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Term:TIRAP-dependent toll-like receptor 4 signaling pathway
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Accession:GO:0035665 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms:exact_synonym: MAL-dependent toll-like receptor 4 signaling pathway;   MyD88 adapter-like dependent toll-like receptor 4 signaling pathway;   TIRAP-dependent TLR4 signaling pathway;   TIRAP-dependent toll-like receptor 4 signalling pathway

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TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:11544529) BHF-UCL PMID:11544529 NCBI chrNW_004624812:433,540...445,517
Ensembl chrNW_004624812:439,319...446,646 		JBrowse link
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Path 1
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  biological_process 15135
    immune system process 2155
      activation of immune response 473
        activation of innate immune response 263
          innate immune response-activating signaling pathway 247
            pattern recognition receptor signaling pathway 246
              toll-like receptor signaling pathway 68
                TIRAP-dependent toll-like receptor signaling pathway 1
                  TIRAP-dependent toll-like receptor 4 signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 15135
    response to stimulus 8179
      response to external stimulus 2161
        response to external biotic stimulus 1347
          response to other organism 1344
            defense response to other organism 935
              defense response to symbiont 756
                innate immune response 689
                  regulation of innate immune response 390
                    positive regulation of innate immune response 321
                      activation of innate immune response 263
                        innate immune response-activating signaling pathway 247
                          innate immune response activating cell surface receptor signaling pathway 73
                            cell surface pattern recognition receptor signaling pathway 71
                              cell surface toll-like receptor signaling pathway 66
                                toll-like receptor 4 signaling pathway 58
                                  TIRAP-dependent toll-like receptor 4 signaling pathway 1
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