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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H3K27me2/H3K27me3 demethylase activity
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Accession:GO:0071558 term browser browse the term
Definition:Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Synonyms:exact_synonym: histone H3-tri/di-methyl-lysine-27 demethylase activity
 broad_synonym: histone demethylase activity (H3-K27 specific)
 related_synonym: histone H3K27me2 demethylase activity;   histone H3K27me3 demethylase activity
 xref: EC:1.14.11.68;   RHEA:60224;   Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter";   Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)";   Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)";   reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin";   reactome:R-HSA-5617887 "HOXC4 chromatin is activated"

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histone H3K27me2/H3K27me3 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624887:1,065,173...1,279,660
Ensembl chrNW_004624887:1,065,883...1,279,186 		JBrowse link
G Kdm6b lysine demethylase 6B enables ISO (PMID:17928865), (PMID:18716661)
(MGI:5574281|PMID:23856522)
(PMID:28262558)		 MGI
BHF-UCL
UniProt		 PMID:17928865 PMID:18716661 PMID:23856522 PMID:28262558 MGI:5574281 NCBI chrNW_004624786:10,413,670...10,435,118
Ensembl chrNW_004624786:10,425,816...10,433,806 		JBrowse link
G Kdm7a lysine demethylase 7A enables ISO (PMID:20023638), (PMID:20194436), (PMID:20622853)
(MGI:4437342|PMID:20194436)		 UniProt PMID:20023638 PMID:20194436 PMID:20622853 MGI:4437342 NCBI chrNW_004624765:20,370,492...20,448,969
Ensembl chrNW_004624765:20,376,684...20,449,026 		JBrowse link
G Phf8 PHD finger protein 8 enables ISO (PMID:20622853), (PMID:20622854) UniProt PMID:20622853 PMID:20622854 NCBI chrNW_004624909:1,481,710...1,639,840 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16311
    catalytic activity 5058
      oxidoreductase activity 630
        dioxygenase activity 85
          2-oxoglutarate-dependent dioxygenase activity 58
            histone H3K27me2/H3K27me3 demethylase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 16311
    catalytic activity 5058
      demethylase activity 36
        protein demethylase activity 27
          histone demethylase activity 27
            histone H3 demethylase activity 24
              histone H3K27me2/H3K27me3 demethylase activity 4
paths to the root