CALM2 (calmodulin 2) - Rat Genome Database

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Gene: CALM2 (calmodulin 2) Canis lupus familiaris
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Symbol: CALM2
Name: calmodulin 2
RGD ID: 12122940
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); calcium ion binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); autophagosome membrane docking (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH cannabis abuse (ortholog); Cocaine-Related Disorders (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); growth cone (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: calmodulin; calmodulin-2; CaMII
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100688103   LOC610013  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,299,698 - 49,314,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,152,937 - 49,167,816 (-)NCBI
ROS_Cfam_1.01050,169,941 - 50,184,842 (-)NCBI
UMICH_Zoey_3.11049,877,637 - 49,892,535 (-)NCBI
UNSW_CanFamBas_1.01050,167,136 - 50,182,012 (-)NCBI
UU_Cfam_GSD_1.01050,351,274 - 50,366,152 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (ISO)
calcium-mediated signaling  (ISO)
detection of calcium ion  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of calcium ion export across plasma membrane  (ISO)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of high voltage-gated calcium channel activity  (IEA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
organelle localization by membrane tethering  (ISO)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of protein dephosphorylation  (ISO)
positive regulation of ryanodine-sensitive calcium-release channel activity  (IBA)
regulation of calcium-mediated signaling  (ISO)
regulation of cardiac muscle cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cyclase activity  (IEA)
regulation of cytokinesis  (IEA)
regulation of heart rate  (IEA)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
substantia nigra development  (ISO)

References

Genomics

Comparative Map Data
CALM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,299,698 - 49,314,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,152,937 - 49,167,816 (-)NCBI
ROS_Cfam_1.01050,169,941 - 50,184,842 (-)NCBI
UMICH_Zoey_3.11049,877,637 - 49,892,535 (-)NCBI
UNSW_CanFamBas_1.01050,167,136 - 50,182,012 (-)NCBI
UU_Cfam_GSD_1.01050,351,274 - 50,366,152 (-)NCBI
CALM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl247,160,083 - 47,176,921 (-)EnsemblGRCh38hg38GRCh38
GRCh38247,160,082 - 47,176,936 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37247,387,221 - 47,404,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,240,809 - 47,257,154 (-)NCBINCBI36hg18NCBI36
Build 34247,298,955 - 47,315,301NCBI
Celera247,226,054 - 47,242,551 (-)NCBI
Cytogenetic Map2p21NCBI
HuRef247,124,359 - 47,140,853 (-)NCBIHuRef
CHM1_1247,317,465 - 47,333,922 (-)NCBICHM1_1
Calm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,740,829 - 87,754,363 (-)NCBIGRCm39mm39
GRCm39 Ensembl1787,740,840 - 87,754,363 (-)Ensembl
GRCm381787,433,401 - 87,446,935 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,433,412 - 87,446,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371787,832,741 - 87,846,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361787,341,743 - 87,355,168 (-)NCBImm8
Celera1791,831,455 - 91,844,939 (-)NCBICelera
Cytogenetic Map17E4NCBI
Calm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,091,624 - 7,104,284 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)Ensembl
Rnor_6.0611,067,675 - 11,080,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1565,506,874 - 65,507,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,052,945 - 21,068,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4664,161,641 - 64,162,751 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11564,177,420 - 64,178,531 (-)NCBI
Celera66,842,934 - 6,855,590 (+)NCBICelera
Cytogenetic Map6q12NCBI
Calm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544113,973,147 - 13,988,665 (-)NCBIChiLan1.0ChiLan1.0
CALM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A48,204,518 - 48,220,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,204,518 - 48,220,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A47,274,722 - 47,290,861 (-)NCBIMhudiblu_PPA_v0panPan3
Calm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,779,344 - 33,795,171 (+)NCBI
SpeTri2.0NW_0049365085,207,909 - 5,223,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,372,045 - 93,438,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,371,765 - 93,386,378 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,567,552 - 99,582,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,027,884 - 60,042,041 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,027,801 - 60,044,951 (+)EnsemblChlSab1.1chlSab2
ChlSab1.1 Ensembl639,957,320 - 39,966,581 (+)EnsemblChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604551,803,526 - 51,818,114 (-)NCBIVero_WHO_p1.0
Calm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473828,525,290 - 28,541,562 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004176   ⟹   ENSCAFP00000003862
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089772   ⟹   ENSCAFP00000063180
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)Ensembl
RefSeq Acc Id: XM_038489226   ⟹   XP_038345154
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11049,877,637 - 49,892,535 (-)NCBI
RefSeq Acc Id: XM_038551229   ⟹   XP_038407157
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01050,351,274 - 50,366,152 (-)NCBI
RefSeq Acc Id: XM_038615126   ⟹   XP_038471054
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01050,167,136 - 50,182,012 (-)NCBI
RefSeq Acc Id: XM_038680510   ⟹   XP_038536438
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01050,169,941 - 50,184,842 (-)NCBI
RefSeq Acc Id: XM_859552   ⟹   XP_864645
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11049,299,698 - 49,314,533 (-)NCBI
Dog10K_Boxer_Tasha1049,152,937 - 49,167,816 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_864645   ⟸   XM_859552
- UniProtKB: E2REK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000003862   ⟸   ENSCAFT00000004176
RefSeq Acc Id: ENSCAFP00000063180   ⟸   ENSCAFT00000089772
RefSeq Acc Id: XP_038345154   ⟸   XM_038489226
RefSeq Acc Id: XP_038471054   ⟸   XM_038615126
RefSeq Acc Id: XP_038536438   ⟸   XM_038680510
RefSeq Acc Id: XP_038407157   ⟸   XM_038551229


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002646 Ensembl
NCBI Gene CALM2 ENTREZGENE
UniProt E2REK6 ENTREZGENE