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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin protein ligase activity
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Accession:GO:0061630 term browser browse the term
Definition:Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Comment:This enzyme catalyzes a transferase reaction.
Synonyms:exact_synonym: protein ubiquitination activity;   ubiquitin ligase activity
 narrow_synonym: APC-Cdc20 complex activity;   APC-fizzy related complex activity;   E3 involved in endoplasmic reticulum-associated degradation;   ubiquitin ligase activity involved in ER-associated degradation pathway;   ubiquitin protein ligase activity involved in ER-associated degradation pathway;   ubiquitin protein ligase activity involved in ERAD pathway;   ubiquitin protein ligase activity involved in chloroplast disassembly;   ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition
 related_synonym: E3;   ER-associated E3 ligase
 alt_id: GO:0090302;   GO:0090622;   GO:1904264;   GO:1904822
 xref: reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL";   reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1";   reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8";   reactome:R-HSA-3322429 "XIAP monoubiquinates TLE";   reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN";   reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1";   reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2";   reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1";   reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization";   reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation";   reactome:R-HSA-5246693 "APC is K63-polyubiquitinated";   reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1";   reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1";   reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3";   reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1";   reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1";   reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2";   reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3";   reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4";   reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1";   reactome:R-HSA-5674022 "BRAP autoubiquitinates";   reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX";   reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1";   reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal";   reactome:R-HSA-5689111 "PARK2 autoubiquitinates";   reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1";   reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II";   reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC";   reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI";   reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC";   reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2";   reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY";   reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53";   reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4";   reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53";   reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate";   reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination";   reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN";   reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin";   reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex";   reactome:R-HSA-8848829 "CBL autoubiquitinates";   reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN";   reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA";   reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7";   reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839";   reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR";   reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del";   reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5";   reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET";   reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination";   reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET";   reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex";   reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC";   reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA";   reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10";   reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2";   reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B";   reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA";   reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA";   reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11";   reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN";   reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN";   reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3";   reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3";   reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11";   reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5";   reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73";   reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2";   reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2";   reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2";   reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2";   reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1";   reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3";   reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11";   reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL";   reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation";   reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216";   reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4";   reactome:R-HSA-990526 "Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1"


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ubiquitin protein ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
RGD:13792537
G Anapc1 anaphase promoting complex subunit 1 JBrowse link 3 121,147,484 121,226,125 RGD:13792537
G Anapc11 anaphase promoting complex subunit 11 JBrowse link 10 109,774,779 109,785,877 RGD:1624291
RGD:13792537
G Anapc4 anaphase promoting complex subunit 4 JBrowse link 14 60,471,962 60,503,803 RGD:13792537
G Anapc5 anaphase-promoting complex subunit 5 JBrowse link 12 39,209,134 39,242,696 RGD:13792537
G Ankib1 ankyrin repeat and IBR domain containing 1 JBrowse link 4 27,473,477 27,597,206 RGD:13792537
G Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 JBrowse link 6 108,630,790 108,796,096 RGD:13792537
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 JBrowse link 8 64,166,359 64,268,555 RGD:13792537
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 JBrowse link 8 117,387,004 117,446,085 RGD:13792537
G Asb1 ankyrin repeat and SOCS box-containing 1 JBrowse link 9 98,668,231 98,689,471 RGD:1624291
RGD:1600115
G Asb12 ankyrin repeat and SOCS box-containing 12 JBrowse link X 64,714,337 64,800,662 RGD:1624291
RGD:13792537
G Asb2 ankyrin repeat and SOCS box-containing 2 JBrowse link 6 127,212,325 127,248,451 RGD:1624291
G Asb4 ankyrin repeat and SOCS box-containing 4 JBrowse link 4 30,461,673 30,501,340 RGD:1624291
RGD:1600115
G Bfar bifunctional apoptosis regulator JBrowse link 10
10
1,464,658
1,464,783
1,471,152
1,497,653
RGD:1624291
RGD:13792537
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:13792537
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:13792537
G Birc7 baculoviral IAP repeat-containing 7 JBrowse link 3 176,438,335 176,443,864 RGD:13792537
G Brap BRCA1 associated protein JBrowse link 12 40,381,892 40,417,764 RGD:1624291
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:1624291
RGD:1600115
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:11576315
RGD:13792537
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:13792537
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:1624291
