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ONTOLOGY REPORT - ANNOTATIONS

Term:uniplex complex
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Accession:GO:1990246 term browser browse the term
Definition:A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
Synonyms:exact_synonym: mitochondrial uniporter complex;   mitochondrial uniporter holocomplex

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uniplex complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MCU mitochondrial calcium uniporter part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 9:58,383,650...58,594,542
Ensembl chr 9:58,383,235...58,571,480 		JBrowse link
G MCUB mitochondrial calcium uniporter dominant negative subunit beta part_of IEA Ensembl GO_REF:0000107 NCBI chr 7:57,481,617...57,591,742
Ensembl chr 7:57,481,568...57,591,609 		JBrowse link
G MICU1 mitochondrial calcium uptake 1 part_of ISO (PMID:24231807), (PMID:24560927), (PMID:32667285), (PMID:32762847), (PMID:32862359)
(PMID:32494073)		 UniProt
ComplexPortal		 PMID:24231807 PMID:24560927 PMID:32494073 PMID:32667285 PMID:32762847 More... NCBI chr 9:58,685,604...58,941,954
Ensembl chr 9:58,685,644...58,944,928 		JBrowse link
G MICU2 mitochondrial calcium uptake 2 part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:1,610,488...1,713,679
Ensembl chr 3:1,609,320...1,713,644 		JBrowse link
G SMDT1 single-pass membrane protein with aspartate rich tail 1 part_of IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr19:24,616,590...24,620,294
Ensembl chr19:24,616,523...24,618,997 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17347
    protein-containing complex 5808
      mitochondrial protein-containing complex 244
        inner mitochondrial membrane protein complex 120
          uniplex complex 5
Path 2
Term Annotations click to browse term
  cellular_component 17347
    cellular anatomical entity 17246
      intracellular anatomical structure 13708
        intracellular organelle 12197
          intracellular membrane-bounded organelle 10879
            mitochondrion 1626
              mitochondrial envelope 701
                mitochondrial membrane 652
                  mitochondrial inner membrane 418
                    inner mitochondrial membrane protein complex 120
                      uniplex complex 5
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