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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195 		JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr10:49,299,698...49,314,533
Ensembl chr10:49,299,897...49,314,457 		JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr 1:109,284,729...109,294,491
Ensembl chr 1:109,286,155...109,294,391 		JBrowse link
G CASQ2 calsequestrin 2 involved_in IDA (PMID:15041652) BHF-UCL PMID:15041652 NCBI chr17:53,233,966...53,299,093
Ensembl chr17:53,224,438...53,299,708 		JBrowse link
G CLIC2 chloride intracellular channel 2 involved_in ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738 PMID:15916532 NCBI chr  X:123,268,867...123,291,467
Ensembl chr  X:123,268,867...123,291,467 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (PMID:17404231) MGI PMID:17404231 NCBI chr32:11,383,441...11,437,603
Ensembl chr32:11,383,424...11,435,438 		JBrowse link
G SRI sorcin involved_in ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr14:14,257,375...14,274,816
Ensembl chr14:14,260,052...14,274,801 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17101
    cellular process 16595
      positive regulation of cellular process 6091
        positive regulation of sequestering of calcium ion 18
          negative regulation of release of sequestered calcium ion into cytosol 16
            negative regulation of ryanodine-sensitive calcium-release channel activity 8
Path 2
Term Annotations click to browse term
  biological_process 17101
    homeostatic process 1910
      chemical homeostasis 1134
        monoatomic ion homeostasis 617
          intracellular monoatomic ion homeostasis 533
            intracellular monoatomic cation homeostasis 520
              intracellular calcium ion homeostasis 308
                sequestering of calcium ion 129
                  regulation of sequestering of calcium ion 127
                    negative regulation of sequestering of calcium ion 125
                      release of sequestered calcium ion into cytosol 125
                        regulation of release of sequestered calcium ion into cytosol 87
                          negative regulation of release of sequestered calcium ion into cytosol 16
                            negative regulation of ryanodine-sensitive calcium-release channel activity 8
paths to the root