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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
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Accession:GO:0070478 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
Synonyms:exact_synonym: 3'-5' NMD;   3'-5' nonsense-mediated decay;   3'-5' nonsense-mediated mRNA decay;   nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay;   nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay;   nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay


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nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Skic2 SKI2 subunit of superkiller complex involved_in ISS
ISO
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr17:35,058,202...35,069,180
Ensembl chr17:35,058,204...35,069,186 		JBrowse link
G Skic3 SKI3 subunit of superkiller complex involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr13:76,246,837...76,338,437
Ensembl chr13:76,246,853...76,338,435 		JBrowse link
G Skic8 SKI8 subunit of superkiller complex involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 9:54,624,437...54,641,833
Ensembl chr 9:54,622,019...54,641,803 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18392
      metabolic process 11624
        macromolecule metabolic process 9569
          nucleic acid metabolic process 5155
            RNA metabolic process 4608
              RNA catabolic process 420
                mRNA catabolic process 363
                  nuclear-transcribed mRNA catabolic process 128
                    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 48
                      nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay 3
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13450
      regulation of biological process 13009
        regulation of cellular process 12632
          negative regulation of cellular process 5852
            negative regulation of metabolic process 3351
              negative regulation of biosynthetic process 2686
                negative regulation of macromolecule biosynthetic process 2590
                  negative regulation of gene expression 1530
                    mRNA catabolic process 363
                      nuclear-transcribed mRNA catabolic process 128
                        nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 48
                          nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay 3
paths to the root