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ONTOLOGY REPORT - ANNOTATIONS

Term:mediator complex binding
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Accession:GO:0036033 term browser browse the term
Definition:Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


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mediator complex binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elk1 ETS transcription factor ELK1 enables IEA
ISO		 GO_REF:0000107
UniProtKB:Q6PGF3|UniProtKB:Q80YQ2|UniProtKB:Q9VSF2 (PMID:7738173)		 Ensembl
RGD		 PMID:7738173 GO_REF:0000107 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Gli3 GLI family zinc finger 3 enables ISO (PMID:17000779) RGD PMID:17000779 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Nipbl NIPBL, cohesin loading factor enables ISO (PMID:20720539) RGD PMID:20720539 NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A enables IEA
ISO		 GO_REF:0000107
(PMID:20720539)		 Ensembl
RGD		 PMID:20720539 GO_REF:0000107 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 enables IEA
ISO		 GO_REF:0000107
(PMID:20720539)		 Ensembl
RGD		 PMID:20720539 GO_REF:0000107 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522 		JBrowse link
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  molecular_function 20626
    binding 17717
      protein-containing complex binding 1613
        mediator complex binding 5
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