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ONTOLOGY REPORT - ANNOTATIONS

Term:NF-kappaB complex
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Accession:GO:0071159 term browser browse the term
Definition:A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.


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NF-kappaB complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rela RELA proto-oncogene, NF-kB subunit part_of ISO (PMID:8246997) RGD PMID:8246997 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps3 ribosomal protein S3 part_of ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
NF-kappaB p50/p65 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor kappa B subunit 1 part_of IEA
ISO		 GO_REF:0000107
(PMID:2001591)		 Ensembl
RGD		 PMID:2001591 GO_REF:0000107 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit part_of ISO
IBA		 (PMID:18045535)
GO_REF:0000033
(PMID:2001591)		 RGD
GO_Central		 PMID:2001591 PMID:18045535 GO_REF:0000033 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20827
    protein-containing complex 6555
      nuclear protein-containing complex 1275
        NF-kappaB complex 3
          NF-kappaB p50/p65 complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20827
    cellular anatomical structure 20627
      organelle 13970
        membrane-bounded organelle 12557
          intracellular membrane-bounded organelle 12005
            nucleus 7451
              nuclear protein-containing complex 1275
                NF-kappaB complex 3
                  NF-kappaB p50/p65 complex 2
paths to the root