RGD:13792537
G Cbll1 Cbl proto-oncogene like 1 JBrowse link 6 50,772,718 50,786,861 RGD:1624291
RGD:13792537
G Ccnb1ip1 cyclin B1 interacting protein 1 JBrowse link 15 27,720,220 27,736,528 RGD:1600115
G Ccnc cyclin C JBrowse link 5 35,865,598 35,883,732 RGD:2304264
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:1624291
G Cdk8 cyclin-dependent kinase 8 JBrowse link 12 10,496,273 10,561,335 RGD:2304264
G Chfr checkpoint with forkhead and ring finger domains JBrowse link 12 52,562,594 52,596,162 RGD:1624291
RGD:1600115
G Cop1 COP1, E3 ubiquitin ligase JBrowse link 13 76,942,883 77,076,015 RGD:1624291
RGD:1600115
G Dcst1 DC-STAMP domain containing 1 JBrowse link 2 188,672,549 188,690,004 RGD:1624291
RGD:1600115
G Dzip3 DAZ interacting zinc finger protein 3 JBrowse link 11 54,404,777 54,475,361 RGD:1600115
G Fancf FA complementation group F JBrowse link 1 107,229,516 107,232,321 RGD:1624291
RGD:1600115
G Fancl FA complementation group L JBrowse link 14 110,675,306 110,740,880 RGD:1624291
RGD:1600115
G Fbxl12 F-box and leucine-rich repeat protein 12 JBrowse link 8 21,656,636 21,662,755 RGD:13792537
G Fbxl18 F-box and leucine-rich repeat protein 18 JBrowse link 12 13,728,155 13,751,781 RGD:13792537
G Fbxl21 F-box and leucine-rich repeat protein 21 JBrowse link 17 8,505,771 8,520,208 RGD:13792537
G Fbxl22 F-box and leucine-rich repeat protein 22 JBrowse link 8 72,198,043 72,204,730 RGD:1624291
RGD:13792537
G Fbxl3 F-box and leucine-rich repeat protein 3 JBrowse link 15 93,647,307 93,667,395 RGD:13792537
G Fbxl6 F-box and leucine-rich repeat protein 6 JBrowse link 7 117,602,056 117,604,954 RGD:13792537
G Fbxl8 F-box and leucine-rich repeat protein 8 JBrowse link 19 37,216,696 37,225,701 RGD:13792537
G Fbxo17 F-box protein 17 JBrowse link 1 86,903,762 86,919,238 RGD:13792537
G Fbxo2 F-box protein 2 JBrowse link 5 164,972,483 164,977,912 RGD:13792537
G Fbxo30 F-box protein 30 JBrowse link 1 5,366,119 5,389,774 RGD:1600115
G Fbxo4 F-box protein 4 JBrowse link 2 53,797,954 53,811,134 RGD:1624291
RGD:1600115
G Fbxo40 F-box protein 40 JBrowse link 11 66,713,913 66,731,195 RGD:1600115
G Fbxo44 F-box protein 44 JBrowse link 5 164,962,921 164,972,273 RGD:13792537
G Fbxo6 F-box protein 6 JBrowse link 5 164,956,285 164,962,075 RGD:1624291
RGD:13792537
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:1624291
RGD:13792537
G G2e3 G2/M-phase specific E3 ubiquitin protein ligase JBrowse link 6 72,092,148 72,123,878 RGD:1624291
G Gid4 GID complex subunit 4 JBrowse link 10 46,784,124 46,810,517 RGD:13792537
G Hace1 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 JBrowse link 20 50,652,489 50,783,937 RGD:13792537
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 JBrowse link 6 72,509,658 72,596,285 RGD:1624291
G Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 17 53,229,997 53,777,474 RGD:13792537
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 9 60,451,476 60,843,160 RGD:13792537
G Hltf helicase-like transcription factor JBrowse link 2 104,854,571 104,914,338 RGD:1624291
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 21,474,627 21,603,348 RGD:13792537
G Irf2bp1 interferon regulatory factor 2 binding protein 1 JBrowse link 1 79,911,516 79,914,217 RGD:1600115
RGD:1624291
G Irf2bpl interferon regulatory factor 2 binding protein-like JBrowse link 6 110,901,940 110,904,288 RGD:1600115
RGD:1624291
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:1624291
RGD:13792537
G Jade2 jade family PHD finger 2 JBrowse link 10 37,269,132 37,315,638 RGD:1624291
RGD:1600115
G Kcmf1 potassium channel modulatory factor 1 JBrowse link 4 100,759,526 100,783,017 RGD:1600115
G LOC100302465 hypothetical LOC100302465 JBrowse link 1 206,324,763 206,417,143 RGD:1624291
G LOC100910646 E3 ubiquitin-protein ligase RLIM-like JBrowse link X 73,757,664 73,778,757 RGD:1624291
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
RGD:13792537
G Ltn1 listerin E3 ubiquitin protein ligase 1 JBrowse link 11 27,023,328 27,080,575 RGD:1624291
