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Term:TRAM-dependent toll-like receptor 4 signaling pathway
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Accession:GO:0035669 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms:exact_synonym: TRAM-dependent TLR4 signaling pathway;   TRAM-dependent toll-like receptor 4 signalling pathway


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TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCE protein kinase C epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:94,351,277...94,864,549
Ensembl chr 3:94,349,889...94,866,306 		JBrowse link
G RAB11FIP2 RAB11 family interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:128,068,085...128,110,949
Ensembl chr14:128,068,959...128,110,512 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184)
(PMID:22685567)		 UniProt PMID:19412184 PMID:22685567 NCBI chr 2:119,758,622...119,778,650 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17668
    immune system process 2519
      activation of immune response 519
        immune response-activating signaling pathway 455
          innate immune response-activating signaling pathway 274
            pattern recognition receptor signaling pathway 269
              toll-like receptor signaling pathway 72
                MyD88-independent toll-like receptor signaling pathway 13
                  TRAM-dependent toll-like receptor signaling pathway 3
                    TRAM-dependent toll-like receptor 4 signaling pathway 3
Path 2
Term Annotations click to browse term
  biological_process 17668
    response to stimulus 10004
      response to external stimulus 2550
        response to external biotic stimulus 1682
          response to other organism 1678
            defense response to other organism 1155
              defense response to symbiont 1040
                innate immune response 871
                  regulation of innate immune response 442
                    positive regulation of innate immune response 360
                      activation of innate immune response 296
                        innate immune response-activating signaling pathway 274
                          innate immune response activating cell surface receptor signaling pathway 82
                            cell surface pattern recognition receptor signaling pathway 76
                              cell surface toll-like receptor signaling pathway 71
                                toll-like receptor 4 signaling pathway 62
                                  TRAM-dependent toll-like receptor 4 signaling pathway 3
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