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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin D3 25-hydroxylase activity
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Accession:GO:0030343 term browser browse the term
Definition:Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.
Synonyms:exact_synonym: cholecalciferol 25-hydroxylase activity
 xref: MetaCyc:RXN-9829;   RHEA:32903;   Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D";   reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D"


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vitamin D3 25-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 enables ISO
IEA
IBA		 RGD
Ensembl
GO_Central		 PMID:2175615 GO_REF:0000033 GO_REF:0000107 RGD:1299597 NCBI chr15:120,809,886...120,852,196
Ensembl chr15:120,809,959...120,852,192 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 enables IEA RHEA GO_REF:0000116 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:44,375,432...44,394,122
Ensembl chr 2:44,375,520...44,396,334 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18690
    catalytic activity 5667
      oxidoreductase activity 736
        monooxygenase activity 128
          vitamin D 25-hydroxylase activity 4
            vitamin D3 25-hydroxylase activity 3
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