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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta complex
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Accession:GO:0106003 term browser browse the term
Definition:Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease.
Comment:An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay).
Synonyms:exact_synonym: Abeta complex;   betaA complex
 narrow_synonym: ADDL complex;   Abeta-derived diffusible ligand complex;   amyloid beta dimer;   amyloid beta heterodimer;   amyloid beta heterooligomer;   amyloid beta heterotrimer;   amyloid beta homodimer;   amyloid beta homooligomer;   amyloid beta homotrimer;   amyloid beta oligomer;   amyloid beta trimer;   amyloid-beta protein 40 complex;   amyloid-beta protein 40/42 complex;   amyloid-beta protein 42 complex;   heterodimer of amyloid beta protein;   heterooligomer of amyloid beta protein;   heterotrimer of amyloid beta protein;   homodimer of amyloid beta protein;   homooligomer of amyloid beta protein;   homotrimer of amyloid beta protein


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amyloid-beta complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein part_of ISO (PMID:23640054)
UniProtKB:P05067-PRO_0000000093 (PMID:22179788)
UniProtKB:P05067-PRO_0000000092 (PMID:23386614)		 RGD PMID:22179788 PMID:23386614 PMID:23640054 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
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  cellular_component 20629
    protein-containing complex 6604
      amyloid-beta complex 2
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