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ONTOLOGY REPORT - ANNOTATIONS

Term:SUMO ligase activity
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Accession:GO:0061665 term browser browse the term
Definition:Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.
Synonyms:related_synonym: E3
 xref: Reactome:R-HSA-9834809 "SUMOylation of PKR";   Reactome:R-HSA-9842868 "TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2"


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SUMO ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBX4 chromobox 4 enables IDA
IBA		 (PMID:27068747) UniProt
GO_Central		 PMID:27068747 GO_REF:0000033 NCBI chr17:79,833,156...79,839,440
Ensembl chr17:79,833,156...79,839,440 		JBrowse link
G EGR2 early growth response 2 enables ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167 		JBrowse link
G KIAA1586 KIAA1586 enables IDA
IBA		 (PMID:26524493) UniProt
GO_Central		 PMID:26524493 GO_REF:0000033 NCBI chr 6:57,046,693...57,066,898
Ensembl chr 6:57,046,532...57,059,041 		JBrowse link
G NSMCE2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase enables IBA GO_Central GO_REF:0000033 NCBI chr 8:125,091,860...125,367,120
Ensembl chr 8:125,091,679...125,367,125 		JBrowse link
G PIAS1 protein inhibitor of activated STAT 1 enables IEA
IBA
IDA		 (PMID:18579533), (PMID:27068747), (PMID:36050397) Ensembl
GO_Central
UniProt		 PMID:18579533 PMID:27068747 PMID:36050397 GO_REF:0000033 GO_REF:0000107 NCBI chr15:68,054,315...68,193,847
Ensembl chr15:68,054,309...68,198,603 		JBrowse link
G PIAS2 protein inhibitor of activated STAT 2 enables IDA
IBA		 (PMID:18579533), (PMID:20408817) ParkinsonsUK-UCL
GO_Central		 PMID:18579533 PMID:20408817 GO_REF:0000033 NCBI chr18:46,803,218...46,920,145
Ensembl chr18:46,803,218...46,920,160 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:145,848,522...145,859,081
Ensembl chr 1:145,848,522...145,859,836 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 enables IEA
IBA
IDA		 (PMID:18579533), (PMID:32832608), (PMID:34048572), (PMID:35013556) Ensembl
GO_Central
BHF-UCL		 PMID:18579533 PMID:32832608 PMID:34048572 PMID:35013556 GO_REF:0000033 GO_REF:0000107 NCBI chr19:4,007,736...4,039,386
Ensembl chr19:4,007,736...4,039,386 		JBrowse link
G RANBP2 RAN binding protein 2 enables IDA (PMID:17264123) UniProt PMID:17264123 NCBI chr 2:108,719,482...109,842,301
Ensembl chr 2:108,719,482...108,785,810 		JBrowse link
G ZBED1 zinc finger BED-type containing 1 enables IDA (PMID:27068747) UniProt PMID:27068747 NCBI chr  X:2,486,435...2,500,976
NCBI chr  Y:2,486,435...2,500,976
Ensembl chr  Y:2,486,414...2,500,976
Ensembl chr  X:2,486,414...2,500,976 		JBrowse link
G ZMIZ1 zinc finger MIZ-type containing 1 enables IBA GO_Central GO_REF:0000033 NCBI chr10:79,068,966...79,316,519
Ensembl chr10:79,068,966...79,316,519 		JBrowse link
G ZMIZ2 zinc finger MIZ-type containing 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:44,748,571...44,769,881
Ensembl chr 7:44,748,581...44,769,881 		JBrowse link
G ZNF451 zinc finger protein 451 enables IDA
IBA		 (PMID:26524494) UniProt
GO_Central		 PMID:26524494 GO_REF:0000033 NCBI chr 6:57,090,188...57,170,305
Ensembl chr 6:57,086,844...57,170,305 		JBrowse link
SUMO-ubiquitin ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRIM60 tripartite motif containing 60 enables IDA (PMID:33184450) UniProt PMID:33184450 NCBI chr 4:165,031,999...165,041,749
Ensembl chr 4:165,016,458...165,041,749 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6023
      catalytic activity, acting on a protein 2462
        ubiquitin-like protein transferase activity 497
          SUMO transferase activity 29
            SUMO ligase activity 14
              SUMO-ubiquitin ligase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6023
      transferase activity 2450
        acyltransferase activity 759
          aminoacyltransferase activity 515
            ubiquitin-like protein transferase activity 497
              ubiquitin-like protein ligase activity 387
                SUMO ligase activity 14
                  SUMO-ubiquitin ligase activity 1
paths to the root