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ONTOLOGY REPORT - ANNOTATIONS

Term:adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
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Accession:GO:0086030 term browser browse the term
Definition:An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.
Synonyms:exact_synonym: Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation;   adrenergic receptor signaling pathway involved in cardiac muscle relaxation
 related_synonym: adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC;   adrenergic receptor-induced cardiac relaxation

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adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G N Chga chromogranin A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624734:9,405,121...9,416,774
Ensembl chrNW_004624734:9,404,916...9,416,902 		JBrowse link
G G CHGA chromogranin A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr24:70,663,040...70,675,827
Ensembl chr24:70,663,298...70,677,116 		JBrowse link
G S Chga chromogranin A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936733:915,700...927,220
Ensembl chrNW_004936733:915,830...927,409 		JBrowse link
G B CHGA chromogranin A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:73,555,834...73,568,547
Ensembl chr14:92,895,450...92,908,159 		JBrowse link
G M Chga chromogranin A involved_in IBA
ISO		 GO_Central GO_REF:0000033 GO_REF:0000096 NCBI chr12:102,521,200...102,531,286
Ensembl chr12:102,521,228...102,531,287 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 197563
    cellular process 182324
      signal transduction 61122
        G protein-coupled receptor signaling pathway 16268
          G protein-coupled receptor signaling pathway involved in heart process 77
            adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 15
              adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation 5
Path 2
Term Annotations click to browse term
  biological_process 197563
    biological regulation 122827
      regulation of biological process 118967
        signaling 66462
          signal transduction 61122
            G protein-coupled receptor signaling pathway 16268
              adenylate cyclase-modulating G protein-coupled receptor signaling pathway 2560
                adenylate cyclase-activating G protein-coupled receptor signaling pathway 1795
                  adenylate cyclase-activating adrenergic receptor signaling pathway 222
                    adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 15
                      adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation 5
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