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Gene: UBR5 (ubiquitin protein ligase E3 component n-recognin 5) Homo sapiens
Symbol: UBR5
Name: ubiquitin protein ligase E3 component n-recognin 5
Description: Exhibits ubiquitin-ubiquitin ligase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of protein import into nucleus; and progesterone receptor signaling pathway. Localizes to several cellular components, including the cytosol; nucleoplasm; and perinuclear region of cytoplasm. Implicated in invasive ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DD5; E3 identified by differential display; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; EDD; EDD1; FLJ11310; HECT-type E3 ubiquitin transferase UBR5; hHYD; HYD; hyperplastic discs protein homolog; KIAA0896; MGC57263; progestin induced protein; progestin-induced protein; ubiquitin-protein ligase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8102,252,273 - 102,412,759 (-)Ensembl
GRCh388102,252,273 - 102,412,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,264,501 - 103,424,947 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,334,745 - 103,493,671 (-)NCBINCBI36hg18NCBI36
Celera899,450,466 - 99,609,463 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef898,463,202 - 98,623,328 (-)NCBIHuRef
CHM1_18103,304,790 - 103,465,221 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on UBR5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605385
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.