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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell degranulation
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Accession:GO:0043320 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.
Synonyms:exact_synonym: NK cell degranulation;   NK cell granule exocytosis;   natural killer cell granule exocytosis

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natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A involved_in ISO (PMID:24760828) UniProt PMID:24760828 NCBI chrNW_004624782:13,106,416...13,111,394
Ensembl chrNW_004624782:13,105,153...13,111,357 		JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa involved_in ISO (PMID:25786175), (PMID:28652325) UniProt PMID:25786175 PMID:28652325 NCBI chrNW_004624826:51,387...59,117 JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (PMID:32839608), (PMID:33911019) UniProt PMID:32839608 PMID:33911019 NCBI chrNW_004624832:3,501,924...3,502,750
Ensembl chrNW_004624832:3,501,973...3,504,773 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO (PMID:11266473) MGI PMID:11266473 NCBI chrNW_004624731:6,315,064...6,355,431
Ensembl chrNW_004624731:6,319,092...6,355,534 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chrNW_004624753:10,150,811...10,180,794
Ensembl chrNW_004624753:10,148,416...10,191,153 		JBrowse link
G Unc13d unc-13 homolog D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17420270) MGI
Ensembl		 PMID:17420270 GO_REF:0000107 NCBI chrNW_004624801:5,720,998...5,736,122
Ensembl chrNW_004624801:5,721,391...5,736,294 		JBrowse link
G Vamp2 vesicle associated membrane protein 2 NOT|involved_in ISO (PMID:18042464) UniProt PMID:18042464 NCBI chrNW_004624786:10,723,791...10,727,654
Ensembl chrNW_004624786:10,724,964...10,727,649 		JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO (PMID:18042464) UniProt PMID:18042464 NCBI chrNW_004624980:40,937...94,547
Ensembl chrNW_004624980:40,843...94,528 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chrNW_004624786:478,048...491,086 JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004624746:13,997,903...14,081,140
Ensembl chrNW_004624746:13,997,681...14,081,197 		JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004624793:661,322...675,603
Ensembl chrNW_004624793:661,342...675,675 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15135
    immune system process 2155
      immune effector process 572
        leukocyte degranulation 79
          natural killer cell degranulation 11
            negative regulation of natural killer cell degranulation 1
            positive regulation of natural killer cell degranulation 2
            regulation of natural killer cell degranulation + 3
Path 2
Term Annotations click to browse term
  biological_process 15135
    response to stimulus 8179
      response to external stimulus 2161
        response to external biotic stimulus 1347
          response to other organism 1344
            defense response to other organism 935
              defense response to symbiont 756
                innate immune response 689
                  natural killer cell mediated immunity 59
                    natural killer cell mediated cytotoxicity 55
                      natural killer cell degranulation 11
                        negative regulation of natural killer cell degranulation 1
                        positive regulation of natural killer cell degranulation 2
                        regulation of natural killer cell degranulation + 3
paths to the root