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ONTOLOGY REPORT - ANNOTATIONS

Term:R2TP complex
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Accession:GO:0097255 term browser browse the term
Definition:A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.


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R2TP complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pih1d1 PIH1 domain containing 1 part_of
located_in		 ISO
IBA		 (PMID:21078300), (PMID:26711270)
GO_REF:0000033
(PMID:29662061)		 RGD
GO_Central		 PMID:21078300 PMID:26711270 PMID:29662061 GO_REF:0000033 NCBI chr 1:95,639,597...95,645,295
Ensembl chr 1:95,639,592...95,645,290 		JBrowse link
G Pih1d2 PIH1 domain containing 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:50,966,885...50,976,901
Ensembl chr 8:50,966,885...50,975,656 		JBrowse link
G Rpap3 RNA polymerase II associated protein 3 part_of
located_in		 ISO
IEA		 (PMID:26711270)
GO_REF:0000107
(PMID:29662061)		 RGD
Ensembl		 PMID:26711270 PMID:29662061 GO_REF:0000107 NCBI chr 7:128,810,820...128,840,006
Ensembl chr 7:128,810,827...128,839,950 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 part_of
located_in		 ISO
IBA
ISS		 (PMID:26711270), (PMID:33367824)
GO_REF:0000033
GO_REF:0000024
(PMID:29662061)		 RGD
GO_Central
UniProt		 PMID:26711270 PMID:29662061 PMID:33367824 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384 		JBrowse link
G Ruvbl1-ps1 RuvB-like AAA ATPase 1, pseudogene 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:1,640,138...1,641,886
Ensembl chr  X:1,640,300...1,641,811 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 part_of
located_in		 ISO
IBA		 (PMID:26711270), (PMID:33367824)
GO_REF:0000033
(PMID:29662061)		 RGD
GO_Central		 PMID:26711270 PMID:29662061 PMID:33367824 GO_REF:0000033 NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
Term paths to the root
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  cellular_component 20624
    protein-containing complex 6602
      R2TP complex 6
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