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ONTOLOGY REPORT - ANNOTATIONS

Term:pH-gated monoatomic ion channel activity
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Accession:GO:0160128 term browser browse the term
Definition:Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).
Comment:While the term suggest this activity may be proton-gated, the mechanism of pH-gating for transporters is by protonation of specific residues in the protein, and not by H+ binding.
Synonyms:related_synonym: acid-sensing ion channel activity;   proton-gated ion channel activity
 xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol"


show annotations for term's descendants           Sort by:
pH-gated monoatomic ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic1 acid sensing ion channel subunit 1 enables
NOT|enables		 IDA
ISS
ISO
IBA		 PMID:11448963
GO_REF:0000024
(PMID:21036899)
(PMID:22760635)
(PMID:21036899), (PMID:24247984)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:21036899 PMID:22760635 PMID:24247984 PMID:11448963 GO_REF:0000024 GO_REF:0000033, RGD:70652 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Pkd1l3 polycystin 1 like 3, transient receptor potential channel interacting enables ISO (PMID:19464260), (PMID:22420714), (PMID:23212381)
(PMID:18535624), (PMID:20406802), (PMID:34381056)		 RGD PMID:18535624 PMID:19464260 PMID:20406802 PMID:22420714 PMID:23212381 More... NCBI chr19:37,585,564...37,650,083
Ensembl chr19:37,585,725...37,650,155 		JBrowse link
G Pkd2l1 polycystin 2 like 1, transient receptor potential cation channel enables ISO (PMID:23212381)
(PMID:16891422), (PMID:18535624), (PMID:19464260)		 RGD PMID:16891422 PMID:18535624 PMID:19464260 PMID:23212381 NCBI chr 1:243,032,891...243,070,031
Ensembl chr 1:243,032,913...243,070,031 		JBrowse link
pH-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp6 aquaporin 6 enables IDA PMID:10647010 UniProt PMID:10647010 RGD:408345219 NCBI chr 7:130,732,216...130,735,149
Ensembl chr 7:130,633,579...130,735,194
Ensembl chr 7:130,633,579...130,735,194 		JBrowse link
G Pacc1 proton activated chloride channel 1 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:31023925)
GO_REF:0000107
(PMID:31023925), (PMID:31318332)		 UniProt
RGD
Ensembl		 PMID:31023925 PMID:31318332 GO_REF:0000024 GO_REF:0000107 NCBI chr13:102,904,668...102,929,770
Ensembl chr13:102,894,612...102,929,770 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    transporter activity 1253
      transmembrane transporter activity 1153
        monoatomic ion transmembrane transporter activity 762
          monoatomic ion channel activity 451
            ligand-gated monoatomic ion channel activity 185
              pH-gated monoatomic ion channel activity 6
                pH-gated calcium channel activity 0
                pH-gated chloride channel activity 2
                pH-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  molecular_function 20634
    transporter activity 1253
      transmembrane transporter activity 1153
        passive transmembrane transporter activity 511
          channel activity 511
            gated channel activity 334
              ligand-gated channel activity 190
                ligand-gated monoatomic ion channel activity 185
                  pH-gated monoatomic ion channel activity 6
                    pH-gated calcium channel activity 0
                    pH-gated chloride channel activity 2
                    pH-gated sodium channel activity 0
paths to the root