RGD:13792537
G March1 membrane associated ring-CH-type finger 1 JBrowse link 16 24,998,709 25,856,327 RGD:1624291
RGD:1600115
G March6 membrane associated ring-CH-type finger 6 JBrowse link 2 84,533,546 84,608,743 RGD:1600115
RGD:1624291
G March8 membrane associated ring-CH-type finger 8 JBrowse link 4 148,285,467 148,398,148 RGD:1624291
RGD:1600115
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
RGD:1600115
RGD:2317402
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:2304264
G Med10 mediator complex subunit 10 JBrowse link 1 36,107,249 36,118,887 RGD:2304264
G Med11 mediator complex subunit 11 JBrowse link 10 57,057,272 57,059,415 RGD:2304263
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:2304264
G Med17 mediator complex subunit 17 JBrowse link 8 13,522,257 13,835,302 RGD:2304264
G Med18 mediator complex subunit 18 JBrowse link 5 150,649,136 150,654,123 RGD:2304264
G Med20 mediator complex subunit 20 JBrowse link 9 15,379,379 15,393,131 RGD:2304264
G Med21 mediator complex subunit 21 JBrowse link 4 180,961,194 180,968,155 RGD:2304264
G Med23 mediator complex subunit 23 JBrowse link 1 21,539,765 21,587,675 RGD:2304264
G Med24 mediator complex subunit 24 JBrowse link 10 86,620,166 86,658,014 RGD:2304264
G Med27 mediator complex subunit 27 JBrowse link 3 7,884,793 8,059,003 RGD:2304264
G Med30 mediator complex subunit 30 JBrowse link 7 92,234,584 92,260,019 RGD:2304264
G Med31 mediator complex subunit 31 JBrowse link 10 58,780,987 58,784,369 RGD:2304264
G Med6 mediator complex subunit 6 JBrowse link 6 105,302,558 105,316,024 RGD:2304264
G Med7 mediator complex subunit 7 JBrowse link 10 31,532,190 31,536,405 RGD:2304264
G Med8 mediator complex subunit 8 JBrowse link 5 137,243,094 137,243,978 RGD:2304264
G Mgrn1 mahogunin ring finger 1 JBrowse link 10 10,832,573 10,881,999 RGD:1624291
RGD:13792537
RGD:1600115
G Mib2 mindbomb E3 ubiquitin protein ligase 2 JBrowse link 5 173,082,943 173,099,353 RGD:1624291
RGD:1600115
G Msl2 MSL complex subunit 2 JBrowse link 8 109,456,097 109,480,143 RGD:13792537
G Mycbp2 MYC binding protein 2 JBrowse link 15
15
87,405,472
93,678,062
87,450,812
93,901,556
RGD:1600115
RGD:1624291
G Mylip myosin regulatory light chain interacting protein JBrowse link 17 19,682,040 19,703,681 RGD:1624291
RGD:1600115
G Nccrp1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) JBrowse link 1
1
85,558,420
85,213,578
85,559,652
85,218,030
RGD:13792537
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:1600115
RGD:13792537
RGD:1624291
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:1624291
RGD:13792537
G Neurl1 neuralized E3 ubiquitin protein ligase 1 JBrowse link 1 266,953,006 267,038,879 RGD:1624291
RGD:13792537
G Neurl1b neuralized E3 ubiquitin protein ligase 1B JBrowse link 10 17,048,251 17,075,139 RGD:13792537
RGD:1624291
G Neurl2 neuralized E3 ubiquitin protein ligase 2 JBrowse link 3 161,296,303 161,299,024 RGD:13792537
G Neurl3 neuralized E3 ubiquitin protein ligase 3 JBrowse link 9 42,831,737 42,841,765 RGD:1624291
RGD:13792537
G Neurl4 neuralized E3 ubiquitin protein ligase 4 JBrowse link 10 56,511,861 56,524,233 RGD:13792537
G Nhlrc1 NHL repeat containing E3 ubiquitin protein ligase 1 JBrowse link 17 18,059,382 18,060,572 RGD:1624291
RGD:13792537
G Nhlrc3 NHL repeat containing 3 JBrowse link 2 142,672,188 142,686,593 RGD:13792537
G Nosip nitric oxide synthase interacting protein JBrowse link 1 101,055,571 101,072,938 RGD:1600115
G Pdzd4 PDZ domain containing 4 JBrowse link X 156,963,343 156,993,591 RGD:13792537
G Pdzrn3 PDZ domain containing RING finger 3 JBrowse link 4 133,717,139 133,951,282 RGD:1624291
RGD:13792537
RGD:1600115
G Pdzrn4 PDZ domain containing RING finger 4 JBrowse link 7 133,856,101 134,004,250 RGD:13792537
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:1624291
RGD:13792537
G Peli2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link 15 24,942,218 25,086,350 RGD:13792537
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
