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Ontology Browser
Term:
histone H3K27me2/H3K27me3 demethylase activity (GO:0071558)
Annotations: Rat: (5) Mouse: (5) Human: (5) Chinchilla: (4) Bonobo: (4) Dog: (5) Squirrel: (4) Pig: (4) Naked Mole-rat: (4) Green Monkey: (4)
Parent Terms Term With Siblings Child Terms
2'-deoxymugineic-acid 2'-dioxygenase activity 
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity 
2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity 
4-coumaroyl 2'-hydroxylase activity 
5-methylcytosine dioxygenase activity  
6-beta-hydroxyhyoscyamine epoxidase activity 
[protein]-asparagine 3-dioxygenase activity  
broad specificity oxidative DNA demethylase activity  
clavaminate synthase activity 
codeine O-demethylase activity 
deacetoxycephalosporin-C hydroxylase activity 
deoxyuridine 1'-dioxygenase activity 
deoxyuridine 2'-dioxygenase activity 
desacetoxyvindoline 4-hydroxylase activity 
flavanone 3-dioxygenase activity 
flavone synthase activity 
flavonol synthase activity 
gamma-butyrobetaine dioxygenase activity  
gibberellin 2-beta-dioxygenase activity 
gibberellin 20-oxidase activity 
gibberellin 3-beta-dioxygenase activity 
glutarate dioxygenase activity 
histone H3K27me2/H3K27me3 demethylase activity  
Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
histone H3K36 demethylase activity +   
histone H3K4 demethylase activity +   
histone H3K4me/H3K4me2/H3K4me3 demethylase activity  
histone H3K56me2/H3K56me3 demethylase activity 
histone H3K9 demethylase activity +   
histone H3K9me/H3K9me2 demethylase activity  
histone H3K9me2/H3K9me3 demethylase activity  
histone H3R2 demethylase activity  
histone H4K20 demethylase activity  
histone H4R3 demethylase activity  
hyoscyamine (6S)-dioxygenase activity 
L-gamma-glutamyl-L-propargylglycine hydroxylase activity 
leucocyanidin oxygenase activity 
mugineic-acid 3-dioxygenase activity 
oxidative RNA demethylase activity +   
peptidyl-arginine 3-dioxygenase activity  
peptidyl-aspartic acid 3-dioxygenase activity  
peptidyl-histidine dioxygenase activity  
peptidyl-lysine 3-dioxygenase activity  
peptidyl-lysine 4-dioxygenase activity  
peptidyl-lysine 5-dioxygenase activity +   
peptidyl-proline dioxygenase activity +   
phytanoyl-CoA dioxygenase activity  
proline 3-hydroxylase activity 
sulfonate dioxygenase activity 
taurine dioxygenase activity 
thebaine 6-O-demethylase activity 
thymine dioxygenase activity 
trimethyllysine dioxygenase activity  
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity  

Synonyms
Exact Synonyms: histone H3-tri/di-methyl-lysine-27 demethylase activity
Broad Synonyms: histone demethylase activity (H3-K27 specific)
Related Synonyms: histone H3K27me2 demethylase activity ;   histone H3K27me3 demethylase activity
Xrefs: EC:1.14.11.68 ;   RHEA:60224 ;   Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter" ;   Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)" ;   Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)" ;   reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin" ;   reactome:R-HSA-5617887 "HOXC4 chromatin is activated"
Definition Sources: GOC:sp, PMID:20622853

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