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Gene: HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) Homo sapiens
Symbol: HUWE1
Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Description: Exhibits ubiquitin-protein transferase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of protein ubiquitination; and protein ubiquitination. Localizes to the cytosol and nucleoplasm. Implicated in syndromic X-linked intellectual disability Turner type.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARF binding protein 1; ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; E3 ubiquitin-protein ligase HUWE1; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; HECTH9; homologous to E6AP carboxyl terminus homologous protein 9; HSPC272; Ib772; KIAA0312; large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; MRXST; MULE; upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; UREB1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX53,532,096 - 53,686,728 (-)Ensembl
GRCh38X53,532,096 - 53,686,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,559,057 - 53,713,697 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,576,476 - 53,697,776 (-)NCBINCBI36hg18NCBI36
CeleraX57,390,630 - 57,545,232 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX50,615,901 - 50,769,910 (-)NCBIHuRef
CHM1_1X53,550,037 - 53,704,948 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants