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ONTOLOGY REPORT - ANNOTATIONS


Term:histone H3 demethylase activity
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Accession:GO:0141052 term browser browse the term
Definition:Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.



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FAD-dependent H3K4me/H3K4me3 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A enables ISO
IBA
(PMID:24843136)
GO_REF:0000033
(PMID:20228790), (PMID:27292636)
RGD
GO_Central
PMID:20228790 PMID:24843136 PMID:27292636 GO_REF:0000033 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Kdm1b lysine demethylase 1B enables ISO (PMID:23260659), (PMID:23266887), (PMID:23357850)
(PMID:19407342), (PMID:19727073)
(PMID:30970244)
RGD PMID:19407342 PMID:19727073 PMID:23260659 PMID:23266887 PMID:23357850 More... NCBI chr17:17,602,961...17,643,865
Ensembl chr17:17,602,961...17,643,800
JBrowse link
FAD-dependent histone H3K9me/H3K9me2 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hr HR, lysine demethylase and nuclear receptor corepressor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:52,036,540...52,056,019
Ensembl chr15:45,626,835...45,646,313
JBrowse link
G Kdm3a lysine demethylase 3A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:103,630,908...103,675,073
JBrowse link
histone H3K27me2/H3K27me3 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A enables IBA
ISO
GO_REF:0000033
(PMID:22949634)
GO_Central
RGD
PMID:22949634 GO_REF:0000033 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062
JBrowse link
G Kdm6b lysine demethylase 6B enables ISO
IBA
(PMID:28262558)
(PMID:17928865), (PMID:18716661), (PMID:23856522)
GO_REF:0000033
RGD
GO_Central
PMID:17928865 PMID:18716661 PMID:23856522 PMID:28262558 GO_REF:0000033 NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,121,848...54,130,794
JBrowse link
G Kdm7a lysine demethylase 7A enables ISO (PMID:20023638), (PMID:20194436), (PMID:20622853)
(PMID:20194436)
RGD PMID:20023638 PMID:20194436 PMID:20622853 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Phf8 PHD finger protein 8 enables ISO (PMID:20622853), (PMID:20622854) RGD PMID:20622853 PMID:20622854 NCBI chr  X:20,524,103...20,623,459
Ensembl chr  X:20,524,558...20,623,410
JBrowse link
G Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  Y:1,018,111...1,178,493
Ensembl chr  Y:924,168...1,103,422
JBrowse link
histone H3K36 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm2a lysine demethylase 2A enables ISO (PMID:20417597), (PMID:21187428), (PMID:28262558) RGD PMID:20417597 PMID:21187428 PMID:28262558 NCBI chr 1:211,041,859...211,125,749
Ensembl chr 1:201,612,453...201,680,787
JBrowse link
G Kdm2b lysine demethylase 2B enables ISO (PMID:26237645)
(PMID:21540074)
RGD PMID:21540074 PMID:26237645 NCBI chr12:39,224,422...39,362,126
Ensembl chr12:33,574,657...33,701,355
JBrowse link
G Kdm4a lysine demethylase 4A enables ISO
IBA
(PMID:16024779), (PMID:21914792)
GO_REF:0000033
RGD
GO_Central
PMID:16024779 PMID:21914792 GO_REF:0000033 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
JBrowse link
G Kdm4b lysine demethylase 4B enables ISO (PMID:21914792)
(PMID:16738407)
RGD PMID:16738407 PMID:21914792 NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,158,752...1,236,543
JBrowse link
G Kdm4c lysine demethylase 4C enables ISO
IBA
(PMID:21914792)
GO_REF:0000033
RGD
GO_Central
PMID:21914792 GO_REF:0000033 NCBI chr 5:93,146,404...93,353,040
Ensembl chr 5:88,100,733...88,306,818
JBrowse link
G Kdm7a lysine demethylase 7A enables ISO (PMID:20622853) RGD PMID:20622853 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Kdm8 lysine demethylase 8 enables ISO
IBA
IEA
ISS
(PMID:20457893)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
RGD
GO_Central
Ensembl
UniProt
PMID:20457893 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:189,444,527...189,459,507
Ensembl chr 1:180,020,656...180,028,841
JBrowse link
G Phf8 PHD finger protein 8 enables ISO (PMID:20208542), (PMID:20622853) RGD PMID:20208542 PMID:20622853 NCBI chr  X:20,524,103...20,623,459
Ensembl chr  X:20,524,558...20,623,410
JBrowse link
G Riox1 ribosomal oxygenase 1 enables IBA
ISO
GO_REF:0000033
