ACSL3 (acyl-CoA synthetase long chain family member 3) - Rat Genome Database

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Gene: ACSL3 (acyl-CoA synthetase long chain family member 3) Chlorocebus sabaeus
Analyze
Symbol: ACSL3
Name: acyl-CoA synthetase long chain family member 3
RGD ID: 18422132
Description: ENCODES a protein that exhibits arachidonate-CoA ligase activity (ortholog); long-chain fatty acid-CoA ligase activity (ortholog); INVOLVED IN fatty acid biosynthetic process (ortholog); long-chain fatty acid import into cell (ortholog); response to nutrient (ortholog); PARTICIPATES IN fatty acid beta degradation pathway; ASSOCIATED WITH asthma (ortholog); breast cancer (ortholog); Experimental Allergic Asthma (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); lipid droplet (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: long-chain-fatty-acid--CoA ligase 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110108,787,341 - 108,867,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10108,787,061 - 108,869,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604090,486,570 - 90,576,665 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ACSL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110108,787,341 - 108,867,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10108,787,061 - 108,869,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604090,486,570 - 90,576,665 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ACSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,861,036 - 222,944,639 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,860,942 - 222,944,639 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,725,754 - 223,809,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,433,976 - 223,516,363 (+)NCBINCBI36Build 36hg18NCBI36
Celera2217,493,969 - 217,573,566 (+)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2215,580,012 - 215,659,429 (+)NCBIHuRef
CHM1_12223,732,626 - 223,813,632 (+)NCBICHM1_1
T2T-CHM13v2.02223,346,613 - 223,427,414 (+)NCBIT2T-CHM13v2.0
Acsl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,635,600 - 78,685,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,635,542 - 78,685,460 (+)EnsemblGRCm39 Ensembl
GRCm38178,657,825 - 78,707,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,657,825 - 78,707,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,654,400 - 78,704,318 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36178,536,898 - 78,586,011 (+)NCBIMGSCv36mm8
Celera179,126,781 - 79,177,063 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.84NCBI
Acsl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8987,563,601 - 87,613,078 (+)NCBIGRCr8
mRatBN7.2980,115,164 - 80,164,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,115,112 - 80,164,627 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx988,544,917 - 88,594,391 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0993,660,348 - 93,709,510 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,056,362 - 92,105,840 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0984,569,601 - 84,593,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl984,569,597 - 84,593,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0984,301,912 - 84,351,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4978,083,239 - 78,106,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1978,266,656 - 78,290,352 (+)NCBI
Celera977,647,726 - 77,671,370 (+)NCBICelera
Cytogenetic Map9q34NCBI
Acsl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,913,786 - 10,947,963 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,916,423 - 10,963,986 (-)NCBIChiLan1.0ChiLan1.0
ACSL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213125,473,216 - 125,554,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B125,488,197 - 125,569,501 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B110,100,210 - 110,181,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B228,706,141 - 228,759,882 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B228,706,142 - 228,759,882 (+)Ensemblpanpan1.1panPan2
ACSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13728,882,264 - 28,929,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3728,864,147 - 28,938,866 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3729,699,888 - 29,765,386 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03728,889,472 - 28,955,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3728,888,886 - 28,955,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13728,798,984 - 28,864,540 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03728,730,857 - 28,796,337 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03728,744,094 - 28,809,662 (+)NCBIUU_Cfam_GSD_1.0
Acsl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303178,431,793 - 178,500,065 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365694,774,542 - 4,844,494 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365694,774,602 - 4,842,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15124,765,854 - 124,816,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115124,741,986 - 124,816,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215138,663,708 - 138,712,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Acsl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248232,324,345 - 2,381,420 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248232,323,939 - 2,387,213 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000005827   ⟹   ENSCSAP00000004047
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl10108,787,061 - 108,869,042 (+)Ensembl
RefSeq Acc Id: XM_038001462   ⟹   XP_037857390
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604090,496,532 - 90,576,568 (-)NCBI
RefSeq Acc Id: XM_038001463   ⟹   XP_037857391
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604090,486,570 - 90,576,665 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037857390 (Get FASTA)   NCBI Sequence Viewer  
  XP_037857391 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004047.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000004047   ⟸   ENSCSAT00000005827
RefSeq Acc Id: XP_037857391   ⟸   XM_038001463
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037857390   ⟸   XM_038001462
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R608 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007784 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005827.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/TrEMBL
InterPro AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/TrEMBL
KEGG Report csab:103217943 UniProtKB/TrEMBL
NCBI Gene ACSL3 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/TrEMBL
  LONG-CHAIN-FATTY-ACID--COA LIGASE 3 UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/TrEMBL
PROSITE AMP_BINDING UniProtKB/TrEMBL
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A0A0D9R608 ENTREZGENE, UniProtKB/TrEMBL