RGD:13792537
G Pja1 praja ring finger ubiquitin ligase 1 JBrowse link X 69,213,645 69,218,601 RGD:1624291
RGD:13792537
G Pja2 praja ring finger ubiquitin ligase 2 JBrowse link 9 111,998,204 112,048,847 RGD:13792537
G Ppil2 peptidylprolyl isomerase like 2 JBrowse link 11 88,147,342 88,169,968 RGD:1624291
G Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 JBrowse link 20 2,094,931 2,098,438 RGD:1624291
RGD:1600115
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1600115
RGD:1624291
RGD:13792537
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1600115
RGD:1624291
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
RGD:1600115
G Rad18 RAD18 E3 ubiquitin protein ligase JBrowse link 4 144,537,329 144,620,606 RGD:13792537
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:1624291
RGD:13792537
G Rag2 recombination activating 2 JBrowse link 3 91,191,837 91,200,134 RGD:1600115
G Rbbp6 RB binding protein 6, ubiquitin ligase JBrowse link 1 192,933,264 192,965,160 RGD:1624291
RGD:1600115
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:1624291
RGD:13792537
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:1600115
RGD:1624291
G RGD1309291 similar to RIKEN cDNA 4930547C10 JBrowse link 5 68,897,812 68,911,390 RGD:13792537
G Ring1 ring finger protein 1 JBrowse link 20 3,812,287 3,815,834 RGD:13792537
G Rnf111 ring finger protein 111 JBrowse link 8 76,864,343 76,940,235 RGD:1624291
RGD:13792537
G Rnf112 ring finger protein 112 JBrowse link 10 47,719,034 47,726,050 RGD:1600115
RGD:1624291
G Rnf115 ring finger protein 115 JBrowse link 2 198,852,392 198,920,000 RGD:1624291
RGD:13792537
G Rnf121 ring finger protein 121 JBrowse link 1 167,095,916 167,165,257 RGD:13792537
G Rnf122 ring finger protein 122 JBrowse link 16 64,766,878 64,787,308 RGD:1624291
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
RGD:1600115
G Rnf126 ring finger protein 126 JBrowse link 7 12,820,796 12,828,325 RGD:1624291
RGD:13792537
G Rnf128 ring finger protein 128 JBrowse link X 110,789,061 110,877,964 RGD:1624291
RGD:13792537
G Rnf13 ring finger protein 13 JBrowse link 2 147,853,423 147,948,277 RGD:1624291
RGD:13792537
G Rnf130 ring finger protein 130 JBrowse link 10 35,537,976 35,610,711 RGD:13792537
G Rnf133 ring finger protein 133 JBrowse link 4 50,681,843 50,686,216 RGD:13792537
G Rnf138 ring finger protein 138 JBrowse link 18 15,146,925 15,167,361 RGD:1600115
RGD:13792537
RGD:1624291
G Rnf139 ring finger protein 139 JBrowse link 7 98,770,840 98,782,025 RGD:13792537
G Rnf14 ring finger protein 14 JBrowse link 18 31,443,424 31,468,641 RGD:13792537
G Rnf144a ring finger protein 144A JBrowse link 6 45,509,895 45,629,233 RGD:1624291
RGD:13792537
G Rnf144b ring finger protein 144B JBrowse link 17 17,817,122 17,947,777 RGD:13792537
G Rnf145 ring finger protein 145 JBrowse link 10 30,169,147 30,207,505 RGD:13792537
G Rnf146 ring finger protein 146 JBrowse link 1 30,856,923 30,873,814 RGD:1600115
G Rnf148 ring finger protein 148 JBrowse link 4 50,687,159 50,693,869 RGD:13792537
G Rnf149 ring finger protein 149 JBrowse link 9 46,285,546 46,309,692 RGD:1624291
RGD:13792537
G Rnf150 ring finger protein 150 JBrowse link 19 24,044,210 24,264,508 RGD:13792537
G Rnf152 ring finger protein 152 JBrowse link 13 25,183,295 25,262,785 RGD:1624291
RGD:13792537
G Rnf157 ring finger protein 157 JBrowse link 10 105,291,148 105,368,316 RGD:13825435
RGD:13792537
G Rnf165 ring finger protein 165 JBrowse link 18 73,831,289 73,873,246 RGD:1624291
RGD:13792537
G Rnf167 ring finger protein 167 JBrowse link 10 57,268,331 57,272,667 RGD:13792537
G Rnf170 ring finger protein 170 JBrowse link 16 70,684,886 70,710,147 RGD:1600115
G Rnf180 ring finger protein 180 JBrowse link 2 35,718,100 35,892,578 RGD:1624291
G Rnf181 ring finger protein 181 JBrowse link 4 100,222,087 100,228,809 RGD:1624291
RGD:13792537
G Rnf183 ring finger protein 183 JBrowse link 5 78,283,722 78,292,729 RGD:1600115
RGD:1624291
G Rnf185 ring finger protein 185 JBrowse link 14 83,648,400 83,685,273 RGD:13792537