(PMID:19927124)
GO_Central
RGD
PMID:19927124 GO_REF:0000033 NCBI chr 6:103,579,642...103,582,260
Ensembl chr 6:103,579,642...103,582,250
JBrowse link
G Riox2 ribosomal oxygenase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
JBrowse link
G Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked enables ISO (PMID:22192413) RGD PMID:22192413 NCBI chr  Y:1,018,111...1,178,493
Ensembl chr  Y:924,168...1,103,422
JBrowse link
histone H3K36me/H3K36me2 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Riox1 ribosomal oxygenase 1 enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr 6:103,579,642...103,582,260
Ensembl chr 6:103,579,642...103,582,250
JBrowse link
histone H3K4 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A enables ISO (PMID:24217620)
(PMID:15620353), (PMID:24217620), (PMID:27292636)
RGD PMID:15620353 PMID:24217620 PMID:27292636 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Kdm1b lysine demethylase 1B enables ISO (PMID:19407342), (PMID:19727073) RGD PMID:19407342 PMID:19727073 NCBI chr17:17,602,961...17,643,865
Ensembl chr17:17,602,961...17,643,800
JBrowse link
G Kdm5a lysine demethylase 5A enables ISO (PMID:18483221) RGD PMID:18483221 NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:153,565,846...153,642,422
JBrowse link
G Kdm5b lysine demethylase 5B enables ISO (PMID:18048344), (PMID:24952722), (PMID:27214403), (PMID:28262558)
(PMID:17320160)
RGD PMID:17320160 PMID:18048344 PMID:24952722 PMID:27214403 PMID:28262558 NCBI chr13:48,554,367...48,625,721
Ensembl chr13:46,002,542...46,073,872
JBrowse link
G Kdm5c lysine demethylase 5C enables ISO (PMID:17320160), (PMID:18078810), (PMID:28262558)
(PMID:23246292)
RGD PMID:17320160 PMID:18078810 PMID:23246292 PMID:28262558 NCBI chr  X:21,345,459...21,387,045
Ensembl chr  X:21,345,481...21,381,870
JBrowse link
G Kdm5d lysine demethylase 5D enables ISO (PMID:17320160) RGD PMID:17320160 NCBI chr  Y:551,621...647,742
Ensembl chr  Y:530,401...624,018
JBrowse link
G Riox1 ribosomal oxygenase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:103,579,642...103,582,260
Ensembl chr 6:103,579,642...103,582,250
JBrowse link
G Riox2 ribosomal oxygenase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
JBrowse link
histone H3K4me/H3K4me2/H3K4me3 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1b lysine demethylase 1B NOT|enables ISO (PMID:19407342), (PMID:19727073) RGD PMID:19407342 PMID:19727073 NCBI chr17:17,602,961...17,643,865
Ensembl chr17:17,602,961...17,643,800
JBrowse link
G Kdm5a lysine demethylase 5A enables ISO
IBA
(PMID:18270511)
GO_REF:0000033
RGD
GO_Central
PMID:18270511 GO_REF:0000033 NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:153,565,846...153,642,422
JBrowse link
G Kdm5b lysine demethylase 5B enables ISO
IBA
(PMID:20228790), (PMID:20403335)
GO_REF:0000033
RGD
GO_Central
PMID:20228790 PMID:20403335 GO_REF:0000033 NCBI chr13:48,554,367...48,625,721
Ensembl chr13:46,002,542...46,073,872
JBrowse link
G Kdm5c lysine demethylase 5C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:21,345,459...21,387,045
Ensembl chr  X:21,345,481...21,381,870
JBrowse link
G Kdm5d lysine demethylase 5D enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  Y:551,621...647,742
Ensembl chr  Y:530,401...624,018
JBrowse link
G Riox1 ribosomal oxygenase 1 enables ISO (PMID:19927124) RGD PMID:19927124 NCBI chr 6:103,579,642...103,582,260
Ensembl chr 6:103,579,642...103,582,250
JBrowse link
histone H3K9 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hr HR, lysine demethylase and nuclear receptor corepressor enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr15:52,036,540...52,056,019
Ensembl chr15:45,626,835...45,646,313
JBrowse link
G Jmjd1c jumonji domain containing 1C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:21,330,990...21,508,580
Ensembl chr20:21,332,147...21,463,122
JBrowse link
G Kdm1a lysine demethylase 1A enables ISO (PMID:16079795), (PMID:20228790) RGD PMID:16079795 PMID:20228790 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Kdm3a lysine demethylase 3A enables ISO
IBA
IEA
(PMID:28262558)
GO_REF:0000033
MGI:3764891 (PMID:17938240), (PMID:17943087), (PMID:17991879)
GO_REF:0000002
RGD
GO_Central
