:37369656)
GO_REF:0000033
RGD
GO_Central
PMID:12403464 PMID:15861136 PMID:36599982 PMID:36599985 PMID:37369656 GO_REF:0000033 NCBI chr 7:62,864,860...62,869,202 JBrowse link
tRNA (guanine(6)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thumpd3 THUMP domain containing 3 enables ISO (PMID:34669960), (PMID:37283053) RGD PMID:34669960 PMID:37283053 NCBI chr 4:146,185,422...146,209,802 JBrowse link
tRNA (guanine(7)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thumpd3 THUMP domain containing 3 enables ISO (PMID:34669960) RGD PMID:34669960 NCBI chr 4:146,185,422...146,209,802 JBrowse link
tRNA (guanine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO (PMID:32558197) RGD PMID:32558197 NCBI chr  X:14,243,684...14,256,555 JBrowse link
G Tarbp1 TAR (HIV-1) RNA binding protein 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:54,398,268...54,449,293 JBrowse link
G Thumpd2 THUMP domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:13,924,742...13,976,657 JBrowse link
G Thumpd3 THUMP domain containing 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:146,185,422...146,209,802 JBrowse link
G Trmt1l tRNA methyltransferase 1-like enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:63,510,097...63,543,268 JBrowse link
tRNA (guanosine(9)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt10a tRNA methyltransferase 10A enables IEA
ISO
GO_REF:0000003
(PMID:23042678), (PMID:32392304)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23042678 PMID:32392304 GO_REF:0000003 GO_REF:0000107 NCBI chr 2:226,669,445...226,684,166 JBrowse link
G Trmt10b tRNA methyltransferase 10B enables IEA
ISO
GO_REF:0000107
(PMID:23042678)
Ensembl
RGD
PMID:23042678 GO_REF:0000107 NCBI chr 5:59,548,845...59,572,529 JBrowse link
G Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit enables ISO (PMID:23042678) RGD PMID:23042678 NCBI chr11:44,584,388...44,589,466 JBrowse link
tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmo tRNA methyltransferase O enables ISS
ISO
GO_REF:0000024
(PMID:25063302)
UniProt
RGD
PMID:25063302 GO_REF:0000024 NCBI chr 5:60,663,106...60,676,423 JBrowse link
tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt2a tRNA methyltransferase 2 homolog A enables ISO (PMID:31361898), (PMID:33799331) RGD PMID:31361898 PMID:33799331 NCBI chr11:82,737,689...82,742,423 JBrowse link
G Trmt2b tRNA methyltransferase 2 homolog B enables ISO (PMID:31948311)
(PMID:31736397)
RGD PMID:31736397 PMID:31948311 NCBI chr  X:97,425,712...97,483,821 JBrowse link
tRNA (uridine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh8 alkB homolog 8, tRNA methyltransferase enables ISO (PMID:20308323)
(PMID:20123966)
RGD PMID:20123966 PMID:20308323 NCBI chr 6:378,779...449,382 JBrowse link
G Trmt44 tRNA methyltransferase 44 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:75,175,331...75,204,291 JBrowse link
tRNA 2'-O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO (PMID:25404562), (PMID:26310293) RGD PMID:25404562 PMID:26310293 NCBI chr  X:14,243,684...14,256,555 JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:204,533,630...204,547,711 JBrowse link
tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt44 tRNA methyltransferase 44 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:75,175,331...75,204,291 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      catalytic activity, acting on a nucleic acid 630
        catalytic activity, acting on RNA 389
          RNA methyltransferase activity 63
            tRNA methyltransferase activity 31
              tRNA (adenine) methyltransferase activity + 3
              tRNA (cytidine) methyltransferase activity + 8
              tRNA (guanine) methyltransferase activity + 12
              tRNA (uridine) methyltransferase activity + 5
              tRNA 2'-O-methyltransferase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      transferase activity 2441
        transferase activity, transferring one-carbon groups 214
          methyltransferase activity 203
            RNA methyltransferase activity 63
              tRNA methyltransferase activity 31
                tRNA (adenine) methyltransferase activity + 3
                tRNA (cytidine) methyltransferase activity + 8
                tRNA (guanine) methyltransferase activity + 12
                tRNA (uridine) methyltransferase activity + 5
                tRNA 2'-O-methyltransferase activity 2
paths to the root