RGD:1624291
RGD:1600115
G Rnf186 ring finger protein 186 JBrowse link 5 157,416,897 157,418,121 RGD:1600115
G Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase JBrowse link 7 75,058,758 75,098,331 RGD:13792537
G Rnf19b ring finger protein 19B JBrowse link 5 147,246,032 147,270,892 RGD:13792537
RGD:1624291
G Rnf2 ring finger protein 2 JBrowse link 13 68,829,714 68,859,920 RGD:1624291
RGD:13792537
RGD:1600115
G Rnf215 ring finger protein 215 JBrowse link 14 84,368,440 84,374,879 RGD:13792537
G Rnf216 ring finger protein 216 JBrowse link 12 13,508,429 13,631,689 RGD:1624291
G Rnf220 ring finger protein 220 JBrowse link 5 136,129,457 136,351,752 RGD:1624291
G Rnf25 ring finger protein 25 JBrowse link 9 81,873,293 81,880,172 RGD:1624291
RGD:13792537
G Rnf26 ring finger protein 26 JBrowse link 8 48,447,113 48,449,311 RGD:1624291
RGD:1600115
G Rnf34 ring finger protein 34 JBrowse link 12 39,164,290 39,185,209 RGD:10047328
RGD:1624291
RGD:1600115
G Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:9831417
G Rnf41 ring finger protein 41 JBrowse link 7 2,827,242 2,854,230 RGD:1624291
RGD:1600115
G Rnf43 ring finger protein 43 JBrowse link 10 74,956,411 75,028,951 RGD:13792537
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:13792537
G Rnf6 ring finger protein 6 JBrowse link 12 10,574,168 10,583,196 RGD:1624291
RGD:1600115
G Rnf7 ring finger protein 7 JBrowse link 8 104,326,719 104,336,098 RGD:13792537
G Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:1624291
RGD:13792537
G Rnft1 ring finger protein, transmembrane 1 JBrowse link 10 73,807,455 73,821,178 RGD:1600115
RGD:1624291
G Sh3rf1 SH3 domain containing ring finger 1 JBrowse link 16 32,062,425 32,227,526 RGD:1600115
RGD:1624291
G Sh3rf2 SH3 domain containing ring finger 2 JBrowse link 18 36,371,041 36,471,020 RGD:1600115
RGD:1624291
G Sh3rf3 SH3 domain containing ring finger 3 JBrowse link 20 28,355,671 28,720,020 RGD:1600115
RGD:1624291
G Shprh SNF2 histone linker PHD RING helicase JBrowse link 1 5,240,139 5,313,064 RGD:1624291
RGD:13792537
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link 19 21,372,163 21,395,773 RGD:1624291
RGD:13792537
G Siah2 siah E3 ubiquitin protein ligase 2 JBrowse link 2 148,874,151 148,891,900 RGD:13792537
RGD:1624291
RGD:1600115
G Siah3 siah E3 ubiquitin protein ligase family member 3 JBrowse link 15 57,505,449 57,568,743 RGD:13792537
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:1624291
RGD:13792537
RGD:1600115
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:1624291
RGD:13792537
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
RGD:13792537
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:13792537
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:1624291
RGD:13792537
G Tmem129 transmembrane protein 129 JBrowse link 14 82,350,734 82,356,084 RGD:1624291
RGD:13792537
G Topors TOP1 binding arginine/serine rich protein JBrowse link 5 56,554,956 56,566,503 RGD:1624291
RGD:13792537
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
RGD:1600115
G Traip TRAF-interacting protein JBrowse link 8 116,730,170 116,750,528 RGD:1624291
RGD:1600115
G Trim11 tripartite motif-containing 11 JBrowse link 10 45,322,199 45,335,030 RGD:1624291
RGD:1600115
G Trim2 tripartite motif-containing 2 JBrowse link 2 183,145,096 183,223,819 RGD:1624291
RGD:13792537
G Trim24 tripartite motif-containing 24 JBrowse link 4 65,632,278 65,684,746 RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1600115
RGD:1624291
G Trim27 tripartite motif-containing 27 JBrowse link 17 45,613,863 45,626,212 RGD:1624291
G Trim3 tripartite motif-containing 3 JBrowse link 1 170,441,662 170,464,341 RGD:1624291
RGD:13792537
RGD:1600115
G Trim32 tripartite motif-containing 32 JBrowse link 5 81,431,554 81,449,023 RGD:1624291
RGD:13792537
G Trim37 tripartite motif-containing 37 JBrowse link 10 74,436,165 74,568,636 RGD:1624291
RGD:1600115
G Trim58 tripartite motif-containing 58 JBrowse link 10 44,271,587 44,282,726 RGD:1624291
