THBS1 (thrombospondin 1) - Rat Genome Database

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Pathways
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Gene: THBS1 (thrombospondin 1) Chlorocebus sabaeus
Analyze
Symbol: THBS1
Name: thrombospondin 1
RGD ID: 18401451
Description: ENCODES a protein that exhibits extracellular matrix binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); blood vessel morphogenesis (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Bloom syndrome (ortholog); Breast Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); sarcoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thrombospondin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12643,410,693 - 43,427,816 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604897,515,387 - 97,532,504 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to pain  (ISO)
blood vessel morphogenesis  (ISO)
cell adhesion  (IEA)
cell migration  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to nitric oxide  (ISO)
cellular response to tumor necrosis factor  (ISO)
chronic inflammatory response  (IEA)
endocardial cushion development  (ISO)
engulfment of apoptotic cell  (IEA)
growth plate cartilage development  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
monocyte aggregation  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of cGMP-mediated signaling  (IEA)
negative regulation of dendritic cell antigen processing and presentation  (IEA)
negative regulation of endothelial cell chemotaxis  (IEA,ISO)
negative regulation of endothelial cell migration  (IEA)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of fibrinolysis  (IEA)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA)
negative regulation of interleukin-12 production  (IEA)
negative regulation of long-chain fatty acid import across plasma membrane  (IEA)
negative regulation of nitric oxide mediated signal transduction  (IEA,ISO)
negative regulation of plasminogen activation  (IEA)
negative regulation of sprouting angiogenesis  (IEA)
nitric oxide-cGMP-mediated signaling  (IEA,ISO)
outflow tract morphogenesis  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of blood coagulation  (IEA)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of chemotaxis  (IEA)
positive regulation of endothelial cell apoptotic process  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
positive regulation of fibroblast migration  (IEA)
positive regulation of macrophage activation  (IEA)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of phosphorylation  (IEA)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of transforming growth factor beta production  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of translation  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
response to calcium ion  (IEA)
response to endoplasmic reticulum stress  (ISO)
response to glucose  (IEA)
response to magnesium ion  (IEA)
response to mechanical stimulus  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (IEA)
sprouting angiogenesis  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
THBS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12643,410,693 - 43,427,816 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604897,515,387 - 97,532,504 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
THBS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371539,873,280 - 39,891,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,009,050 (+)NCBICHM1_1
T2T-CHM13v2.01537,385,886 - 37,404,273 (+)NCBIT2T-CHM13v2.0
Thbs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,942,357 - 117,957,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)EnsemblGRCm39 Ensembl
GRCm382118,111,876 - 118,127,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372117,937,658 - 117,952,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,046,897 - 119,061,990 (+)NCBIMGSCv36mm8
MGSCv362117,803,363 - 117,818,574 (+)NCBIMGSCv36mm8
Celera2119,257,347 - 119,271,479 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.34NCBI
Thbs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,510,250 - 125,525,402 (+)NCBIGRCr8
mRatBN7.23105,056,293 - 105,071,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,056,292 - 105,071,440 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3108,721,861 - 108,736,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,317,382 - 117,332,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,977,769 - 114,992,820 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03109,862,120 - 109,873,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3109,862,117 - 109,873,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,411,045 - 116,422,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3103,978,436 - 103,990,486 (+)NCBICelera
Cytogenetic Map3q35NCBI
Thbs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBIChiLan1.0ChiLan1.0
THBS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21628,821,736 - 28,838,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11532,972,998 - 32,987,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01518,521,802 - 18,538,172 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11536,776,756 - 36,793,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1536,776,756 - 36,793,170 (+)Ensemblpanpan1.1panPan2
THBS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1306,770,212 - 6,786,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl306,769,470 - 6,784,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha306,824,809 - 6,841,468 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0306,896,290 - 6,912,963 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl306,895,539 - 6,911,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1306,820,232 - 6,836,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0306,926,083 - 6,942,777 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,055,241 - 7,071,904 (+)NCBIUU_Cfam_GSD_1.0
Thbs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,216,385 - 85,233,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,064,422 - 3,081,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,064,466 - 3,081,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,728,784 - 131,746,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,728,781 - 131,746,098 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,905,998 - 146,923,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Thbs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248046,849,670 - 6,867,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248046,849,660 - 6,866,164 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 33 7 20
Low 3 13 40
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008017083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000005297   ⟹   ENSCSAP00000003523
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)Ensembl
RefSeq Acc Id: XM_008017083   ⟹   XP_008015274
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12643,410,693 - 43,427,816 (-)NCBI
Vero_WHO_p1.0NW_02366604897,515,387 - 97,532,504 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008015274 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003523
  ENSCSAP00000003523.1
Reference Protein Sequences
RefSeq Acc Id: XP_008015274   ⟸   XM_008017083
- UniProtKB: A0A0D9R4I4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003523   ⟸   ENSCSAT00000005297


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005297.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  4.10.1080.10 UniProtKB/TrEMBL
  6.20.200.20 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/TrEMBL
  TSPN-like_N UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
KEGG Report csab:103245860 UniProtKB/TrEMBL
NCBI Gene THBS1 ENTREZGENE
PANTHER PTHR10199:SF78 UniProtKB/TrEMBL
  THROMBOSPONDIN UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
  TSP_3 UniProtKB/TrEMBL
  TSP_C UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSP3 UniProtKB/TrEMBL
  TSP_CTER UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSPN UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF103647 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A0D9R4I4 ENTREZGENE, UniProtKB/TrEMBL