InterPro
PMID:17938240 PMID:17943087 PMID:17991879 PMID:28262558 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:103,630,908...103,675,073
JBrowse link
G Kdm3b lysine demethylase 3B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:26,655,004...26,710,814
Ensembl chr18:26,380,964...26,436,628
JBrowse link
G Kdm4a lysine demethylase 4A enables IBA
ISO
GO_REF:0000033
(PMID:16738407)
GO_Central
RGD
PMID:16738407 GO_REF:0000033 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
JBrowse link
G Kdm4b lysine demethylase 4B enables ISO
IBA
(PMID:28262558)
(PMID:16738407)
GO_REF:0000033
RGD
GO_Central
PMID:16738407 PMID:28262558 GO_REF:0000033 NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,158,752...1,236,543
JBrowse link
G Kdm4c lysine demethylase 4C enables ISO
IBA
(PMID:18066052), (PMID:28262558)
(PMID:16738407), (PMID:17938240)
GO_REF:0000033
RGD
GO_Central
PMID:16738407 PMID:17938240 PMID:18066052 PMID:28262558 GO_REF:0000033 NCBI chr 5:93,146,404...93,353,040
Ensembl chr 5:88,100,733...88,306,818
JBrowse link
G Kdm4d lysine demethylase 4D enables ISO
IBA
(PMID:25124442)
MGI:5051955 (PMID:16738407), (PMID:21293030), (PMID:24550317)
GO_REF:0000033
RGD
GO_Central
PMID:16738407 PMID:21293030 PMID:24550317 PMID:25124442 GO_REF:0000033 NCBI chr 8:11,279,756...11,304,920
Ensembl chr 8:11,268,859...11,305,290
JBrowse link
G Kdm7a lysine demethylase 7A enables ISO (PMID:20023638), (PMID:20194436), (PMID:20622853)
(PMID:20194436)
RGD PMID:20023638 PMID:20194436 PMID:20622853 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Phf2 PHD finger protein 2 enables ISO (PMID:21532585) RGD PMID:21532585 NCBI chr17:15,783,221...15,851,209
Ensembl chr17:15,781,864...15,851,208
JBrowse link
G Phf8 PHD finger protein 8 enables ISO (PMID:20023638), (PMID:20208542), (PMID:20346720), (PMID:20622853), (PMID:20622854) RGD PMID:20023638 PMID:20208542 PMID:20346720 PMID:20622853 PMID:20622854 NCBI chr  X:20,524,103...20,623,459
Ensembl chr  X:20,524,558...20,623,410
JBrowse link
histone H3K9me/H3K9me2 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hr HR, lysine demethylase and nuclear receptor corepressor enables IEA GO_REF:0000003
GO_REF:0000116
UniProt
RHEA
GO_REF:0000003 GO_REF:0000116 NCBI chr15:52,036,540...52,056,019
Ensembl chr15:45,626,835...45,646,313
JBrowse link
G Kdm3a lysine demethylase 3A enables ISO
IEA
(PMID:16603237)
GO_REF:0000107
RGD
Ensembl
PMID:16603237 GO_REF:0000107 NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:103,630,908...103,675,073
JBrowse link
histone H3K9me2/H3K9me3 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A enables ISO (PMID:20833138) RGD PMID:20833138 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Kdm4a lysine demethylase 4A enables ISO (PMID:21914792) RGD PMID:21914792 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
JBrowse link
G Kdm4b lysine demethylase 4B enables ISO (PMID:21914792) RGD PMID:21914792 NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,158,752...1,236,543
JBrowse link
G Kdm4c lysine demethylase 4C enables ISO (PMID:17277772), (PMID:21914792) RGD PMID:17277772 PMID:21914792 NCBI chr 5:93,146,404...93,353,040
Ensembl chr 5:88,100,733...88,306,818
JBrowse link
G Kdm4d lysine demethylase 4D enables ISO (PMID:21914792) RGD PMID:21914792 NCBI chr 8:11,279,756...11,304,920
Ensembl chr 8:11,268,859...11,305,290
JBrowse link
histone H3R2 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase enables ISO
IEA
ISS
(PMID:17947579)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17947579 GO_REF:0000024 GO_REF:0000107 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,041,120...102,047,182
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      demethylase activity 42
        protein demethylase activity 30
          histone demethylase activity 30
            histone H3 demethylase activity 26
              histone H3K27me2/H3K27me3 demethylase activity 5
              histone H3K36 demethylase activity + 11
              histone H3K4 demethylase activity + 8
              histone H3K56me2/H3K56me3 demethylase activity 0
              histone H3K9 demethylase activity + 12
              histone H3R2 demethylase activity 1
paths to the root