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ONTOLOGY REPORT - ANNOTATIONS

Term:L-type voltage-gated calcium channel complex
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Accession:GO:1990454 term browser browse the term
Definition:A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
Comment:Examples of this are CACNA1S, CACNA2D1, CACNB1, CACNG1 in rabbit (UniProt symbol P07293, P13806, P19517 and P19518) in PMID:12946355 (inferred from direct assay).
Synonyms:narrow_synonym: cardiac muscle L-type voltage-gated calcium channel complex;   skeletal muscle L-type voltage-gated calcium channel complex

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L-type voltage-gated calcium channel complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C part_of ISO PMID:15170217
(PMID:15454078)		 UniProt
BHF-UCL		 PMID:15170217 PMID:15454078 RGD:11558004 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D part_of ISO (PMID:1309651) BHF-UCL PMID:1309651 NCBI chrNW_004955430:3,450,151...3,796,983
Ensembl chrNW_004955430:3,268,953...3,794,592 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 part_of ISO (PMID:1309651)
PMID:25527503		 BHF-UCL PMID:1309651 PMID:25527503 RGD:11059598 NCBI chrNW_004955410:3,544,398...3,963,582
Ensembl chrNW_004955410:3,619,740...3,964,239 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 part_of ISO (PMID:1309651)
PMID:26680202		 BHF-UCL
UniProt		 PMID:1309651 PMID:26680202 RGD:12907551 NCBI chrNW_004955429:9,642,725...9,966,175
Ensembl chrNW_004955429:9,644,053...9,966,175 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 part_of ISO PMID:25527503
PMID:10666413
PMID:15170217		 BHF-UCL
UniProt		 PMID:10666413 PMID:15170217 PMID:25527503 RGD:11059598 RGD:11558004 RGD:13673808 NCBI chrNW_004955500:7,676,331...7,685,174
Ensembl chrNW_004955500:7,672,828...7,687,420 		JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 part_of ISO PMID:9049149 UniProt PMID:9049149 RGD:69791 NCBI chrNW_004955478:6,295,046...6,305,625
Ensembl chrNW_004955478:6,294,974...6,305,669 		JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 part_of ISO (PMID:21127204) UniProt PMID:21127204 NCBI chrNW_004955478:6,219,637...6,278,759
Ensembl chrNW_004955478:6,219,631...6,280,169 		JBrowse link
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 part_of ISO (PMID:21127204) UniProt PMID:21127204 NCBI chrNW_004955604:189,261...205,058
Ensembl chrNW_004955604:185,430...205,088 		JBrowse link
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 part_of ISO (PMID:21127204) UniProt PMID:21127204 NCBI chrNW_004955604:242,627...260,594
Ensembl chrNW_004955604:241,170...260,594 		JBrowse link
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 part_of ISO (MGI:6164122|PMID:21127204) UniProt PMID:21127204 MGI:6164122 NCBI chrNW_004955604:204,482...221,833 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12560
    cellular anatomical entity 12404
      T-tubule 72
        L-type voltage-gated calcium channel complex 10
Path 2
Term Annotations click to browse term
  cellular_component 12560
    cellular anatomical entity 12404
      membrane 5051
        membrane protein complex 879
          transmembrane transporter complex 312
            monoatomic ion channel complex 223
              cation channel complex 161
                calcium channel complex 56
                  voltage-gated calcium channel complex 36
                    L-type voltage-gated calcium channel complex 10
paths to the root