RGD:1600115
G Trim59 tripartite motif-containing 59 JBrowse link 2 165,629,903 165,641,751 RGD:1624291
RGD:1600115
G Trim6 tripartite motif containing 6 JBrowse link 1 169,410,084 169,423,305 RGD:1624291
RGD:1600115
G Trim63 tripartite motif containing 63 JBrowse link 5 152,533,362 152,547,138 RGD:1624291
G Trim71 tripartite motif containing 71 JBrowse link 8 122,553,015 122,604,787 RGD:1624291
RGD:13792537
G Trim72 tripartite motif containing 72 JBrowse link 1 199,450,042 199,457,902 RGD:1624291
RGD:1600115
G Ube2o ubiquitin-conjugating enzyme E2O JBrowse link 10 105,505,721 105,553,167 RGD:1624291
RGD:13792537
G Ube3a ubiquitin protein ligase E3A JBrowse link 1 116,586,901 116,678,161 RGD:1624291
RGD:1600115
G Ube3d ubiquitin protein ligase E3D JBrowse link 8 93,948,689 94,120,477 RGD:1624291
RGD:13792537
G Ube4a ubiquitination factor E4A JBrowse link 8 49,229,713 49,271,894 RGD:1624291
G Ube4b ubiquitination factor E4B JBrowse link 5 166,156,033 166,259,069 RGD:1624291
G Ubox5 U-box domain containing 5 JBrowse link 3 123,130,249 123,171,875 RGD:1624291
RGD:13792537
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 JBrowse link 9 16,003,058 16,080,152 RGD:1624291
RGD:13792537
G Ubr3 ubiquitin protein ligase E3 component n-recognin 3 JBrowse link 3 56,125,927 56,283,908 RGD:1624291
RGD:13792537
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:625681
RGD:1624291
RGD:10047284
G Ubr7 ubiquitin protein ligase E3 component n-recognin 7 (putative) JBrowse link 6 126,636,596 126,656,513 RGD:1600115
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:1624291
RGD:13792537
RGD:1600115
G Uhrf2 ubiquitin like with PHD and ring finger domains 2 JBrowse link 1 248,228,496 248,291,984 RGD:1624291
RGD:13792537
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:1624291
RGD:13792537
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 5 33,608,489 33,696,487 RGD:1624291
RGD:13792537
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 19 39,543,246 39,614,624 RGD:1624291
RGD:13792537
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:1624291
RGD:13792537
G Zfp598 zinc finger protein 598 JBrowse link 10 14,035,114 14,047,100 RGD:1624291
G Znrf1 zinc and ring finger 1 JBrowse link 19 43,750,205 43,834,962 RGD:1624291
RGD:1600115
G Znrf2 zinc and ring finger 2 JBrowse link 4 85,009,350 85,090,914 RGD:1624291
RGD:1600115
G Znrf4 zinc and ring finger 4 JBrowse link 9 10,535,340 10,536,528 RGD:13792537
G Zswim2 zinc finger, SWIM-type containing 2 JBrowse link 3 71,274,341 71,295,641 RGD:1624291
RGD:1600115
ubiquitin-ubiquitin ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
RGD:1600115
G Anapc11 anaphase promoting complex subunit 11 JBrowse link 10 109,774,779 109,785,877 RGD:1624291
G Ppil2 peptidylprolyl isomerase like 2 JBrowse link 11 88,147,342 88,169,968 RGD:1624291
RGD:13792537
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
RGD:1600115
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:1624291
RGD:1600115
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
RGD:1600115
G Ube2k ubiquitin-conjugating enzyme E2K JBrowse link 14 44,289,247 44,348,691 RGD:1624291
RGD:1600115
G Ube4a ubiquitination factor E4A JBrowse link 8 49,229,713 49,271,894 RGD:1600115
RGD:13792537
RGD:1624291
G Ube4b ubiquitination factor E4B JBrowse link 5 166,156,033 166,259,069 RGD:1624291
RGD:13792537
G Ubox5 U-box domain containing 5 JBrowse link 3 123,130,249 123,171,875 RGD:1624291
RGD:13792537
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:1624291
RGD:1600115

Term paths to the root
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Term Annotations click to browse term
  molecular_function 18263
    catalytic activity 5790
      transferase activity 2294
        ubiquitin-like protein transferase activity 403
          ubiquitin-protein transferase activity 381
            ubiquitin protein ligase activity 223
              ubiquitin-ubiquitin ligase activity 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.