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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of isotype switching to IgE isotypes
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Accession:GO:0048294 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:exact_synonym: down regulation of isotype switching to IgE isotypes;   downregulation of isotype switching to IgE isotypes;   negative regulation of class switch recombination to IgE isotypes;   negative regulation of class switching to IgE isotypes;   negative regulation of isotype switch recombination to IgE isotypes
 narrow_synonym: inhibition of isotype switching to IgE isotypes

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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004624774:1,245,587...1,353,253
Ensembl chrNW_004624774:1,303,773...1,353,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    developmental process 6156
      negative regulation of developmental process 941
        negative regulation of isotype switching 4
          negative regulation of isotype switching to IgE isotypes 3
Path 2
Term Annotations click to browse term
  biological_process 15093
    metabolic process 9086
      biosynthetic process 6359
        cellular biosynthetic process 5998
          macromolecule biosynthetic process 5518
            gene expression 5114
              production of molecular mediator of immune response 224
                immunoglobulin production 108
                  immunoglobulin production involved in immunoglobulin-mediated immune response 59
                    somatic diversification of immunoglobulins involved in immune response 55
                      somatic recombination of immunoglobulin genes involved in immune response 55
                        isotype switching 55
                          regulation of isotype switching 38
                            negative regulation of isotype switching 4
                              negative regulation of isotype switching to IgE isotypes 3
paths to the root