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ONTOLOGY REPORT - ANNOTATIONS

Term:Delta4-3-oxosteroid 5beta-reductase activity
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Accession:GO:0047787 term browser browse the term
Definition:Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Synonyms:exact_synonym: delta4-3-oxosteroid 5-beta-reductase activity
 narrow_synonym: cholestenone 5-beta-reductase activity;   cholestenone 5b-reductase activity;   cortisone b-reductase activity;   cortisone beta-reductase activity
 broad_synonym: 5-beta-reductase activity
 related_synonym: 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity;   3-oxo-Delta(4)-steroid 5-beta-reductase activity;   3-oxo-delta4-steroid 5beta-reductase activity;   4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity;   5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity;   5beta-reductase activity;   androstenedione 5-beta-reductase activity;   androstenedione 5beta-reductase activity;   cholestenone 5beta-reductase activity;   cortisone 5-beta-reductase activity;   cortisone 5beta-reductase activity;   cortisone delta(4)-5-beta-reductase activity;   cortisone delta4-5beta-reductase activity;   delta(4)-3-ketosteroid 5-beta-reductase activity;   delta(4)-5-beta-reductase activity;   delta(4)-hydrogenase activity;   delta4-3-ketosteroid 5beta-reductase activity;   delta4-5beta-reductase activity;   delta4-hydrogenase activity;   steroid 5-beta-reductase activity;   steroid 5beta-reductase activity;   testosterone 5-beta-reductase activity;   testosterone 5beta-reductase activity
 alt_id: GO:0047752
 xref: EC:1.3.1.3;   MetaCyc:RXN-23672;   RHEA:54412


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Delta4-3-oxosteroid 5beta-reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) enables ISO (PMID:16983398) UniProt PMID:16983398 NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043 		JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 enables IEA InterPro GO_REF:0000002 NCBI chr16:1,499,251...1,583,965 JBrowse link
G LOC119874618 aldo-keto reductase family 1 member D1 enables IEA InterPro GO_REF:0000002
G LOC119874631 aldo-keto reductase family 1 member D1-like enables IEA InterPro GO_REF:0000002
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  molecular_function 21949
    catalytic activity 5722
      oxidoreductase activity 775
        oxidoreductase activity, acting on the CH-CH group of donors 60
          oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 31
            enone reductase activity 6
              Delta4-3-oxosteroid 5beta-reductase activity 4
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