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ONTOLOGY REPORT - ANNOTATIONS

Term:long-chain fatty acid import into cell
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Accession:GO:0044539 term browser browse the term
Definition:The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Comment:While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
Synonyms:exact_synonym: long-chain fatty acid uptake
 related_synonym: long-chain fatty acid import

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long-chain fatty acid import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL1 acyl-CoA synthetase long chain family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:130,712,633...130,783,360
Ensembl chr 7:130,712,308...130,763,756 		JBrowse link
G ACSL3 acyl-CoA synthetase long chain family member 3 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:20219900) UniProt
Ensembl		 PMID:20219900 GO_REF:0000107 NCBI chr10:108,787,341...108,867,523
Ensembl chr10:108,787,061...108,869,042 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:33,498,098...33,556,553
Ensembl chr16:33,497,392...33,556,453 		JBrowse link
G SLC27A1 solute carrier family 27 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:15,967,126...15,995,039 JBrowse link
G SLC27A2 solute carrier family 27 member 2 acts_upstream_of ISO (PMID:22022213) UniProt PMID:22022213 NCBI chr26:33,080,844...33,134,467
Ensembl chr26:33,083,317...33,134,433 		JBrowse link
G SLC27A4 solute carrier family 27 member 4 involved_in ISO (MGI:5314874|PMID:21750264), (MGI:5703705|PMID:24503477)
(PMID:22022213)
(MGI:6232786|PMID:23024797)		 ARUK-UCL
UniProt		 PMID:21750264 PMID:22022213 PMID:23024797 PMID:24503477 MGI:5314874 MGI:5703705 MGI:6232786 NCBI chr12:9,769,242...9,788,214 JBrowse link
G SPX spexin hormone involved_in ISO (MGI:5574430|PMID:24550067) UniProt PMID:24550067 MGI:5574430 RGD:8693351 NCBI chr11:21,391,660...21,401,860
Ensembl chr11:21,392,621...21,396,923 		JBrowse link
long-chain fatty acid import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO leukotriene LTC4 transport RGD PMID:12867490 RGD:2303048 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669 		JBrowse link
G SLC27A1 solute carrier family 27 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:15,967,126...15,995,039 JBrowse link
G SLC27A5 solute carrier family 27 member 5 acts_upstream_of_or_within ISO (PMID:16618416) MGI PMID:16618416 NCBI chr 6:50,782,713...50,793,816
Ensembl chr 6:50,781,544...50,792,515 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 involved_in ISO (PMID:10227690) ARUK-UCL PMID:10227690 NCBI chr20:89,974,567...90,007,977
Ensembl chr20:90,002,030...90,008,033 		JBrowse link
negative regulation of long-chain fatty acid import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in ISO (PMID:16814735) BHF-UCL PMID:16814735 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:34,688,585...34,740,458
Ensembl chr 6:34,690,462...34,720,781 		JBrowse link
G IRS2 insulin receptor substrate 2 involved_in ISO (PMID:16814735) BHF-UCL PMID:16814735 NCBI chr 3:88,045,439...88,076,468 JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:43,410,693...43,427,816
Ensembl chr26:43,410,580...43,427,812 		JBrowse link
positive regulation of long-chain fatty acid import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL1 acyl-CoA synthetase long chain family member 1 involved_in ISO PMID:24503477 ARUK-UCL PMID:24503477 RGD:39458020 NCBI chr 7:130,712,633...130,783,360
Ensembl chr 7:130,712,308...130,763,756 		JBrowse link
G ACSL5 acyl-CoA synthetase long chain family member 5 ISO RGD PMID:16263710 RGD:2312807 NCBI chr 9:105,259,546...105,311,500
Ensembl chr 9:105,257,429...105,311,690 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 ISO RGD PMID:15655248 RGD:2312811 NCBI chr23:34,787,097...34,846,387
Ensembl chr23:34,787,432...34,829,042 		JBrowse link
positive regulation of long-chain fatty acid import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP3 fatty acid binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:101,464,899...101,472,223
Ensembl chr20:101,464,960...101,474,350 		JBrowse link
regulation of long-chain fatty acid import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPRS1 glutamyl-prolyl-tRNA synthetase 1 involved_in ISO (MGI:5913528|PMID:28178239)
(PMID:28178239)		 UniProt PMID:28178239 MGI:5913528 NCBI chr25:9,534,747...9,618,119
Ensembl chr25:9,534,114...9,618,141 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16523
    localization 5260
      establishment of localization 4560
        transport 4261
          import into cell 892
            long-chain fatty acid import into cell 19
              long-chain fatty acid import across plasma membrane + 12
              negative regulation of long-chain fatty acid import into cell + 4
              positive regulation of long-chain fatty acid import into cell + 4
              regulation of long-chain fatty acid import into cell + 9
Path 2
Term Annotations click to browse term
  biological_process 16523
    localization 5260
      establishment of localization 4560
        transport 4261
          organic acid transport 362
            carboxylic acid transport 360
              monocarboxylic acid transport 185
                fatty acid transport 124
                  long-chain fatty acid transport 67
                    long-chain fatty acid import into cell 19
                      long-chain fatty acid import across plasma membrane + 12
                      negative regulation of long-chain fatty acid import into cell + 4
                      positive regulation of long-chain fatty acid import into cell + 4
                      regulation of long-chain fatty acid import into cell + 9
paths to the root