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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-ubiquitin ligase activity
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Accession:GO:0034450 term browser browse the term
Definition:Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
Synonyms:exact_synonym: E4
 xref: reactome:R-HSA-937050 "Pellino ubiquitinates hp-IRAK1";   reactome:R-HSA-975122 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
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show annotations for term's descendants           Sort by:
ubiquitin-ubiquitin ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor enables IDA (PMID:24810856) ParkinsonsUK-UCL PMID:24810856 NCBI chr16:56,361,452...56,425,545
Ensembl chr16:56,361,452...56,425,545 		JBrowse link
G ANAPC11 anaphase promoting complex subunit 11 enables IDA (PMID:10230407) MGI PMID:10230407 NCBI chr17:81,890,790...81,900,533
Ensembl chr17:81,890,790...81,900,991 		JBrowse link
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 enables IDA (PMID:27746020) UniProt PMID:27746020 NCBI chr  X:53,532,096...53,686,719
Ensembl chr  X:53,532,096...53,686,752 		JBrowse link
G ITCH itchy E3 ubiquitin protein ligase enables IDA (PMID:29378950) UniProt PMID:29378950 NCBI chr20:34,363,273...34,511,773
Ensembl chr20:34,363,235...34,511,773 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 enables TAS
IDA		 (PMID:30952868) Reactome
UniProt		 PMID:30952868 Reactome:R-HSA-937050 Reactome:R-HSA-975122 NCBI chr 2:64,092,652...64,144,420
Ensembl chr 2:64,092,652...64,144,420 		JBrowse link
G PELI2 pellino E3 ubiquitin protein ligase family member 2 enables TAS Reactome Reactome:R-HSA-937050 Reactome:R-HSA-975122 NCBI chr14:56,118,411...56,301,524
Ensembl chr14:56,117,814...56,301,524 		JBrowse link
G PPIL2 peptidylprolyl isomerase like 2 enables IDA (PMID:11435423) MGI PMID:11435423 NCBI chr22:21,666,012...21,700,015
Ensembl chr22:21,666,000...21,700,015 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 enables IDA (PMID:11435423) MGI PMID:11435423 NCBI chr11:60,890,547...60,906,585
Ensembl chr11:60,890,547...60,906,585 		JBrowse link
G RBX1 ring-box 1 enables IDA (PMID:10230407) MGI PMID:10230407 NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 enables ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:680,410...682,801
Ensembl chr16:680,224...682,870 		JBrowse link
G TRAF6 TNF receptor associated factor 6 enables IDA (PMID:15465037), (PMID:27746020) UniProt PMID:15465037 PMID:27746020 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K enables IDA (PMID:17873885) UniProt PMID:17873885 NCBI chr 4:39,698,136...39,782,792
Ensembl chr 4:39,698,109...39,782,792 		JBrowse link
G UBE4A ubiquitination factor E4A enables IEA
IBA		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr11:118,359,600...118,399,211
Ensembl chr11:118,359,600...118,399,211 		JBrowse link
G UBE4B ubiquitination factor E4B enables IEA
IBA		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:10,032,958...10,181,239
Ensembl chr 1:10,032,832...10,181,239 		JBrowse link
G UBOX5 U-box domain containing 5 enables IEA
IBA
ISS		 Ensembl
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:3,107,573...3,159,865
Ensembl chr20:3,107,573...3,160,196 		JBrowse link
G UBR5 ubiquitin protein ligase E3 component n-recognin 5 enables IBA
IDA		 (PMID:21118991), (PMID:29378950) GO_Central
UniProt		 PMID:21118991 PMID:29378950 GO_REF:0000033 NCBI chr 8:102,252,273...102,412,700
Ensembl chr 8:102,252,273...102,412,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6024
      catalytic activity, acting on a protein 2462
        ubiquitin-like protein transferase activity 497
          ubiquitin-protein transferase activity 466
            ubiquitin protein ligase activity 367
              ubiquitin-ubiquitin ligase activity 16
Path 2
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6024
      transferase activity 2450
        acyltransferase activity 759
          aminoacyltransferase activity 515
            ubiquitin-like protein transferase activity 497
              ubiquitin-like protein ligase activity 387
                ubiquitin protein ligase activity 367
                  ubiquitin-ubiquitin ligase activity 16
paths to the root